Mild cognitive genetic basal ganglia cerebrovascular disease. Medical search. Frequent questions

Vascular cognitive impairment and dementia is acute or chronic cognitive deterioration due to diffuse or focal cerebral infarction that is most often related to cerebrovascular disease. (msdmanuals.com)
Overview of Delirium and Dementia Delirium (sometimes called acute confusional state) and dementia are the most common causes of cognitive impairment, although affective disorders (eg, depression) can also disrupt cognition. (msdmanuals.com)
Vascular cognitive impairment and dementia is the 2nd most common cause of dementia among older people. (msdmanuals.com)
Subcortical ischemic vascular cognitive impairment and dementia is caused mainly by small vessel disease. (msdmanuals.com)
Approximately 15% of patients follow a primary progressive or progressive relapsing course from disease onset, usually characterized by symptoms of progressive myelopathy (gait instability, spasticity, bladder symptoms) and cognitive impairment. (medscape.com)
Dementia, characterized by impairment of overall intellectual functioning, is a chronic condition and is distinct from the normal cognitive decline observed with old age. (therecoveryvillage.com)
Early recognition of dementia symptoms may allow for treatment to slow down the rate of cognitive impairment. (therecoveryvillage.com)
There are a variety of different scales or rating systems used by clinicians to determine the degree of cognitive impairment in patients living with dementia. (therecoveryvillage.com)
The Global Deterioration Scale provides the clinician with a global overview of the impairment caused by dementia in terms of cognitive decline, functional abilities and behavioral symptoms, and divides the progression of dementia into seven stages. (therecoveryvillage.com)
The first three stages of the GDS scale are pre-dementia stages with the third stage characterized by mild cognitive impairment. (therecoveryvillage.com)
This stage is characterized by the absence of any symptoms of cognitive or functional impairment. (therecoveryvillage.com)
Deterioration beyond the mild cognitive impairment observed in stage 3 marks the onset of dementia. (therecoveryvillage.com)
As these risk factors overshadow aging and nonvascular factors, CKD patients represent a potential model of accelerated vascular cognitive impairment. (neurologyindia.com)
Parkinson's disease is a neurological disorder characterized by tremors, slowed movements, changes in writing and speech, and (at times) cognitive impairment. (rupahealth.com)
High levels of manganese can cause a disorder called manganism which mimics PD closely and includes tremors, bradykinesia, cognitive impairment, and more. (rupahealth.com)
It considers the clinical manifestations of the chronic form of the disease, including cognitive impairment. (ima-press.net)

Dementia is defined as a set of symptoms indicating cognitive decline without a loss of consciousness, typically appearing gradually in adulthood. (thedepression.org)
The most common form of dementia is Alzheimer's disease. (thedepression.org)
The life expectancy for geriatric dementia is shorter if the symptoms are more severe at the beginning of the disease. (thedepression.org)
Alzheimer's Disease is the most common cause of dementia, accounting for 70 to 80% of all cases. (thedepression.org)
People with this form of dementia experience progressive cognitive decline and significant memory loss, often coupled with focal neurological signs such as hemiparesis (partial paralysis), heightened reflexes, Babinski sign, ataxia (lack of coordination), pseudobulbar palsy, bradykinesia (slowness of movement), walking difficulties, and swallowing issues. (thedepression.org)
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring. (elsevierpure.com)
Dementia is caused by a variety of diseases that may result in an irreversible, gradual decline in cognitive functioning. (therecoveryvillage.com)
Dementia is a clinical syndrome or group of symptoms that are the outcome of disease rather than being a disease itself. (therecoveryvillage.com)
Dementia is caused by a variety of diseases, with Alzheimer's disease and vascular dementia (caused by pathologies of blood vessels in the brain) being the most common. (therecoveryvillage.com)
Dementia is defined by the loss of intellectual or cognitive abilities that are severe enough to impair social and occupational functioning. (therecoveryvillage.com)
Dementia is characterized by chronic symptoms of cognitive decline that worsen over time. (therecoveryvillage.com)
Vascular dementia is a heterogeneous entity with a large clinicopathological spectrum that has been classically linked to cortical and subcortical ischemic changes resulting from systemic, cardiac, or local large- or small-vessel disease occlusion. (medscape.com)
In a clinical setting, differences between the cognitive disturbances in vascular dementia and Alzheimer disease are of limited value in distinguishing the 2 conditions. (medscape.com)
Vascular dementia may have less significant memory dysfunction than Alzheimer disease. (medscape.com)
One study highlighted the interaction of environmental and genetic factors contributing to the predisposition to vascular dementia. (medscape.com)
The diagnosis of vascular dementia is usually made on the basis of clinical, neuroimaging, or neuropathologic evidence of cerebral ischemia in the presence of progressive cognitive decline. (medscape.com)
Management of vascular disease and dementia in a young patient with suspected uncommon causes of stroke (eg, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [CADASIL] or angiitis) involves ruling out these conditions with the appropriate testing procedures (ie, skin biopsy, cerebral angiography). (medscape.com)
Numerous epidemiological studies have shown that DM is closely associated with dementia and cognition dysfunction, with recent research focusing on the role of DM-mediated cerebrovascular damage in dementia. (hindawi.com)
The aims of this paper are (1) to provide an updated overview on the association between DM and cognitive dysfunction and (2) to review the scientific evidence underpinning the use of TCM interventions for the treatment and prevention of DM-induced cognitive dysfunction and dementia. (hindawi.com)
Indeed, several epidemiological studies have shown that people with T2DM have a significantly higher risk of developing cognitive impairments and dementia when compared to those with normal blood glucose levels [ 3 - 5 ]. (hindawi.com)
A recent population-based longitudinal study has shown that the relative risk of Alzheimer's diseases (AD) and vascular dementia (VaD) in the DM population was 1.46 (95% CI: 1.20-1.77) and 2.5 (95% CI: 2.1-3.0), respectively, when compared to people without DM [ 6 ]. (hindawi.com)
Although the exact pathophysiology of DM-mediated dementia has not been fully elucidated, existing evidence has shown that both cerebrovascular changes and neurodegeneration are implicated in the development and progression of DM-mediated cognitive dysfunction [ 5 ]. (hindawi.com)
Parkinson disease is by far the most common cause of the parkinsonian syndrome , accounting for approximately 80% of cases (the remainder being due to other neurodegenerative diseases, such as Lewy body dementia ) 1 . (radiopaedia.org)
disease duration, 6.3+3.2 years) without dementia. (ima-press.net)
We aimed to comprehensively explore the associations between serum 25(OH)D deficiency and risk of dementia and Alzheimer's disease(AD). (biomedcentral.com)
Dementia is an incurable neurodegenerative disease of unknown cause. (biomedcentral.com)
In addition to other potentially modifiable risk factors for dementia, such as being overweight, smoking, diabetes mellitus, hypertension, hypercholesterolemia, and cardiovascular diseases, a potential prognostic role of vitamin D deficiency has been proposed [ 5 ]. (biomedcentral.com)
Alzheimer disease (AD) is the most common progressive degenerative form of dementia, strongly associated with advancing age. (medscape.com)
[9] Around half of people with ALS develop at least mild difficulties with thinking and behavior, and about 15% develop frontotemporal dementia . (wikipedia.org)
Dementia is a progressive loss of cognitive and intellectual functioning without loss of consciousness. (medfriendly.com)

In contrast, a cognitively impaired patient with vascular risks factors but no history of cerebrovascular disease is most likely to have Alzheimer disease. (medscape.com)

Stage 2: Very mild cognitive decline. (therecoveryvillage.com)
Stage 3: Mild cognitive decline. (therecoveryvillage.com)
however numerous clinical-pathological studies have suggested a significant contribution of cerebrovascular diseases to cognitive decline [ 11 , 12 ]. (hindawi.com)
To date, several systematic reviews and clinical trials have discussed the relationship between vitamin D deficiency and cognitive decline, but the conclusions of these studies are contradictory. (biomedcentral.com)

As the disease progresses to an intermediate stage, cognitive deficits increase. (thedepression.org)
An enhanced CR may lead to less cognitive deficits despite severe pathological lesions. (e-jmd.org)
Cognitive deficits become objectively recognizable at this stage. (therecoveryvillage.com)

Diffusion-weighted imaging did not reveal abnormal restricted diffusion ruling out an acute basal ganglia stroke. (jpgmonline.com)
In addition to providing acute and critical cerebrovascular care at UC Davis, he established a novel OMM clinic for stroke survivors with chronic physical disability. (osteopathic.org)
Microfibrillar-associated protein 4 as a potential marker of acute relapse in inflammatory demyelinating diseases of the central nervous system: Pathological and clinical aspects. (cuanschutz.edu)
The paper is devoted to the most common variant of cerebral small-vessel disease Р sporadic cerebral non-amyloid microangiopathy (SCNAMA) in the context of acute and chronic cerebral circulatory disorders. (ima-press.net)
CLASSIFICATION OF DISEASES AND INJURIES I. INFECTIOUS AND PARASITIC DISEASES (001-139) Includes: diseases generally recognized as communicable or transmissible as well as a few diseases of unknown but possibly infectious origin Excludes: acute respiratory infections (460-466) influenza (487. (cdc.gov)

Parkinson's disease (PD) is also a common neurodegenerative disease and is mainly characterized by motor dysfunction related to striatal dopaminergic depletion. (e-jmd.org)
Despite the therapeutic benefits of antidiabetic agents for the treatment of DM-mediated cognitive dysfunction, most of these pharmaceutical agents are associated with various undesirable side-effects and their long-term benefits are therefore in doubt. (hindawi.com)
however, DM-induced cognitive dysfunction is seldom addressed and is not as well understood. (hindawi.com)
The brain pathology underlying cognitive dysfunction is heterogeneous and is highly complicated. (hindawi.com)
To date, there are no DM-specific treatments to prevent or ameliorate cognitive dysfunction. (hindawi.com)
Nevertheless, numerous reports have highlighted the therapeutic potential of antidiabetic therapies in the treatment and prevention of cognitive dysfunction [ 13 - 15 ]. (hindawi.com)

This group includes lysosomal storage disorders, various mitochondrial diseases, other neurometabolic disorders, and several other miscellaneous disorders. (medscape.com)
Numerous studies have demonstrated that DM can cause damage to multiple systems, leading to complications such as heart disease, cancer, and cerebrovascular disorders. (hindawi.com)
Depressive disorders do not exhibit manic or hypomanic components characteristic of bipolar disease. (pharmacology2000.com)
In this article, the disease-related and treatment-related neurological complications of renal disorders will be reviewed. (neurologyindia.com)
The "Surprise Question" for Prognostication in People with Parkinson's Disease & Related Disorders. (cuanschutz.edu)
For a group of muscle-wasting disorders, see Motor neuron diseases . (wikipedia.org)
ALS is a motor neuron disease , which is a group of neurological disorders that selectively affect motor neurons , the cells that control voluntary muscles of the body. (wikipedia.org)

Although no lesions are present in the basal ganglia in primary spasmodic torticollis, fMRI and PET studies have shown abnormalities of the basal ganglia and hyper activation of the cortical areas. (wikipedia.org)
cerebrovascular disease and brain space-occupying lesions are the main causes in adults. (medlink.com)

These conditions are listed below: Central nervous system tumor Central pontine myelinolysis Cerebrovascular diseases Drug induced Infectious or post infectious encephalopathies Kernicterus Metabolic Paraneoplastic syndromes Perinatal (during birth) cerebral injury Peripheral or central trauma Toxins Secondary spasmodic torticollis is diagnosed when any of the following are present: history of exogenous insult or exposure, neurological abnormalities other than dystonia, abnormalities on brain imaging, particularly in the basal ganglia. (wikipedia.org)
Since that year, rarer autosomal dominant disease forms with variable penetrance with or without chromosome 9 abnormalities have also been described. (medscape.com)
The major cause of primary PKD is genetic abnormalities, and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete penetrance. (biomedcentral.com)

The concept of cognitive reserve (CR) in Alzheimer's disease (AD) explains the differences between individuals in their susceptibility to AD-related pathologies. (e-jmd.org)
Journal of Alzheimer's Disease. (elsevierpure.com)
Even with all our knowledge about exercise, there is still no agreement concerning the optimal exercise intensity or prescription strategy for patients suffering from Alzheimer's disease or Parkinson's disease. (issuu.com)
The molecules acting through RAS predominantly ARBs and ACEI are found to be effective in various ongoing and completed clinical trials related to cognition, memory, Alzheimer's disease (AD), and pain. (hindawi.com)
It is the second most common neurodegenerative disorder - behind only Alzheimer's disease in its incidence. (rupahealth.com)
APOE4 Alzheimer's gene: a variant of the APOE gene that has been strongly associated with a higher risk of developing Alzheimer's disease, a progressive brain disorder that affects memory, thinking, and behavior. (drpaulkilgore.com)

Moyamoya disease is an idiopathic, nonatherosclerotic, noninflammatory, chronic progressive cerebrovascular disease characterized by bilateral stenosis or occlusion of the arteries around the circle of Willis, typically the supraclinoid internal carotid arteries, followed by extensive collateralization, which are prone to thrombosis, aneurysm, and hemorrhage. (jpgmonline.com)
Multiple sclerosis is a common, chronic demyelinating neurological disease primarily affecting young adults, with a prevalence of ~0.1% in the Caucasian population (Miller and Leary, 2007). (medscape.com)
Hypertension, carotid stenosis, chronic kidney disease and metabolic syndrome all showed a strong association with SBI. (biomedcentral.com)
The impact of the osteopathic approach on chronic disease and elderly care: Proposals should explore the impact of the osteopathic approach on chronic disease and elderly care through clinical, translational or basic science research. (osteopathic.org)
He has authored 20 original peer-reviewed papers relating to the use of osteopathic manipulation for pneumonia, chronic obstructive lung disease, influenza vaccine, improving immune function, applications of osteopathic philosophy, falls prevention, leg length discrepancies and, most recently, leg edema. (osteopathic.org)
Chronic kidney disease (CKD) is a critical and rapidly growing global health problem. (neurologyindia.com)

Research on the signs, symptoms, and pathogenesis of WNV disease has greatly intensified in the past 5 years. (cdc.gov)
The most common treatment for spasmodic torticollis is the use of botulinum toxin type A. Initial symptoms of spasmodic torticollis are usually mild. (wikipedia.org)
Toxic metal exposures can cause nervous system symptoms that look very much like Parkinson's disease. (rupahealth.com)
[3] The goal of treatment is to slow the disease progression, and improve symptoms. (wikipedia.org)
Unbiased means of diagnosing AD using computational algorithms that integrate multidisciplinary inputs, ranging from nanoscale biomarkers to cognitive assessments, and integrating both biochemical and physical changes may provide solutions to these limitations due to lack of understanding for the dynamic progress of the disease coupled with multiple symptoms in multiscale. (regenerativemedicine.net)

Enzymes involved in the synthesis and elimination of 1,25-(OH) 2 D 3 are expressed in brain regions such as the thalamus, hippocampus, and basal ganglia, suggesting that vitamin D has both autocrine and paracrine pathways in the central nervous system [ 10 , 11 ]. (biomedcentral.com)

These RAS peptides are present in astrocytes, glial cells, oligodendrocytes, and neurons of various areas of the brain [ 14 , 15 ] such as the basal ganglia, cerebral cortex, and hippocampus [ 16 ]. (hindawi.com)

This variant is associated with severe, poorly controlled hypertension and systemic vascular disease. (msdmanuals.com)
CBAs were rare and predominantly seen in elderly individuals, many of whom had multiple systemic and cerebrovascular comorbidities including hypertension, myocardial and cerebral infarcts, and CAA. (nature.com)
Patients with CKD exhibit a high incidence of symptomatic and occult cerebrovascular diseases, associated tremendously high levels of inflammatory factors and homocysteine, as well as anemia, hypertension, and diabetes. (neurologyindia.com)

Alzheimer Disease Alzheimer disease causes progressive cognitive deterioration and is characterized by beta-amyloid deposits and neurofibrillary tangles in the cerebral cortex and subcortical gray matter. (msdmanuals.com)
As the disease progresses to a more advanced stage, the deterioration of nerve cells intensifies, rendering patients increasingly bedridden and incapable of self-care. (thedepression.org)
Usually, a series of such incidents lead to reduced blood and oxygen supply to specific brain areas, causing a gradual, step-by-step deterioration in cognitive functions. (thedepression.org)

Defects in such disparate systems (ie, basal ganglia and erythrocytes) have led to the suggestion that a common neurohematological membrane defect is involved. (medscape.com)
Most patients will continue with intractable epilepsia partialis continua and also develop neurologic and cognitive defects. (medlink.com)

Genetic analysis and natural history of Charcot-Marie-Tooth disease CMTX1 due to GJB1 variants. (cuanschutz.edu)
[6] [13] About half of these genetic cases are due to disease-causing variants in one of four specific genes . (wikipedia.org)
We validated the algorithm's predictions by characterizing 646 genetic system variants, encoded in plasmids and genomes, expressed in six gram-positive and gram-negative bacterial hosts. (omictools.com)

The nearly abolished dopamine transporter uptake identified by 18F-FP-CIT PET is frequently found in patients with FBXO7 mutations, which is different from the usual rostrocaudal gradient that is observed in patients with Parkinson's disease. (e-jmd.org)
Parkinson's disease affects an estimated 4% of people over the age of 50 - a number that exceeds 10 million people across the globe each year. (rupahealth.com)
The diagnosis of Parkinson's disease is generally made by a neurologist after physical examination and testing. (rupahealth.com)
Parkinson's disease is generally defined as the loss of dopamine-producing neurons in a particular part of the brain called the substantia nigra. (rupahealth.com)
Certain pesticides , herbicides, fungicides, rodenticides, and fumigant exposures are linked with the development of Parkinson's disease. (rupahealth.com)
While Parkinson's disease existed long before the invention of these chemicals, we know that exposure to them makes a person more likely to develop PD today. (rupahealth.com)
Much of the research in PD is devoted to understanding the genetic underpinnings of Parkinson's disease due to its perceived heritability - or likelihood of occurring in families. (rupahealth.com)
Males are about 1.5 times as likely to experience Parkinson's disease as women. (rupahealth.com)
Some familial forms of Parkinson's disease, in fact, are due to genetic mutations (LRRK2, Leucine-rich repeat kinase) 21 . (radiopaedia.org)
Effects of deep brain stimulation on quantitative sleep electroencephalogram during non-rapid eye movement in Parkinson's disease. (cuanschutz.edu)
Daytime sleepiness is one of the clinically significant non-motor manifestations of Parkinson's disease (PD). (ima-press.net)

CBAs may not be a significant cause of ICH but are a manifestation of severe cerebral small vessel disease including both hypertensive arteriopathy and CAA. (nature.com)
Maple syrup urine disease (MSUD) is categorized as classic (severe), intermediate, or intermittent. (nih.gov)
If the subthreshold noxious stimulus is too mild or negligibly mild, it may not induce any response, whereas if it is sufficient enough, it may serve as a PC trigger, or if it is too severe, over the threshold, may permanently injure tissues. (biomedcentral.com)

Dr. Yee's previous research focused on neurologic prognostication in patients with critical brain disease. (osteopathic.org)

A small number of patients develop the disorder as a result of another disorder or disease. (wikipedia.org)
CONCLUSIONS: Preoperative chemotherapy should be suggested in patients with high disease burden. (bvsalud.org)
Treat patients with risk factors for cerebrovascular disease. (medscape.com)
For asymptomatic patients with uncomplicated coronary disease resumption of activity was recommended by some following six weeks of convalescence. (pharmacology2000.com)
In this update, the author discusses advancements in the epidemiology, diagnosis, treatment, and prognosis of patients with arterial ischemic stroke and cerebral venous thrombosis associated with genetic and acquired thrombophilia, including the antiphospholipid antibody syndrome. (medlink.com)
In patients with juvenile Parkinson disease, its function is impaired, and the formation of Lewy bodies is impossible. (radiopaedia.org)
Secondary hypogammaglobulinemia in patients with multiple sclerosis on anti-CD20 therapy: Pathogenesis, risk of infection, and disease management. (cuanschutz.edu)
Reducing the receipt of contraindicated medications in patients with Parkinson disease. (cuanschutz.edu)
In this consensus, we review the clinical manifestations, etiology, clinical diagnostic criteria and therapeutic recommendations for PKD, and results of genetic analyses in PKD patients performed in domestic hospitals. (biomedcentral.com)
In patients with coronary heart disease (CHD) or at high risk of CHD, ZOCOR® can be started simultaneously with diet. (globalrph.com)
It's important to note that treatment approaches for these two risk groups may differ, with high-risk patients typically receiving more intensive therapies to address the increased complexity and aggressiveness of their disease. (neurosurgery.directory)
Many patients with dry AMD are asymptomatic and unaware of the disease. (org.es)
Real-time diagnostic updates of progression could be made on the basis of the changes in the physical biomarkers and the cognitive assessment scores of patients over time. (regenerativemedicine.net)

Two CBAs in the basal ganglia demonstrated associated microhemorrhages, while three demonstrated infarcts in the vicinity. (nature.com)

A variety of conditions can cause brain injury, from external factors to diseases. (wikipedia.org)
In particular, some premorbid experiences (i.e., physical activity and education) and modifiable factors (i.e., body mass index and white matter hyperintensity on brain image studies) could modulate an individual's capacity to tolerate PD pathology, which can be maintained throughout disease progression. (e-jmd.org)
The individual approach combines a vascular risk factor modification and various therapies addressing the specific subtypes of stroke (eg, antiplatelet drugs to prevent cerebral infarction in large and small artery diseases of the brain, carotid endarterectomy or stenting for tight carotid artery stenosis, and oral anticoagulants to prevent cardiac emboli). (medscape.com)
This is because the word "bovine" refers to cows (and other related animals) and the last two words refer to this being a disease of the brain and spinal cord (encephalopathy) that causes it to have a spongy appearance (spongiform). (medfriendly.com)
A progressive brain disorder that causes memory loss, confusion, and other cognitive problems. (drpaulkilgore.com)
Our vision is to prevent and cure disease and disability of the brain and nervous system. (edu.au)

Parkinson disease (PD) , also known as idiopathic parkinsonism , is a neurodegenerative disease and movement disorder characterized by resting tremor, rigidity and hypokinesia due to progressive degeneration of dopaminergic neurons in the substantia nigra . (radiopaedia.org)

Although moyamoya disease (MMD) is a common cause of transient ischemic stroke in Asian children and young adults, there have been very few cases of MMS in thalassemia published in the literature. (jpgmonline.com)
Genetic and acquired hypercoagulable states, such as factor V Leiden deficiency, prothrombin G20210A mutation, and antiphospholipid syndrome, are associated with cerebrovascular events, including cerebral venous thrombosis and ischemic stroke. (medlink.com)
Cerebrovascular manifestations of a hypercoagulable state are arterial ischemic stroke and cerebral venous thrombosis. (medlink.com)

Since MMS is a progressive disease, it is important to diagnose and initiate treatment to prevent worsening of the disease and recurrence of stroke. (jpgmonline.com)

This review highlights new information regarding the virology, clinical manifestations, and pathology of WNV disease, which will provide a new platform for further research into diagnosis, treatment, and possible prevention of WNV through vaccination. (cdc.gov)
Parkinson disease is characterized by both motor and non-motor clinical features. (radiopaedia.org)
Inherited Neuropathies Consortium-Rare Disease Clinical Research Network. (cuanschutz.edu)
An increasing number of studies has revealed the clinical and genetic characteristics, as well as the underlying mechanisms of PKD. (biomedcentral.com)
Subsequent studies have revealed clinical and genetic characteristics of PKD. (biomedcentral.com)
However, it is important to acknowledge that our current understanding of prognosis is based on treatment approaches guided by clinical risk factors such as postoperative residual tumor volume and the presence of metastatic disease. (neurosurgery.directory)

Heart failure, coronary artery disease, hyperhomocysteinemia and obstructive sleep apnea are also likely of significance. (biomedcentral.com)

[5] Mechanical ventilation can prolong survival but does not stop disease progression. (wikipedia.org)
Using a computational algorithm, developed to integrate these biomarkers and cognitive assessments, we demonstrate an approach to impartially diagnose AD and predict its progression. (regenerativemedicine.net)
Additionally, the Nyquist-Shannon sampling theorem was used to determine the minimum number of necessary patient checkups to effectively predict disease progression. (regenerativemedicine.net)

The pathology and pathogenesis of WNV disease have been described more completely than ever before. (cdc.gov)

and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. (childrensmercy.org)

Although Alzheimer disease (AD) is more frequent in individuals with Down syndrome (DS), the main contributing factor is unknown. (medscape.com)

Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes. (biomedcentral.com)

Utility and safety of rituximab in pediatric autoimmune and inflammatory CNS disease. (jamanetwork.com)

With the increasing prevalence of Alzheimer s disease (AD), significant efforts have been directed toward developing novel diagnostics and biomarkers that can enhance AD detection and management. (regenerativemedicine.net)

The prognosis is poor as no treatment is available for the primary disease. (medscape.com)

Amyotrophic lateral sclerosis ( ALS ), also known as motor neurone disease ( MND ) or Lou Gehrig's disease , is a rare and terminal neurodegenerative disease that results in the progressive loss of motor neurons that control voluntary muscles . (wikipedia.org)

[12] The remaining 5% to 10% of cases have a genetic cause, often linked to a history of the disease in the family , and these are known as familial ALS (hereditary). (wikipedia.org)

Explanations of this concurrence includes simple coexistence at the time of the medical diagnosis, a reaction to the psychological stress of dealing with the disease, an effect resulting from the disease itself or occurring secondary to the medication used to treat the disorder. (pharmacology2000.com)

A number of other regions including parts of the basal ganglia , brainstem , autonomic nervous system and cerebral cortex 3 . (radiopaedia.org)

Although autopsy studies have documented histological and ultrastructural changes associated with AMD in the retina, retinal pigment epithelium (RPE), choriorcapillaris and choroid in middle age, the disease typically does not manifest clinically before age 55 (10). (org.es)

Mad cow disease is a deadly condition caused by an abnormal protein known as a prion, which enters the body when cows are fed the remains of other cows or infected sheep. (medfriendly.com)

Amyloidosis: a group of rare diseases caused by the buildup of amyloid protein in various tissues and organs. (drpaulkilgore.com)

this contribution is of the same order as noted for ischemic heart disease. (pharmacology2000.com)

Anatomy3

Diseases7

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Information Science3

Geographicals1

Impairment16

Dementia30

History of cerebrovascular disease1

Decline4

Deficits3

Acute5

Dysfunction6

Disorders7

Lesions2

Abnormalities3

Alzheimer's Disease6

Chronic6

Symptoms5

Thalamus1

Hippocampus1

Hypertension3

Deterioration3

Defects2

Variants3

Parkinson's Disease11

Severe3

Neurologic1

Patients13

Infarcts1

Brain6

Idiopathic1

Ischemic stroke3

Stroke1

Clinical6

Coronary artery1

Progression3

Pathology1

Onset1

Alzheimer Disease1

Neurological diseases1

Inflammatory1

Biomarkers1

Prognosis1

Progressive1

Hereditary1

Diagnosis1

Nervous System1

Clinically1

Abnormal1

Amyloid1

Contribution1