Mitochondria drosophila proteins. Medical search. Frequent questions

Only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. (sdbonline.org)
Disruption of the MRM2 Drosophila melanogaster orthologue leads to mitochondria-related developmental arrest. (nature.com)
In this study, novel probiotic and synbiotic formulations are shown to combinatorially extend longevity in male Drosophila melanogaster through mechanisms of gut-brain-axis communication with implications in chronic disease management. (provivapharma.com)
Identification of proteins interacting with the mitochondrial small heat shock protein Hsp22 of Drosophila melanogaster: Implication in mitochondrial homeostasis. (nih.gov)
Protein-focused research has been challenging in Drosophila melanogaster due to few specific antibodies for Western blotting and the lack of effective labeling methods for quantitative proteomics. (biomed.news)
However, precisely how FKBP12 is regulated and effects calcium signaling in Drosophila melanogaster remains largely unknown. (biomedcentral.com)
These finding indicate that DmFKBP12 and RyR associated calcium signaling plays an essential role in the successful development of Drosophila melanogaster . (biomedcentral.com)
In insect, Drosophila melanogaster ryanodine receptor ( DmRyR ) cDNA was cloned from lava and the physical features of DmRyR single channel were characterized with in vitro overexpression system [ 16 ]. (biomedcentral.com)
In this paper, we show that Syntaxin17 is recruited to the outer membrane of autophagosomes to mediate fusion through its interactions with ubisnap (SNAP-29) and VAMP7 in Drosophila melanogaster . (rupress.org)
Because of the availability of remarkably powerful genetic, molecular and cell biological tools, we use the fruitfly, Drosophila melanogaster, as our primary model for investigating the fundamental mechanisms of PCP signaling. (stanford.edu)

To alter the expression of Buffy in the dopaminergic neurons of Drosophila. (sdbonline.org)
The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
It is concluded that the inhibition of Buffy in DA neurons produces a novel model of PD in Drosophila. (sdbonline.org)
Attributed to the failure of neurons to clear dysfunctional mitochondria , loss of gene expression leads to loss of nigrostriatal neurons. (sdbonline.org)
DRP1 is required for proper cellular distribution of mitochondria, and in mutant neurons, mitochondria are largely absent from synapses, thus providing a genetic tool to assess the role of mitochondria at synapses. (nih.gov)
Overexpression of the RAPGEF2 mutant in Drosophila motor neurons reduces the stability of axonal microtubules and disrupts the distribution of mitochondria to distal axons and neuromuscular junction (NMJ) synapses. (en-journal.org)
In Drosophila, loss-of-perform mutations in PINK1 and parkin outcome in enlarged and swollen mitochondria and degeneration of flight muscle, sperm and dopaminergic neurons [nine,10,eleven,twelve,13,14]. (dna-alkylating.com)

The Parkinson's disease genes pink1 and parkin , which encode a mitochondrially targeted protein kinase, and an E3 ubiquitin ligase, respectively, participate in a key mitochondrial quality-control pathway that eliminates damaged mitochondria. (sdbonline.org)
PANK2 is the only one out of four PANK genes encoding an isoform which localizes to mitochondria. (benthamscience.com)
At least two other NBIA genes (PLA2G6, C19orf12) encode proteins that share with PANK2 a mitochondrial localization and all are suggested to play a role in lipid homeostasis. (benthamscience.com)
In a forward screen for genes affecting neurotransmission in Drosophila, we identified mutations in dynamin-related protein (drp1). (nih.gov)
To date, two-thirds of fALS are associated with mutations in any of more than 25 genes [ 3 , 4 , 5 ], encoding proteins involved in protein homeostasis, RNA metabolism, vesicular trafficking, and cytoskeletal organization. (en-journal.org)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
Self-splicing introns populate several highly conserved protein-coding genes in fungal and plant mitochondria. (genestogenomes.org)
By purifying and analysing mitochondria from different cell types, we show that PINK-1 and PDR-1 are required to set heteroplasmy differences between major somatic tissue groups in C. elegans and that removal of these genes equalises ΔmtDNA heteroplasmy across the organism. (biorxiv.org)

This study evaluated the roles of PINK1 mitochondrial kinase, and Parkin E3 ubiquitin ligase in targeting depolarized mitochondria for degradation in vivo, using quantitative measurements of mitochondria in Drosophila nervous system. (sdbonline.org)
The hypotheses was tested that impairment of mitochondrial quality control via suppression of PINK1 function should produce failures of turnover, accumulation of senescent mitochondria in the axon, defects in mitochondrial traffic, and a significant shift in the mitochondrial fission-fusion steady state. (sdbonline.org)
Loss of PINK1 also produced specific, directionally balanced defects in mitochondrial transport, without altering the balance between stationary and moving mitochondria. (sdbonline.org)
This study established an in vivo PINK1 / Parkin -induced photoreceptor neuron degeneration model in Drosophila with the aim of dissecting the PINK1/Parkin pathway in detail. (sdbonline.org)
Using LC-MS/MS analysis, Serine 346 was identified as the sole autophosphorylation site of Drosophila PINK1 and it was found that substitution of Serine 346 to Alanine completely abolishes the PINK1 autophosphorylation. (sdbonline.org)
The Pink1/parkin pathway plays a role in the quality control mechanism aimed at eliminating defective mitochondria, and the failure of this mechanism results in a reduced lifespan and impaired locomotor ability, among other phenotypes. (sdbonline.org)
In cell culture models, Parkin is recruited to acutely depolarised mitochondria by PINK1. (mdc-berlin.de)
PINK1 activates Parkin activity leading to ubiquitination of multiple proteins, which in turn promotes clearance of mitochondria by mitophagy. (mdc-berlin.de)
Most of our understanding of Pink1 and Parkin function comes from Drosophila. (adenosine-kinase.com)
Genetic analysis in Drosophila showed that Pink1 acts upstream of Parkin [258]. (adenosine-kinase.com)
These research indicate that each Pink1 and Parkin are involved in the removal of dysfunctional mitochondria, and loss of Pink1 or Parkin led to the accumulation of abnormal mitochondria, which causes oxidative tension and neurodegeneration [262, 263]. (adenosine-kinase.com)
PINK1 encodes a mitochondrially qualified serine/threonine kinase, whilst parkin encodes an E3 MEK162 ubiquitin-protein ligase. (dna-alkylating.com)
PINK1 and Parkin have also been demonstrated to influence mitochondrial morphology in vertebrates, even though, in contrast to the reports carried out in Drosophila, mitochondrial fragmentation is the most frequently observed phenotype on diminished PINK1 and Parkin exercise in mammalian mobile culture [19,twenty,21,22]. (dna-alkylating.com)
In our current operate, we analyzed the speculation that PINK1 and Parkin impact mitochondrial morphology in Drosophila by acting straight on core components of the mitochondrial fission- or fusion-advertising apparatus. (dna-alkylating.com)
We found that the conserved PTEN-induced putative kinase (PINK1/PINK-1) and the E3 ubiquitin-protein ligase parkin (PDR-1), which are required for mitochondrial autophagy (mitophagy), underlie stereotyped differences in heteroplasmy of a deleterious mitochondrial genome mutation (ΔmtDNA) between major somatic tissues types in Caenorhabditis elegans . (biorxiv.org)

Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)

Finally, increasing microtubule stability through pharmacological inhibition of histone deacetylase 6 (HDAC6) rescues defects in the intracellular distribution of mitochondria and BAX. (en-journal.org)

Following Parkin Wild-Type (WT) and Parkin Ligase dead (LD) expression we analysed by mass spectrometry and stringent bioinformatics analysis those proteins differentially ubiquitinated to provide the first survey of steady state Parkin substrates using an in vivo model. (mdc-berlin.de)
RESULTS: We identified 35 proteins that are more prominently ubiquitinated following Parkin over-expression. (mdc-berlin.de)
Recruitment of Parkin to mitochondria causes the ubiquitination of mfn within a Pink1dependent manner. (adenosine-kinase.com)
All round mitochondrial protein turnover in parkin null Drosophila was related to that in Atg7 deficient mutants. (adenosine-kinase.com)

Much of our attention has been focusSed on the tko25t strain, which carries a point mutation in the gene for mitoribosomal protein S12, and is a useful model for studying human mitochondrial disease. (tuni.fi)
Ction mutation in Drosophila blue cheese gene (bchs) outcomes in an age-dependent accumulation of ubiquitinated protein aggregates and amyloid precursor-like proteins and reduces life span. (adenosine-kinase.com)
Using a forward genetic Inhibitors,research,lifescience,medical approach we positionally cloned and identified a novel pathogenic mutation affecting SOD2 in Drosophila. (phosphorylase-signal.com)

My research interests include mitochondria, mitochondrial disease and cellular energy metabolism. (tuni.fi)
Mechanistically, this resistance requires sustained activation of mTORC1 and the mechanistic target of rapamycin (mTOR)C1-dependent induction of sterol regulatory element-binding protein 1 (SREBP1), a central transcription factor regulating lipid metabolism. (biomed.news)
Nocturnin (NOCT) is a rhythmically expressed protein that regulates metabolism under the control of circadian clock. (princeton.edu)
We provide evidence for NOCT targeting to mitochondria and propose that NADP(H) regulation, which takes place at least in part in mitochondria, establishes the molecular link between circadian clock and metabolism. (princeton.edu)

These cellular defects were improved by the light-dependent activation of mitochondrion-targeted dR (mito-dR). (nature.com)
Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
Fluorescent reporter proteins in the Drosophila model system offer a degree of specificity that allows monitoring cellular and biochemical phenomena in vivo, such as autophagy, mitophagy, and changes in the redox state of cells. (intechopen.com)
The AAA-ATPase (ATPases associated with diverse cellular activities) valosin-containing protein (VCP), is essential for many cellular pathways including but not limited to endoplasmic reticulum-associated degradation (ERAD), DNA damage responses, and cell cycle regulation. (portlandpress.com)
The LINC complex can perform distinct cellular functions by pairing various KASH domain proteins with the same SUN domain protein. (ucdavis.edu)
Although DmFKBP12 is distributed evenly between the anterior to posterior poles of the blastoderm egg, the protein is expressed more strongly in the cortex of the early Drosophila gastrula with the highest concentration found in the basement membrane of the cellular blastoderm. (biomedcentral.com)
Fertilized egg, through the profile as under-membrane cortex distribution concentering onto basement at cellular blastoderm, to the profile as three-gem layer localization in primitive neuronal and digestion architecture of early Drosophila gastrula. (biomedcentral.com)
As a unique isoform of RyR in insect, the binding protein DmFKBP12 is essential as well in insect physiological and cellular processes. (biomedcentral.com)
Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
Mitotic segregation of mitochondria may result in asymmetric proportions of heteroplasmic allelic variants in descendant cellular lineages [ 5 ]. (biorxiv.org)

VCP primarily identifies ubiquitylated proteins in these pathways and mediates their unfolding and degradation by the 26S proteasome. (portlandpress.com)
VCP interacts with adaptor proteins to identify ubiquitylated substrates for degradation by the proteasome. (portlandpress.com)
Alfy-mediated aggrephagy makes use of p62/SQSTM1, the human homologue of Drosophila Ref(2)P. Alfy, with each other withBioMed Research International target a variety of OMM substrates for example Mfn: ubiquitinating them and targeting them for proteasomal degradation [257]. (adenosine-kinase.com)

Although the senescent cells remain viable, they show typical changes with enlarged and flattened cell bodies, apoptosis resistance, increased activity of senescence-associated β -galactosidase (SA- β -gal), and upregulation of cyclin-dependent kinase (CDK) inhibitors including p16 INK4A , ARF proteins, and p21 [ 13 - 16 ]. (hindawi.com)
Fusion allows the exchange of contents, DNA, and metabolites between neighboring mitochondria, including damaged or senescent mitochondria, promoting their survival [2, 3]. (centrodinoferrari.com)

We use various Drosophila mutants with defects in mitochondrial function to analyse the contributions of nuclear and mitochondrial genotype, as well as environmental factors such as diet and exposure to antibiotics, to organismal phenotype. (tuni.fi)

Drosophila CHCHD2 ( dCHCHD2 ) knockout flies exhibit PD-like phenotypes in an age-dependent manner, which include dysfunction in motor ability, DA neuron loss, increased oxidative stress and mitochondrial cristae degeneration 2 . (nature.com)
The inhibition of porin under the control of neuronal Ddc-Gal4 result in short lifespan and in an age-dependent loss in locomotor function, phenotypes that are strongly associated with Drosophila models of Parkinson disease . (sdbonline.org)

In this study, by adapting dR to mitochondria in Drosophila , we present a potential therapeutic approach to preserve mitochondria from degeneration caused by CHCHD2 loss. (nature.com)

The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)
Dynamin-related protein 1 (DRP1), a cytosolic dynamin-related GTPase, plays a central role in fission by promoting mitochondrial division through its oligomerization into multimeric spiral structures [5]. (centrodinoferrari.com)

Pervasive adaptive protein evolution apparent in diversity patterns around amino acid substitutions in Drosophila simulans. (1library.org)

Given the numerous degrees of mitochondrial protein turnover impairment in response to a deficit in either proteasom- associated variables or selective autophagy regulators, two theories try to pinpoint the pathways involved in mitophagy. (adenosine-kinase.com)

While RNA makes up most of the composition of bacterial and cytosolic eukaryotic ribosomes, mammalian mitochondrial ribosomes present a more elaborate protein shell, which aids coping with the oxidative microenvironment. (nature.com)
Additionally, mitochondria contribute substantial amounts of ROS during oxidative phosphorylation ( Hamanaka and Chandel, 2010 ). (frontiersin.org)
They house their own genome (mtDNA), as well as RNA and protein-synthesizing systems, which together code and coordinate the assembly of core subunits of oxidative phosphorylation (OXPHOS). (biorxiv.org)

CHCHD2 (mutations of which cause an autosomal dominant form of PD) encodes a mitochondrial intermembrane protein 1 . (nature.com)
Alterations in mitochondrial dynamics due to mutations in proteins involved in the fusion-fission machinery represent an important pathogenic mechanism of human diseases. (centrodinoferrari.com)

These include several mitochondrial proteins and a number of endosomal trafficking regulators such as v-ATPase sub-units, Syx5/STX5, ALiX/PDCD6IP and Vps4. (mdc-berlin.de)

Throughout these described changes in expression, DmFKBP12 mRNA remain stable, which indicates that protein dynamics are attributed to regulation at the mRNA to protein translation level. (biomedcentral.com)
Throughout these changes in distribution, in situ DmFKBP12 mRNA monitoring detected equal distribution of DmFKBP12 mRNA, once again indicating that regulation of DmFKBP12 occurs at the translational level in Drosophila development. (biomedcentral.com)
Role of ATP-dependent calcium regulation in modulation of Drosophila synaptic thermotolerance. (neurotree.org)
Hyperthermic preconditioning of presynaptic calcium regulation in Drosophila. (neurotree.org)
This basic two-step process has been confirmed in most mammalian cells, although its regulation and the repertoire of specific accessory proteins are likely to be highly context dependent. (centrodinoferrari.com)

Another feasible model requires mitochondria-derived vesicles, which carry selected cargo directly towards the lysosome, in an autophagy-independent manner [266]. (adenosine-kinase.com)

SILAF is based on standard fly routines in a basic wet lab environment and provides a flexible and cost-effective tool for quantitative protein expression analysis. (biomed.news)

The linker of the nucleoskeleton and cytoskeleton (LINC) complex is formed by the conserved interactions between Sad-1 and UNC-84 (SUN) and Klarsicht, ANC-1, SYNE homology (KASH) domain proteins, providing a physical coupling between the nucleoskeleton and cytoskeleton that mediates the transfer of physical forces across the nuclear envelope. (ucdavis.edu)
They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
A hormone-responsive C1-domain-containing protein At5g17960 mediates stress response in Arabidopsis thaliana. (1library.org)

Here, a genome-wide analysis of the human mitochondrial transcriptome shows that 2'- O -methylation is limited to residues of the mitoribosomal large subunit (mtLSU) 16S mt-rRNA, introduced by MRM1, MRM2 and MRM3, with the modifications installed by the latter two proteins being interdependent. (nature.com)

Proc Natl Acad Sci USA 2010) and that knocking out TDP1 results in a neurological phenotype in drosophila (Guo et al Proc Natl Acad Sci USA 2014). (cancer.gov)

Our data suggest a specific role for mitochondria in regulating synaptic strength. (nih.gov)
Silencing synaptic communication between random interneurons during Drosophila larval locomotion. (neurotree.org)
Peptide-induced modulation of synaptic transmission and escape response in Drosophila requires two G-protein-coupled receptors. (neurotree.org)

The metabolites NADP and NADPH are the targets of the circadian protein Nocturnin (Curled). (princeton.edu)

Alfy is a substantial, 3527 amino acid lengthy protein, which contains many different functional domains, which includes a FYVE domain suggesting an affinity for PI(three)-P wealthy endosomes. (adenosine-kinase.com)
Surprisingly, modeling of the missense Inhibitors,research,lifescience,medical mutant does not predict an alteration in the structure of the SOD2 protein despite an amino acid substitution (G138D) that is different in both size and charge. (phosphorylase-signal.com)

LW1564 also significantly decreased overall ATP levels by inhibiting mitochondrial electron transport chain (ETC) complex I and downregulated mammalian target of rapamycin (mTOR) signaling by increasing the AMP/ATP ratio, which increased AMP-activated protein kinase (AMPK) phosphorylation. (biomed.news)
Her work on the T cell tyrosine kinase ITK has revealed a critical role for this TCR signaling protein in autoreactive T cell trafficking into tissues such as the pancreas and the intestine. (cuanschutz.edu)

The intracellular distribution, ultrastructure, and function of mitochondria are also impaired in patient cells. (en-journal.org)

In accordance with its tumor suppressor role, the Retinoblastoma protein pRb can ensure pro-apoptotic functions. (sdbonline.org)

VCP identifies ubiquitylated substrates through numerous dedicated adaptor proteins and unfolds substrates by threading them through a central pore in the hexamer ( Figure 1 ). (portlandpress.com)

As a critical component of the signaling pathway, the RyR medicated calcium-induced calcium release signaling system, has been well studied along with their regulator FK506-binding protein 12 (FKBP12/Calstabin). (biomedcentral.com)

Subsequently, the expression of Buffy was altered in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
Violin plots show distribution of expression levels for Mitochondria localized glutamic acid rich protein (SMED30017321) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
Expression of Mitochondria localized glutamic acid rich protein (SMED30017321) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells. (stowers.org)
In this study, we identified both temporal and localization changes in expression of DmFKBP12, a translational and transcriptional regulator of Drosophila RyR (DmRyR) and FKBP12, through embryonic development. (biomedcentral.com)
In addition to temporal changes in expression, dynamic expression profiles during Drosophila development also revealed DmFKBP12 localization. (biomedcentral.com)
As a critical regulator of the DmRyR-FKBP complex, DmFKBP12 expression in Drosophila fluctuates temporally and geographically with the formation of organ systems. (biomedcentral.com)

Further study on the differences between mammalian RyR-FKBP12 and Drosophila DmRyR-FKBP12 can be exploited to develop safe pesticides. (biomedcentral.com)

These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
Protein crowding induces membrane curvatures through an entropic mechanism. (portlandpress.com)

Predicted to enable protein transmembrane transporter activity. (nih.gov)

Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)

Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)
Fission also regulates apoptosis through segregation of the most critically injured mitochondria [1, 4]. (centrodinoferrari.com)

The ubiquitinated protein aggregates in bchs mutants are positive for Ref(2)P [244]. (adenosine-kinase.com)

Recently, studies in the PANK Drosophila model "fumble" revealed improvement by the compound pantethine which is hypothesized to feed an alternate CoA biosynthesis pathway. (benthamscience.com)
The data presented here support a cytoplasmic integrity model where ANC-1 localizes to the ER membrane and extends into the cytoplasm to position nuclei, ER, mitochondria, and likely other organelles in place. (ucdavis.edu)
One particular model revolves around the chaperone-mediated extraction of mitochondrial proteins [265]. (adenosine-kinase.com)

iPLA2-VIA binds the retromer subunits Vps35 and Vps26 and enhances retromer function to promote protein and lipid recycling. (nih.gov)
The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix. (nih.gov)
The yellow box identifies muscles … Discussion SOD2 proteins perform a critical function in antioxidant defense within mitochondria. (phosphorylase-signal.com)
Nonetheless, these studies suggested that the mutant protein could retain wildtype function and that altered stability of the protein might underlie SOD2bwd pathogenesis. (phosphorylase-signal.com)

Nuclear positioning is mediated by a conserved network of nuclear envelope proteins that interacts with force generators in the cytoskeleton. (ucdavis.edu)

METHODS: Here we utilized the recently introduced BioUb strategy to isolate ubiquitinated proteins in flies. (mdc-berlin.de)
Furthermore, in this chapter, we provide a protocol for mitochondrial enrichments from Drosophila larvae and flies together with a procedure to generate high-quality peptides for further analysis by mass spectrometry. (biomed.news)

Light-dependent activation of mitochondrion-targeted dR (mito-dR) but not a mito-dR inactive mutant successfully transformed mitochondria from an OXPHOS-dependent powerhouse to a photoenergetic powerhouse, which accordingly reinforced the mitochondrial functions of the nerve terminals in terms of ATP production and Ca 2+ -buffering activity, suppressing ROS generation 10 , 11 . (nature.com)
To assess the pathogenic effects of this variant, we have used patient-derived skin fibroblasts and motor neuron-specific overexpression of the RAPGEF2-E1357K mutant protein in Drosophila . (en-journal.org)

Anatomy49

Organisms12

Diseases2

Chemicals and Drugs91

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Psychiatry and Psychology3

Phenomena and Processes86

Disciplines and Occupations1

Information Science4

Health Care1

Melanogaster10

Neurons7

Genes9

Pink115

Ubiquitin ligase1

Distribution of mitochondria1

Parkin4

Mutation3

Metabolism4

Cellular10

Degradation3

Senescent2

Defects1

Phenotypes2

Degeneration1

Drp12

SIMULANS1

Mitochondrial protein1

Oxidative3

Mutations2

Several mitochondrial1

Regulation5

Vesicles1

Quantitative1

Mediates3

Genome1

Phenotype1

Synaptic3

Metabolites1

Amino acid2

Kinase2

Ultrastructure1

Tumor1

Substrates1

Calcium1

Expression6

Mammalian1

Mechanism2

TRANSMEMBRANE1

Physiological1

Apoptosis2

Mutants1

Model3

Function4

Interacts1

Flies2

Mutant2