• Dysphagia and dysarthria (and occasionally anarthria) are common manifestations of olivopontocerebellar atrophy (OPCA). (medscape.com)
  • Generally, cerebellar signs and extrapyramidal signs are the predominant signs of olivopontocerebellar atrophy (OPCA). (medscape.com)
  • A unifying etiology of olivopontocerebellar atrophy (OPCA) has not been established. (medscape.com)
  • Care of olivopontocerebellar atrophy (OPCA) is directed to the treatment of symptoms. (medscape.com)
  • At times, olivopontocerebellar atrophy (OPCA) patients may require enteral feeding to decrease the risk of aspiration. (medscape.com)
  • As dysphagia progresses with olivopontocerebellar atrophy (OPCA), a pureed diet or enteral feeding may be required. (medscape.com)
  • Available at https://www.ninds.nih.gov/health-information/disorders/olivopontocerebellar-atrophy . (medscape.com)
  • The term olivopontocerebellar atrophy is used when the disorder starts later in life and the process is a primary degeneration of cerebellar neurons. (nih.gov)
  • Convit Ade Asis Jde Leon MJTarshish CYDe Santi SRusinek H Atrophy of the medial occipitotemporal, inferior, and middle temporal gyri in non-demented elderly predict decline to Alzheimer's disease. (jamanetwork.com)
  • The Sporadic Early-onset Alzheimer's Disease Signature Of Atrophy: Preliminary Findings From The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) Cohort Alzheimers Dement. (usc.edu)
  • Sex and APOE e4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease Alzheimers Dement. (usc.edu)
  • Results of the 2-part, 18-month GATHER1 trial suggest that avacincaptad pegol can significantly reduce the progression of geographic atrophy (GA) secondary to age-related macular degeneration (AMD) with few adverse effects. (aao.org)
  • The association with atrophy progression in cognitively impaired participants was stronger for p-tau181 than for NfL. (medscape.com)
  • In grade 3, due to the progression of atrophy, the medial outline of the CN becomes straight. (hindawi.com)
  • Evidence shows that brain atrophy in general accumulates throughout the course of multiple sclerosis and is associated with disability progression. (disabled-world.com)
  • This analysis is important because it confirms the link between reduced brain atrophy and reduced disability progression found in the CLARITY study," said Nicola De Stefano, lead author of the publication and Associate Professor of Neurology, Department of Medicine, Surgery and Neuroscience, University of Siena. (disabled-world.com)
  • The brain atrophy analysis evaluated the effect of Cladribine tablets on brain volume loss (BVL) over 2 years in RMS and the association of BVL with confirmed disability progression in 1,025 (77.3%) of the patients in CLARITY. (disabled-world.com)
  • Findings of steatorrhea, mucosal malabsorption of 2 substances (eg, fat, D-xylose), and villous atrophy (demonstrated by means of biopsy) are adequate to make a diagnosis. (medscape.com)
  • Subtotal villous atrophy (H&E, orig. (medscape.com)
  • Despite major advancements in AMD treatment, there is still a large unmet need for geographic atrophy treatment, which remains a leading cause of AMD-related central vision loss. (aao.org)
  • There is slowly progressive loss of central vision, with central geographic atrophy, including loss of underlying choriocapillaris. (hpathy.com)
  • Huntington's disease (HD) is an autosomal dominant inherited disorder belonging to the group of systemic brain atrophies. (hindawi.com)
  • Dominant optic atrophy is inherited in an autosomal dominant fashion. (msdmanuals.com)
  • Apathy was further related to frontotemporal and subcortical atrophy, as well as WML. (lu.se)
  • Macrocephaly was noted at birth, and rocephaly, frontotemporal brain atrophy his head circumference continued to grow and acute encephalopathic episodes char- parallel to the 98th centile. (who.int)
  • Bilateral hippocampal volume atrophy at 1 year was reduced by approximately 20% compared to the matched subjects from AD Neuroimaging Initiative. (biospace.com)
  • The symptoms include mild to moderate leg muscle weakness, tremors , and mild breathing problems. (medlineplus.gov)
  • These therapies may also improve blood flow and slow muscle weakness and atrophy. (medlineplus.gov)
  • Muscle loss (muscle atrophy) in our dogs can occur for a variety of different reasons. (cleanrun.com)
  • On baseline postoperative images, 21 flaps showed moderate or intense enhancement of the muscular graft component relative to nonenhancing native muscle, three flaps showed mild enhancement, and three showed no enhancement. (ajnr.org)
  • Developmental disuse (i.e. hind limb immobilization) associated with PA induced muscle fiber atrophy, extracellular matrix changes in the muscle, and mild to moderate ankle and knee joint degeneration at levels greater than disuse alone. (cdc.gov)
  • Muscle atrophy, caused by a progressive loss of the anterior horn cells in the spinal cord, is universal. (medscape.com)
  • Spinal muscular atrophies (SMAs) represent a rare group of inherited disorders that cause progressive degeneration of the anterior horn cells of the spinal cord. (medscape.com)
  • Infantile onset progressive cerebellar atrophy and anterior horn cell degeneration--a late onset variant of PCH-1? (nih.gov)
  • However, anterior horn cell degeneration has also been described in cases with later onset pontocerebellar atrophy and recently the spectrum has even been further extended to include the association of anterior horn cell degeneration and cerebellar atrophy without pontine involvement. (nih.gov)
  • OBJECTIVE: Clinically differentiating multiple system atrophy cerebellar type (MSA-C) and spinocerebellar ataxias (SCAs) is challenging, especially at early disease stages, because of their similarities in clinical manifestation and imaging results. (bvsalud.org)
  • of the head shows fronto-temporal atrophy carnitine levels in urine were elevated and and bilateral subdural haemorrhage glutaryl-CoA dehydrogenase activity in cul- tured fibroblasts was low. (who.int)
  • The only symptom is slowly progressive bilateral vision loss, usually mild until late in life. (msdmanuals.com)
  • Both physicians conducted autopsies on their patients and found severe atrophy of the ventral roots of the spinal cord. (medscape.com)
  • Patients with MCI who were treated with galantamine demonstrated a lower rate of whole brain atrophy, but not of hippocampal atrophy, over a 24-month treatment period, compared to those treated with placebo. (biomedcentral.com)
  • NfL, however, was associated with progressive atrophy in frontal regions among cognitively unimpaired participants. (medscape.com)
  • Retinal assessments have been discussed as biomarkers for brain atrophy. (nature.com)
  • Dilated fundus exam demon-strated diffuse retinal pigment epithelium atrophy with pigment deposition and a bull's-eye pattern. (aao.org)
  • OCT exhibited diffuse outer retinal atrophy, spar-ing the foveal region (Fig. 1). (aao.org)
  • Magnetic resonance imaging and 18F-flutemetamol-positron emission tomography quantified brain atrophy, WML, and Aβ deposition. (lu.se)
  • We recorded whole brain and hippocampal volumes, and calculated annual atrophy rates. (biomedcentral.com)
  • Linear regression analysis was used to calculate adjusted mean differences in the rate of whole brain and hippocampal atrophy, between MCI patients treated with galantamine and with placebo. (biomedcentral.com)
  • This protective effect of galantamine on whole brain atrophy rate in MCI was only present in APOE ϵ4 carriers. (biomedcentral.com)
  • Can milder bouts injure the brain, too? (alzforum.org)
  • Yes, say scientists led by Gwenaëlle Douaud and Stephen Smith at the University of Oxford, U.K. In Nature on March 7, they reported that four months after a mild COVID infection, adults ages 51 to 81 had slightly thinner gray matter and more signs of tissue damage in their olfactory areas than they did before infection, even after accounting for age-related brain changes that showed up in uninfected controls. (alzforum.org)
  • Average annualised per cent change in ventricular volume was computed as a measure of brain atrophy. (bmj.com)
  • at 24 months, the reduction in brain atrophy no longer reached statistical significance. (bmj.com)
  • Phase III CLARITY study data revealed significant reduction in brain atrophy in patients on short course of investigational Cladribine Tablets over two years. (disabled-world.com)
  • Post hoc analysis of Phase III CLARITY study data recently published in Multiple Sclerosis Journal showed statistically significant reduction in brain atrophy in patients on a short course of investigational Cladribine Tablets over two years compared with patients receiving placebo. (disabled-world.com)
  • The post hoc analysis showed that Cladribine Tablets reduced the annualised rate of brain volume loss - also known as brain atrophy - compared with placebo in patients with relapsing remitting multiple sclerosis (RRMS). (disabled-world.com)
  • Life After Mild Traumatic Brain Injury: Widespread Structural Brain Changes Associated With Psychological Distress Revealed With Multimodal Magnetic Resonance Imaging Biol Psychiatry Glob Open Sci. (usc.edu)
  • Soon after, Professor Johann Hoffmann from Heidelberg University presented a paper describing a syndrome of progressive atrophy, weakness, and death during the early childhood period of siblings with genetically normal parents. (medscape.com)
  • this is bizarre pattern of progressive chorioretinal atrophy that spreads from two foci located just temporal and just nasal to the disk. (hpathy.com)
  • After mild infection, abnormalities appeared in limbic system structures connected to sense of smell. (alzforum.org)
  • Most patients with dominant optic atrophy have no associated neurologic abnormalities, although nystagmus and hearing loss have been reported. (msdmanuals.com)
  • the rest recovered at home from a mild to moderate course. (alzforum.org)
  • A few expected transient injection site reactions of mild-to-moderate intensity were reported immediately after treatment. (jcadonline.com)
  • To extend its potential clinical applications, we sought to determine whether LM11A-31 could reverse cholinergic neurite atrophy when treatment begins in AD mouse models having mid- to late stages of pathology. (plos.org)
  • CLINICAL EXAM: Mild curling of right toes. (alsforums.com)
  • His clinical exam found mild right foot drop. (alsforums.com)
  • Diagnosis of dominant optic atrophy and Leber hereditary optic atrophy is mainly clinical. (msdmanuals.com)
  • Early or mild fungal nail infection can be treated by ciclopirox 8% nail lacquer (Penlac®) to be applied once daily for 48 weeks, with nail debridement performed by a health professional. (skintherapyletter.com)
  • Ciclopirox 8% nail lacquer is effective in the milder forms of nail infection. (skintherapyletter.com)
  • Most common adverse events were mild nausea and COVID infection, with no drug-related serious events and no events of ARIA-E. (biospace.com)
  • He explained that these patients were not treatment naive and had a history of atrophy before enrollment. (hcplive.com)
  • BFCN atrophy involves aberrant signaling through the neurotrophin receptor p75 (p75 NTR ). (plos.org)
  • Migration nematode seen in multiple transverse sections, surrounded by mild chronic infl ammation and reactive changes. (cdc.gov)
  • Abnormal uterine findings were de Recherche et d'Application en identified in 95.8% of patients attending hysteroscopy at GESHRTH. (who.int)
  • Mild hearing loss means that the quietest sound heard is between 25 and 34 dB. (harcourthealth.com)
  • Individuals with mild loss notice some trouble hearing conversations in a noisy environment. (harcourthealth.com)
  • Clinically, AC manifests as discoloration and loss of mucosal elasticity, erosions, atrophy, erythema and ulceration, in addition to a blurring of the demarcation between the vermillion border of the lip and the skin 1,2,7 . (bvsalud.org)
  • the sister shows a much milder course. (nih.gov)
  • Anterior segment exam revealed mild nuclear sclerosis of the lens. (aao.org)