Spinal musculaCognitiveDementiaOlivopontocerebellar atrophyRates of brain atrophyAlzheimer'sProgressionVillous atrophyGeographic atrophyAutosomal dominantFrontotemporalHippocampal VolumeMuscleDisordersCerebellarBilateralSevereTreated with placeboFrontalRetinalDepositionBrainProgressiveSignificantlyAbnormalitiesModerateClinicalInfectionTreatmentInvolvesChronicFindingsLossMusclesShowsExam
Spinal muscula24
- What is spinal muscular atrophy (SMA)? (medlineplus.gov)
- Spinal muscular atrophy (SMA) is a group of genetic diseases that damages and kills motor neurons. (medlineplus.gov)
- What are the types of spinal muscular atrophy (SMA) and what are their symptoms? (medlineplus.gov)
- How is spinal muscular atrophy (SMA) diagnosed? (medlineplus.gov)
- What are the treatments for spinal muscular atrophy (SMA)? (medlineplus.gov)
- Spinal muscular atrophy (SMA) is a genetic condition that causes muscle weakness and atrophy (when muscles get smaller). (kidshealth.org)
- What Are the Signs & Symptoms of Spinal Muscular Atrophy? (kidshealth.org)
- When they think a child might have spinal muscular atrophy, doctors will order genetic testing to look for mutations in the SMN1 gene. (kidshealth.org)
- Newborn screening is important - the earlier spinal muscular atrophy is diagnosed, the better the chances for the child to get early treatment and possibly avoid serious problems. (kidshealth.org)
- How Is Spinal Muscular Atrophy Treated? (kidshealth.org)
- Kugelberg Welander spinal muscular atrophy (also known as Wohlfart-Kugelberg-Welander syndrome or mild SMA) is a milder form of SMA, with symptoms typically presenting after age 18 months. (medscape.com)
- Hoffmann called the syndrome spinale muskelatrophie (spinal muscular atrophy). (medscape.com)
- Spinal muscular atrophy (SMA) is caused by successive motor unit degeneration. (medscape.com)
- Spinal muscular atrophy has an estimated incidence of 1 case per 15,000 live births. (medscape.com)
- Spinal muscular atrophy has an estimated incidence of 1 case per 15,000-20,000 live births worldwide. (medscape.com)
- Spinal muscular atrophy (SMA) types III and IV, unlike types I and II, are consistent with survival well into adulthood. (medscape.com)
- Spinal muscular atrophy and Farber disease due to ASAH1 variants: A case report. (cdc.gov)
- Clinical practice guidelines for spinal muscular atrophy]. (cdc.gov)
- Spinal Muscular Atrophy in the Black South African Population: A Matter of Rearrangement? (cdc.gov)
- Result of carrier screening for spinal muscular atrophy among 3049 reproductive-age individuals from Yunnan region]. (cdc.gov)
- Nusinersen in adults with 5q spinal muscular atrophy: a non-interventional, multicentre, observational cohort study. (cdc.gov)
- Analysis of FUS, PFN2, TDP-43, and PLS3 as potential disease severity modifiers in spinal muscular atrophy. (cdc.gov)
- Intragenic variants in the SMN1 gene determine the clinical phenotype in 5q spinal muscular atrophy. (cdc.gov)
- The Importance of Digging into the Genetics of SMN Genes in the Therapeutic Scenario of Spinal Muscular Atrophy. (cdc.gov)
Cognitive25
- To evaluate the utility of MRI hippocampal and entorhinal cortex atrophy in predicting conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD). (nih.gov)
- The aim of this investigation was to assess the effect of galantamine, an acetylcholinesterase inhibitor and allosteric modulator of nicotinic receptors, on brain atrophy in individuals with mild cognitive impairment (MCI), and to assess effect modification by apolipoprotein E (APOE) genotype. (biomedcentral.com)
- Mild cognitive impairment (MCI) is a heterogeneous syndrome characterized by a level of cognitive function (typically memory) that is worse than expected based on age and educational level, but which does not meet clinical criteria for dementia [ 1 ]. (biomedcentral.com)
- Petersen RCSmith GEWaring SCIvnik RJTangalos EGKokmen E Mild cognitive impairment: clinical characterization and outcome. (jamanetwork.com)
- Mild cognitive impairment represents early-stage Alzheimer disease. (jamanetwork.com)
- Medial temporal lobe atrophy and memory dysfunction as predictors for dementia in subjects with mild cognitive impairment. (jamanetwork.com)
- Visser PJVerhey FRHofman PAScheltens PJolles J Medial temporal lobe atrophy predicts Alzheimer's disease in patients with minor cognitive impairment. (jamanetwork.com)
- Of the latter group, 73% had mild cognitive impairment, and 27% had AD dementia. (medscape.com)
- The inclusion criteria were respondents aged 60 years or over with mild cognitive impairment (MCI) who agreed not to consume other fermented food during the study period. (karger.com)
- It precedes neuron loss and is associated with mild cognitive impairment, a predecessor of AD [1] . (plos.org)
- Objective To determine the effect of intravenous immunoglobulin (IVIG) on brain atrophy and cognitive function in mild cognitive impairment (MCI) due to Alzheimer's disease (AD). (bmj.com)
- Divergent regional patterns of cerebral hypoperfusion and gray matter atrophy in mild cognitive impairment patients. (mpg.de)
- Impact of leptin on memory function and hippocampal structure in mild cognitive impairment. (mpg.de)
- Genetic variants of the FADS gene cluster are associated with erythrocyte membrane LC PUFA levels in patients with mild cognitive impairment. (mpg.de)
- Combined omega-3 fatty acids, aerobic exercise and cognitive stimulation prevents decline in gray matter volume of the frontal, parietal and cingulate cortex in patients with mild cognitive impairment. (mpg.de)
- Vitamin B-12 concentration, memory performance, and hippocampal structure in patients with mild cognitive impairment. (mpg.de)
- An object location memory paradigm for older adults with and without mild cognitive impairment. (mpg.de)
- In addition, the analysis found that patients with lower rates of brain atrophy showed the highest probability of remaining free from disability progression at two years.1 This supports existing findings that increased brain volume loss over time is associated with worse clinical outcomes such as increased disability progression and cognitive changes, in patients with multiple sclerosis. (disabled-world.com)
- All treatments for relapsing MS disease hope to minimize inflammation, which is believed to contribute both to cognitive and physical disability progression, which in turn correlates with the irreversible loss of brain tissue that can be measured by MRI as brain atrophy. (disabled-world.com)
- Comparison of genetic and health risk factors for mild cognitive impairment and Alzheimer's disease between Hispanic and non-Hispanic white participants Alzheimers Dement. (usc.edu)
- In vivo Analysis of Hippocampal Subfield Atrophy in Mild Cognitive Impairment via Semi-Automatic Segmentation of T2-Weighted MRI. (pennmedicine.org)
- Amyloid imaging in mild cognitive impairment subtypes. (pennmedicine.org)
- In this study, we investigated associations between neuropsychiatric symptoms (i.e., apathy, anxiety, and depression) and cerebral atrophy, white matter lesions (WML), beta-amyloid (Aβ) deposition, and cognitive decline in a nondemented sample. (lu.se)
- 104 cognitively unimpaired and 53 subjects with mild cognitive impairment were followed for up to 4 years within the Swedish BioFINDER study. (lu.se)
- Dysexecutive mild cognitive impairment associated to frontal atrophy. (bvsalud.org)
Dementia2
- Hippocampal volume discriminates between normal cognition: questionable and mild dementia in the elderly. (jamanetwork.com)
- The study reported that dementia risk doubled with mild hearing loss. (harcourthealth.com)
Olivopontocerebellar atrophy8
- Dysphagia and dysarthria (and occasionally anarthria) are common manifestations of olivopontocerebellar atrophy (OPCA). (medscape.com)
- Generally, cerebellar signs and extrapyramidal signs are the predominant signs of olivopontocerebellar atrophy (OPCA). (medscape.com)
- A unifying etiology of olivopontocerebellar atrophy (OPCA) has not been established. (medscape.com)
- Care of olivopontocerebellar atrophy (OPCA) is directed to the treatment of symptoms. (medscape.com)
- At times, olivopontocerebellar atrophy (OPCA) patients may require enteral feeding to decrease the risk of aspiration. (medscape.com)
- As dysphagia progresses with olivopontocerebellar atrophy (OPCA), a pureed diet or enteral feeding may be required. (medscape.com)
- Available at https://www.ninds.nih.gov/health-information/disorders/olivopontocerebellar-atrophy . (medscape.com)
- The term olivopontocerebellar atrophy is used when the disorder starts later in life and the process is a primary degeneration of cerebellar neurons. (nih.gov)
Rates of brain atrophy1
- Brain scans showed increased rates of brain atrophy (shrinkage) with hearing loss. (harcourthealth.com)
Alzheimer's3
- Convit Ade Asis Jde Leon MJTarshish CYDe Santi SRusinek H Atrophy of the medial occipitotemporal, inferior, and middle temporal gyri in non-demented elderly predict decline to Alzheimer's disease. (jamanetwork.com)
- The Sporadic Early-onset Alzheimer's Disease Signature Of Atrophy: Preliminary Findings From The Longitudinal Early-onset Alzheimer's Disease Study (LEADS) Cohort Alzheimers Dement. (usc.edu)
- Sex and APOE e4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease Alzheimers Dement. (usc.edu)
Progression6
- Results of the 2-part, 18-month GATHER1 trial suggest that avacincaptad pegol can significantly reduce the progression of geographic atrophy (GA) secondary to age-related macular degeneration (AMD) with few adverse effects. (aao.org)
- The association with atrophy progression in cognitively impaired participants was stronger for p-tau181 than for NfL. (medscape.com)
- In grade 3, due to the progression of atrophy, the medial outline of the CN becomes straight. (hindawi.com)
- Evidence shows that brain atrophy in general accumulates throughout the course of multiple sclerosis and is associated with disability progression. (disabled-world.com)
- This analysis is important because it confirms the link between reduced brain atrophy and reduced disability progression found in the CLARITY study," said Nicola De Stefano, lead author of the publication and Associate Professor of Neurology, Department of Medicine, Surgery and Neuroscience, University of Siena. (disabled-world.com)
- The brain atrophy analysis evaluated the effect of Cladribine tablets on brain volume loss (BVL) over 2 years in RMS and the association of BVL with confirmed disability progression in 1,025 (77.3%) of the patients in CLARITY. (disabled-world.com)
Villous atrophy2
- Findings of steatorrhea, mucosal malabsorption of 2 substances (eg, fat, D-xylose), and villous atrophy (demonstrated by means of biopsy) are adequate to make a diagnosis. (medscape.com)
- Subtotal villous atrophy (H&E, orig. (medscape.com)
Geographic atrophy2
- Despite major advancements in AMD treatment, there is still a large unmet need for geographic atrophy treatment, which remains a leading cause of AMD-related central vision loss. (aao.org)
- There is slowly progressive loss of central vision, with central geographic atrophy, including loss of underlying choriocapillaris. (hpathy.com)
Autosomal dominant2
- Huntington's disease (HD) is an autosomal dominant inherited disorder belonging to the group of systemic brain atrophies. (hindawi.com)
- Dominant optic atrophy is inherited in an autosomal dominant fashion. (msdmanuals.com)
Frontotemporal2
Hippocampal Volume1
- Bilateral hippocampal volume atrophy at 1 year was reduced by approximately 20% compared to the matched subjects from AD Neuroimaging Initiative. (biospace.com)
Muscle6
- The symptoms include mild to moderate leg muscle weakness, tremors , and mild breathing problems. (medlineplus.gov)
- These therapies may also improve blood flow and slow muscle weakness and atrophy. (medlineplus.gov)
- Muscle loss (muscle atrophy) in our dogs can occur for a variety of different reasons. (cleanrun.com)
- On baseline postoperative images, 21 flaps showed moderate or intense enhancement of the muscular graft component relative to nonenhancing native muscle, three flaps showed mild enhancement, and three showed no enhancement. (ajnr.org)
- Developmental disuse (i.e. hind limb immobilization) associated with PA induced muscle fiber atrophy, extracellular matrix changes in the muscle, and mild to moderate ankle and knee joint degeneration at levels greater than disuse alone. (cdc.gov)
- Muscle atrophy, caused by a progressive loss of the anterior horn cells in the spinal cord, is universal. (medscape.com)
Disorders1
- Spinal muscular atrophies (SMAs) represent a rare group of inherited disorders that cause progressive degeneration of the anterior horn cells of the spinal cord. (medscape.com)
Cerebellar3
- Infantile onset progressive cerebellar atrophy and anterior horn cell degeneration--a late onset variant of PCH-1? (nih.gov)
- However, anterior horn cell degeneration has also been described in cases with later onset pontocerebellar atrophy and recently the spectrum has even been further extended to include the association of anterior horn cell degeneration and cerebellar atrophy without pontine involvement. (nih.gov)
- OBJECTIVE: Clinically differentiating multiple system atrophy cerebellar type (MSA-C) and spinocerebellar ataxias (SCAs) is challenging, especially at early disease stages, because of their similarities in clinical manifestation and imaging results. (bvsalud.org)
Bilateral2
- of the head shows fronto-temporal atrophy carnitine levels in urine were elevated and and bilateral subdural haemorrhage glutaryl-CoA dehydrogenase activity in cul- tured fibroblasts was low. (who.int)
- The only symptom is slowly progressive bilateral vision loss, usually mild until late in life. (msdmanuals.com)
Severe1
- Both physicians conducted autopsies on their patients and found severe atrophy of the ventral roots of the spinal cord. (medscape.com)
Treated with placebo1
- Patients with MCI who were treated with galantamine demonstrated a lower rate of whole brain atrophy, but not of hippocampal atrophy, over a 24-month treatment period, compared to those treated with placebo. (biomedcentral.com)
Frontal1
- NfL, however, was associated with progressive atrophy in frontal regions among cognitively unimpaired participants. (medscape.com)
Retinal3
- Retinal assessments have been discussed as biomarkers for brain atrophy. (nature.com)
- Dilated fundus exam demon-strated diffuse retinal pigment epithelium atrophy with pigment deposition and a bull's-eye pattern. (aao.org)
- OCT exhibited diffuse outer retinal atrophy, spar-ing the foveal region (Fig. 1). (aao.org)
Deposition1
Brain11
- We recorded whole brain and hippocampal volumes, and calculated annual atrophy rates. (biomedcentral.com)
- Linear regression analysis was used to calculate adjusted mean differences in the rate of whole brain and hippocampal atrophy, between MCI patients treated with galantamine and with placebo. (biomedcentral.com)
- This protective effect of galantamine on whole brain atrophy rate in MCI was only present in APOE ϵ4 carriers. (biomedcentral.com)
- Can milder bouts injure the brain, too? (alzforum.org)
- Yes, say scientists led by Gwenaëlle Douaud and Stephen Smith at the University of Oxford, U.K. In Nature on March 7, they reported that four months after a mild COVID infection, adults ages 51 to 81 had slightly thinner gray matter and more signs of tissue damage in their olfactory areas than they did before infection, even after accounting for age-related brain changes that showed up in uninfected controls. (alzforum.org)
- Average annualised per cent change in ventricular volume was computed as a measure of brain atrophy. (bmj.com)
- at 24 months, the reduction in brain atrophy no longer reached statistical significance. (bmj.com)
- Phase III CLARITY study data revealed significant reduction in brain atrophy in patients on short course of investigational Cladribine Tablets over two years. (disabled-world.com)
- Post hoc analysis of Phase III CLARITY study data recently published in Multiple Sclerosis Journal showed statistically significant reduction in brain atrophy in patients on a short course of investigational Cladribine Tablets over two years compared with patients receiving placebo. (disabled-world.com)
- The post hoc analysis showed that Cladribine Tablets reduced the annualised rate of brain volume loss - also known as brain atrophy - compared with placebo in patients with relapsing remitting multiple sclerosis (RRMS). (disabled-world.com)
- Life After Mild Traumatic Brain Injury: Widespread Structural Brain Changes Associated With Psychological Distress Revealed With Multimodal Magnetic Resonance Imaging Biol Psychiatry Glob Open Sci. (usc.edu)
Progressive2
- Soon after, Professor Johann Hoffmann from Heidelberg University presented a paper describing a syndrome of progressive atrophy, weakness, and death during the early childhood period of siblings with genetically normal parents. (medscape.com)
- this is bizarre pattern of progressive chorioretinal atrophy that spreads from two foci located just temporal and just nasal to the disk. (hpathy.com)
Significantly1
- Rates of hippocampal atrophy did not differ significantly between study groups. (biomedcentral.com)
Abnormalities2
- After mild infection, abnormalities appeared in limbic system structures connected to sense of smell. (alzforum.org)
- Most patients with dominant optic atrophy have no associated neurologic abnormalities, although nystagmus and hearing loss have been reported. (msdmanuals.com)
Moderate2
- the rest recovered at home from a mild to moderate course. (alzforum.org)
- A few expected transient injection site reactions of mild-to-moderate intensity were reported immediately after treatment. (jcadonline.com)
Clinical4
- To extend its potential clinical applications, we sought to determine whether LM11A-31 could reverse cholinergic neurite atrophy when treatment begins in AD mouse models having mid- to late stages of pathology. (plos.org)
- CLINICAL EXAM: Mild curling of right toes. (alsforums.com)
- His clinical exam found mild right foot drop. (alsforums.com)
- Diagnosis of dominant optic atrophy and Leber hereditary optic atrophy is mainly clinical. (msdmanuals.com)
Infection3
- Early or mild fungal nail infection can be treated by ciclopirox 8% nail lacquer (Penlac®) to be applied once daily for 48 weeks, with nail debridement performed by a health professional. (skintherapyletter.com)
- Ciclopirox 8% nail lacquer is effective in the milder forms of nail infection. (skintherapyletter.com)
- Most common adverse events were mild nausea and COVID infection, with no drug-related serious events and no events of ARIA-E. (biospace.com)
Treatment1
- He explained that these patients were not treatment naive and had a history of atrophy before enrollment. (hcplive.com)
Involves1
Chronic1
- Migration nematode seen in multiple transverse sections, surrounded by mild chronic infl ammation and reactive changes. (cdc.gov)
Findings1
- Abnormal uterine findings were de Recherche et d'Application en identified in 95.8% of patients attending hysteroscopy at GESHRTH. (who.int)
Loss3
- Mild hearing loss means that the quietest sound heard is between 25 and 34 dB. (harcourthealth.com)
- Individuals with mild loss notice some trouble hearing conversations in a noisy environment. (harcourthealth.com)
- Clinically, AC manifests as discoloration and loss of mucosal elasticity, erosions, atrophy, erythema and ulceration, in addition to a blurring of the demarcation between the vermillion border of the lip and the skin 1,2,7 . (bvsalud.org)
Muscles2
- As the motor neurons die off, your muscles start to weaken and atrophy (waste away). (medlineplus.gov)
- Because the muscles don't move, they get smaller (or atrophy). (kidshealth.org)
Shows1
- the sister shows a much milder course. (nih.gov)
Exam1
- Anterior segment exam revealed mild nuclear sclerosis of the lens. (aao.org)