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  • high
  • Administration of the NAD(P)H oxidase inhibitor diphenyleneiodonium, apocynin, the protein kinase C (PKC) inhibitor chelerythrine or staurosporin or the removal of extracellular Ca 2+ during high P i treatment prevented the increases in O 2 ·− production, whereas administration of losartan or captopril had no effect. (ahajournals.org)
  • role
  • Also, we aimed to elucidate the contribution of possible vascular sources of O 2 ·− , including NAD(P)H oxidases, 4,5 and the role of mechanosensitive pathways, such as Ca 2+ and protein kinase C (PKC)-dependent signaling mechanisms. (ahajournals.org)
  • receptors
  • The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens. (abbreviations.com)
  • When NOD-like receptors are activated by bacterial peptidoglycans, they oligomerize and recruit cIAP1, cIAP2, TRAF2 and RIP2. (wikipedia.org)
  • The PTGFR gene is located on human chromosome 1 at position p31.1 (i.e. 1p31.1), contains 7 exons, and codes for a G protein coupled receptor (GPCR) of the rhodopsin-like receptor family, Subfamily A14 (see rhodopsin-like receptors#Subfamily A14). (wikipedia.org)
  • interaction
  • The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. (nih.gov)
  • The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly. (nih.gov)
  • differentiation
  • Differentiation of CD4+ T cells to Th1 cells requires MAP kinase JNK2. (uniprot.org)
  • MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. (wikipedia.org)
  • The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. (wikipedia.org)
  • receptor
  • We will not only review the well-known members of the family, such as kinase suppressor of Ras (KSR), but also put a special focus on the function of the recently identified or less studied scaffolders, such as fibroblast growth factor receptor substrate 2, flotillin-1 and mitogen-activated protein kinase organizer 1. (mdpi.com)
  • Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. (uniprot.org)
  • Standard prostanoids have the following relative efficacies as receptor ligands in binding to and activating FP: PGF2α>PGD2>PGE2>PGI2=TXA2. (wikipedia.org)
  • mediate
  • ATF-2 may mediate oncogenesis caused by mutant Ras protein and regulate maintenance of the aggressive cancer phenotype of some types of epithelial cells. (wikipedia.org)
  • tumor
  • This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. (wikipedia.org)
  • cIAP1 is a multi-functional protein which can be found in the cytoplasm of cells and in the nucleus of tumor cells. (wikipedia.org)
  • regulators
  • MPK3 and MPK6 are very similar proteins and have a function as regulators in abscission, stomatal development, signaling various abiotic stresses, and defense responses to certain pathogens. (wikipedia.org)
  • signals
  • While animals produce internal signals that can drive the cell cycle forward, external mitogens can cause it to progress without these signals. (wikipedia.org)
  • binds
  • SAPK3/p38gamma binds to a variety of these proteins, such as alpha1-syntrophin, SAP90/PSD95 and SAP97/hDlg , and under stress conditions is able to phosphorylate them and modulate their activity (Hasegawa et al. (atlasgeneticsoncology.org)
  • This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. (wikipedia.org)
  • immunity
  • T cells undergo mitosis when stimulated by mitogens to produce small lymphocytes that are then responsible for the production of lymphokines, which are substances that modify the host organism to improve its immunity. (wikipedia.org)
  • Cells
  • In addition, ERK5 may be activated by the cytokine Interleukin-6 in B cells. (atlasgeneticsoncology.org)
  • N-terminal kinase, and c-Src are activated in human aortic smooth muscle cells by pressure stress. (nih.gov)
  • The overexpression of MAP kinase in these cells aids in their proliferation. (wikipedia.org)
  • B cells, on the other hand, divide to produce plasma cells when stimulated by mitogens, which then produce immunoglobulins, or antibodies. (wikipedia.org)
  • This is how the mitogen works, that is, by inducing mitosis in memory B cells to cause them to divide, with some becoming plasma cells. (wikipedia.org)
  • Studies in mice indicate that FP mRNA and/or protein is expressed in diverse tissues including the kidney (distal tubules), uterus, and ovary (Luteal cells of corpus luteum. (wikipedia.org)
  • substrate
  • In order for the substrate adapter unit Cdc4 to bind to Sic1, a minimum of any six of the nine cyclin-dependent kinase sites on Sic1 have to be phosphorylated. (wikipedia.org)
  • cascade
  • The general hypothesis is that the preconditioning stimulus will induce the activation of a cascade of stress-responsive kinases, which in turn transduce the stress signal into the generation of a protective protein or activation of a protective kinase. (ahajournals.org)
  • regulate
  • Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. (uniprot.org)
  • MAPK15 has also been found to negatively regulate protein O-glycosylation with acetyl galactosamine (GalNAc), a process in which a sugar molecule is covalently attached to an oxygen atom on an amino acid residue. (wikipedia.org)