AcetaminophenAnalgesics, Non-NarcoticDrug-Induced Liver InjuryIminesDrug OverdoseAntipyreticsIbuprofenAnti-Inflammatory Agents, Non-SteroidalLiver Failure, AcuteLiverAdministration, RectalAntidotesHydrocodoneGlutathioneDose-Response Relationship, DrugCytochrome P-450 CYP2E1PhenacetinAlanine TransaminaseChromatography, High Pressure LiquidAcetylcysteineDouble-Blind MethodAnalgesicsHalf-LifeAminophenolsAdministration, OralFeverBenzoquinonesArea Under CurveCross-Over StudiesPain, PostoperativeAnalgesics, OpioidMicrosomes, LiverNonprescription DrugsDrug LabelingNecrosisPain MeasurementDrug Administration ScheduleTime FactorsHepatocytesInjections, IntravenousElectrophoresis, Polyacrylamide GelKineticsHaemophilus parainfluenzaeGlucuronatesAspartate AminotransferasesDrug CombinationsEscherichia coliCodeineGlutathione DisulfideSolubilityAspirinGlucuronidesPain