• Fass environmental information for Novantrone (mitoxantrone) (downloaded 2019-04-25). (janusinfo.se)
  • The addition of mitoxantrone (Novantrone) to interferon beta-1b (IFN beta-1b, Betaseron) therapy for the treatment of patients with aggressive multiple sclerosis (MS) unresponsive to standard therapy may reduce the number of new enhancing lesions as well as life-threatening risks associated with mitoxantrone therapy. (psychiatrictimes.com)
  • Tell your doctor and pharmacist if you are taking or have ever received certain cancer chemotherapy medications such as daunorubicin (Cerubidine), doxorubicin (Doxil), epirubicin (Ellence), or idarubicin (Idamycin), or if you have ever been treated with mitoxantrone in the past. (medlineplus.gov)
  • Cyclophosphamide and fluorouracil combined with mitoxantrone versus doxorubicin for breast cancer: superiority of doxorubicin. (mcmaster.ca)
  • Mitoxantrone has activity similar to that of doxorubicin, is less cardiotoxic, and is widely used to treat prostate cancer. (elsevierpure.com)
  • Mitoxantrone should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. (medlineplus.gov)
  • Mitoxantrone may increase your risk for developing leukemia (cancer of the white blood cells), especially when it is given in high doses or together with certain other chemotherapy medications. (medlineplus.gov)
  • Chemotherapy with mitoxantrone plus prednisone or prednisone alone for symptomatic hormone-resistant prostate cancer: a Canadian randomized trial with palliative end points. (mcmaster.ca)
  • Despite aggressive chemotherapy including mitoxantrone and etoposide, relapse occurs for almost half of children with acute myeloid leukemia (AML). (oncotarget.com)
  • The subject product, Mitoxantrone Hydrochloride, is indicated for use as an antineoplastic drug. (faqs.org)
  • The applicable subheading for Mitoxantrone Hydrochloride, imported in bulk form, will be 2922.50.2500 , Harmonized Tariff Schedule of the United States (HTS), which provides for "Oxygen-function amino-compounds: Amino-alcohol-phenols, amino-acid-phenols and other amino compounds with oxygen function: Aromatic: Other: Drugs: Other: Other. (faqs.org)
  • Mitoxantrone is a member of the antibiotics/antineoplastics drug class and is commonly used for Acute Nonlymphocytic Leukemia, Mantle Cell Lymphoma, Multiple Sclerosis, and others. (drugs.com)
  • Therapeutic effect of mitoxantrone combined with methylprednisolone in multiple sclerosis: a randomised multicentre study of active disease using MRI and clinical criteria. (bmj.com)
  • OBJECTIVE: To evaluate the efficiency of mitoxantrone in multiple sclerosis. (bmj.com)
  • METHODS: Forty two patients with confirmed multiple sclerosis, selected as having a very active disease on clinical and MRI criteria were randomised to receive either mitoxantrone (20 mg intravenously (IV) monthly) and methylprednisolone (1 g iv monthly) or methylprednisolone alone over six months. (bmj.com)
  • CONCLUSION: In this selected group of patients with multiple sclerosis with very active disease, mitoxantrone combined with methylprednisolone was effective in improving both clinical and MRI indices of disease activity over a period of six months whereas methylprednisolone alone was not. (bmj.com)
  • The primary use for mitoxantrone is to treat multiple sclerosis . (medicalnewstoday.com)
  • The cost for mitoxantrone intravenous solution (2 mg/mL) is around $186 for a supply of 10 milliliters, depending on the pharmacy you visit. (drugs.com)
  • The combination of mitoxantrone and prednisone is approved as a second-line treatment for metastatic hormone-refractory prostate cancer. (wikipedia.org)
  • The current study sought to evaluate the toxicity and activity of mitoxantrone plus ketoconazole in a cohort of patients with hormone-refractory prostate cancer. (elsevierpure.com)
  • Mitoxantrone plus ketoconazole is well tolerated, is active in hormone-refractory prostate cancer, and should be studied further. (elsevierpure.com)
  • Determine the clinical effectiveness of bevacizumab, cytarabine, and mitoxantrone in patients with poor-risk hematologic malignancies. (knowcancer.com)
  • After mitoxantrone was added to the initial IFN beta-1b therapy, enhancing lesion frequency was reduced by an average of 90%, enhancing lesion volume decreased by 96%, and relapse rates decreased by 70% at month 7. (psychiatrictimes.com)
  • The combination of fludarabine/ mitoxantrone/dexamethasone (FND) has been a well-tolerated and effective regimen for the treatment of indolent lymphomas. (houstonmethodist.org)
  • Mitoxantrone is used to treat certain types of cancer, mostly acute myeloid leukemia. (wikipedia.org)
  • Mitoxantrone is used to treat leukemia and other cancers. (webmd.com)
  • Mitoxantrone injection is also used with other medications to treat certain types of leukemia. (medlineplus.gov)
  • When mitoxantrone injection is used to treat leukemia, you will continue to receive this medication based on your condition and how you respond to the treatment. (medlineplus.gov)
  • One of the drawbacks of mitoxantrone-and it has several-is that once a cumulative dose of 140 mg/m 2 has been reached, risk of leukemia and cardiotoxicity in the form of congestive heart failure emerges. (psychiatrictimes.com)
  • Because mitoxantrone (MTX) is a strong BCRP substrate and is often used in the treatment of leukemia, we investigated the effect of 24 h proadifen pre-treatment on the cytotoxicity of MTX in leukemic cell lines that are sensitive to MTX (HL-60) and MTX-resistant ABCG2-overexpressing subclone (cBCRP). (spandidos-publications.com)
  • Those studies showed that acute leukemia occurred in .07 percent to .25 percent of MS patients taking mitoxantrone. (scienceblog.com)
  • The potential risk of leukemia should be carefully considered against the potential benefits of mitoxantrone treatment on every single patient. (scienceblog.com)
  • It is vital that all MS patients treated with mitoxantrone undergo prolonged and careful hematological follow-up to check for acute leukemia," Martinelli said. (scienceblog.com)
  • When we added mitoxantrone to the therapeutic regimen of patients who were breaking through with IFN beta-1b, the disease activity measured by MRI in clinical parameters was remarkably diminished,' said Douglas Jeffery, MD, PhD, associate professor in neurology at Wake Forest University School of Medicine in Winston-Salem, North Carolina. (psychiatrictimes.com)
  • Because of the risk of cardiomyopathy, mitoxantrone carries a limit on the cumulative lifetime dose (based on body surface area) in MS patients. (wikipedia.org)
  • When Jeffery and colleagues combined mitoxantrone and IFN beta-1b therapies, symptoms and disease activity substantially declined in patients participating in a pilot trial. (psychiatrictimes.com)
  • Patients received 12 mg/m 2 mitoxantrone at month 3 and 5 mg/m 2 at months 4 and 5. (psychiatrictimes.com)
  • of these patients, about 30% are treated with mitoxantrone. (psychiatrictimes.com)
  • We use mitoxantrone in patients who have had an inadequate response to optimal immunomodulating therapy, whose MS is worsening, or in those who have extremely aggressive disease right from the onset,' said Jeffery. (psychiatrictimes.com)
  • Use of palliative end points to evaluate the effects of mitoxantrone and low-dose prednisone in patients with hormonally resistant prostate cancer. (mcmaster.ca)
  • In the mitoxantrone group there was a month by month decrease almost to zero in the number of new enhancing lesions, and in the total number of enhancing lesions, whereas both remained high in the steroid alone group. (bmj.com)
  • and problems with vision, speech, and bladder control), your doctor will also perform certain tests before each dose of mitoxantrone injection and yearly after you have completed your treatment. (medlineplus.gov)
  • After enrollment onto a multicenter local consortium study, subjects were treated with mitoxantrone at a dose of 12 mg/m 2 intravenously every 3 weeks plus continuous oral ketoconazole at a dose of 400 mg 3 times daily and ascorbic acid at a dose of 250 mg. (elsevierpure.com)
  • They also had a greater cumulative dose of mitoxantrone. (scienceblog.com)
  • Mitoxantrone injection may cause damage to your heart at any time during your treatment or months to years after your treatment has ended. (medlineplus.gov)
  • Your doctor will examine you and perform certain tests to check how well your heart is working before beginning treatment with mitoxantrone and if you show any signs of heart problems. (medlineplus.gov)
  • The results of Jeffery's study suggest that a longer duration of treatment with mitoxantrone may result in a greater reduction in disease activity. (psychiatrictimes.com)
  • Hepatic arterial infusion of mitoxantrone in the treatment of primary hepatocellular carcinoma. (mcmaster.ca)
  • Mitoxantrone is an immunosuppressant drug approved by the FDA for treatment of several forms of advancing MS. It is one of only two drugs that has been shown to benefit people with secondary progressive MS who are having attacks. (scienceblog.com)
  • The study participants all had at least one cycle of mitoxantrone treatment and were observed for at least one year. (scienceblog.com)
  • Further double blinded long term studies are needed to properly evaluate the effect of mitoxantrone on progression in disability. (bmj.com)
  • The combination of IFN beta-1b and mitoxantrone reduces these adverse effects, which are associated with mitoxantrone therapy, while effectively suppressing MS-associated inflammation, explained Jeffery. (psychiatrictimes.com)
  • Read the Medication Guide provided by your pharmacist before you start receiving mitoxantrone and each time you get a refill. (webmd.com)
  • The risk of heart damage may depend on the total amount of mitoxantrone given to a person over a lifetime, so your doctor will probably limit the total number of doses you receive if you are using this medication for MS. If you experience any of the following symptoms, call your doctor immediately: difficulty breathing, chest pain, swelling of the legs or ankles, or irregular or fast heartbeat. (medlineplus.gov)
  • Mitoxantrone injection is also used together with steroid medications to relieve pain in people with advanced prostate cancer who did not respond to other medications. (medlineplus.gov)
  • Mitoxantrone injection is in a class of medications called anthracenediones. (medlineplus.gov)
  • Additionally, low stroma-induced STAT3 activity and strong stroma-induced mitoxantrone resistance were associated with inferior clinical outcome. (oncotarget.com)
  • Talk to your doctor about the risks of using mitoxantrone injection. (medlineplus.gov)
  • abstract = "The binding and the diffusion of mitoxantrone (MTX) through the plasma membrane was performed by F{\"o}rster resonance energy transfer (FRET) from the membrane fluorescent donor (4Di-10ASP) to the co-localized acceptor MTX. (lih.lu)
  • There are 0 terms under the parent term 'Mitoxantrone' in the ICD-10-CM Drugs Index . (icd.codes)
  • Mitoxantrone must be given only by injection into a vein. (webmd.com)
  • Mitoxantrone injection comes as a liquid to be given intravenously (into a vein) by a doctor or nurse in a hospital or clinic. (medlineplus.gov)
  • When mitoxantrone injection is used to treat MS, it is usually given once every 3 months for about 2 to 3 years (for a total of 8 to 12 doses). (medlineplus.gov)
  • When mitoxantrone injection is used to treat prostate cancer, it is usually given once every 21 days. (medlineplus.gov)
  • Mitoxantrone may cause a decrease in the number of white blood cells in the blood. (medlineplus.gov)
  • T2 lesion burden and T1 hypointense lesion burden increased slightly during the baseline phase and decreased after initiation of mitoxantrone therapy. (psychiatrictimes.com)
  • Mitoxantrone treats MS by stopping certain cells of the immune system from reaching the brain and spinal cord and causing damage. (medlineplus.gov)
  • Mitoxantrone treats cancer by stopping the growth and spread of cancer cells. (medlineplus.gov)
  • DNA-PK inhibition alleviated mitoxantrone resistance for AML cells on and off stromal cells. (oncotarget.com)
  • Mitoxantrone is an immunosuppressive drug for worsening forms of MS, and it has been shown to extend the time between relapses. (psychiatrictimes.com)
  • Herein we describe how the drug mitoxantrone can bind, induce folding of and stabilise i-motif forming DNA sequences, even at physiological pH. (brad.ac.uk)
  • Risk of environmental impact of mitoxantrone cannot be excluded, since no ecotoxicity data are available. (janusinfo.se)
  • Mitoxantrone offers may take the form of printable coupons, rebates, savings or copay cards, trial offers, or free samples. (drugs.com)
  • indicates that mitoxantrone has a low potential to bioaccumulate. (janusinfo.se)
  • Additionally, mitoxantrone was found to bind i-motif forming sequences preferentially over double helical DNA. (brad.ac.uk)