Mitotic cell proliferation. Medical search. Frequent questions

The addition of tubulin ligands can affect microtubule stability and function, including mitosis, cell motion and intracellular organelle transport. (wikipedia.org)
These compounds inhibit cell mitosis by binding to the protein tubulin in the mitotic spindle and preventing polymerization or depolymerization into the microtubules. (wikipedia.org)
Microtubules are the key components of the cytoskeleton of eukaryotic cells and have an important role in various cellular functions such as intracellular migration and transport, cell shape maintenance, polarity, cell signaling and mitosis. (wikipedia.org)
They play a critical role in cell division by involving in the movement and attachment of the chromosomes during various stages of mitosis. (wikipedia.org)
Mitotic count (mitosis per mm 2 ) was assessed on H&E sections, and Ki-67 expression was estimated by immunohistochemistry on standard sections. (biomedcentral.com)
Although Ki-67 positivity is a marker of proliferative cells, it is uncertain how many of the cells expressing Ki-67 will actually undergo mitosis. (biomedcentral.com)
The increased multipolar mitotic spindles were associated with an increased number of cells in the G2 phase of mitosis, indicating a mitotic checkpoint response. (cdc.gov)
Percentages of CD30+ cells that entered mitosis and those with DNA strand breaks were of a similar order of magnitude and correlated significantly in a linear fashion. (nih.gov)
Additionally, we detected hundreds of proteins with previously unknown relations to mitosis and the cell cycle, many being linked to proliferation and oncogenic functions. (kth.se)
DESIGN: Proliferation, mitosis and the expression of progenitor lineage markers were assessed in normal squamous oesophagus from 10 patients by immunofluorescence on 3D epithelial whole mounts. (who.int)
Tumor cells were arranged in solid sheets [Fig. 2(A)]. Numerous mitosis and necrosis were observed. (medscape.com)

In recent years, interest in the possible molecular regulators of cell proliferation and differentiation in a wide range of regeneration models has grown significantly, but the cell kinetics of this process remain largely a mystery. (mdpi.com)
However, a major unresolved question is how each cell regulates the precise number of its motile cilia during differentiation. (elifesciences.org)
The effect of QA on cell survival and differentiation has therefore been examined on SH-SY5Y human neuroblastoma cells. (nih.gov)
Retinoic acid (RA, 10 μm) induced differentiation of SH-SY5Y cells into a neuronal phenotype showing neurite growth. (nih.gov)
Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)
Finally, a new class was defined called carcinoma with pleomorphic, sarcomatoid, or sarcomatous elements, which brings together a number of proliferations characterized by a spectrum of epithelial to mesenchymal differentiation. (ersjournals.com)
Malignant proliferation showing large monomorphic cells with some epithelioid (A1E/AE3) or angiocentric aspects without clear vascular differentiation. (medscape.com)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

Spindle cell lipoma is an histological type of lipoma which are rarely found in the oral cavity. (scirp.org)
We describe two cases of intraoral spindle cell lipomas. (scirp.org)
The final diagnosis was spindle cell lipomas. (scirp.org)
Oral spindle cell lipomas are unexpected to occur in the oral mucosa, and the main differential diagnosis is well-differentiated liposar- coma/atypical lipoma. (scirp.org)
Darling, M., Thompson, I. and Schneider, J. (2002) Spindle cell lipoma of the alveolar mucosa: a case report. (scirp.org)
We have previously shown mitotic spindle aberrations in cultured primary and immortalized human airway epithelial cells exposed to 24, 48 and 96 µg/cm2 single-walled carbon nanotube s (SWCNT). (cdc.gov)
To investigate mitotic spindle aberrations at concentrations anticipated in exposed workers, primary and immortalized human airway epithelial cells were exposed to SWCNT for 24-72 h at doses equivalent to 20 weeks of exposure at the Permissible Exposure Limit for particulates not otherwise regulated. (cdc.gov)
Nanotube s were observed in association with mitotic spindle microtubules, the centrosomes and condensed chromatin in cells exposed to 0.024, 0.24, 2.4 and 24 µg/cm2 SWCNT. (cdc.gov)
Our results show significant disruption of the mitotic spindle by SWCNT at occupationally relevant doses. (cdc.gov)
The patient underwent a second TSS, and histology of the specimen revealed neoplastic proliferation of astrocytes and spindle-shaped cells with fascicles. (ajnr.org)
The identified DEGs included 20 downregulated genes and 51 upregulated genes, which were highly associated with the cell cycle, organelle fission, chromosome segregation, cell division and spindle stability. (cancerindex.org)
The histopathological diagnosis of ovarian fibromatous tumor is usually unequivocal due to their distinct spindle-cell morphology and fascicular growth pattern. (iiarjournals.org)
Our results are the first to tubes (SWCNT) suggest the potential to interact report disruption of the mitotic spindle by with critical biological structures. (cdc.gov)
The nanotube bundles are similar to the potential of nanotubes to induce genetic damage size of microtubules that form the mitotic spindle in normal lung cells, cultured primary and immor- and may be incorporated into the mitotic spindle talized human airway epithelial cells were apparatus. (cdc.gov)
The mitotic kinase monopolar spindle 1 (Mps1) is a key regulator of the Spindle assembly checkpoint, which ensures the correct chromosome segregation. (lu.se)

This difference allows healthy cells to recover from chemotherapy more quickly than do malignant cells, and this is the rationale for current cyclic dosage schedules. (medscape.com)
Since tumor cell proliferation is an increasingly important prognostic factor in many malignant tumors, its value in cutaneous melanoma has been examined in the present report by a comparison of several different markers. (biomedcentral.com)
Our aim was to establish a live cell culture to enable the understanding of the cellular processes driving the non-malignant growth of these tumors. (frontiersin.org)
Although these tumors are considered to be non-malignant, they have a high rate of proliferation and can reach large sizes before being diagnosed. (frontiersin.org)
Diagnosis of TBL is challenging given its resemblance to basal cell carcinoma (BCC) but is important given possible malignant transformation and potential metastasis. (karger.com)
Misregulation of the cell cycle may result in malignant cell proliferation, tumorigenesis or cell death. (intechopen.com)
Histologic analysis of the brain lesion demonstrated a malignant proliferation of pleomorphic and hyperchromatic cells in a background of necrosis. (hindawi.com)
Non-Hodgkin Lymphomas Non-Hodgkin lymphomas are a heterogeneous group of disorders involving malignant monoclonal proliferation of lymphoid cells in lymphoreticular sites, including lymph nodes, bone marrow, the. (msdmanuals.com)
Burkitt lymphoma is the most rapidly growing human tumor, and pathology reveals a high mitotic rate, a monoclonal proliferation of B cells, and a "starry-sky" pattern of benign macrophages that have engulfed apoptotic malignant lymphocytes. (msdmanuals.com)
A malignant variant (malignant angioendotheliomatosis [MAE]) is an angiotropic lymphoma mostly of the B-cell phenotype. (medscape.com)
The lesions of malignant angioendotheliomatosis are thought to result from a sludging effect of the circulating malignant lymphoid cells. (medscape.com)
Squamous cell carcinomas are the most commonly diagnosed oral malignancy, accounting for about 90% of all malignant oral lesions. (bvsalud.org)

5-7 Morphologically, BL involves monomorphic medium-sized B cells with basophilic cytoplasm, numerous mitotic figures, rounded nuclei with finely clumped chromatin, myriad apoptosis, and tingible body macrophages, which result in a classic "starry sky" pattern. (cancernetwork.com)
There were foci of eosinophilia, stellate cytoplasm, and occasional gemistocytic morphology, and many cells were positive for glial fibrillary acidic protein (GFAP). (ajnr.org)
These cell exhibit moderate pleomorphism, basophilic cytoplasm, oval nucleus and moderate mitotic activity. (vin.com)
Large eosinophilic hepatocytes (eosinophilic granular cytoplasm represents peroxisome proliferation), biliary hyperplasia (ducts, ductules, oval cells), several mitotic figures, and pigment are present in the liver of this mouse fed a diet containing di-(2-ethylhexyl)-phthalate (DEHP) for 10 months. (nih.gov)
Histologic examination revealed a hypercellular tumoral proliferation formed by large atypical monomorphic cells with large vesicular nuclei, prominent nucleoli, and abundant light eosinophilic cytoplasm. (medscape.com)
The period of the cell cycle when CELLS divide their nucleus and cytoplasm. (bvsalud.org)

Rates of cell division vary for different tumors. (medscape.com)
During the progression of NSCLC, E2F1 overexpression could produce more aggressive tumors with a high proliferation rate and chemoresistance. (aacrjournals.org)
Given the high frequency of DDX5 amplification in breast cancer, our results highlight DDX5 as a promising candidate for targeted therapy of breast tumors with DDX5 amplification, and indeed we show that DDX5 inhibition sensitizes a subset of breast cancer cells to trastuzumab. (aacrjournals.org)
These tumors exhibit slow growth and very little multiplication of cells and very rarely invade the brain tissue. (brainsciencefoundation.org)
Since tumors with increased mitotic activity but no diffuse moderate-to-severe cytological atypia have not been categorized ( 7 ), this kind of tumor has been diagnosed mostly as fibrosarcoma. (iiarjournals.org)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

In addition, Plk1 also prevented partial epithelial-mesenchymal transition (pEMT) of tubular epithelial cells via autophagy pathway. (nature.com)
In this study, we explored the role of Plk1 in the classical kidney fibrosis model, UUO, and cultured fibroblast and renal tubular epithelial cells by using specific Plk1 inhibitors, genetic silencing, and heterozygous global knockout mice. (nature.com)
Other particles may be engulfed by epithelial cells, primarily in the vicinity of the bronchial-alveolar duct junctions, and retained for much longer periods, with gradual removal to lymph nodes. (cdc.gov)
In HHV-1 and HHV-2 oral infections, viral replication within the oral epithelium may cause lysis of epithelial cells, with vesicle formation. (medscape.com)

Cellular apoptosis (ie, programmed cell death) is another potential mechanism of many antineoplastic agents. (medscape.com)
These molecules are involved in cell division, metastasis, apoptosis, cell cycle regulation and regulation of protein degradation. (pennmedicine.org)

Colony formation assays showed an increased proliferation seven days after exposure. (cdc.gov)
MTT colorimetric assays, colony formation assays and 5‑ethynyl‑20‑deoxyuridine incorporation assays were also conducted to evaluate ACC cell proliferation. (cancerindex.org)
Experts with a good knowledge of cell-based assays and handling software & instruments are required for their optimum utilization. (emailwire.com)
Their self-renewing potential was investigated by colony forming cells assays and in vitro organotypic culture models. (who.int)
The current investigation aimed to demonstrate how interpretation of results from several standard cytotoxicity and proliferation assays vary in dependence on contributions from the pentose phosphate pathway (PPP). (cdc.gov)
Non-tumorigenic Beas-2B cells were treated with graded concentrations of benzo[a]pyrene (B[a]P) for 24 and 48h prior to cytotoxicity and proliferation assessment with commonly used MTT, MTS, WST1, and Alamar Blue assays. (cdc.gov)

These results bear on the control of cell proliferation. (ebi.ac.uk)
Control of cell proliferation by the MDM2 mitotic timer: every double minute counts! (dundee.ac.uk)
Defects in the control of cell proliferation are a hallmark of cancer, and DNA replication is a key process for cell proliferation. (aacrjournals.org)

abstract = 'Propagation of the chromatin landscape across cell divisions is central to epigenetic cell memory. (ku.dk)
Mechanistic analysis of the interplay between DNA replication, the cell cycle, and the epigenome has provided insights into replication-coupled chromatin assembly and post-replicative chromatin maintenance. (ku.dk)
The narrow diame- association with cellular and mitotic tubulin as ter and great length of single-walled carbon nano- well as the chromatin. (cdc.gov)

Intravascular histiocytic cell proliferation may be a neoplastic proliferation of histiocytes (intralymphatic histiocytosis) or an early stage of classic reactive angioendotheliomatosis. (medscape.com)

The aim of the present study was to evaluate the prognostic impact of mitotic count, Ki-67 expression and novel proliferation markers phosphohistone H3 (PHH3), minichromosome maintenance protein 4 (MCM4) and mitosin, and to compare the results with histopathological variables. (biomedcentral.com)
Nestin is an intermediate filament protein known to play several roles, including as a marker of neural progenitor and proliferating endothelial cells. (molvis.org)
Nestin was also observed in some vascular cells, as demonstrated by the co-immunoreactivity of the protein with vWF in the choroid and retina. (molvis.org)
After any retinal injury in experimental conditions, glial cells are activated and undergo reactive gliosis with increased an expression level of glial fibrillary acid protein (GFAP), which leads to overgrowth of outer Müller glial cell processes. (molvis.org)
The precise regulations of pre-RC protein levels and assembly are effective ways to prevent reassembly of de novo MCM2-7 onto the replicated origins to re-license and re-replicate the genomic DNA in the subsequent phases of the same cell cycle ( Figure 1) . (intechopen.com)
In the longer run, this also means better understanding of cells in the context of health and disease, since protein malfunction and mislocalization are two important factors during disease development. (kth.se)
Apart from enabling exploration of the organellar proteomes, we conclude that half of the human proteins localize to multiple compartments, and that almost one fifth display cell-to-cell variations in terms of protein expression. (kth.se)
The algorithm was capable of classifying protein location in images containing several challenging localization problems, such as multilocalizing proteins, cell line variations and rare classes. (kth.se)
Paper IV presents a systematic dissection of the variable proteome drafted in Paper I. We show evidence for 539 proteins being correlated to cell cycle variations, of which a minority are also cycling at a transcriptional level, suggesting protein regulation at a translational or post-translational level. (kth.se)

Cellular senescence is a multifaceted process that arrests the proliferation of cells that are at risk of neoplastic transformation. (nature.com)
Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. (nature.com)
Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing. (nature.com)
The drug leads to single-stranded and double-stranded DNA breaks that arrest cellular proliferation in the late S or early G2 phase of cell cycle. (medscape.com)
mitotically active cells of intact segments do not significantly contribute to the blastemal cellular sources. (mdpi.com)
The cellular composition of the neurohypophysis is that of specialized glial cells (pituicytes) together with their axons. (ajnr.org)
This mass was resected via a transspenoidal approach, and histology revealed a moderately cellular astrocytomas with compact fibrillated cells in a fascicular pattern. (ajnr.org)
Analysis of XY byg/byg gonads at 11.5 d post coitum reveals a growth deficit and a failure to support mesonephric cell migration, both early cellular processes normally associated with testis development. (plos.org)
We are using genetics, genomics and biochemical approaches to establish unknown pathways involved in these cellular events and attempting to develop models that explain how gammaherpesviruses establish transformation in human cells. (pennmedicine.org)
These results demonstrate differential sensitivity of standard cytotoxicity assessments on the PPP, thus (1) decoupling 'mitochondrial activity' as an interpretation of cellular formazan and Alamar Blue metabolism, and (2) demonstrating the implicit requirement for investigators to sufficiently verify interaction of these methods in routine cytotoxicity and proliferation characterization. (cdc.gov)

The value of Phosphohistone H3 as a cell proliferation marker in oral squamous cell carcinoma. (bvsalud.org)
HPV infections have received particular attention in recent years, as high-risk strains have been linked to some cases of oral squamous cell carcinoma. (medscape.com)

In 2002, he joined Stanford University where he initially utilized his experience from Geron Corporation to research cardiovascular and endothelial progenitor cell function. (stanford.edu)

To this end, we assessed the relative frequency of mitotic phases and nuclear damage (detected by in situ end-labeling of DNA strand breaks) in CD30+ large cells of nodular sclerosis and mixed cellularity HD. (nih.gov)
Histologically, MACF displayed frequent mitotic figures, as well as increased cellularity and mild cytological atypia. (iiarjournals.org)
The 2003 WHO Classification designated ovarian fibromatous tumor with markedly increased cellularity, increased mitotic activity (≥4 per 10 HPFs), and diffuse moderate-to-severe cytological atypia as fibrosarcoma ( 2 ). (iiarjournals.org)
The degree of cellularity, atypia, and mitotic activity is high. (medscape.com)

Microtubules play an important role in eukaryotic cells. (wikipedia.org)

In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
The objective of this study was to evaluate clinical and microscopic features of squamous cell carcinomas using immunohistochemical analysis and assessing biological markers of angiogenesis and tumor vascular activity (anti-CD31, anti-CD34, Factor VIII), cell proliferation (Ki-67), and loss of cell suppression (p53). (bvsalud.org)
Six patients seen at the Stomatology Service of a university hospital in Canoas, southern Brazil, with a suspected diagnosis of squamous cell carcinoma were analyzed. (bvsalud.org)
Squamous cell carcinoma. (bvsalud.org)
Squamous cell carcinomas (SCCs) are among the malignancies most commonly diagnosed affecting the oral cavity, accounting for 90% of all cases of neoplasms. (bvsalud.org)
Typically, SCCs show an uncontrolled proliferation of cells on the squamous layer of the epithelium, where cells express various degrees of similarity with their original cells 1 . (bvsalud.org)

Microscopic evaluation of the uterus demonstrated multiple sites of ovoid and fusiform mesenchymal cell proliferation, atrophic endometrial glands, with deep smooth muscle infiltration. (vin.com)

Both RA and QA increased expression of the neuronal marker β3-tubulin in whole-cell homogenates and in the neuritic fraction assessed using a neurite outgrowth assay. (nih.gov)

We have now demonstrated fragmented centrosomes, disrupted mitotic spindles and aneuploid chromosome number at those doses. (cdc.gov)
Also, the mitotic chromosome proteins are enriched for intrinsically disordered domains, suggesting liquid-like properties of the perichromosomal layer. (kth.se)

This immunophenotype excluded a carcinoma, a lymphoid, melanocytic, germ cell, or neuroglial proliferation, and the diagnosis of sellar and suprasellar epithelioid angiosarcoma was made. (medscape.com)

In mammalian organisms, cells that express markers of senescence have been shown to accumulate with age and at sites of certain age-related pathologies. (nature.com)
Both 2D monolayer and 3D neurospheres were successfully cultured and characterized for proliferative potential, intrinsic plasticity, presence of cancer stem cells and the expression of stem cell markers. (frontiersin.org)
Cells expressing differential levels of epithelial and progenitor markers were isolated using flow cytometry sorting and characterised by qPCR and IF. (who.int)
A benign reactive variant (reactive angioendotheliomatosis [RAE]) is a rare and poorly defined disorder characterized by intravascular proliferation of cells expressing endothelial cell markers. (medscape.com)

Cancer chemotherapy is based on an understanding of tumor cell growth and how drugs affect it. (medscape.com)
Tumor cell proliferation is a predictor of survival in cutaneous melanoma. (biomedcentral.com)
Tumor cell proliferation by Ki-67 had significant prognostic impact by multivariate analysis. (biomedcentral.com)

Recent breakthroughs have uncovered more and more DNA replication licensing machinery proteins (ORC, Cdc6, Cdt1, geminin, etc.) functioning in other cell cycle events, including centrosome replication, mitotic events, transcription and so on. (intechopen.com)

For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)
Airway progenitor cells contain two parental centrioles (PC) and form structures called deuterosomes that nucleate centrioles during amplification. (elifesciences.org)

Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)

however, after three days, significant cytotoxicity was observed in the SWCNT-exposed cells. (cdc.gov)
However, potentially erroneous characterization of cytotoxicity and cell proliferation can arise if verification of baseline interaction of test article with method employed is neglected. (cdc.gov)

Final pathology showed epithelioid foamy stromal cells with abundant thin-walled capillary-like vessels. (surgicalneurologyint.com)

Cells were immunopositive for S100 pro- tein and CD34 (one case), with low mitotic activity (Ki-67). (scirp.org)
There was no significant mitotic activity. (ajnr.org)
A comparative study with Ki-67 and the mitotic activity index. (bvsalud.org)
In 1981, Prat and Scully suggested increased mitotic activity as the most important morphological criterion to differentiate CF from fibrosarcoma ( 1 ). (iiarjournals.org)
However, previous studies noted a remarkably favorable prognosis for the subset of CF with particularly high mitotic activity ( 4 - 6 ). (iiarjournals.org)
However, it has been suggested that the clinicopathological characteristics of CF with increased mitotic activity are significantly different from those of fibrosarcoma. (iiarjournals.org)
The 2014 WHO Classification of Tumours of Female Reproductive Organs recognized a separate entity of CF that displays particularly high mitotic activity but no diffuse moderate-to-severe cytological atypia as MACF. (iiarjournals.org)

In interfering with cell reproduction, some antineoplastic agents are specific to certain phases of the cell cycle, whereas others (eg, alkylating agents, anthracyclines, cisplatin) are not phase specific. (medscape.com)
The proliferation marker Ki-67 is expressed in all phases of the cell cycle [ 12 ], and elevated Ki-67 in tumor cells was associated with the most aggressive melanomas in our previous study [ 13 ]. (biomedcentral.com)

Furthermore, high mitotic count and elevated Ki-67 expression were also associated with Clark's level of invasion and presence of vascular invasion. (biomedcentral.com)
High expression of PHH3 and MCM4 was correlated with high mitotic count, elevated Ki-67 expression and tumor ulceration, and increased PHH3 frequencies were associated with tumor thickness and presence of tumor necrosis. (biomedcentral.com)
Univariate analyses showed a worse outcome in cases with elevated Ki-67 expression and high mitotic count, whereas PHH3, MCM4 and mitosin were not significant. (biomedcentral.com)
P. Connor Johnson, MD, and Jeremy S. Abramson MD, MMSc, discuss available treatments for patients with Burkitt lymphoma and high-grade B-cell lymphoma. (cancernetwork.com)
This article reviews the current data and future directions in the management of Burkitt lymphoma (BL) and high-grade B-cell lymphoma (HGBL). (cancernetwork.com)
1 A significant minority of these cases were the especially aggressive B-cell lymphomas Burkitt lymphoma (BL) and high-grade B-cell lymphoma (HGBL), the latter of which includes the histologic subtypes HGBL with MYC and BCL2 and/or BCL6 translocations (conventionally referred to as double-hit lymphoma [DHL]) and HGBL, not otherwise specified (NOS). (cancernetwork.com)
A spontaneous cell line-like cell culture with high percentage of stem cells has been established from a DIG tumor for the first time. (frontiersin.org)
The growth of this market is attributed to the technological advancements in image acquisition, data analysis, and storage capabilities and the need to obtain information on changes in cell morphology through high-quality images. (emailwire.com)
The mean mitotic count was 8.7 per 10 high-power fields. (iiarjournals.org)
Histopathology shows high mitotic index and multinucleated giant cells. (hindawi.com)
Immunohistochemistry confirmed the glial origin and high proliferation rate and PAFG positive (d). (hindawi.com)
Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count. (medscape.com)

The results suggest ways to arrest the mitotic oscillator by altering the maximum rates of the converter enzymes. (ebi.ac.uk)
Our results show that a) most CD30+ cells in HD exhibit abortive mitoses, with a highly significant arrest at the metaphase-ana/telophase transition, and b) many of these elements, i.e. mainly H-RS cells, show fragmentation of nuclear DNA, suggesting imminent or actual death. (nih.gov)

HHVs replicate in the host cell nucleus. (medscape.com)

Overexpression of cyclophilins has been observed in HCC increasing proliferation, metastasis and promoting chemoresistance. (lu.se)

atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. (ersjournals.com)

We investigated the clinical significance of E2F1 gene expression in relation to its target genes, thymidylate synthase ( TS ) and Survivin , in case of non-small-cell lung cancer (NSCLC). (aacrjournals.org)
The present study revealed that E2F1 gene expression correlates with TS and Survivin gene expressions and tumor proliferation. (aacrjournals.org)
Increased mitotic count and elevated Ki-67 expression were strongly associated with increased tumor thickness, presence of ulceration and tumor necrosis. (biomedcentral.com)
Second is an increased proliferation due to an increased expression of the JAK-STAT pathway ligand Upd3 . (sdbonline.org)
Expression of the neuronal proliferation marker doublecortin revealed that, unlike RA, QA did not decrease the number of mitotic cells. (nih.gov)
The effects on dopamine (DA) release and dopamine transporter (DAT) gene expression were assayed in hypothalamic HypoE22 cells. (researchgate.net)
In the same experimental system, IL-10 and BDNF gene expressions increased, and in HypoE22 cells, the extract decreased the extracellular dopamine level and increased the DAT gene expression due to the direct interaction of parthenolide with the DAT. (researchgate.net)

In some recent studies, however, mitotic frequency is a powerful predictor of survival [ 6 - 11 ], and the inclusion of this marker in staging of primary melanomas has been included in the 2010 edition of the AJCC pTNM staging system. (biomedcentral.com)
However, the co-immunoreactivity of nestin and GS, a marker of mature functional Müller cells, could be observable only from the seventh day. (molvis.org)

Atypical meningiomas represent approximately 7-8% of meningiomas and exhibit increased tissue and cell abnormalities. (brainsciencefoundation.org)

Originally described by Headington in the 1970s, trichoblastoma (TBL) is now appreciated as a rare benign tumor that originates from the follicular germ cell line [1, 2]. (karger.com)

These agents inhibit cell growth and proliferation. (medscape.com)

The gross appearance of the tumor was suggestive of a highly vascular lesion, and so intraoperatively, a decision was made to attempt an en-bloc resection. (surgicalneurologyint.com)
Angioendotheliomatosis is a histopathological term characterized by proliferation of cells within vascular lumina with secondary intravascular thrombi and obliteration of the vessels. (medscape.com)
Although the exact stimulus for the proliferation of endothelial cells is not known, occlusion of vascular lumina of different causes seems to be the common feature of this disease. (medscape.com)
In diffuse dermal angiomatosis, in which the vessels are partially occluded by atherosclerotic plaques, a local increase of vascular endothelial growth factor (VEGF) caused by hypoxia that can subsequently lead to endothelial cell proliferation is a possible cause. (medscape.com)

Hayflick, L. The limited in vitro lifetime of human diploid cell strains. (nature.com)
NV556 treatment in an in vitro 3D human liver Extracellular Matrix (ECM) cultured with a TGFβ1-activated human hepatic stellate cell line led to decreased collagen production. (lu.se)

The Lara-Gonzalez lab studies the mechanisms of cell division and how these are impacted by developmental cues, using a variety of techniques that includes genomic editing, microscopy, biochemistry and proteomic analyses. (uci.edu)
We are investigating the fundamental mechanisms utilized by these gammaherpesviruses to induce cell mediated growth transformation. (pennmedicine.org)

We could confirm the increased polyploidy upon Mps1 inhibition in neuroblastoma cell lines and PDX model, leading to mitotic catastrophe activating the caspase-dependent mitochondrial apoptotic pathway. (lu.se)

Some studies showed that blocking cell cycle progression ameliorated fibrosis. (nature.com)
Doxorubicin's maximum toxicity occurs during the S phase of cell cycle. (medscape.com)
Amputation-induced proliferation occurred predominantly within the epidermal and intestinal epithelium, as well as wound-adjacent muscle fibers, where clusters of cells at the same stage of the cell cycle were found. (mdpi.com)
We consider a minimal cascade model previously proposed for the mitotic oscillator driving the embryonic cell division cycle. (ebi.ac.uk)
Afterwards, many responding cells going through a conherent cycle to produce specific immunity. (pharmacology2000.com)
The cell cycle is the process of accurate self-reproduction and proliferation of a cell. (intechopen.com)
In this chapter, we mainly discuss the coordination regulations between DNA replication initiation and other cell cycle events that ensure genomic integrity. (intechopen.com)
DNA replication occurs once and only once per cell cycle mainly regulated by DNA replication initiation factors in eukaryotic cells. (intechopen.com)
Several pathways involved in cell cycle and DNA repair were affected upon NV651 treatment. (lu.se)
This combination caused a disturbance in the cell cycle and a decrease in the capacity of the cell to repair interstrand crosslinks. (lu.se)
Targeting the cell cycle has been proposed as a therapeutic strategy in cancer treatment with special interest in the mitotic phase. (lu.se)

Our results confirmed the presence of nestin in glial (e.g., astrocytes), reactive Müller, and endothelial cells. (molvis.org)

Clinically, grade 3B follicular lymphoma is treated like diffuse large B-cell lymphoma . (medscape.com)
HGBL, not otherwise specified (NOS) is a heterogeneous, aggressive, mature B-cell lymphoma that does not meet criteria for BL, DHL, or diffuse large B-cell lymphoma NOS. (cancernetwork.com)

Enrichment of cancer stem cells was observed in neurospheres by FACS using CD133 antibody and RT-PCR. (frontiersin.org)
He also has professional interests in stem cell research, the biology of aging, cancer as well as telomere and telomerase biology. (stanford.edu)
Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016? (lu.se)
Recent news of an impending clinical cell transplantation trial in Parkinson's disease using parthenogenetic stem cells as a source of donor tissue have raised hopes in the patient community and sparked discussion in the research community. (lu.se)
Based on discussions held by a global collaborative initiative on translation of stem cell therapy in Parkinson's disease, we have identified a set of key questions that we believe should be addressed ahead of every clinical stem cell-based transplantation trial in this disorder. (lu.se)
In this article, we first provide a short history of cell therapy in Parkinson's disease and briefly describe the current state-of-art regarding human stem cell-derived dopamine neurons for use in any patient trial. (lu.se)
With this background information as a foundation, we then discuss each of the key questions in relation to the upcoming therapeutic trial and critically assess if the time is ripe for clinical translation of parthenogenetic stem cell technology in Parkinson's disease. (lu.se)
Stem cell-based therapies for Parkinson's dis- ogy company International Stem Cell Corporation ease (PD) are rapidly moving towards clinical trials. (lu.se)
Several academic and industry efforts are well under owned subsidiary Cyto Therapeutics, it had received way to produce dopaminergic neurons from stem approval by the Australian government to conduct a cells under conditions compliant with use in patients. (lu.se)
A second press release [2] has indicated stem cell source, resulting in widespread excitement that the program is planning to move forward very rapidly, with all of the patients being enrolled in the Correspondence to: Roger A. Barker, John van Geest Centre first quarter of 2016 and interim results being shared for Brain Repair, Department of Clinical Neurosciences, Univer- in October 2016. (lu.se)

We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)
DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
Understanding how DNA replication is regulated in human cells can provide insight into cancer development and may reveal vulnerabilities that can be exploited therapeutically. (aacrjournals.org)

[ 5 , 6 ] In a localized primary infection, the virus penetrates the mucosal epithelium and invades the cells of the basal layer, where the viral DNA inserts into the host DNA. (medscape.com)

Lung cancer is a major cause of cancer-related deaths, and non-small-cell lung cancer (NSCLC) comprises ∼75% of all lung cancers ( 1 ). (aacrjournals.org)

The Ki-67 proliferation index and the apoptotic index using the terminal deoxyribonucleotidyl transferase-mediated dUTP nick-end labeling method were also evaluated. (aacrjournals.org)

In CKD patients or obstructive mice model, we observed that Plk1, a critical mitotic regulator, was upregulated in kidneys. (nature.com)

Finally, a period of mitotic cell division (phase M) occurs. (medscape.com)
Here we review these findings in the broader context of epigenetic inheritance across mitotic cell division. (ku.dk)

The data further demonstrated multipolar mitotic spindles comprised 95 percent of the disrupted mitoses. (cdc.gov)

Microsco- pically, both lesions presented a solid proliferation of mature fat cells intermixed with bundles of connec- tive tissue. (scirp.org)
Cells cultured as 3D were embedded as tissue blocks. (frontiersin.org)
The tumor is heterogeneous with meningeal tumor cells, mainly a mixture of fibroblast like cells, and neuroepithelial cells in a background of connective tissue. (frontiersin.org)

On the basis of these facts, it is understandable that the hypophyseal stalk or posterior pituitary can be a host to all the neoplastic processes that originate from the glial cell series. (ajnr.org)

Anatomy41

Organisms14

Diseases11

Chemicals and Drugs95

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes67

Disciplines and Occupations1

Information Science3

Mitosis11

Differentiation8

Spindle15

Malignant12

Cytoplasm6

Tumors6

Epithelial cells4

Apoptosis2

Assays6

Control of cell proliferation3

Chromatin3

Neoplastic proliferation1

Protein9

Cellular10

Oral squamous2

Endothelial prog1

Cellularity4

Microtubules1

Squamous6

Mesenchymal1

Tubulin1

Chromosome2

Lymphoid1

Markers4

Tumor cell3

Centrosome1

Airway2

Regulation1

Cytotoxicity2

Pathology1

Activity7

Phases2

High12

Arrest2

Nucleus1

Chemoresistance1

Hyperplasia1

Expression7

Marker2

Atypical1

Germ cell1

Inhibit cell1

Vascular4

Vitro2

Mechanisms2

Neuroblastoma1

Cycle11

Astrocytes1

Diffuse2

Stem10

Replication3

Basal layer1

Lung1

Apoptotic1

Regulator1

Division2

Mitoses1

Tissue3

Glial cell1