• Macrophage migration inhibitory factor (MIF), also known as glycosylation-inhibiting factor (GIF), L-dopachrome isomerase, or phenylpyruvate tautomerase is a protein that in humans is encoded by the MIF gene. (wikipedia.org)
  • Macrophage migration inhibitory factor assembles into a trimer composed of three identical subunits. (wikipedia.org)
  • Overexpression of macrophage migration inhibitory factor (MIF) was identified in human GBM specimens that were MGMT methylated but showed poor survival. (nature.com)
  • Macrophage migration inhibitory factor gene polymorphisms and plasma levels in children with obstructive sleep apnea. (uchicago.edu)
  • In this study, we define an early glycation profile of human brain using fluorescent phenylboronate gel electrophoresis and identify early glycation and oxidation of macrophage migration inhibitory factor (MIF) in AD brain. (bath.ac.uk)
  • Although macrophage migration inhibitory factor (MIF) was originally identified as a lymphokine that inhibits the migration of macrophages, its ubiquitous expression suggests it may have a role beyond the immune system. (elsevierpure.com)
  • ObjectiveThe aim of this study was to investigate (a) macrophage migration inhibitory factor (MIF) levels in polytrauma patients and rats after haemorrhagic shock (HS), (b) the potential of the MIF inhibitor ISO-1 to reduce multiple organ dysfunction syndrome (MODS) in acute (short-term and long-term follow-up) HS rat models and (c) whether treatment with ISO-1 attenuates NF-kappa B and NLRP3 activation in HS. (unito.it)
  • Macrophage Migration Inhibitory Factor Family in Cancer" Encyclopedia , https://encyclopedia.pub/entry/16148 (accessed December 01, 2023). (encyclopedia.pub)
  • Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that plays a key role in several diseases, including cancer. (encyclopedia.pub)
  • It is not clear how the macrophage Migration Inhibitory Factor (MIF) in vivo protects neurons. (openaccessjournals.com)
  • Contribution of the macrophage migration inhibitory factor superfamily" by P. Fagone, E. Mazzon et al. (hofstra.edu)
  • Macrophage migration inhibitory factor (MIF) is an important regulator of innate immunity with key roles in neural regeneration and responses to pathogens, amongst a multitude of other functions. (edu.au)
  • Macrophage Migration Inhibitory Factor (MIF) Supports Homing of Osteoclast Precursors to Peripheral Osteolytic Lesions. (bvsalud.org)
  • Lung as source of Macrophage migration inhibitory factor (MIF) in sept" by Hans J. Lee, Erfan Hussain et al. (aku.edu)
  • To assess the lung as a source of Macrophage Migration Inhibitory Factor (MIF) in septic shock patients. (aku.edu)
  • Gremlin-1 reduces macrophage formation by inhibiting macrophage migration inhibitory factor (MIF), a cytokine critically involved in atherosclerotic plaque progression and vulnerability. (leuphana.de)
  • We previously identified Macrophage Migration Inhibitory Factor (MIF) as a novel factor that can support the proliferation and/or survival of NSPCs based on in vitro functional cloning strategy and revealed that MIF can support the proliferation of human brain tumor-initiating cells (BTICs). (elsevierpure.com)
  • In this study, we have identified Macrophage migration inhibitory factor protein (MIF) as a novel interaction partner of N protein by yeast two-hybrid system. (academicjournals.org)
  • Severe acute respiratory syndrome (SARS) coronavirus, nucleocapsid protein, macrophage migration inhibitory factor protein, yeast two-hybrid. (academicjournals.org)
  • Objective This study aimed to determine how different resistance training protocols affect gremlin 1, macrophage migration inhibitory factor (MIF), cardiometabolic, and anthropometric measures in obese men. (ac.ir)
  • Macrophage migration inhibitory factor (MIF), a pleotropic inflammation cytokine, plays an important role in the pathophysiology of cardiovascular diseases. (tmu.edu.tw)
  • Trying to better understand the disease, the leader of the study, Heitor De Souza, from IDOR, decided to look for a molecule called MIF (macrophage migration inhibitory factor), which his group had already seen involved in other allergenic inflammations. (sciencedaily.com)
  • MIF (macrophage migration inhibitory factor) is a pro-inflammatory cytokine that is released during microbial infection, ARDS, rheumatoid arthritis, atherosclerosis, type 2 diabetes, and cancer. (rndsystems.com)
  • MIF (macrophage migration inhibitory factor) was one of the first cytokine activities to be discovered and was initially described as a T cell-derived factor that inhibits the random migration of macrophages (Weiser 1989). (thermofisher.com)
  • Ibudilast is an investigational, first-in-class, orally bioavailable small-molecule phosphodiesterase-4 and -10 inhibitor and macrophage migration inhibitory factor inhibitor. (medscape.com)
  • Activation of synovial cell p38 MAP kinase by macrophage migration inhibitory factor. (jrheum.org)
  • This development occurs under the influence of macrophage colony-stimulating factor (M-CSF), which is secreted by various cell types (eg, endothelial cells, fibroblasts). (msdmanuals.com)
  • At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
  • Macrophage Migration-Inhibitory Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • This graph shows the total number of publications written about "Macrophage Migration-Inhibitory Factors" by people in this website by year, and whether "Macrophage Migration-Inhibitory Factors" was a major or minor topic of these publications. (uchicago.edu)
  • Below are the most recent publications written about "Macrophage Migration-Inhibitory Factors" by people in Profiles. (uchicago.edu)
  • 2001 Fingerle-Rowson and Bucala 2001 MIF also inhibits the random migration of monocytes/macrophages the anti-inflammatory effects of glucocorticoids (Calandra et al. (acancerjourney.info)
  • Furthermore, glucocorticoids also stimulate white blood cells to release MIF and hence MIF partially counteracts the inhibitory effects that glucocorticoids have on the immune system. (wikipedia.org)
  • MIF plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. (wikipedia.org)
  • MIF was released from macrophages and T cells in response to physiological concentrations of glucocorticoids. (thermofisher.com)
  • LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA 1-6 , to induce various cellular processes including wound healing, differentiation, proliferation, migration, and survival. (hindawi.com)
  • Treatment of ApoE -/- mice with a dimeric recombinant fusion protein, m Gremlin1-Fc, but not with equimolar control Fc or inactivated m Gremlin1-Fc, reduced TNF-α expression, the content of monocytes/macrophages of atherosclerotic lesions, and attenuated atheroprogression. (leuphana.de)
  • MIF was identified as a major regulator of atherogenesis by promoting the recruitment of mononuclear cells, activating inflammatory signaling pathways, and transdifferentiating macrophages into foam cells in the vessel wall as well as by enhancing collagenase expression and matrix degradation, the latter contributing to plaque destabilization [ 18 - 20 ]. (hindawi.com)
  • 1999 MIF is usually produced by a wide variety of cell types including lymphocytes monocytes/macrophages endothelial cells and fibroblasts (Calandra and Roger 2003 Its biological effects are mediated by a receptor complex involving CD74 (Leng et al. (acancerjourney.info)
  • MIF antagonist ISO-1 of 10 M, CD74 neutralized Ab of 10 g/ml, or CXCR2 neutralized Ab of 10 g/ml) on the electrical activity, ionic currents and calcium homeostasis by patch clamp, fluorescence and western blot in atrial myocytes (HL-1), and in cardiac fibroblast activity (migration, proliferation, and collagen production). (tmu.edu.tw)
  • The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
  • M1, "classically activated," pro-inflammatory macrophages are stimulated by cytokines such as IFN-gamma and by various microbial components (eg, lipopolysaccharide). (msdmanuals.com)
  • Herein we also show that rOos-MIF-1.1 inhibited migration of bovine macrophages and restored glucocorticoid-suppressed lipopolysaccharide (LPS)-induced TNF-α and IL-8 in human and/or bovine Isotetrandrine macrophages. (acancerjourney.info)
  • In particular, we focus on the hypothesis that the macrophage is an important cell type in the propagation of inflammation and induction of insulin resistance in obesity. (jci.org)
  • We also demonstrated that MIF mediated segregation between OECs and J774a.1 cells (a monocyte/macrophage cell line) in co-culture, which suggests that MIF contributes to the fact that macrophages are largely absent from olfactory nerve fascicles. (edu.au)
  • Macrophages are phagocytic cells present in tissues throughout the body. (msdmanuals.com)
  • Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
  • Because of the inconsistency of previous study results, our intention was to prove the inhibitory deficit by means of behavioral data and ERPs and hereby draw conclusions about a dysfunctional activation of the frontocingulate network. (uni-marburg.de)
  • More recently, histiocytic diseases have been reclassified into five groups: (1) Langerhans-related, (2) cutaneous and mucocutaneous, (3) malignant histiocytosis, (4) Rosai-Dorfman disease, and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. (medscape.com)
  • Gremlin-1 binds with high affinity to MIF (K D = 54 nM), as evidenced by surface plasmon resonance analysis and co-immunoprecipitation, and reduces MIF-induced release of TNF-α from macrophages. (leuphana.de)
  • Here we report that Gremlin-1 is highly expressed primarily by monocytes/macrophages in aortic atherosclerotic lesions of ApoE -/- mice and is secreted from activated monocytes and during macrophage development in vitro. (leuphana.de)
  • Une étude a été menée dans des unités de soins intensifs en chirurgie pour adultes de l'hôpital universitaire de Zagazig, (Égypte) auprès de 25 patients atteints de septicémie, de 27 patients atteints d'une septicémie sévère et de 28 témoins. (who.int)
  • Gremlin-1/Drm is crucial in embryo-/organogenesis and has been shown to be expressed in the adult organism at sites of arterial injury and to inhibit monocyte migration. (leuphana.de)
  • Characterization of a secreted macrophage migration inhibitory factor homologue of the parasitic nematode Haemonchus Contortus acting at the parasite-host. (oncotarget.com)
  • The role of the cytokine, macrophage migration inhibitory factor (MIF), and its receptor, CD74, was assessed in autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). (nih.gov)
  • Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine and counterregulator of glucocorticoids, has recently emerged as a critical mediator of innate immunity and experimental sepsis, and it is an attractive new target for the treatment of sepsis. (eur.nl)
  • Macrophage migration inhibitory factor (MIF) is an immune-regulatory cytokine playing a central role in modulating innate and adaptive immunity. (huji.ac.il)
  • Macrophage migration inhibitory factor (MIF), a multifunctional cytokine , is secreted by various cells and participates in inflammatory reactions, including innate and adaptive immunity . (bvsalud.org)
  • MIF (macrophage migration inhibitory factor) is a pro-inflammatory cytokine that is released during microbial infection, ARDS, rheumatoid arthritis, atherosclerosis, type 2 diabetes, and cancer. (rndsystems.com)
  • CD74 also forms heterodimers with CD44 to generate receptors to macrophage migration inhibitory factor (MIF), a proinflammatory cytokine. (nih.gov)
  • Macrophages are activated by cytokines (eg, IFN-gamma, interleukin (IL)-4, IL-13) and by various microbial components (eg, lipopolysaccharide). (msdmanuals.com)
  • The aim of the study was to detect the saliva chemokine (C-X-C motif) ligand 13 (CXCL13), macrophage migration inhibitory factor (MIF), and interleukin 35 (IL-35) levels in patients with primary Sjögren's syndrome (pSS) and pSS-associated interstitial lung disease (pSS-ILD), and to explore the relationship between CXCL13, MIF, IL-35 levels, and disease severity. (termedia.pl)
  • Macrophage migration inhibitory factor (MIF), also known as glycosylation-inhibiting factor (GIF), L-dopachrome isomerase, or phenylpyruvate tautomerase is a protein that in humans is encoded by the MIF gene. (wikipedia.org)
  • The aim of this study was to confirm the implication of macrophage migration inhibitory factor (MIF) gene in SSc susceptibility or clinical phenotypes in a large European population. (uni-koeln.de)
  • Correlation between genetic susceptibility of tuberculosis and macrophage migration inhibitory factor. (cdc.gov)
  • When monocyte migrates into the tissue spaces, it divides/differentiate into a macrophage , which is also capable of similar immune functions. (biologyonline.com)
  • Macrophage migration inhibitory factor -173 G/C polymorphism is associated with an increased risk of pulmonary tuberculosis in Zahedan, Southeast Iran. (cdc.gov)
  • Macrophage migration inhibitory factor-794 CATT microsatellite polymorphism and risk of tuberculosis: a meta-analysis. (cdc.gov)
  • Correlation of serum levels of macrophage migration inhibitory factor with disease severity and clinical outcome in dengue patients. (ejournals.ca)
  • Publications] Yabunaka,N.: 'Elevated serum content of macrophage migration inhibitory factor in patients with type 2 diabetes. (nii.ac.jp)
  • Publications] Mizue,Y.: 'Quantitation of macrophage migration inhibitory factor (MIF) using the one-step sandwich enzyme immunosorbent assay : Elevated serum MIF concentrations in patients with autoimmune diseases and identification of MIF in erythrocytes. (nii.ac.jp)
  • Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability. (ejournals.ca)
  • We have also researched the inhibitory factor of macrophage migration and its governing of endothelial cell sensitivity to LPS-induced apoptosis. (hopkinsmedicine.org)
  • Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population. (cdc.gov)
  • Functional polymorphisms in the gene encoding macrophage migration inhibitory factor (MIF) are associated with active pulmonary tuberculosis. (cdc.gov)
  • Based on different gene expression profiles, subtypes of macrophages (eg, M1, M2), which have different roles in amplifying or limiting the inflammatory response, have been identified. (msdmanuals.com)
  • A novel allosteric inhibitor of macrophage migration inhibitory factor (MIF). (rndsystems.com)
  • 2015), while monocytes can migrate into the CNS to become macrophages in adulthood following neurological injury. (medscape.com)
  • In the absence of lipopolysaccharide (LPS), CCR5 adopts a topology consistent with that of GPCR, allowing mouse peritoneal macrophages to migrate toward its ligand CCL5. (elifesciences.org)
  • Publications] Ogawa,H.: 'An antibody for macrophage migration inhibitory factor suppresses tumor growth and inhibits tumor-associated angiogenesis. (nii.ac.jp)
  • Publications] Onodera,S.: 'Macrophage migration inhibitory factor (MIF) up-regulates expression of matrix metalloproteinases in synovial fibroblasts of rheumatoid arthritis. (nii.ac.jp)
  • Publications] Kitaichi,N.: 'Inhibition of experimental autoimmune uveoretinitis with anti-macrophage migration inhibitory factor antibodies. (nii.ac.jp)
  • The present study is the first characterization of Neospora caninum macrophage migration inhibitory factor (NcMIF). (pacificimmunology.com)
  • The immunomodulator Macrophage Migration Inhibitory Factor (MIF) exerts pleiotropic immunomodulatory activities and has been implicated in the pathogenesis of diverse inflammatory diseases. (uni-luebeck.de)
  • Background:Â Macrophage migration inhibitory factor (MIF) is known had pleiotropic properties particularly participating in inflammatory and immune responses. (ejournals.ca)
  • 2016). Also, unlike T cells and the Th1/Th2 system that the M1/M2 system mirrored, microglia and macrophages do not expand clonally and thus do not give rise to comparably distinct subsets (Martinez and Gordon, 2014). (medscape.com)
  • The source of GAMMs includes brain-intrinsic microglia that become activated in response to tumour growth, and infiltration of systemic monocytes that mature into macrophages. (medscape.com)
  • The roles of macrophage migration inhibitory factor in retinal diseases. (bvsalud.org)
  • Despite its rather specific name, macrophage migration inhibitory factor (MIF) has multiple roles. (bioworld.com)
  • Modulation and suppression of the immune response of the host by nematode parasites have been reported extensively and the migration inhibitory factor (MIF) is identified as one of the major immunomodulator. (oncotarget.com)
  • CD36 + cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor. (nih.gov)
  • However, this requires the homing and migration of MSCs to a target tissue. (wjgnet.com)
  • Publications] Abe,R.: 'Enhancement of macrophage migration inhibitory factor (MIF) expression in injured epidermis and cultured fibroblasts. (nii.ac.jp)
  • LPS-activated macrophages returned to their inactivated original shape, i.e., they looked like naïve macrophages, through the treatment with high concentrations of cordycepin (40 microg/ml). (researchgate.net)
  • Publications] Mitamura,Y.: 'Macrophage migration inhibitory factor levels in the vitreous of patients with proliferative diabeteic retinopathy. (nii.ac.jp)
  • Macrophage migration inhibitory factor induced by dengue virus infection increases vascular permeability. (ejournals.ca)
  • Dengue Virus Infection Induced NF-Κb-dependent Macrophage Migration Inhibitory Factor Production. (ejournals.ca)
  • Low expression Macrophage Migration Inhibitory Factor (MIF) alleles and tuberculosis in HIV infected South Africans. (cdc.gov)
  • LPS stimulation results in increased production of dihydroceramide, which inverts the topology of CCR5, preventing macrophages from migrating toward CCL5. (elifesciences.org)
  • Association of tuberculosis and polymorphisms in the promoter region of macrophage migration inhibitory factor (MIF) in a Southwestern China Han population. (cdc.gov)
  • 4. Macrophage migration inhibitory factor may be used as an early diagnostic marker in colorectal carcinomas. (nih.gov)
  • They found that, in the early stages of Alzheimer's, an enzyme called MIF (macrophage migration inhibitory factor) is damaged by a process called glycation. (fabresearch.org)