• Solitary fibrous tumors (SFTs) must be carefully distinguished from other entities, such as synovial sarcoma and angiosarcoma, which have a worse prognosis and different treatment course. (medscape.com)
  • Lymph node involvement was observed in 13 patients (N1, 23%), regarded as metastatic spreading in 4 angiosarcomas, 3 epithelioid sarcomas, 2 leiomyosarcomas, 2 undifferentiated sarcomas and 2 synovial sarcomas. (jcancer.org)
  • Synovial sarcoma is a high-grade soft tissue malignancy, for which current cytotoxic chemotherapies provide limited benefit. (nature.com)
  • Although histone deacetylase (HDAC) inhibitors are known to suppress synovial sarcoma in vitro and in vivo , the exact mechanism is not clear. (nature.com)
  • In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. (nature.com)
  • The SS18-SSX oncoprotein, characteristic of synovial sarcoma, maintains EGR1 expression at low levels, whereas it is significantly increased after HDAC inhibitor treatment. (nature.com)
  • Using a combination of gain- and loss-of-function approaches, we show that EGR1 modulation of PTEN contributes to HDAC inhibitor-induced apoptosis in synovial sarcoma. (nature.com)
  • Finally, restoration of EGR1 or PTEN expression is sufficient to induce synovial sarcoma cell death. (nature.com)
  • Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
  • 2008). Molecular characterization of synovial sarcoma in children and adolescents: evidence of akt activation. (nature.com)
  • The SYT protein involved in the t(X;18) synovial sarcoma translocation is a transcriptional activator localised in nuclear bodies. (nature.com)
  • NKX2.2 immunohistochemistry in the distinction of Ewing sarcoma from cytomorphologic mimics: Diagnostic utility and pitfalls. (nih.gov)
  • Usefulness of NKX2.2 Immunohistochemistry for Distinguishing Ewing Sarcoma from Other Sinonasal Small Round Blue Cell Tumors. (nih.gov)
  • Evaluation of NKX2-2 expression in round cell sarcomas and other tumors with EWSR1 rearrangement: imperfect specificity for Ewing sarcoma. (nih.gov)
  • NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma. (nih.gov)
  • The tumor which bears his name is generally referred to as Ewing's sarcoma when spoken and either Ewing's sarcoma or Ewing sarcoma when written. (sarcomahelp.org)
  • Pathologists have long known that Ewing sarcoma looks very similar to an even rarer soft tissue tumor called primitive neuroectodermal tumor ( PNET ). (sarcomahelp.org)
  • She continued her studies at the University of Aberdeen where she was awarded a Master of Science degree in Medical Physics in 1977 for research on the disruption of iron metabolism in laboratory rats with Yoshida sarcomas. (wikipedia.org)
  • Disruption of iron metabolism in rats with Yoshida sarcomas (MSc thesis). (wikipedia.org)
  • In previous reports, Prasad and Shethna (4,5) suggested that these proteins have antitumoral activity against Yoshida ascites sarcoma in rats (4) and enhance the immune response to sheep red blood cells (5). (scielo.br)
  • The biopsy should be placed in line with the incision for definitive tumor resection to allow en-bloc resection of the biopsy tract. (medscape.com)
  • Subsequently, these two tumors have been grouped into a class of cancers entitled Ewing's Sarcoma Family of Tumor (ESFT), all of which demonstrate this translocation. (sarcomahelp.org)
  • Crettenand F, Martin D, Cherix S, Demartines N, Matter M. Occurrence and prognosis of lymph node metastases in patients selected for isolated limb perfusion with soft tissue sarcoma. (jcancer.org)
  • Kure S, Yoshie O: A syngeneic monoclonal antibody to murine Meth-A sarcoma (HepSS-1) recognizes heparan sulfate glycosaminoglycan (HS-GAG): cell density and transformation dependent alteration in cell surface HS-GAG defined by HepSS-1. (exbio.cz)
  • In fact, PD-1 deficiency results in spontaneous autoimmunity in murine models of Type 1 diabetes and systemic lupus erythematosus [14,17-25]. (studylib.net)
  • Lysosome purinergic receptor P2X4 regulates neoangiogenesis induced by microvesicles from sarcoma patients. (ucsd.edu)
  • Conventional HPCs and SFTs have a better prognosis than some older studies may suggest, in that these studies may have inadvertently included sarcomas with HPC-like features. (medscape.com)
  • Approximately 1%-2% of solid tumors are soft-tissue sarcomas, and leiomyosarcomas comprise roughly 2%-9% of these sarcomas. (medscape.com)
  • 4] Demicco et al, in a study comparing five such models designed for soft-tissue and/or pleural SFT-(1) modified Demicco, (2) Pasquali, (3) Salas overall survival (OS), (4) Salas metastasis, and (5) Salas local recurrence (LR)-in 303 patients with extrameningeal SFT found that models (1), (3), and (4) models predicted metastasis and recurrence-free survival and that model (2) correlated best with overall survival. (medscape.com)
  • Tumors in the Ewing's family of sarcomas are made of primitive cells, which are cells that haven't yet decided what type of cell they are. (sarcomahelp.org)
  • Furthermore, upregulation of PD-L1 by cancer cells results in cancer invasion and correlates with poor prognostic outcomes in breast, gastric, meningioma, non-small-cell lung carcinoma (NSCLC) and soft-tissue sarcoma patients [9,26-29]. (studylib.net)
  • Therapeutic targeting of P2X4 receptor and mitochondrial metabolism in clear cell renal carcinoma models. (ucsd.edu)
  • This is in contrast to other soft tissue sarcomas in which the lung is the most common site of metastasis. (medscape.com)
  • The family and friends of Michael Lio have raised more than $100,000 for Ewing's sarcoma research in his memory. (sarcomahelp.org)
  • The family and friends of Nicholas Theodore Strub have raised more than $17,000 for Ewing's sarcoma research in his memory. (sarcomahelp.org)
  • Various risk models have been proposed in an effort to predict outcome in patients with SFT. (medscape.com)
  • Extensive surgery is often required for advanced soft tissue sarcoma (STS) of the limb. (jcancer.org)
  • Soft tissue sarcomas (STS) are tumours arising from connective tissues, with an incidence of about 5 per 100'000 [ 1 ]. (jcancer.org)
  • Primary gastrointestinal (GI) sarcomas in general are a very rare entity, accounting for 1%-2% of GI malignancies. (medscape.com)
  • Despite an increasing interest for radical lymph node dissection as part of treatment for sarcomas, there is currently no study on a standardized population in which radical lymph node dissection was performed systematically. (jcancer.org)
  • Experimentally induced neoplasms of CONNECTIVE TISSUE in animals to provide a model for studying human SARCOMA. (curehunter.com)
  • Among the extracellular matrix compounds used in this study, two (collagen I and fibronectin) allowed only a weak attachment of cortical neurons to the substratum, while the others (collagen IV, laminin, and basal lamina from Engelbreth-Holm-Swarm sarcoma) allowed both firm attachment and moderate to extensive neurite outgrowth from neuronal cell bodies. (curehunter.com)
  • Molecular characterization of canine SHP2 mutants and anti-tumour effect of SHP2 inhibitor, SHP099 , in a xenograft mouse model of canine histiocytic sarcoma. (go.jp)
  • Chihara G, Maeda Y, Hamuro J, Sasaki T, Fukuoka F. Inhibition of mouse sarcoma 180 by polysaccharides from Lentinus edodes (Berk. (neoplasiaresearch.com)
  • Drs. Gabriela Mercado and Frederic Barr of the University of Pennsylvania present an excellent discussion of chromosomal translocations in sarcomas elsewhere on this site. (sarcomahelp.org)
  • A study of the redox properties of haem in proteins and model systems. (wikipedia.org)