Perinatal asphyxia, more appropriately known as hypoxic-ischemic encephalopathy (HIE), is characterized by clinical and laboratory evidence of acute or subacute brain injury due to asphyxia. (medscape.com)
Despite the advent of hypothermia therapy for the treatment of hypoxic-ischemic encephalopathy (HIE), treatment options following asphyxia at birth remain limited, particularly in low-resource settings where the incidence of birth asphyxia is highest. (frontiersin.org)
Mild total body hypothermia, induced by cooling a baby to 33-34°C for three days after birth, is nowadays a standardized treatment after moderate to severe hypoxic ischemic encephalopathy in full-term and near to fullterm neonates. (wikipedia.org)
Hypoxic ischemic encephalopathy has many causes and is defined essentially as the reduction in the supply of blood or oxygen to a baby's brain before, during, or even after birth. (wikipedia.org)
Recognition of infants with marginal external signs of asphyctic damage at birth, who still develop moderate hypoxic ischemic encephalopathy would be enhanced by finding more reliable bio-markers or physiologic tests accurately predicting the risk for progressive damage. (wikipedia.org)
Therapeutic hypothermia (TH) aims to ameliorate further injury in infants with moderate and severe hypoxic ischemic encephalopathy (HIE). (nature.com)
Hypoxic ischemic encephalopathy (HIE) occurs in 1-6 per 1,000 live full-term births and is caused by the interruption of blood and/or oxygen supply to the brain in the perinatal period ( 1 , 2 ). (nature.com)
Therapeutic hypothermia2
A 2013 Cochrane review found that therapeutic hypothermia is useful in full term babies with encephalopathy. (wikipedia.org)
Therapeutic hypothermia (TH) is now standard of care for infants with moderate and severe HIE ( 15 ). (nature.com)
Asphyxia1
The fetal sheep asphyxia model also suggests a six-hour window post asphyxia in which hypothermia will have greatest benefit. (wikipedia.org)
Infants1
At present data relate only to full term infants, and all human studies of hypothermia treatment have so far been restricted to infants >36 weeks out of an expected 40 weeks gestation. (wikipedia.org)
Moderate1
In doing so, we aimed to (i) assess the general association between HRV and EEG grade of HIE (ii) assess the nature of this association by comparing HRV within each EEG grade of HIE (mild-moderate, mild-severe, and moderate-severe) to identify where differences are most pronounced (iii) compare HRV between pre-TH and TH groups for mild, moderate, and severe EEG grade of HIE. (nature.com)
Long-term1
None of these programmes have sufficient power to make confident assessments of the long-term effect of hypothermia, however even these underpowered studies give important information on whether the therapeutic effects of cooling are sustained beyond the first two years after birth. (wikipedia.org)
Brain1
There are both more potential side effects on the developing premature with lung disease, and there is more evident protection by hypothermia when a greater volume of complex brain is actively developing. (wikipedia.org)
Hypoxic11
Perinatal asphyxia, more appropriately known as hypoxic-ischemic encephalopathy (HIE), is characterized by clinical and laboratory evidence of acute or subacute brain injury due to asphyxia. (medscape.com)
Providing standard intensive care support, correcting metabolic acidosis, close monitoring of the fluid status, and seizure control are the main elements of treatment in patients with hypoxic-ischemic encephalopathy (HIE). (medscape.com)
Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes. (medscape.com)
Effect of depth and duration of cooling on death or disability at age 18 months among neonates with hypoxic-ischemic encephalopathy: a randomized clinical trial. (medscape.com)
Mild total body hypothermia, induced by cooling a baby to 33-34°C for three days after birth, is nowadays a standardized treatment after moderate to severe hypoxic ischemic encephalopathy in full-term and near to fullterm neonates. (wikipedia.org)
Hypoxic ischemic encephalopathy has many causes and is defined essentially as the reduction in the supply of blood or oxygen to a baby's brain before, during, or even after birth. (wikipedia.org)
Recognition of infants with marginal external signs of asphyctic damage at birth, who still develop moderate hypoxic ischemic encephalopathy would be enhanced by finding more reliable bio-markers or physiologic tests accurately predicting the risk for progressive damage. (wikipedia.org)
Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. (evelinalondon.nhs.uk)
Assessment of brain tissue injury after moderate hypothermia in neonates with hypoxic-ischaemic encephalopathy: a nested substudy of a randomised controlled trial. (evelinalondon.nhs.uk)
This study aimed to identify potential biomarkers of neonatal hypoxic-ischemic encephalopathy (HIE) via a novel proteomic approach, the isobaric tags for absolute and relative quantification (iTRAQ) method. (biomedcentral.com)
Neonatal hypoxic ischemic encephalopathy (HIE) is a severe form of neonatal brain damage caused by an asphyxia-related decrease in cerebral blood flow and hypoxia. (biomedcentral.com)
Neonates1
Blood samples were collected from neonates with mild ( n = 4), moderate ( n = 4), or severe ( n = 4) HIE who were admitted to the neonatal intensive care unit of Children's Hospital of Soochow University between Oct 2015 and Oct 2017. (biomedcentral.com)
Birth asphyxia2
His research work focuses on treatment and prevention of brain damage in newborn infants, and his research group has worked for many years on the discovery and implementation of hypothermia to treat birth asphyxia. (evelinalondon.nhs.uk)