• proteins
  • The MSH1 and MSH2 genes of Saccharomyces cerevisiae are predicted to encode proteins that are homologous to the Escherichia coli MutS and Streptococcus pneumoniae HexA proteins and their homologs. (genetics.org)
  • Cerebellar dysfunction Ataxia In terms of the genetics of autosomal dominant cerebellar ataxia 11 of 18 known genes are caused by repeated expansions in corresponding proteins, sharing the same mutational mechanism. (wikipedia.org)
  • Gene expression is affected instead of proteins in subtype two SCAs because of this. (wikipedia.org)
  • However, in 2001, a 14th biologically active protein called humanin was discovered, and was found to be encoded by the mitochondrial gene MT-RNR2 which also encodes part of the mitochondrial ribosome (made out of RNA): Unlike the other proteins, humanin does not remain in the mitochondria, and interacts with the rest of the cell and cellular receptors. (wikipedia.org)
  • The adenine-thymine rich hairpin loops of the Borrelia bacteria range in size from 5 kilobase pairs (kb) to over 200 kb and contain the genes responsible for producing a group of major surface proteins, or antigens, on the bacteria that allow it to evade the immune response of its infected host. (wikipedia.org)
  • In molecular biology, TCL-1/MTCP-1 is a protein domain found in proteins encoded for by two related protooncogenes, other words by genes that help promote cancer. (wikipedia.org)
  • Human HSPs are classified into 5 major groups according to the HNGC (HUGO gene nomenclature committee): HSP70 DnaJ (HSP40) HSPB (small heat shock proteins) HSPC (HSP90) chaperonins Chaperonins are characterized by their barrel-shaped structure with binding sites for client proteins inside the barrels. (wikipedia.org)
  • TOM70 (translocase of the outer mitochondrial membrane of ~70 kDa) mediates translocation of client proteins through the import pore into the mitochondrial matrix. (wikipedia.org)
  • tRNA genes
  • All rearrangement-mediating duplications include either the origin of light strand replication and the nearby tRNA genes or the regions flanking the origin of heavy strand replication. (unt.edu)
  • rRNA
  • and 12S rRNA genes. (nii.ac.jp)
  • gene provided 69 variable sites, and the sequenced 410-bp segment of 12S rRNA gene provided 21 variable sites. (nii.ac.jp)
  • gene within ingroup were 0.0022~0.0205 at the populational level, 0.0368~0.0462 at the racial or subspecific level, and 0.1038~0.1244 at the specific level, whereas those of the 12S rRNA gene were 0~0.0074 at the populational or subspecific level, and 0.0378~0.0456 at the specific level. (nii.ac.jp)
  • Genetic
  • In diagnosing autosomal dominant cerebellar ataxia the individuals clinical history or their past health examinations, a current physical examination to check for any physical abnormalities, and a genetic screening of the patients genes and the genealogy of the family are done. (wikipedia.org)
  • Moving further into SCA7's pathology, a similar genetic process is described, while the function of ATXN7 (an ataxin gene) is much like a component of the SAGA complex. (wikipedia.org)
  • Mitochondrial inheritance is therefore non-Mendelian, as Mendelian inheritance presumes that half the genetic material of a fertilized egg (zygote) derives from each parent. (wikipedia.org)
  • The mitochondrial diseases are genetic disorders carried in mitochondrial DNA, or nuclear DNA coding for mitochondrial components. (wikipedia.org)
  • There also exists virulence plasmids that contain the genetic elements necessary for bacteria to become pathogenic as well as degradative plasmids that harbor the genes that allow bacteria to degrade a variety of substances such as aromatic compounds and xenobiotics. (wikipedia.org)
  • divergence
  • Shimizu, K. & Banno, Y. (2002): Significant Levels of Sequence Divergence and Gene Rearrangements have Occurred Between the Mitochondrial Genomes of the Wild Mulberry Silkmoth, Bombyx mandarina, and its Close Relative, the Domesticated Silkmoth, Bombyx mori. (wikipedia.org)
  • amplification
  • Investigation of mitochondrial DNA revealed an about three‐fold enhanced mitochondrial gene copy number in white compared to green leaf cells, but no differential amplification of mitochondrial genes. (deepdyve.com)
  • Amplification of the CCND1 gene is present in: non-small cell lung cancers (30-46%) head and neck squamous cell carcinomas (30-50%) pancreatic carcinomas (25%) bladder cancer (15%) pituitary adenomas (49-54%) breast carcinoma (13%) Cyclin D1 overexpression is strongly correlated to ER+ breast cancer and deregulation of cyclin D1 is associated with hormone therapy resistance in breast cancer. (wikipedia.org)
  • analyses
  • While gene order is most similar to that of the brachiopod Terebratulina retusa , sequence based analyses of mitochondrial genes place nemerteans close to molluscs, phoronids and entoprocts without clear preference for one of these taxa as sister group. (biomedcentral.com)
  • circular
  • Circular bacterial plasmids are classified according to the special functions that the genes encoded on the plasmid provide. (wikipedia.org)
  • Naturally occurring circular plasmids can be modified to contain multiple resistance genes and several unique restriction sites, making them valuable tools as cloning vectors in biotechnology applications. (wikipedia.org)
  • chromosomal
  • Because mitochondrial diseases (diseases due to malfunction of mitochondria) can be inherited both maternally and through chromosomal inheritance, the way in which they are passed on from generation to generation can vary greatly depending on the disease. (wikipedia.org)
  • paternal
  • Metta, Muralidhar & Nagaraju, J. (2006): Molecular phylogeny of silkmoths reveals the origin of domesticated silkmoth, Bombyx mori from Chinese Bombyx mandarina and paternal inheritance of Antheraea proylei mitochondrial DNA. (wikipedia.org)
  • functional
  • A functional MSH1 gene present on a single-copy centromere plasmid was incapable of rescuing the established msh1 petite phenotype. (genetics.org)
  • Ancestral
  • An ancestral gene order reconstruction shows that Orthurethra in contrast to other Stylommatophora, have tRNA-H before tRNA-G and that the gene order in the 'non-achatinoid' clade is identical to that of closely related non-stylommatophoran taxa. (biomedcentral.com)
  • Ancestral gene order reconstructions reveal rearrangements that characterize systematic groups. (biomedcentral.com)
  • plasmid
  • Once delivered into the host, the products of the plasmid genes will then stimulate both the innate immune response and the adaptive immune response of the host. (wikipedia.org)
  • mutation
  • The his4x mutation, lying near the 5' end of the gene, was converted with equal frequency in both wild-type and msh2 strains. (genetics.org)