Migration cho cells. Medical search. Frequent questions

Many proteins are made in a compartment within the cell called the endoplasmic reticulum and 'chaperone' proteins help them fold correctly. (elifesciences.org)
Cells carefully regulate the levels of chaperone proteins. (elifesciences.org)
If there are too few chaperones in the cell, then newly-made proteins may fold incorrectly and interrupt other processes. (elifesciences.org)
If a cell experiences stressful conditions, or if there is a sudden demand for more proteins to be made, protein folding can be disrupted. (elifesciences.org)
This leads to an increase in the number of unfolded proteins in the endoplasmic reticulum and so the cell increases the levels of chaperone proteins to cope with this. (elifesciences.org)
These proteins can be present in a cell as single molecules (monomers) or as a group of several chaperone molecules (oligomers). (elifesciences.org)
Previous research has suggested that the chaperone proteins in oligomers are inactive, but the oligomers may be rapidly broken down into monomers when the cell needs to fold more proteins. (elifesciences.org)
Further experiments challenged cells with chemicals that caused the number of unfolded proteins in the cells to increase. (elifesciences.org)
However, when the levels of unfolded proteins rise, cells can rapidly break up these oligomers to make active monomers that help to deal with the excess numbers of unfolded proteins. (elifesciences.org)
Further work is needed to understand how changes in the number of unfolded proteins in cells leads to the formation and disassembly of BiP oligomers. (elifesciences.org)
Adhesion complexes (i.e., focal adhesions and focal complexes) and cell-cell contacts are specialized structures that harbor a large number of cytoskeletal proteins and one of the highest concentrations of signaling molecules in cells ( Ruoslahti and Obrink, 1996 ). (rupress.org)
For example, matrix metalloproteinases (MMPs), such as MMP-2 and −9, have been shown to be typical NF-κB target proteins that are responsible for extracellular matrix breakdown and cell invasion ( 7 ). (spandidos-publications.com)
Chinese hamster ovary (CHO) cells are an epithelial cell line derived from the ovary of the Chinese hamster, often used in biological and medical research and commercially in the production of therapeutic proteins. (labroots.com)
By generating specific Abs, we demonstrate that hS100A7 and hS100A15 proteins are differentially expressed by specific cell types in the skin. (aai.org)
In recent years, with increasing interest being directed toward cultured cell-based production of vaccines, and in vivo proteins such as enzymes, hormones, antibodies and cytokines, as well as cell grafts for use in regenerative medicine, greater focus has been placed on efficient and convenient methodologies for mass cell culturing. (justia.com)
These results indicate that the inhibition of STAT3 signaling may be a mechanism by which kaempferol regulates the expression of proteins involved in regulating the migration and invasion of DU145 cells. (jcpjournal.org)

A vinculin fragment (amino acids 811-1066) containing the paxillin binding site restored apoptosis and suppressed ERK activity in vin −/− cells. (rupress.org)
Transfection with paxillin Y31FY118F dominant-negative mutant in these cells inhibits ERK activation and restores apoptosis. (rupress.org)
It is reportedly involved in many physiological functions of cells, including apoptosis, proliferation, invasion and angiogenesis ( 5 ). (spandidos-publications.com)
Changes in migration, adhesion, proliferation and the apoptosis rate of EPCs were detected. (biomedcentral.com)
The data showed that chemerin enhanced the adhesion and migration abilities of EPCs, and reduced the apoptosis ratio and that this effect might be mediated through the p38 MAPK pathway. (biomedcentral.com)
In conclusion, chemerin can enhance the adhesion and migration abilities of human EPCs and reduce the apoptosis ratio. (biomedcentral.com)
In the present study, the mechanistic role of Foxc1 on microglial migration, neuroinflammation and neuronal apoptosis during the occurrence of cognitive dysfunction in SAE was investigated. (spandidos-publications.com)
Lipopolysaccharide (LPS) treatment was found to trigger BV‑2 cell migration, inflammation and neuronal apoptosis. (spandidos-publications.com)
After Foxc1 was overexpressed, the cognitive dysfunction of mice that underwent CLP surgery was improved, with the expression of IκBα also increased, microglial cell migration, the expression of p65, IL‑1β and TNF‑α and neuronal apoptosis were all decreased in vivo and in vitro , which were in turn reversed by the inhibition of IκBα in vitro . (spandidos-publications.com)
Overall, these results suggest that the overexpression of Foxc1 inhibited microglial migration whilst suppressing the inflammatory response and neuronal apoptosis by regulating the IκBα/NF‑κB pathway, thereby improving cognitive dysfunction during SAE. (spandidos-publications.com)
Next, SW480, SW620 and LOVO cell viability, apoptosis, migration and adhesion were assessed to explore the effects of exogenous overexpressed SDC-1 on colorectal carcinoma. (biomedcentral.com)
SDC-1 overexpression inhibited cell proliferation via suppressing CyclinD1 and c-Myc expression, meanwhile stimulated cell apoptosis via increasing the expression levels of B-cell lymphoma-2-associated x (Bax) and Cleaved-Caspase-3. (biomedcentral.com)
In this paper, we verified the mRNA and protein expression of SDC-1 in human colorectal carcinoma tissues and focused on the biological cellular effects of SDC-1 on human colorectal carcinoma cell lines (SW620, SW480 and LOVO), by evaluating cell viability, apoptosis, migration and adhesion. (biomedcentral.com)
Previous studies have reported that kaempferol has anti-proliferative activities and induces apoptosis in many cancer cell lines. (jcpjournal.org)
Etoposide does not influence phenotype of this sub-population of melanoma cells, while a combined treatment with Etoposide and Bevacizumab significantly abolished P1 sphere-forming ability, an effect associated with apoptosis of this subset of cells. (oncotarget.com)
Hypoxic melanoma cells sorted for VEGF-R2/CD133 positivity also undergo apoptosis when exposed to Etoposide and Bevacizumab. (oncotarget.com)
[ 6 ] NF-KB protects cells from apoptosis in response to tumor necrosis factor-alpha (TNF-alpha). (medscape.com)
In the skin, NF-KB regulates cell growth in the stratified epithelium and apoptosis. (medscape.com)

Bves is a highly conserved, transmembrane protein that is involved in cell adhesion, cell motility, and most recently has been shown to play a role in vesicular transport. (wikipedia.org)
Grossly, cell motility and cell adhesion are impaired. (wikipedia.org)
Upon Bves disruption, cell rounding is increased, a phenotype indicative of decreased adhesion and disruption of integrin function. (wikipedia.org)
Both vinY822F and vin −/− cells exhibit increased interaction between paxillin and focal adhesion kinase (FAK) and increased paxillin and FAK phosphorylation. (rupress.org)
demonstrating their involvement in heterotypic cell adhesion and the metastatic spread of cancer. (peprotech.com)
Bioinspired multifunctional TiO2 hierarchical micro/nanostructures of conical-shaped TiO2 (CTO), regular TiO2 nanotubes (RTO) and irregular TiO2 nanotubes (ITO) with tunable improved cell growth and inhibited bacteria adhesion were synthesized. (sharif.edu)
In conclusion, this study showed that chemerin enhances the adhesion and migration abilities of EPCs and increases the instability of plaques and abnormal lipid accumulation in ApoE−/− mice. (biomedcentral.com)
Additionally, SDC-1 overexpression restrained cell migration via inhibiting the protein expression of matrix metallopeptidase 9 (MMP-9), and elicited cell adhesion through increasing intercellular cell adhesion molecule-1 (ICAM-1). (biomedcentral.com)
By observing the numbers of cells attached and the area occupied by the cells, we concluded that asiaticoside also enhanced the initial skin cell adhesion. (indexindex.com)
Kaempferol dose-dependently inhibited the migration, invasion, and adhesion of DU145 cells. (jcpjournal.org)

In spite of such accumulating knowledge of Rac1 and Cdc42 downstream pathways, little is known about the functional differences between Rac1 and Cdc42, in particular, how these Rho GTPases participate in cell migration. (nature.com)
In the current study, the anti‑invasive activities and associated signaling pathways of celastrol were determined in ovarian cancer cells. (spandidos-publications.com)
In general, the evidence from this study suggested that SDC-1 suppressed cell growth, migration through blocking JAK1/STAT3 and Ras/Raf/MEK/ERK pathways in human colorectal carcinoma cells. (biomedcentral.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Although constitutive CXCL14 expression in normal epithelial cells may help protect against infection by activating immune systems, its expression in cancer cells has raised controversy regarding its possible role in tumorigenesis. (korea.ac.kr)
The active, un-phosphorylated form of GSK3β maintains both (i) epithelial phenotypes by inhibiting the expression and stabilization of Snail and Slug and (ii) high E-cadherin expression ( Boble and Woodgett, 2007 ) in resting epithelial cells. (molcells.org)

Antioxidant, proliferation and migration assay of GSE was performed with human dermal papilla cells (hDPCs). (biomedcentral.com)
CXCL14 enhanced proliferation and migration in NCI-H460 but had no effect on NCI-H23. (korea.ac.kr)
Collectively, these results demonstrate that CXCL14 binding to glycoproteins harboring heparan sulfate proteoglycans and sialic acids leads proliferation and migration of some cancer cells. (korea.ac.kr)

The EPCs plays critical role in postnatal vasculogenesis through pivotal bioactivities of mobilization, homing, migration, differentiation, and proliferation in angiovasculogenic tissues [ 6 ]. (hindawi.com)
In the 1980's, Arnold Caplan and his colleagues published an isolation method of fibroblast-like stromal cells from bone marrow and first identified them as mesenchymal stem cells (MSCs) because of their multilineage differentiation potential ( Caplan, 1991 ). (frontiersin.org)
Originally identified as a differentiation antigen of mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas, Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored, cell-surface glycoprotein predominantly secreted by cells of the mesothelium. (peprotech.com)
Originally isolated from the HPC-Y5 pancreatic cell line, MPF has been suggested to play a role in the proliferation and differentiation of megakaryoctyes, and the regulation of resultant platelet production. (peprotech.com)
Although their in vivo functions remain largely unknown, in vitro extracellular application of S1P induces distinct S1P receptor-dependent cellular responses including proliferation, differentiation, and migration. (mdc-berlin.de)
Characterizing control of memory CD8 T cell differentiation by BTB-ZF transcription factor Zbtb20. (dartmouth.edu)
Zbtb20 Restrains CD8 T Cell Immunometabolism and Restricts Memory Differentiation and Antitumor Immunity. (dartmouth.edu)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

Cells lacking vinculin are highly metastatic and motile. (rupress.org)
Cancer cells, particularly, have been shown to be softer than normal tissue, and the changes in mechanical properties are linked to tumor formation and metastatic potential. (wfu.edu)
In this study, we investigated the anti-metastatic effects of kaempferol in DU145 human prostate cancer cells and elucidates the relevant mechanisms. (jcpjournal.org)
They constitute a pool of self-renewing cells with the ability of sustaining tumor growth and promoting metastatic dissemination. (oncotarget.com)
Resident memory CD8(+) T cells in regional lymph nodes mediate immunity to metastatic melanoma. (dartmouth.edu)

Cell proliferation was tested by MTT assay. (spandidos-publications.com)
Biotechnology applications include cell line engineering for controlled gene expression and protein production, cell-based assay development (with a focus on inflammatory processes) and biofuel production. (innovation.ca)
A scratch wound-healing assay was used to detect the migration of VSMCs, and immunocytochemistry and western blotting for SM22ɑ were used to evaluate phenotypic transformation. (hindawi.com)
The MTT assay demonstrated excellent biological performance for RTO and CTO sample with 98.1% and 103.1% of cell viability, respectively. (sharif.edu)
A reporter gene assay with various transcription factor response elements revealed that only nuclear factor-κB (NF-κB) signaling was activated by CXCL14 in NCI-H460 cells, which was blocked by BAPTA-AM, TPCA-1, and brefeldin A. Exogenous expression of some glycoproteins such as syndecan-4, podoplanin, and CD43 in these cells enhanced CXCL14 binding and NF-κB activity. (korea.ac.kr)
Putative CSCs were isolated from human melanoma cells of a different aggressiveness, Hs294T and A375 cell lines, grown under hypoxia using "sphere-forming assay", CD133 surface expression and migration ability. (oncotarget.com)

Peptide-induced keratinocyte migration was mediated by purinergic receptors and metalloproteases. (nature.com)
Bacteria can release endotoxins like lipopolysaccharide (LPS) or other pathogenicity factors such as lipopoteins/peptides (LP) from their cell envelope, even due to treatment with conventional antibiotics, being able to activate Toll-like receptors (TLRs) and induce a strong inflammatory response. (nature.com)

Cell migration was detected by wound healing and Transwell assays, while cell invasion was detected by a Matrigel‑coated Transwell method. (spandidos-publications.com)
We also present a thorough analysis of the role of succinate in the initiation of metabolic and epigenetic changes that contribute to the development of cancer, as well as its effects on angiogenesis, cell invasion, and migration. (scientificarchives.com)
In the present study, we report that baicalein significantly inhibits the expression of Cyr61 and migration and invasion of MDA-MB231 human breast cancer cells. (molcells.org)

To study the migration of microglia across the BBB, we developed an in vitro co-culture system of mouse brain endothelial cells (MBECs) and Ra2 microglia using Transwell inserts. (portlandpress.com)
The method of stimulating isolated cells with CSE in vitro has been explored and frequently applied to determine the direct causes in the relationships between cigarette smoking and cellular functions [ 15 ]. (hindawi.com)
In this study, in attempt to provide fresh information about the impact of CS on proliferation of EPCs to elucidate the pathophysiological mechanisms of the diseases related to CS in cellular level, we assessed the proliferation of EPCs after interfering the cells with a series of concentrations of CSE for various times of exposure in vitro . (hindawi.com)
A microglia‑mediated inflammation model was induced by LPS in BV‑2 microglial cells in vitro , whilst a SAE‑related cognitive impairment model was established in mice using cecal ligation and perforation (CLP) surgery. (spandidos-publications.com)
Employing in vitro cell culture of inherited mitochondrial disease and an in vivo animal experimental model of low-grade inflammation (high fat feeding), we show human-derived MSCs to alter mitochondrial function. (frontiersin.org)
Using in vitro systems, we observed the effects of asiaticoside on normal human skin cell behaviors related to healing. (indexindex.com)
Our laboratory uses a variety of cutting-edge molecular techniques coupled with in vivo and in vitro models to understand the fundamental programming of memory T cell responses. (dartmouth.edu)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)

Overexpression of S1P4 in Jurkat T cells induces pertussis toxin-sensitive cell motility even in the absence of exogenously added S1P. (mdc-berlin.de)
Zika virus directly infects peripheral neurons and induces cell death. (upenn.edu)

Endothelial progenitor cells (EPCs) contribute to neovascularization and play an important role in the development of these diseases. (hindawi.com)
The bone-marrow-derived endothelial progenitor cells (EPCs) provide an alternative source of endothelial cells (ECs) that contributes to neovessel formation in endothelium structure [ 4 , 5 ]. (hindawi.com)
This study aimed to explore the effects of chemerin on the functions of human endothelial progenitor cells (EPCs) and to investigate its role in lipid accumulation in ApoE-knockout (ApoE−/−) mice. (biomedcentral.com)
Likewise, these cells give rise to progenitor cells committed to a particular cell lineage, and play a crucial role in tissue repair and homeostasis. (bvsalud.org)

In cell proliferation assays, asiaticoside induced an increase in the number of normal human dermal fibroblasts. (indexindex.com)

Furthermore, ATP promoted the migration of microglia but not macrophages across the MBEC monolayer. (portlandpress.com)
Total cells, macrophages, and eosinophils recovered in BALF lavage were significantly elevated in the OVA + PM/OVA compared to OVA/OVA group. (cdc.gov)

Bves interacts with GEFT, a protein that modulates Rho GTPases, Rac1 and Cdc42, which are important for cell motility through modulation of the actin cytoskeleton. (wikipedia.org)
In this approach, we performed FRET time-lapse imaging of Rac1 and Cdc42, members of Rho GTPases which are responsible for cell motility and quantitatively identified the response functions that describe the conversion from the molecular activities to the morphological changes. (nature.com)
The enhanced motility of vin −/− and vinY822F cells is also shown to be due to a similar mechanism. (rupress.org)

propose that BiP oligomers act as reservoirs to store BiP molecules when they aren't needed by the cell. (elifesciences.org)
We propose a new computation-based approach for elucidating how signaling molecules are decoded in cell migration. (nature.com)
Moreover, a quantified discussion has been missing: although these molecules are involved in cell migration, how much are they quantitatively responsible for? (nature.com)

Although mesenchymal stem cells (MSCs) have been shown as a novel approach in tissue regeneration, the therapeutic potential of MSCs mediated by the interaction between MSC-derived paracrine mediators and Mφs remains elusive. (frontiersin.org)
Mesenchymal stem cells (MSCs) are the most commonly used cells in tissue engineering and regenerative medicine. (frontiersin.org)

Hence, our study indicates that a combined exposure to Etoposide and Bevacizumab targets melanoma cells endowed with stem-like properties and might be considered a novel approach to treat cancer-initiating cells. (oncotarget.com)

GSE treatment significantly reduced the number of mast cells and the expression of transforming growth factor beta 1 in mouse skin tissues. (biomedcentral.com)
Cell culture on the scaffold and put it in the bioreactor is a critical step in the formation of tissues or organs. (sharif.edu)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)

however, due to glycosylation, protein migration occurs at an apparent molecular weight of approximately 33‐35 kDa by SDS‐PAGE analysis under both reducing and non‐reducing conditions. (reliatech.de)
Using the response function, we could predict the morphological change from molecular activity and its predictive performance provides a new quantitative measure of how much the Rho GTPases participate in the cell migration. (nature.com)
To examine this issue, we focused on cell migration as a model biological system, because both molecular activity (as input signal) and morphological changes (as output signal) during cell migration can be monitored by FRET imaging. (nature.com)
Many studies have extensively investigated the molecular mechanisms involved in cell migration and have recognized the Rho small GTPases as key regulators of actin dynamics 7 , 8 . (nature.com)
PeproTech's CHO cell-derived Recombinant Human MPF is the 250 amino acid-length fragment of the Mesothelin sequence, and has a calculated molecular weight of approximately 26.7 kDa. (peprotech.com)
Notably, many natural compounds have been found to effectively suppress NF-κB signaling, providing an experimentally validated molecular explanation for their functional outcomes in tumor cells ( 14 ). (spandidos-publications.com)
Researchers at IMBL have diverse expertise in the areas of cancer biology, immunology, molecular biology, protein and lipid biochemistry, plant cell biology. (innovation.ca)

Epidemiology of Renal Cell Carcinoma: 2022 Update. (who.int)

MIF exhibits potent paracrine and autocrine stimulatory effects on cell growth and survival and enhances the production of inflammatory cytokines. (rndsystems.com)

This importance is focussed on the target binding site - epitope, where epitope selection as a part of design thinking beyond traditional antigen selection using whole cell or whole protein immunisation can positively impact success. (preprints.org)

E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)
The relationship between blood pressure and risk of renal cell carcinoma. (who.int)
Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)

Taken together, these data demonstrate that Bves modulates Rho GTPase signaling cascades through interaction with GEFT to affect cell movement and morphology. (wikipedia.org)
The histological morphology of hair follicles demonstrated an active anagen phase with the induction of stem cell factor. (biomedcentral.com)
MSC co-culture with skin fibroblasts from mitochondrial disease patients rescued aberrant mitochondrial morphology from a fission state to a more fused appearance indicating an effect of MSC co-culture on host cell mitochondrial network formation. (frontiersin.org)

AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, elevated smooth muscle 22 α (SM22 α ) expression, repressed VSMC proliferation, elevated miR-466f-3p and miR-425-3p expression, and suppressed miR-27a-5p and miR-128-5p expression in ox-LDL-induced VSMCs. (hindawi.com)
The migration, phenotypic transformation, and proliferation of VSMCs lead to vascular wall remodeling, which is mediated by activation of extracellular regulated protein kinases 1/2 (ERK1/2) signalling [ 9 ]. (hindawi.com)
Chemerin is an adipocytokine involved in the recruitment of immune cells [ 11 ] and serves as a bridge between various immune cells from the initial stage of inflammatory diseases through the development process [ 12 ], and its receptor CMKLR1 (also named ChemR23 in humans) is a specific functional member of the G protein receptor family. (biomedcentral.com)
CHO cells are the most commonly used mammalian hosts for industrial production of recombinant protein therapeutics. (labroots.com)
The α-syn, encoded by the SNCA1/PARK1 gene, is a ubiquitous protein that is abundantly expressed in kidneys and blood cells, but highly enriched in the brain, particularly in the presynaptic terminals of the neocortex, hippocampus, substantia nigra (SN), thalamus, and cerebellum. (encyclopedia.pub)
Mapping cytoskeletal protein function in cells by means of nanobodies. (scriptiebank.be)

Conditioned medium from adipose derived stem cells (ADSC-CM) stimulates both collagen synthesis and migration of fibroblasts, and accelerates wound healing in vivo. (indexindex.com)

Thus, it is urgent to explore novel targets that may provide potential resolutions for metastasis in colorectal carcinoma cells. (biomedcentral.com)

However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)

Expression of Ki-67 and stem cell factor were analyzed by immunohistochemistry. (biomedcentral.com)
We have been using two complementary model systems, the genetically modified mouse system and patient-derived induced pluripotent stem cell (iPSC) model systems. (upenn.edu)
Cell Stem Cell 28: 1657-1670, Sep 2021. (upenn.edu)
Cell Stem Cell 27: 937-950, Dec 2020. (upenn.edu)
Cell Stem Cell 26: 766-781, May 2020. (upenn.edu)
Cell stem cell 20(6): 749-753, Jun 2017. (upenn.edu)
Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)
Stem cell niche. (bvsalud.org)

Although Mesothelin is expressed at restricted levels by normal mesothelial cells of the pleural,pericardial, and peritoneal membranes, aberrant expression has been documented in the aforementioned cancers, as well as in endometriod uterine adenocarcinomas and squamous cell carcinomas of the esophagus, stomach, lung, and cervix. (peprotech.com)
Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)

In LPS-stimulated human monocyte-derived dendritic cells and Langerhans-like cells, the peptides blocked IL-6 secretion, downregulated expression of maturation markers and inhibited dendritic cell migration. (nature.com)
Immunobiology of dendritic cells. (scriptiebank.be)

Bladder Cancer Extracellular Vesicles Elicit a CD8 T Cell-Mediated Antitumor Immunity. (rochester.edu)
Assessing the Magnitude of Immunogenic Cell Death Following Chemotherapy and Irradiation Reveals a New Strategy to Treat Pancreatic Cancer. (rochester.edu)
With regard to cancer treatment, celastrol has been shown to exert considerable cell-killing effects and to shrink xenografted tumors in tissue and animal models of various malignancies including cancers of the prostate ( 16 - 18 ), breast ( 19 ), liver ( 20 , 21 ) and lung ( 22 , 23 ). (spandidos-publications.com)
Additionally, a viable therapeutic strategy may involve triggering the cell death mechanism in cancer cells by blocking mitochondrial metabolism with a natural substance. (scientificarchives.com)
NAR can be encapsulated by chitosan nanoparticles-TPP conjugates, thereby improving NAR cellular absorption and cytotoxicity against cancer cells. (scientificarchives.com)
Evidence indicating that OXPHOS plays a substantial role in the development of many cancer cells has led to the growing recognition of cancer as a metabolic disease. (scientificarchives.com)
Tumors contain a sub-population of self-renewing and expanding cells known as cancer stem cells (CSCs). (oncotarget.com)
Indeed, a 5-year survival rate of advanced stage malignant melanoma is less than 10% and resistance to chemotherapy, most likely due to the presence of cancer stem cells (CSCs), is the major cause of treatment failure [ 1 - 3 ]. (oncotarget.com)
In fact, a major positive prognostic indicator for adoptive T cell therapies targeting cancer is the length of time that these T cells are sustained in the patient. (dartmouth.edu)
Endometrial Cancer Suppresses CD8+ T Cell-Mediated Cytotoxicity in Postmenopausal Women. (dartmouth.edu)
MIF (macrophage migration inhibitory factor) is a pro-inflammatory cytokine that is released during microbial infection, ARDS, rheumatoid arthritis, atherosclerosis, type 2 diabetes, and cancer. (rndsystems.com)
99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)

Both SALPs showed a low cytotoxicity in all investigated cell types. (nature.com)

Disruption of Bves results in decreased cell speed and increased cell roundness, which are cell processes modulated by the Rho GTPases, Rac1 and Cdc42. (wikipedia.org)
Interestingly, we discovered distinct predictive performance of Rac1 and Cdc42 depending on the migration modes, indicating that Rac1 and Cdc42 contribute to persistent and random migration, respectively. (nature.com)

Interestingly, binding to NCI-H460 cells was prevented by heparan sulfate and N-acetyl neuraminic acid. (korea.ac.kr)

In serial passaging cultures of mouse embryonic stem (ES) cells, we employed a dendrimer-immobilized substrate that displayed D-glucose as a terminal ligand. (sharif.edu)
Most cases of this condition result from new (de novo) mutations in the gene that occur during the formation of reproductive cells (eggs or sperm) in an affected individual's parent or in early embryonic development. (medlineplus.gov)
The skin manifestations occur along the lines of Blaschko, which represent the routes of embryonic cell migration. (medscape.com)

J Cell Biol (2004) 165 (3): 371-381. (rupress.org)
J Cell Biol. (dartmouth.edu)

MSCs can promote host tissue repair through several different mechanisms including donor cell engraftment, release of cell signaling factors, and the transfer of healthy organelles to the host. (frontiersin.org)

Our research showed that the migration, phenotypic transformation, and proliferation of ox-LDL-induced VSMCs were repressed by AA through inhibiting miR-128-5p by targeting the p21 gene, which may provide an effective option for the treatment of atherosclerosis. (hindawi.com)
These range from manipulation of transcriptional regulation, cell-extrinsic signaling and gene editing to metabolic reprogramming of T cells. (dartmouth.edu)
which means one copy of the altered gene in each cell is sufficient to cause the disorder. (medlineplus.gov)

Furthermore, SALPs markedly promoted cell migration via EGFR transactivation and ERK1/2 phosphorylation and accelerated artificial wound closure in keratinocytes. (nature.com)

CXCL14 is a chemokine family member that is involved in various cellular responses in addition to immune cell activation. (korea.ac.kr)
While there is typically a large expansion of T cells early during an immune response, only a minority of these cells have the ability to survive long-term in the host. (dartmouth.edu)
At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
There are two hallmark phenotypes of allergic asthma: (1) inflammatory, due to a T helper cell type 2 (Th2)-mediated immune response resulting in elevated inflammatory cells in the airways, and (2) airway hyper-reactivity, during which volume and flow of inhaled air decreases as a consequence of airway constriction. (cdc.gov)

Proteolytic cleavage of Mesothelin yields a soluble, polypeptide fragment designated megakaryocyte potentiating factor (MPF) based on its ability to stimulate megakaryocyte colony-forming activity of murine interleukin-3 in murine bone marrow cell cultures. (peprotech.com)

VSMCs were transfected with the miR-128-5p mimic and inhibitor, and the migration, phenotypic modulation, and proliferation of VSMCs were investigated. (hindawi.com)
The inhibitor increased p21, p27, and SM22ɑ expression and repressed the migration, phenotypic transformation, and proliferation of VSMCs. (hindawi.com)
Several studies have shown that miRNAs play multiple roles in the phenotypic transformation, migration, and proliferation of VSMCs by inhibiting ERK1/2 activation [ 11 , 12 ], partly by regulating the tissue inhibitor of metalloproteinases (TIMPs)-MMPs and p21-cyclins interactions [ 13 - 18 ]. (hindawi.com)

It has been shown that inflammation caused by oxidized low-density lipoprotein (ox-LDL) contributes to the occurrence and development of AS [ 1 ], which can promote vascular smooth muscle cell (VSMC) migration, proliferation, and transformation from a contractile to a synthetic phenotype [ 2 - 6 ]. (hindawi.com)

Mitochondrial function or the ability to generate energy through OXPHOS (oxidative phosphorylation) is vital for cell homeostasis and its dysfunction has been linked to the pathogenesis of nearly all chronic diseases ( Pieczenik and Neustadt, 2007 ). (frontiersin.org)

We are interested in addressing a broad range of topics, from neuronal migration, axon and dendritic development, synapse formation, circuitry integration to plasticity of developing neurons, and functional regeneration of mature neurons. (upenn.edu)

Enhancement of convection increases shear stress on the cells that is. (sharif.edu)

Wound healing proceeds through a complex collaborative process involving many types of cells. (indexindex.com)
In a wound closure seeding model, asiaticoside increased migration rates of skin cells. (indexindex.com)

Syndecan-1 (SDC-1) is a crucial membrane proteoglycan, which is confirmed to participate in several tumor cell biological processes. (biomedcentral.com)

The miR-128-5p mimic promoted the migration and proliferation of VSMCs and suppressed p21, p27, and SM22ɑ expression. (hindawi.com)
We found that a cell sub-population enriched for P1 sphere-initiating ability and CD133 expression also express larger amount of VEGF-R2. (oncotarget.com)

In conclusion, we offer evidence that microglia migration across the brain endothelial cell monolayer is increased in the presence of ATP in a manner that involves MMP secretion. (portlandpress.com)
Recently, the production and secretion of growth factors has been identified as an essential function of adipose-derived stem cells (ADSCs). (indexindex.com)

Thus, our proposed predictive approach enabled us to uncover the hidden information processing rules of Rho GTPases in the cell migration. (nature.com)

GSE treatment proliferated and migrated human dermal papilla cells (hDPCs) more than treatment of 10 μM minoxidil. (biomedcentral.com)

Anatomy32

Organisms10

Diseases3

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Psychiatry and Psychology1

Phenomena and Processes50

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science5

Health Care2

Proteins16

Apoptosis18

Adhesion10

Pathways4

Epithelial2

Proliferation and migration3

Differentiation8

Metastatic5

Assay6

Receptors2

Invasion3

Vitro8

Induces2

Progenitor4

Assays1

Macrophages2

Motility3

Molecules3

Mesenchymal2

Melanoma Cells1

Tissues4

Molecular7

20221

Enhances1

Antigen1

Renal4

Morphology3

Protein6

Fibroblasts1

Metastasis1

Biology1

Stem cell8

Squamous cell2

Dendritic cells2

Cancer12

Cytotoxicity1

Rac1 and Cdc422

Heparan sulfate1

Embryonic3

Biol2

Mechanisms1

Gene3

Markedly1

Immune4

Murine1

Inhibitor3

Inflammation1

Homeostasis1

Neuronal1

Increases1

Wound2

Proteoglycan1

Expression2

Secretion2

GTPases1

Human dermal1