Mitochondrial atp binding cassette transporters. Medical search. Frequent questions

ATP-binding cassette sub-family B member 8, mitochondrial is a protein that in humans is encoded by the ABCB8 gene. (wikipedia.org)
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. (wikipedia.org)
This protein may also play a role in the transport of phospholipids into mitochondrial membranes. (wikipedia.org)
The ABCB7 gene provides instructions for making a protein known as an ATP-binding cassette (ABC) transporter. (medlineplus.gov)
Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation. (medlineplus.gov)
In addition to involvement in splicing as a P-type PPR protein, we found that FLO22 interacted with DYW3, a DYW-type PPR protein, and they may function synergistically in mitochondrial RNA editing. (jipb.net)
After the buffer optimization, the purified CntI was analyzed by Size Exclusion Chromatography coupled with Multi-Angle Laser Light Scattering (SEC-MALLS), UV absorbance, and Refractive Index detectors, in order to determine the absolute molar mass of the protein-detergent complex, the detergent amount bound to the protein and the amount of protein-free detergent micelles. (bvsalud.org)
Abcb10, a mitochondrial inner membrane ATP-binding cassette transporter highly induced during erythroid maturation in hematopoietic tissues, was found as one key protein that physically interacts with Mfrn1 during mouse erythroleukemia (MEL) cell differentiation. (anthropogeny.org)
In undifferentiated MEL cells, cotransfected Abcb10 specifically interacts with Mfrn1 to enhance its protein stability and promote Mfrn1-dependent mitochondrial iron importation. (anthropogeny.org)
These results suggest the tight regulation of mitochondrial iron acquisition and heme synthesis in erythroblasts is mediated by both transcriptional and posttranslational mechanisms, whereby the high level of Mfrn1 is stabilized by oligomeric protein complexes. (anthropogeny.org)
Researchers from the University of Toronto have created a map of the protein interactions of 19 members of the ATP-binding cassette transporter class in a species of yeast, combining this data with previously-reported ABC transporter interactions into a comprehensive "interactome. (genomeweb.com)
One half of a split ubiquitin molecule is attached to an ABC transporter (or another cellular protein of interest) and the other half to its potential interaction targets. (genomeweb.com)
Our findings include compounds that killed by inducing phosphodiesterase 3A-Schlafen 12 complex formation, vanadium-containing compounds whose killing depended on the sulfate transporter SLC26A2, the alcohol dependence drug disulfiram, which killed cells with low expression of metallothioneins, and the anti-inflammatory drug tepoxalin, which killed via the multidrug resistance protein ATP-binding cassette subfamily B member 1 (ABCB1). (nature.com)
Using biochemical and fluorescence imaging analyses, we show that Shh signaling activity reduces mitochondrial fission and promotes mitochondrial elongation, at least in part, via suppression of the mitochondrial fission protein dynamin-like GTPase Drp1. (janelia.org)
protein_coding" "AAC74319","hns","Escherichia coli","global DNA-binding transcriptional dual regulator H-NS [Ensembl]. (ntu.edu.sg)
LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
As we previously described, proadifen, a P450 monooxygenase inhibitor, might also be able to inhibit some ABC transporters, including breast cancer resistance protein (BCRP). (spandidos-publications.com)
More than 40 ABC transporters have been identified so far, but just a few play a role in MDR, including the breast cancer resistance protein (BCRP/ABCG2). (spandidos-publications.com)
Homo sapiens CGG triplet repeat binding protein 1 (CGGBP1), transcript variant 1, mRNA. (dbcls.jp)

Abcb10 interacts with Mfrn1 to promote Mfrn1-dependent mitochondrial iron importation. (anthropogeny.org)

ABC transporter proteins carry many types of molecules across membranes in cells. (medlineplus.gov)
An ubiquitous and conserved proteolytic system regulates the stability of mitochondrial inner membrane proteins. (silverchair.com)
In this review, we summarize some of the latest knowledge on mitochondrial dysregulation in major depression (depicted in Figure 1 ) and also discuss how mitochondrial dysfunction could instigate downstream changes in extracellular matrix proteins such as reelin, neuronal nitric oxide (nNOS), oxidative stress, and inflammation, and finally adult hippocampal neurogenesis. (frontiersin.org)
Though the group did the mapping with ABC transporters from a yeast species - Saccharomyces cerevisiae - many of the proteins are homologous to disease-linked human ABC proteins. (genomeweb.com)
ABC transporters are one of these pharmaceutically very important proteins because they play a role in health and disease, specifically drug resistance," Stagljar explained. (genomeweb.com)
The latter, Stagljar said, is an important area for drug development, because it opens the possibility that you could block ABC transporter activity by blocking associated zinc transport proteins. (genomeweb.com)
Multidrug resistance caused by the overexpression of ABC transporter proteins in cancer cells remains a major obstacle limiting chemotherapy efficacy. (spandidos-publications.com)
A number of mechanisms involved in the occurrence of MDR have been described, including the overexpression of one or more ATP binding cassette (ABC) transporter proteins that mediate the efflux of many clinically relevant drugs. (spandidos-publications.com)
It was previously reported that proadifen (SKF-525A), a well-known cytochrome P450 monooxygenase inhibitor, not only has anti-proliferative potential in some cancer cell lines, but it is also able to inhibit BCRP and MRP1 transporter proteins ( 8 ). (spandidos-publications.com)

From the abstract: 'Genome sequencing (GS) is one of the most comprehensive assays that interrogate single nucleotide variants, copy number variants, mitochondrial variants, repeat expansions, and structural variants in one assay. (cdc.gov)

Mitochondrial dysfunction has also been associated with ageing and most of the so-called age-related diseases [ 13 - 17 ]. (hindawi.com)
In this paper, we make the case that mitochondrial dysfunction could play an important role in the pathophysiology of depression. (frontiersin.org)
However, the data in relation to antidepressant drug effects are contradictory: some studies reveal they have no effect on mitochondrial function or even potentiate dysfunction, whereas other studies show more beneficial effects. (frontiersin.org)
Mitochondria could be targeted in the development of novel antidepressant drugs, and specific forms of mitochondrial dysfunction could be identified as biomarkers to personalize treatment and aid in early diagnosis by differentiating between disorders with overlapping symptoms. (frontiersin.org)
The focus of this review is the link between mitochondrial dysfunction and major depression. (frontiersin.org)
As a result of loss of ABCD1, there is pathogenic accumulation of very long chain fatty acids which leads to mitochondrial dysfunction. (cusabio.com)
At the cellular level, aging is marked by depletion of adult stem cell reservoirs, the inability to maintain baseline homeostasis, a reduced response to stress, an increased accumulation of damaged DNA leading to telomere shortening, and mitochondrial dysfunction [ 1,2 ]. (karger.com)

Alterations in mitochondrial functions such as oxidative phosphorylation (OXPHOS) and membrane polarity, which increase oxidative stress and apoptosis, may precede the development of depressive symptoms. (frontiersin.org)
Controls also the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization. (cusabio.com)

Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A). Hum Mol Genet. (medlineplus.gov)

mainly involved in uptake, and ABC transporters (ABCs), mainly involved in efflux (e.g. (biorxiv.org)
Among the multiple cellular mechanisms underlying the resistant phenotype, the enhanced efflux of anticancer drugs mediated by members of the ATP-binding cassette family of transporters such as P-glycoprotein (Pgp) and the reduced apoptosis due to dysregulation of the process are the most common causes of drug resistance. (cnr.it)
Taken together, the evidence suggests that APOL1-G1 and -G2 risk variants impaired reverse cholesterol transport through decreased expression of cholesterol efflux transporters suggesting a possible mechanism to promote macrophage foam cell formation, driving inflammation in the glomerulus and renal interstitium. (omicsdi.org)
Several compounds have been shown to inhibit the efflux activity of ABC transporters, thereby increasing intracellular drug accumulation and sensitising cancer cells to therapy. (spandidos-publications.com)

Slc25a37), a member of the solute carrier family localized in the mitochondrial inner membrane, functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters in erythroblasts. (anthropogeny.org)

Mitochondria are the energy producing organelles in eukaryotic cell providing ATP through oxidative phosphorylation (OXPHOS). (hindawi.com)
In line with this notion, mitochondria are highly dynamic organelles that undergo fission and fusion and move into the cell along the microtubules to generate the mitochondrial network [ 6 ]. (hindawi.com)
This tracer is a lipophilic cation that accumulates in mitochondria in response to plasma membrane e mitochondrial membrane potentials. (cnr.it)

Peptides generated upon proteolysis in the matrix space are transported across the inner membrane by an ATP-binding cassette transporter. (silverchair.com)
ATP-binding cassette, sub-family B (MDR/TAP), member 10 is a mitochondrial inner membrane ATP-binding cassette transporter which is highly expressed during erythroid maturation in hematopoietic tissues. (anthropogeny.org)

These involve cellular and molecular biological experiments aimed at investigating the role of members of the multidrug transporter gene family in determining clinical outcome of the childhood cancer neuroblastoma and other malignancies. (edu.au)

ABCG5 and ABCG8 are two heterodimeric ATP-binding cassette (ABC) transporters on hepatic canalicular membrane and are major contributors of hepatocytes cholesterol secretion into bile [ 4 ], as evidenced by approximately 75% reduced biliary cholesterol secretion rate in Abcg5 and/or Abcg8 KO mice [ 5 ]. (ijbs.com)

In this review, we discuss the functional cross talk of proteostasis and mitostasis in cellular homeodynamics and the impairment of mitochondrial quality control during ageing, cancer, and neurodegeneration. (hindawi.com)
Age-related gene expression profiles of the short-lived model animals Caenorhabditis elegans and Drosophila melanogaster share a common adult-onset expression program of genes involved in mitochondrial metabolism, DNA repair, catabolism, peptidolysis and cellular transport 3 . (nature.com)
This broad association "suggests that [ABC transporters] involvement in cellular function is more complex than previously demonstrated," the authors wrote. (genomeweb.com)
The transporter associated with antigen processing (TAP) is an ATP-binding cassette (ABC) transporter essential to cellular immunity against viral infection. (janelia.org)

Few genes show differential expression with age in tissues (brain, liver and kidney) of naked mole rats and, contrary to other mammals and short-lived model animals, mitochondrial gene expression does not change with age 13 . (nature.com)
c-Myc transrepression is mediated by blockade of the transactivating activity of Miz-1, which occurs mainly through a Sp1-binding site in the proximal promoter of the gene. (aacrjournals.org)

The type of active transport that uses chemical energy in the form of ATP for transporting molecules across a membrane is known as primary or direct active transport. (aakash.ac.in)
The group went on in its recent study to investigate two potentially interesting associations revealed in the yeast ABC transporter interactome map: physical interactions of ABC transporters with one another and the interaction of these molecules with members of the zinc transport system. (genomeweb.com)

ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. (cusabio.com)
Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation. (cusabio.com)

An interconnected highly integrated system of mitochondrial and cytosolic chaperones and proteases along with the fission/fusion machinery represents the surveillance scaffold of mitostasis. (hindawi.com)

Interestingly, antidepressant medication can restore the mitochondrial oxidant/antioxidant balance, and therefore help to rescue the negative effects of mitochondrial dysregulation (green lines). (frontiersin.org)

Furthermore, the binding domain of Mfrn1-Abcb10 interaction maps to the N terminus of Mfrn1. (anthropogeny.org)

The reduced expression of genes involved in mitochondrial oxidative respiration occurs in early adulthood, before the onset of functional decline, and more abruptly than a damage-response model would predict, which supports the possibility of programmed age-related transcriptional regulation 3 . (nature.com)
We analyse two comprehensive transcriptome datasets from human tissues and human-derived cell lines in terms of the expression profiles of the SLC and ABC families of membrane transporters. (biorxiv.org)
The Gini index (coefficient) characterises inequalities of distributions, and is used in a novel way to describe the distribution of the expression of each transporter among the different tissues and cell lines. (biorxiv.org)
Similar trends hold true for the expression profiles of transporters in different cell lines, suggesting that cell lines exhibit largely similar transport behaviour to that of tissues. (biorxiv.org)

Structure of the transporter associated with antigen processing trapped by herpes simplex virus. (janelia.org)

If the two bind, the ubiquitin molecule reforms, triggering the yeast cell to signal the interaction by turning blue, Stagljar explained. (genomeweb.com)

In many cases, transporters exhibit extremely high Gini coefficients, even when their supposed substrates might be expected to be available to all tissues, indicating a much higher degree of specialisation than is usually assumed. (biorxiv.org)
By contrast, the Gini coefficients for ABC transporters tend to be larger in cell lines than in tissues, implying that some kind of a selection process has taken place. (biorxiv.org)

In particular, with some exceptions such as olfactory receptors and genes involved in keratin production, transporter genes are significantly more heterogeneously expressed than are most non-transporter genes. (biorxiv.org)

Mutation of FLO22 resulting in defective trans -splicing of mitochondrial nad1 intron 1 and perhaps causing instability of mature transcripts affected assembly and activity of complex Ⅰ, and mitochondrial morphology and function. (jipb.net)
Overall, the data suggest an intriguing link between mitochondrial function and depression that warrants further investigation. (frontiersin.org)

Mitochondrial GPX1 silencing triggers differential photosynthesis impairment in response to salinity in rice plants [J]. J Integr Plant Biol. (jipb.net)

We showed [in the paper] for the first time this interaction between some ABC transporters of the PDR subfamily and zinc transporters," Stagljar said. (genomeweb.com)

The present work indicated that FLO22 plays an important role in endosperm development and plant growth by participating in nad1 maturation and multi-site editing of mitochondrial messager RNA. (jipb.net)

Moreover, nonreversible mitochondrial damage targets the organelle to a specific autophagic removal, namely, mitophagy. (hindawi.com)
It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. (rcsb.org)
Key biliary cholesterol transporters ABCG5 and ABCG8 were identified as direct targets of miRNA-223. (ijbs.com)

This process uses transmembrane ATPases for the hydrolysis of ATP to generate energy. (aakash.ac.in)

Murakami, S., Okadam U., van Veen, H. W. (2020) Tripartite transporters as mechano-transmitters in periplasmic alternating-access mechanisms. (cam.ac.uk)

The brain is particularly dependent on mitochondrial activity due to both its high levels of energy use and its inability to store large amounts of energy reserves in the form of glycogen. (frontiersin.org)
Coupled to the ATP-dependent transporter activity has also a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process. (cusabio.com)
Sonic Hedgehog Pathway activation increases mitochondrial abundance and activity in hippocampal neurons. (janelia.org)

Moreover, we revealed the ability of proadifen to increase the intracellular hypericin content in HT-29 cells most likely via the inhibition of BCRP and MRP1 transporters ( 8 ). (spandidos-publications.com)

Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS2) is a potential regulatory point in the pathway that converts acetyl-CoA to ketone bodies ( 1 - 3 ). (aacrjournals.org)

Perland and Fredriksson, 2017 ) or the pharmaceutical drug substrates of these transporters, and one clue to this may be to understand their differential tissue distribution. (biorxiv.org)

In the group's ABC transporter study, Stagljar and his team used MYTH to map the interactions of all of S. cerevisiae's 19 non-mitochondrial ABC transporters. (genomeweb.com)
They then combined the MYTH screening results with previously reported ABC transporter physical interactions available through the BioGRID database. (genomeweb.com)

Here, we present the purification protocol of CntI from Pseudomonas aeruginosa, a new metallophore exporter of the Drug Metabolite Transporter (DMT) family involved in pseudopaline secretion. (bvsalud.org)
YbaB/EbfC DNA-binding family [Interproscan]. (ntu.edu.sg)

Mitochondrial mass was increased significantly in neurons treated with Shh. (janelia.org)

Cavadini P, Biasiotto G, Poli M, Levi S, Verardi R, Zanella I, Derosas M, Ingrassia R, Corrado M, Arosio P. RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload. (medlineplus.gov)
Here, we used the strategy of in vivo epitope-tagging affinity purification and mass spectrometry to investigate Mfrn1-mediated mitochondrial iron homeostasis. (anthropogeny.org)
Oxidoreductase FAD-binding domain, Oxidoreductase NAD-binding domain, 2Fe-2S iron-sulfur cluster binding domain [Interproscan]. (ntu.edu.sg)

Human and animal studies suggest an intriguing link between mitochondrial diseases and depression. (frontiersin.org)
In this study, we determined the structure of human TAP bound to ICP47 by electron cryo-microscopy (cryo-EM) to 4.0 Å. (janelia.org)

We further show that Shh protects neurons against a variety of stresses, including the mitochondrial poison rotenone, amyloid β-peptide, hydrogen peroxide, and high levels of glutamate. (janelia.org)

Anatomy13

Organisms7

Diseases4

Chemicals and Drugs88

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes42

Information Science3

Protein19

Promote Mfrn1-dependent mitochondrial iron importation1

Proteins9

Nucleotide1

Dysfunction7

Oxidative stress2

Putative1

Efflux4

Heme1

Mitochondria3

Inner membrane2

Multidrug transporter1

Heterodimeric1

Cellular4

Gene2

Molecules2

Fatty acid2

Fission1

Dysregulation1

ABCB101

Expression4

Antigen1

Molecule1

Tissues2

Genes1

Function2

Biol1

Zinc1

Maturation1

Targets3

Hydrolysis1

Periplasmic1

Activity3

Inhibition1

Synthase1

20171

Interactions2

Family2

Significantly1

Iron3

Human2

Protects1