• protein
  • Mitochindrial associated membranes associated with Alzheimer's disease have been reported to have an up-regulation of lipids synthesized in the MAMs juxtaposition and an up regulation of protein complexes present in the contact region between the ER and mitochondria. (wikipedia.org)
  • Using worms and mice as models, they discovered that boosting mitochondria defenses against a particular form of protein stress, enables them to not only protect themselves, but to also reduce the formation of amyloid plaques. (eurekalert.org)
  • As a member of the death-associated protein (DAP) family, DAP3 can also be found outside of the mitochondria to initiate the extrinsic apoptotic pathway through its interactions with apoptotic factors, such as tumor necrosis factor-alpha, Fas ligand, and gamma interferon. (wikipedia.org)
  • However, once the full-length protein is imported into the mitochondria, this sequence is excised to produce the 184-residue mature protein. (wikipedia.org)
  • This protein is part of the FASTKD family, which is known for regulating the energy balance of mitochondria under stress and cell cycle progression. (wikipedia.org)
  • Though Miro has been predominantly studied in neurons, the protein has also been observed to participate in the transport of mitochondria in lymphocytes toward inflamed endothelia. (wikipedia.org)
  • pathways
  • Mitochondria are very versatile organelles and they are involved in a plethora of cellular functions, such as energy production, regulation of death pathways, calcium buffering. (hupo.org)
  • This volume also discusses the death pathways that are initiated by the mitochondria. (springer.com)
  • While we have known for a while that mitochondria are dysfunctional in the brains of Alzheimer's patients, this is the first evidence that they actually try to fight the disease by boosting quality control pathways. (eurekalert.org)
  • These defense and recycle pathways of the mitochondria are essential in organisms, from the worm C. elegans all the way to humans," says Vincenzo Sorrentino, first author of the paper. (eurekalert.org)
  • cytosol
  • Though SOD1 is synthesized in the cytosol and can mature there, the fraction of expressed, and still immature, SOD1 targeted to the mitochondria must be inserted into the intermembrane space. (wikipedia.org)
  • enzyme
  • Mitochondria are well known as the key energy generators in our cells, but we found that during inflammation they switch from that role to instead making toxic products from oxygen using an enzyme called succinate dehydrogenase, which promotes inflammation. (medicalnewstoday.com)
  • cells
  • Incidentally, I agree vis a vis mitochondria: they are the major (95%) source of intracellular free radicals and therefore one of the major sources of entropic damage within cells. (bio.net)
  • It clearly occurs in somatic cells (you are correct) and yet it clearly has not occurred within the inherited maternal germ cell line of mitochondria for an astounding timespan. (bio.net)
  • The investigators found that during the initial phase of the macrophage response, the cells alter the activity of mitochondria. (medicalnewstoday.com)
  • The organelles are quite flexible, however, and time-lapse studies of living cells have demonstrated that mitochondria change shape rapidly and move about in the cell almost constantly. (conservapedia.com)
  • The cooling process may help stop the death of brain and heart cells initiated by the mitochondria once they are deprived of oxygen. (slashdot.org)
  • Taking this line of thought, Johan Auwerx's lab at EPFL looked at mitochondria, which are the energy-producing powerhouses of cells, and thus central in metabolism. (eurekalert.org)
  • During normal aging and age-associated diseases such as Alzheimer's, cells face increasing damage and struggle to protect and replace dysfunctional mitochondria. (eurekalert.org)
  • Since mitochondria provide energy to brain cells, leaving them unprotected in Alzheimer's disease favors brain damage, giving rise to symptoms like memory loss over the years. (eurekalert.org)
  • Miro functions to tether the complex to the mitochondrion while the complex transports the mitochondrion via microtubules within cells. (wikipedia.org)
  • oxygen
  • mitochondrion ), are rod-shaped organelles that are responsible for the lions share of energy metabolism within a cell, converting oxygen and nutrients into Carbon dioxide and water and synthesizing ATP in the process. (conservapedia.com)
  • mechanism
  • Considering that physiological factors such as activation of glutamate receptors in dendrites, action potentials in axons, and neuromodulators may elevate calcium ion levels, this regulatory mechanism likely serves to keep mitochondria in such areas to provide calcium ion buffering and active export and, thus, maintain homeostasis. (wikipedia.org)
  • research
  • Breaking research discovers how macrophages turn mitochondria into toxic chemical-producing inflammation-promoters. (medicalnewstoday.com)
  • His research is focused on myocardial protection including the role of mitochondria, and had significant impact on cardiac surgery where he was a member of the team that received the UK Hospital Doctor Award in 2005 for innovative surgery. (springer.com)
  • High
  • High quality Mitochondria inspired T-Shirts, Posters, Mugs and more by independent artists and designers from around the world. (redbubble.com)
  • years
  • It is as though mitochondria are biologically immortal (and homeostatically flawless) for billions of years until you and I inherit them, and then go downhill almost instantly (in comparison). (bio.net)
  • For many years after their discovery, mitochondria were commonly believed to transmit hereditary information. (conservapedia.com)
  • sites
  • Also up increased connectivity between the ER and the mitochondria at MAM sites has been observed in human patients diagnosed with familial AD (FAD) by increase of the contact sites. (wikipedia.org)
  • title
  • It came with a disc with the PV of the title track "Mitochondria" and peaked at #20 on the Oricon charts All lyrics written by Kenichi Suzumura. (wikipedia.org)
  • full-length
  • With this line-up Mitochondrion has recorded two full-length studio albums, the self-released Archaeaeon (2008) and Parasignosis (2011), which was released through Profound Lore Records. (wikipedia.org)
  • Transport
  • Transport of phosphatidylserine into mitochondria from the ER for decarboxylation to phosphatidylethanolamine through the ER-mitochondria lipid which transform phosphatidic acid (PA) into phosphatidylserine (PS) by phosphatidylserine synthases 1 and 2 (PSS1, PSS2) in the ER and then transfers PS to mitochondria, where phosphatidylserine decarboxylase (PSD) transform into phosphatidylethanolamine (PE). (wikipedia.org)
  • goes
  • PE which is synthesized at mitochondria goes back to ER where phosphatidylethanolamine methyltransferase 2 (PEMT2) synthesizes PC (phosphatidylcholine). (wikipedia.org)
  • heart
  • Though ubiquitously expressed in all tissues, TBRG4 appears more abundantly in skeletal muscle, heart muscle, and other tissues enriched in mitochondria. (wikipedia.org)