AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceHealth Care
Lactic AcidLactobacillusLactobacillaceaeLactobacillalesLeuconostocPediococcusFermentationLactatesLactobacillus plantarumLactococcusLactococcus lactisFood MicrobiologyLactobacillus acidophilusHydrogen-Ion ConcentrationLactobacillus brevisLactobacillus delbrueckiiStreptococcus thermophilusLactobacillus caseiBifidobacteriumStreptococcaceaeProbioticsAcidosis, LacticCheeseBreadBacteriocinsAcetic AcidLactobacillus fermentumAntibiosisRNA, Ribosomal, 16SCultured Milk ProductsFood PreservationStreptococcusIndustrial MicrobiologyWeissellaFood PreservativesCulture MediaL-Lactate DehydrogenaseWineGlucoseOenococcusGram-Positive Asporogenous RodsMonocarboxylic Acid TransportersDNA, BacterialDNA, RibosomalColony Count, MicrobialMeat ProductsNisinLactobacillus reuteriSilageGram-Positive CocciAcidosisAcidsYogurtFood PackagingMolecular Sequence DataSequence Analysis, DNALactate DehydrogenasesCarbohydrate MetabolismCarboxylic AcidsFood HandlingAnaerobiosisPhylogenySodium AcetateBacteriaWaste ProductsCacaoAerobiosisFatty Acids, VolatileGlycolysisSodium LactateMilkHydrochloric AcidPolymersBioreactorsLactobacillus helveticusDenaturing Gradient Gel ElectrophoresisAcetobacterRefrigerationFlourFood StorageCitric AcidTemperatureCarbon DioxideFood IndustryBacterial ProteinsFormatesTime FactorsSpecies SpecificityRumenFructosePyruvatesEnterococcus faecalisButanonesReticulumBiodegradable PlasticsPropionibacteriumAcetatesGram-Positive BacteriaStreptococcus mutansBiotechnology
Higher risk of lactic acidosisSerum Lactic AcidEvidence of hypoperfusionAnaerobicBicarbonateBacteriaAcidosis dueHypoperfusionAcidemiaGlucoseMetabolicAccumulationBody'sPyruvateFermentationLactate DehydrogenasePhysical exertionResuscitation7.35MetabolismAnionIncreasesOrganicFatty acidsSevereMitochondrialAerobicBloodConjugateRisk FactorsTypically occursCliniciansRenalHepaticProductionCholesterolLiverRespiratoryFluidMortalityIntenseLevelsGenerateExcessive
Higher risk of lactic acidosis1
Serum Lactic Acid2
  • Serum lactic acid (LA) levels were measured at arrival and at proscribed intervals. (nih.gov)
  • Serum lactic acid following aneurysmal subarachnoid hemorrhage is a marker of disease severity but is not associated with hospital outcomes. (neurologyadvisor.com)
Evidence of hypoperfusion1
  • Lactic acid: 21.2mmol/L, blood pH: 7.2, Anion Gap: 34, K+: 5.0mEq/L, and PO4-: 5.9mg/dL, LDH 2212 U/L, CPK 55 U/L. Elevated lactic acid without evidence of hypoperfusion and his electrolytic disturbances suggest rapid destruction of tumor cells by rituximab leading to CRS. (asn-online.org)
Anaerobic4
  • This point is called your anaerobic threshold (usually at around 4,0 mmol/L). (suunto.com)
  • Since lactic acid is a product of anaerobic metabolism, lactate levels rise and exceed the rate at which lactic acid can be cleared by the liver and kidneys. (vin.com)
  • The Impact of Elevated Lactic Acid Levels When lactic acid levels exceed 2mmol/L, it indicates a reliance on anaerobic energy sources due to the intensity of physical exertion. (isotekindo.co.id)
  • The carbohydrates present in the diet are the main energy source in an anaerobic process (mainly lactic fermentation) resulting in the production of organic acids. (bvsalud.org)
Bicarbonate4
  • ABGs reveal a pH of 7.46, partial pressure of carbon dioxide (pCO2) of 44.6 mm Hg, partial pressure of oxygen (pO2) of 94.7 mm Hg, and bicarbonate of 31.4 mmol/L. (medpagetoday.com)
  • If it does not resolve, then look for other potential Choice A, B and C: Use of bicarbonate in the treatment of lactic acidosis is very controversial and is recommended only in severe acute acidosis with pH (diabetestalk.net)
  • Primary metabolic acidoses that occur as a result of a marked increase in endogenous acid production (eg, lactic or keto acids) or progressive accumulation of endogenous acids when excretion is impaired by renal insufficiency are characterized by decreased plasma bicarbonate concentration and increased anion gap without hyperchloremia. (medscape.com)
  • The kidneys maintain acid-base balance by bicarbonate reclamation and acid excretion. (medscape.com)
Bacteria3
Acidosis due2
  • For example, having lactic acidosis due to sepsis means the doctor will take a targeted approach to managing sepsis. (healthnews.com)
  • Type B lactic acidosis - Due to drug- or toxin-induced impairment of cellular metabolism, ischemia, nutritional deficient state, or rarely malignancy. (logicalimages.com)
Hypoperfusion1
  • Type A lactic acidosis - Associated with tissue hypoperfusion caused by circulatory failure from shock, which can be due to many things including sepsis, heart failure, hypovolemia, neurologic compromise, or respiratory failure. (logicalimages.com)
Acidemia4
  • Patients with aneurysmal subarachnoid hemorrhage often present with early lactic acidemia, which is associated with both the clinical and radiographic grade of hemorrhage, according to a study published in Frontiers of Neurology . (neurologyadvisor.com)
  • The primary study objective was to determine the incidence rate of lactic acidemia when patients were admitted. (neurologyadvisor.com)
  • The study also sought to determine whether patient outcomes, including delayed cerebral ischemia, mortality, discharge disposition, and vasospasm, were partially dependent on admission lactic acidemia. (neurologyadvisor.com)
  • Methylmalonic acidemia is an autosomal recessive disorder of amino acid metabolism, involving a defect in the conversion of methylmalonyl-coenzyme A (CoA) to succinyl-CoA. (medscape.com)
Glucose8
Metabolic5
  • It is a form of metabolic acidosis, in which excessive acid accumulates due to a problem with the body's oxidative metabolism. (wikipedia.org)
  • Respiratory acidosis is often present, but can be veiled by the mixed acid-base disorder created by other aspects of GDV (metabolic acidosis created by increased lactate vs. metabolic alkalosis created by sequestration of H + ions in the gastric lumen). (vin.com)
  • 4 mmol/L. It is the most common cause of metabolic acidosis and can be associated with an anion gap metabolic acidosis or mixed acid-base disorder. (logicalimages.com)
  • Because of slow metabolism of D-lactic acid, systemic absorption leads to elevated plasma D-lactic acid levels and metabolic acidosis. (logicalimages.com)
  • The Role of Lactic Acid in Muscle Function Initially viewed as a metabolic byproduct, lactic acid was believed to solely contribute to muscle fatigue and post-exercise cramping. (isotekindo.co.id)
Accumulation3
  • The onset of acidosis during periods of vigorous exercise is usually due to the accumulation of hydrogen separated from lactic acid. (e-jer.org)
  • The term congenital lactic acidosis (CLA) refers to a group of inborn errors of mitochondrial metabolism variably characterised by progressive neuromuscular deterioration and accumulation of lactate and hydrogen ions in blood, urine and/or cerebrospinal fluid, frequently resulting in early death. (bmj.com)
  • Some authors suggest that the accumulation of methylmalonic acid and odd-chain fatty acids may be directly toxic to neuronal and glial cells. (medscape.com)
Body's1
Pyruvate3
  • In hypoxic conditions, LDH can convert pyruvate to lactic acid to support tumor cells [ 12 ]. (hindawi.com)
  • Lactate dehydrogenase (LDH) catalyzes the conversion of lactic acid to pyruvate. (e-jer.org)
  • 2 4 A few cases have been reported that involve deficiencies in enzymes of the tricarboxylic acid cycle, such as fumarase, or of gluconeogenesis, such as pyruvate carboxylase (PC) or phosphoenolpyruvate carboxykinase (PEPCK). (bmj.com)
Fermentation1
Lactate Dehydrogenase1
  • By day 6, creatinine kinase and lactic acid are normal, and there are elevations in lactate dehydrogenase (312 units/L), ferritin (767 ng/mL), and interleukin-6 (52 pg/mL). (medpagetoday.com)
Physical exertion1
  • 7.35, lactate ≤11.8 mmol/L) as a result of physical exertion during induction improved during anesthesia. (vin.com)
Resuscitation1
  • In the prospective study, patients with two consecutive LA levels greater than 2.5 mmol/L underwent invasive monitoring and vigorous resuscitation to correct their lactic acidosis. (nih.gov)
7.351
  • A diagnosis is confirmed when the blood PH and lactate levels are lower than 7.35 and higher than 5 mmol/L, respectively. (healthnews.com)
Metabolism7
  • The human metabolism produces about 20 mmol/kg of lactic acid every 24 hours. (wikipedia.org)
  • In "type A" lactic acidosis, the production of lactate is attributable to insufficient oxygen for aerobic metabolism. (wikipedia.org)
  • Lactic acidosis is a medical condition driven by heightened levels of lactic acid in the bloodstream caused by an inadequate supply of oxygen to the body tissue or an altered metabolism mediated by drugs or toxins. (healthnews.com)
  • On the other hand, lactic acidosis type B is a rare type resulting from altered metabolism by drugs or toxins. (healthnews.com)
  • Ammonia is biosynthesized through normal amino acid metabolism and is toxic at high concentrations. (e-jer.org)
  • reference interval 0.8-2.0 mmol/L). As other causes of encephalopathy and hyperlactatemia were ruled out, an inborn error of lactate metabolism was suspected. (huji.ac.il)
  • Loss of glomerular function (associated with decreased glomerular filtration rate [GRF]) results in the retention of many end products of metabolism, including the anions of various organic and inorganic acids and urea. (medscape.com)
Anion2
Increases3
  • As the intensity increases, lactic acid starts to build in your muscles. (suunto.com)
  • As exercise intensity increases, lactic acid is produced to buffer muscle acidity and reduce fatigue. (spotmebro.com)
  • Lactic acid treatment reduces the production of pro-inflammatories and increases the production of anti-inflammatories in the body. (healthnews.com)
Organic1
  • Quantitative organic acid analysis showed marked elevations of urine lactic acid, pyruvic acid and gamma-hydroxybutyric acid (or 4-hydroxybutyric acid) concentrations. (huji.ac.il)
Fatty acids4
  • In vivo oxidation rates of systemically infused medium-chain fatty acids were evaluated using neonatal pigs. (ncsu.edu)
  • Unanesthetized piglets (1.6 kg, n = 20) were housed in respiration chambers for total collection of expired CO2 and were continuously infused with [1-14C]-7:0, 8:0, 9:0 or 10:0 fatty acids via a central catheter. (ncsu.edu)
  • The fatty acids were administered at rates of 25, 50 or 100 μmol/min for 5 h and provided 74 kBq of 14C per h. (ncsu.edu)
  • The various fatty acids were oxidized equally well, regardless of chain length, and satisfied up to 60 to 70% of the animals’ energy requirements, depending on the rate of infusion. (ncsu.edu)
Severe2
  • We herein present a man with B-Cell lymphoma who became critically ill with severe lactic acidosis, altered mental status, and renal failure within minutes of receiving his first rituximab dose. (asn-online.org)
  • This report describes a case of severe lactic acidosis associated with a suspected succinic semialdehyde dehydrogenase (SSADH) deficiency in a 5-month-old Chihuahua. (huji.ac.il)
Mitochondrial3
  • In rare chronic forms of lactic acidosis caused by mitochondrial disease, a specific diet or dichloroacetate may be used. (wikipedia.org)
  • A number sign (#) is used with this entry because of evidence that mitochondrial neurodevelopmental disorder with abnormal movements and lactic acidosis and with or without seizures (NEMMLAS) is caused by homozygous or compound heterozygous mutation in the WARS2 gene ( 604733 ) on chromosome 1p12. (diabetestalk.net)
  • Lactic acidosis typically occurs when lactic acid production exceeds clearance, often in the setting of impaired tissue oxygenation and defective mitochondrial oxygenation. (logicalimages.com)
Aerobic3
  • In training terminology this is your aerobic threshold (usually marked at 1,5-2,0 mmol/L). (suunto.com)
  • As you can see from the graph below, when you're using your aerobic energy system at rest, you don't accumulate excess hydrogen or lactic acid. (spotmebro.com)
  • During aerobic exposure, treatment of HMEC with BS seemed to reduce the disappearance of water-soluble carbohydrates, whereas Ecosyl seemed to reduce lactic acid. (ncsu.edu)
Blood11
  • During light or moderate efforts the energy is supplied by the oxidative system, burning fat and carbs, and your blood lactate levels remain the same as at rest (0,8-1,5 mmol/L). (suunto.com)
  • Lactic acidosis is caused by elevated levels of lactic acid in the blood due to several factors used to characterize the two types of lactic acidosis: type A and type B. Lactic acidosis type A is a common type resulting from an inadequate supply of oxygen to the blood tissue. (healthnews.com)
  • In conclusion, mild to moderate alterations in arterial blood gases and acid-base balance were identified in anesthetized brown bears. (vin.com)
  • The measurement of lactic acid levels in cases of lactic acidosis can be conveniently and effectively conducted using a reliable Point of Care Test (POCT) tool called THE EDGE ™ Blood Lactate Monitoring System. (isotekindo.co.id)
  • This system is capable of examining the lactic acid profile in the blood and is suitable for individuals with conditions such as diabetes mellitus, asthma, sepsis, and chronic obstructive pulmonary disease. (isotekindo.co.id)
  • The broad measuring range of THE EDGE ™ Blood Lactate Monitoring System facilitates comprehensive monitoring of lactic acid levels in both low and high conditions. (isotekindo.co.id)
  • This system provides a quick reading of lactic acid profiles in the blood, enabling prompt decision-making for subsequent actions. (isotekindo.co.id)
  • With a minimal sample requirement of whole blood (3µL), THE EDGE ™ Blood Lactate Monitoring System accurately depicts the lactic acid profile, minimizing discomfort associated with blood sample collection. (isotekindo.co.id)
  • Guidelines from the American Diabetes Association recommended blood sugar levels before meals should be between 70 to 130 mg/dL (4.0 to 7.0 mmol/L). (lesliebeck.com)
  • Lactic acidosis is a pathological condition that develops with a persistent increase in the level of lactic acid in the blood to 5 mmol / l or more. (medic-journal.com)
  • Portal blood samples were drawn from umbilical vein catheters for determination of 3-hydroxy-butyrate and plasma fatty acid concentrations. (ncsu.edu)
Conjugate1
  • Unlike other species, cats conjugate bile acids almost exclusively with taurine and do not substitute glycine for taurine when taurine availability becomes limited (Rabin et al. (ncsu.edu)
Risk Factors1
  • Older age, low oxygen saturation and elevated respiratory rate on admission, and initial lab derangements including renal and hepatic dysfunction and elevated procalcitonin and lactic acid are risk factors for in-hospital death. (wustl.edu)
Typically occurs1
Clinicians2
  • Clinicians order a rapid nucleic acid amplification test for influenza A and B, which is negative. (medpagetoday.com)
  • According to the investigators, levels of admission lactic acid "may help clinicians identify potentially reversible pathophysiologic processes, including hypovolemia. (neurologyadvisor.com)
Renal1
  • An increased AG is associated with renal failure, ketoacidosis, lactic acidosis, and ingestion of certain toxins. (medscape.com)
Hepatic2
  • this caused by accelerated production of lactic acid in muscle and reduced hepatic lactate uptake however this post ictal lactic acidosis is transeint and resloves without treatment within 60 to 90 min so best intervention is to observe with 60 to 90 min. (diabetestalk.net)
  • This is caused by accelerated production of lactic acid in muscle and reduced hepatic lactate uptake. (diabetestalk.net)
Production1
  • LACTIC ACID is used frequently in the cosmetic industry due to the effect of promoting collagen production, helping to firm the skin against wrinkles and sagging. (atamankimya.com)
Cholesterol1
Liver2
  • Although comorbidities such as liver, kidney, and heart diseases are strongly associated with lactic acidosis, trauma or adverse reaction to medication can also contribute to the development of lactic acidosis. (healthnews.com)
  • People who have uncontrolled diabetes, or liver, kidney, or heart diseases are at a higher risk of developing lactic acidosis than those without these comorbidities. (healthnews.com)
Respiratory2
  • Reducing equivalents (NADH, FADH 2 ) are generated by reactions catalysed by the PDC and the tricarboxylic acid cycle and donate electrons (e - ) that enter the respiratory chain at NADH ubiquinone oxidoreductase (complex I) or at succinate ubiquinone oxidoreductase (complex II). (bmj.com)
  • This compensates for the respiratory and lactic acidosis that develops during the apneic phase. (medscape.com)
Fluid1
  • Laboratory investigations this time showed elevated inflammatory markers with normal AST 18(U/L), ALT 44 (U/L), amylase 8 (U/L), lipase 39 (U/L) and lactic acid 2.2 (mmol/L). PD fluid WBC count was high and consistent with neutrophilic PD peritonitis (neutrophils 86%) (Table 1). (clinnephrologyjournal.com)
Mortality1
  • Initial lactic acidosis is associated with lower cardiac performance and higher morbidity and mortality. (nih.gov)
Intense2
Levels4
Generate1
  • Lactic acid is used by the body to generate ATP - the energy currency used by your cells. (spotmebro.com)
Excessive1