Mitotic. Medical search. Frequent questions

These interact with the mitotic spindles to assure that each daughter cell ultimately has a full set of chromosomes. (dummies.com)
The chromatids line up exactly along the centerline of the cell (or the equatorial plane), attaching to the mitotic spindles by the centromeres. (dummies.com)
We have now demonstrated fragmented centrosomes, disrupted mitotic spindles and aneuploid chromosome number at those doses. (nih.gov)
The data further demonstrated multipolar mitotic spindles comprised 95% of the disrupted mitoses. (nih.gov)
The increased multipolar mitotic spindles were associated with an increased number of cells in the G2 phase of mitosis, indicating a mitotic checkpoint response. (nih.gov)
Using a specialized microscope equipped with a time-lapse camera to image fluorescence-tagged proteins in real-time, an NIH-funded team has captured a critical step in the process of cell division, or mitosis: how filaments called microtubules (red) form new branches (green) and fan out to form mitotic spindles. (nih.gov)
Petry's ultimate goal is to learn how to build mitotic spindles, molecule by molecule, in the lab. (nih.gov)
We presented mitotic spindles with a length of 11.40 ± 0.54 m and a spindle width of 8.05 ± 0.55 m as new characterization in LSC culture. (listlabs.com)
2.12 ± 2.10% of mitotic spindles exhibited a multipolar phenotype during metaphase, and 3.84 ± 3.77% of anaphase cells had a DNA signal present within the spindle midzone, indicating a chromosome bridge or lagging chromosome phenotype. (listlabs.com)
The mitotic spindles arise from which cell structure Show Hint. (netlify.app)
The ratio of number of meiotic spindles and mitotic spindles formed during the developmentiof embryosac having egg apparatus, polar nuclei and antipodals from a megaspore mother cell, respectively will be 1. (eduncle.com)

Mitotic inhibitors are also used in cytogenetics (the study of chromosomes), where they stop cell division at a stage where chromosomes can be easily examined. (wikipedia.org)
Cytogenetics, the study of chromosomal material by analysis of G-Banded chromosomes, uses mitotic inhibitors extensively. (wikipedia.org)
The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. (yeastgenome.org)
Accurate segregation requires the alignment of all chromosomes by the mitotic spindle at the metaphase plate, and any misalignment must be corrected before anaphase is triggered. (cicancer.org)
spindle orientation is then The astral and kinetochore microtubules are two of the principal components of the mitotic spindle, and the mitotic spindle apparatus provides the means to are the only fibers seen to be attached at the kinetochores, most models of force generation for anaphase movement of chromosomes assume that microtubules Fibers comprising the mitotic spindle are functionally divided into two species. (netlify.app)
As the centrioles move, a spindle The structure of the kinetochore allows for the fibers to shorten without onto the chromosomes in a very specific way so let's go through this mitotic spindle step Spindle fibers are the cellular structures which are mainly used during cell division. (netlify.app)
Chromosomes have not attached to the spindle … 1977-03-01 2017-02-08 Define mitotic spindle fibers As a result of the EU's General Data Protection Regulation (GDPR).We are not permitting internet traffic to Byju's website from countries within European Union at this time.No tracking or performance measurement cookies were served with this page. (netlify.app)
Targeting Aurora B to DNA circles or centromere-ablated chromosomes or releasing Shugoshin from PP2A-dependent inhibition bypassed the centromere requirement for condensation and enhanced the mitotic stability of DNA circles. (ethz.ch)
We found that RCC1 not associated with chromosomes during mitosis is sequestered and inhibited in RCC1/Ran/RanBP1 heterotrimeric complexes and that the sequestration is crucial for normal mitotic spindle assembly. (nih.gov)
The canonical role of cohesin is to co-align sister chromatids, while condensin generally compacts mitotic chromosomes. (fudenberg.team)

A mitotic inhibitor is a drug that inhibits mitosis, or cell division. (wikipedia.org)
Mitotic inhibitors are derived from natural substances such as plant alkaloids, and prevent cells from undergoing mitosis by disrupting microtubule polymerization, thus preventing cancerous growth. (wikipedia.org)
The Mitotic Counting algorithm was trained on over 100,000 individual mitosis and across seven scanner models. (fox5sandiego.com)
In cell cycle, the exit through the mitotic state is triggered from the release from the phosphatase Cdc14 through the anaphase stage of mitosis from nucleolar chromatin, where it really is held and sequestered inactive. (bioinf.org)
Liberated Cdc14 dephosphorylates mitotic Clb cyclin reliant kinases (Clb-CDKs) and their substrates to market leave from mitosis [3]C[6]. (bioinf.org)
It should be noted that knockdown of LGN or During mitosis, the spindle fibers are called the mitotic spindle. (netlify.app)
In mitosis, centrosomes are critical for accurate construction of the mitotic spindle to ensure faithful chromosome segregation to the two daughter cells. (nih.gov)
Consistent with the major role of the centrosome in mitosis, mutations in these centrosome-related microcephaly (CRM) genes are thought to affect neurogenesis by depleting the pool of neural progenitor cells, primarily through apoptosis as a consequence of mitotic failure, or premature differentiation as a consequence of cell cycle delay and randomization of spindle orientation. (nih.gov)
During mitosis, after nuclear envelope breakdown, Ran-GTP is concentrated in the region close to mitotic chromatin, while Ran-GDP is the major form distal to chromatin. (nih.gov)
We introduced autocatalytic transcription of E2F, E2F regulated transcription of cyclin B, Cdc20/Cdh1 mediated E2F degradation, enhanced transcription of mitotic cyclins during late S/early G2 phase, and the sustained synthesis of cyclin B during mitosis. (ebi.ac.uk)

Meiotic and mitotic aneuploidies drive arrest of in vitro fertilized human preimplantation embryos. (physiciansweekly.com)
NuMA, HsEg5 Spindle fibres constitute mitotic and meiotic spindle during cell division. (netlify.app)
7 A female embryo after 18 weeks contains four phases of FGCs, i.e. mitotic, retinoid acid-responsive, meiotic prophase and oogenetic FGCs, and a male embryo after 9 weeks contains two phases of FGCs, i.e. mitotic, and mitotic-arrest FGCs. (nature.com)

Our results demonstrate a novel, isoform-specific localization of CaV1 channels during cell division and suggest a possible role for these channels in the calcium-dependent events underlying mitotic progression in pituitary corticotrophs. (hindawi.com)
the critical point at which progression through mitotic stages is closely regulated has also been shown [ 20 - 24 ]. (hindawi.com)
Following the HAC by live cell imaging experiments, we show that U2OS-Phoenix cells have low inherent levels of CIN, but HAC missegregation is markedly increased by treatment with agents that target mitotic progression through distinct mechanisms such as Reversine, an inhibitor of Mps1, and microtubule agents Nocodazole and Taxol. (nih.gov)
Understanding the activities of individual nucleoporins in each of these contexts has been complicated by their multi-faceted nature: for example, RNAi (RNA interference)-mediated depletion of nucleoporins in mammalian cells causes phenotypic defects, including altered gene expression and abnormal mitotic progression. (nih.gov)
Down-regulation of tricarboxylic acid (TCA) cycle genes blocks progression through the first mitotic division in Caenorhabditis elegans embryos. (nih.gov)

Microtubules are essential to mitotic reproduction, so through the inactivation of the microtubule function of a cell, taxanes inhibit the cell's division. (wikipedia.org)
Nanotubes were observed in association with mitotic spindle microtubules, the centrosomes and condensed chromatin in cells exposed to 0.024, 0.24, 2.4 and 24 μg/cm(2) SWCNT. (nih.gov)
Then, using time-lapse microscopy, the researchers watch the mechanical behavior of GFP-labeled microtubules [2] to see how they work to position the mitotic spindle. (nih.gov)
2019-07-07 · The mitotic spindle, composed of microtubules and proteins, forms in the cytoplasm. (netlify.app)
The release of duplicated mitotic spindle pole bodies (SPBs) that begins with the nucleation of microtubules from each SPB within the nucleus, leading to V-shaped spindle microtubules. (planteome.org)

Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum. (pacb.com)
Morley, AA 1991, ' Mitotic recombination in mammalian cells in vivo ', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis , vol. 250, no. 1-2, pp. 345-349. (edu.au)

Amplification/overexpression of a mitotic kinase gene in human bladder cancer. (nih.gov)
The mitotic kinase-encoding gene STK15/BTAK/ AuroraA is associated with aneuploidy and transformation when overexpressed in mammalian cells. (nih.gov)
STK15 gene amplification and associated increased expression of the mitotic kinase it encodes are associated with aneuploidy and aggressive clinical behavior in human bladder cancer. (nih.gov)
The yeast polo kinase Cdc5 regulates the shape of the mitotic nucleus. (nih.gov)

To address this problem, we have developed the first Human Artificial Chromosome (HAC)-based quantitative live-cell assay for mitotic chromosome segregation in human cells, with which we can score the rates of CIN within one cell division. (nih.gov)
Link to all annotated objects annotated to mitotic sister chromatid segregation. (planteome.org)
Link to all direct and indirect annotations to mitotic sister chromatid segregation. (planteome.org)
Accurate chromosomal segregation is monitored by the mitotic checkpoint, and an increased rate of chromosomal missegregation leads to chromosomal instability (CIN). (ajou.ac.kr)

The polar fibers extend to the center of the spindle pole towards the metaphase The discovery of mitotic cell division in 1875 was followed by decades of research, in which the existence of the so-called spindle fibers and astral arrays was However, in the case of the cytoplasmic patterns it only applies to the staining of the spindle fibers. (netlify.app)

4/mm 2 ), the optimal way to use mitotic rate remains unclear, and even this simplification requires determining the raw number per square millimeter. (medscape.com)
Yet, despite these recent results regarding the importance of mitotic rate in melanoma, we have observed that approximately 30% of outside pathology reports on primary melanomas make no mention of mitotic rate, and just 35% provide the quantitative result of mitotic rate per square millimeter of tumor tissue. (medscape.com)
The M/V index expresses the mitotic activity of epithelial cancer as the number of mitotic figures per square millimeter of neoplastic epithelium in the microscope field. (ac.be)

Ran is a Ras-family GTPase that plays critical roles in many cellular processes, including nucleo-cytoplasmic transport, nuclear envelope assembly, and mitotic spindle assembly. (nih.gov)
The Ran-GTP gradient guides mitotic spindle assembly by releasing spindle assembly factors (SAFs) from karyopherins based on local Ran-GTP concentrations. (nih.gov)

We have focused on several genes critical for mitotic spindle development and centrosome function. (nih.gov)

First, cohesin is responsible for compacting mitotic chromosome arms, independently of sister chromatid cohesion. (fudenberg.team)

In order to prepare a slide for cytogenetic study, a mitotic inhibitor is added to the cells being studied. (wikipedia.org)
Griseofulvin, derived from a species of Penicillium is an mitotic inhibitor that is used as an antifungal drug. (wikipedia.org)

Mitotic inhibitors are used in cancer treatment, because cancer cells are able to grow and eventually spread through the body (metastasize) through continuous mitotic division. (wikipedia.org)
Mitotic inhibitors interfere with the assembly and disassembly of tubulin into microtubule polymers. (wikipedia.org)
Examples of mitotic inhibitors frequently used in the treatment of cancer include paclitaxel, docetaxel, vinblastine, vincristine, and vinorelbine.Colchicine and griseofulvin are mitotic inhibitors used in the treatment of gout and toenail fungus, respectively. (wikipedia.org)
Wikimedia Commons has media related to Mitotic inhibitors. (wikipedia.org)

HBx binding to BubR1 attenuates the association between BubR1 and CDC20, an activator of the anaphase-promoting complex/cyclosome (APC/C) and induces slippage of mitotic arrest in the presence of microtubule poisons. (ajou.ac.kr)

In the course of this study we observed CaV1 channels localized near components of the mitotic apparatus in dividing cells. (hindawi.com)
We have previously shown mitotic spindle aberrations in cultured primary and immortalized human airway epithelial cells exposed to 24, 48 and 96 μg/cm(2) single-walled carbon nanotubes (SWCNT). (nih.gov)
To investigate mitotic spindle aberrations at concentrations anticipated in exposed workers, primary and immortalized human airway epithelial cells were exposed to SWCNT for 24-72 h at doses equivalent to 20 weeks of exposure at the Permissible Exposure Limit for particulates not otherwise regulated. (nih.gov)
The spindle poles and the spindle fibers are stained in mitotic cells. (netlify.app)
Blebbishields and mitotic cells exhibit robust macropinocytosis. (bvsalud.org)
Ongoing work is directed at understanding the mechanism by which the mitotic spindle self-assembles from component parts as cells prepare to divide and how mitotic motor proteins that are critical for this process are spatially and temporally regulated. (umass.edu)
Imaging Protein Dynamics in Live Mitotic Cells. (umass.edu)

The M/V index is less subject to variation in the amount of neoplastic epithelium between neoplasms or in size of the microscope field than conventional mitotic index (mitoses/high power fields). (ac.be)

AJOU Open Repository: HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint. (ajou.ac.kr)

Matrin3 regulates mitotic spindle dynamics by controlling alternative splicing of CDC14B. (nih.gov)

Because the collective information provided by tumor thickness, mitotic rate, ulceration, patient age, and site of tumor about hard outcomes such as 5-year fatality is limited and because measuring mitotic rate requires extra time, we recommend that mitotic rate need not be part of routine reports on cutaneous melanoma. (medscape.com)
To examine further the importance of mitotic rate in cutaneous melanoma and, in particular, to compare its importance with that of tumor ulceration, we studied these issues in a large group of cases of cutaneous melanoma and with relatively long follow-up. (medscape.com)
Is using the mitotic index mast cell tumor diagnosis useful? (dogcancerblog.com)
Determining just how aggressive the tumor is up front is important when it comes to making treatment decisions, which is why Dr. Ettinger, my oncologist co-author , suggests looking at the mitotic index for mast cell tumor assessment. (dogcancerblog.com)
You will not know the grade of your dog's mast cell tumor until after the biopsy is performed, of course, so you can't use the mitotic index for mast cell tumor assessment until AFTER you get that tumor surgically removed (with wide margins, please! (dogcancerblog.com)
However, these instruments were not designed to assess the mitotic activity index for tumor grading, and they do not record MF microscopy field-of-view by field-of-view, do not function to sum the counts, and do not export data for inclusion in a pathology report. (nih.gov)

2017. Slow Feature Analysis for Mitotic Event Recognition. (itiis.org)
Hint: B. Attachment of the mitotic spindle fibers to the kinetochores is a characteristic of which 2017-07-19 · Mitotic spindle: kinetochore fibers hold on tight to interpolar bundles Abstract. (netlify.app)

Here, we demonstrate that the HBV X protein (HBx) binds BubR1, a component of the mitotic checkpoint complex and co-localizes with BubR1 at the kinetochores. (ajou.ac.kr)
This provides a novel mechanism for dysregulation of the mitotic checkpoint by a viral pathogen linking it to the accumulation of chromosomal instability in HBV-associated hepatocarcinogenesis. (ajou.ac.kr)

It is made up of Spindle fibers are also called the mitotic spindle. (netlify.app)
Discover free flashcards, games, and test prep activities designed to help you learn about Mitotic Spindle Fibers and other concepts. (netlify.app)

Any telomere maintenance via semi-conservative replication that is involved in mitotic cell cycle. (mcw.edu)

Our data show that p63-positive CK3-negative LSCs grown in vitro for clinical purposes undergo mitotic processes with extremely high fidelity, suggesting high karyotype stability. (listlabs.com)

Egr-5 is a post-mitotic regulator of planarian epidermal differentiation. (stowers.org)

Hannu Haapasalo , «Volume corrected mitotic index (m/v index) in ovarian cancer», Acta Stereologica [En ligne], Volume 11 (1992), Number 1 - Quantitative histopathology - Aug. 1992, 89-98 URL : https://popups.ulg.ac.be/0351-580x/index.php?id=1834. (ac.be)

Through standardization enabled by the application, interobserver variance in MF counting can be reduced and transcription errors eliminated, enhancing the accuracy of mitotic index generation that will improve patient care. (nih.gov)

It forms a protein They are also known as mitotic spindle. (netlify.app)

Then, mitotic chromosome stability and normal mitotic outcomes were explored by using live-cell imaging. (listlabs.com)

The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous DNA region that occurs during mitotic cell cycles. (mcw.edu)

In this review, I summarize what is known about how the APC/C selects its targets during mitotic exit and review the evidence that substrate targeting after anaphase onset may be required for the correct execution of events at this time in the cell cycle. (portlandpress.com)

The budding yeast nuclear envelope adjacent to the nucleolus serves as a membrane sink during mitotic delay. (nih.gov)

Mitotic event recognition is a crucial and challenging task in biomedical applications. (itiis.org)

It's grade 2 mast cell tumors that can most benefit from a mitotic index measurement. (dogcancerblog.com)

In ovarian cancer, the mitotic activity had the best reproducibility among histoquantitative variables between different observers and laboratories. (ac.be)
A study was made on the diurnal rhythm of mitotic activity in the glomerular zone of the adrenal gland and in the corneal epithelium in 7- and 17-day-old rats and their mothers respectively. (eurekamag.com)
The model depends on Cdh1-regulated cyclin degradation during G1, regulation of B cyclin/Cdk1 activity by cyclin A/Cdk via Wee1, and transcriptional control of the mitotic cyclins that reflects some of the current literature. (ebi.ac.uk)

Cite this: Mitotic Rate in Melanoma: A Reexamination - Medscape - Mar 01, 2007. (medscape.com)

The position of this mitotic spindle tells the cell where to divide, allowing each daughter cell to contain its own identical set of DNA. (nih.gov)

Link to all annotated objects annotated to initial mitotic spindle pole body separation. (planteome.org)
Link to all direct and indirect annotations to initial mitotic spindle pole body separation. (planteome.org)

Conclusion This manuscript provides, for the first time, detailed characterization of the parameters of fidelity of the mitotic process and mitotic spindle morphologies of LSCs used in a direct clinical application. (listlabs.com)

Function within the last 10 years offers elucidated two pathways, dubbed worries (Cdc Fourteen Early Anaphase Launch) network as well as the Males (Mitotic Leave Network), that control the discharge of Cdc14 [7] collectively,[8]. (bioinf.org)

Spindles11

Chromosomes10

Mitosis10

Meiotic3

Progression5

Microtubules5

Recombination2

Kinase4

Segregation4

Metaphase1

Square millimeter3

Spindle assembly2

Genes1

Chromosome Arms1

Inhibitor2

Inhibitors4

Arrest1

Cells7

Mitoses1

Induces1

Regulates1

Tumor6

20172

Checkpoint2

Fibers2

Replication1

Processes1

Differentiation1

Quantitative1

Transcription1

Protein1

Stability1

Molecule1

Cell cycle1

Yeast1

Crucial1

Index1

Activity3

Cite1

Divide1

Separation2

Process1

Control1