Migration epithelial cells. Medical search. Frequent questions

Collective cell migration and metastases induced by an epithelial-to-mesenchymal transition in Drosophila intestinal tumors. (whiterose.ac.uk)
While metastases re-epithelialize over time, we found that early metastases are remarkably mesenchymal, discarding the requirement for a mesenchymal-to-epithelial transition for early stages of metastatic growth. (whiterose.ac.uk)
Since epithelial-to-mesenchymal transition (EMT) and the acquisition of cancer stem cell traits are important for cancer onset and progression, we sought to determine the role of AUF1 in these two important processes. (nature.com)
Epithelial mesenchymal transition was assessed by analyzing the expression of Vimentin and E-Cadherin. (unicatt.it)
LIPUS promoted the differentiation of colon cancer cells, affected epithelial-to-mesenchymal transition, promoted the closure of a wound as well as increased the release of EVs compared with untreated cells. (unicatt.it)
Significantly, there are additional non-epithelial stromal cells (NES) that exist alongside TEC within thymic microenvironments, including multiple subsets of mesenchymal and endothelial cells. (frontiersin.org)
Broadly separated into mesenchymal and endothelial cells, NES have been implicated in thymus organogenesis, thymocyte development, tolerance induction and development/maintenance of epithelial stroma. (frontiersin.org)
In early experiments, physical separation of mesenchymal and epithelial stroma from embryonic murine thymus resulted in defective thymus development when epithelium was cultured in vitro in the absence of mesenchyme ( 7 ). (frontiersin.org)
Carbonic Anhydrase III Promotes Cell Migration and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma. (nih.gov)
The conversion of an epithelial cell to a mesenchymal cell is critical to metazoan embryogenesis and a defining structural feature of organ development. (rupress.org)
Current interest in this process, which is described as an epithelial-mesenchymal transition (EMT), stems from its developmental importance and its involvement in several adult pathologies. (rupress.org)
The EMT International Association was formed in 2002 to provide an international body for those interested in EMT and the reverse process, mesenchymal-epithelial transition, and, most importantly, to bring together those working on EMT in development, cancer, fibrosis, and pathology. (rupress.org)
Formation and maintenance of epithelial cell polarity, epithelial to mesenchymal transition, cell migration. (bath.ac.uk)
Disappearance of Cav1 enables cells to undergo epithelial-mesenchymal transition (EMT). (cipsm.de)
The formation of CSCs is highly associated with cancer cell epithelial-mesenchymal transition (EMT), which contributes to the plasticity of cancer cells and comprises an initial step for metastasis. (ku.edu)
The acquisition of a mesenchymal phenotype is a critical step in the metastatic progression of epithelial carcinomas. (jci.org)
Adherens junctions (AJs) are required for suppressing this epithelial-mesenchymal transition (EMT) but less is known about the role of tight junctions (TJs) in this process. (jci.org)
Conversely, interfering with BVES function by expressing a dominant-negative mutant in human corneal epithelial cells induced mesenchymal features. (jci.org)
To investigate the effects of zerumbone on cell invasion, epithelial-mesenchymal transition (EMT) and the potential signaling pathway involved in ovarian cancer cells. (ajol.info)
LncRNA SNHG3 is also characterized by its involvement in the microRNA pathway of HCC, where miR-128/CD151 signaling of SNHG3 induces epithelial mesenchymal transition (EMT). (hindawi.com)
Arginase-1 promotes lens epithelial-to-mesenchymal transition in different models of anterior subcapsular cataract. (bvsalud.org)
The mechanisms of ARG1 in epithelial-to-mesenchymal transition (EMT)-associated cataracts were studied herein. (bvsalud.org)

Besides double positive-single positive transition, TCR-MHC interaction also triggers the expression of CCR7, chemokine receptor which recognizes chemokines CCL19 and CCL21, that are largely produced by mTECs in the medulla, and positively selected T cells start to migrate to medulla via their gradient. (wikipedia.org)

Dimethylarginine dimethylaminohydrolase (DDAH) overexpression enhances wound repair in airway epithelial cells exposed to agricultur al organic dust. (cdc.gov)

Cortical thymic epithelial cells (cTECs) form unique parenchyma cell population of the thymus which critically contribute to the development of T cells. (wikipedia.org)
Major role of thymic epithelial cells is to test, whether TCRs are "functional" and on the other hand "harmless" to our body. (wikipedia.org)
While cTECs control the functionality of TCRs during the process called positive selection, Medullary thymic epithelial cells (mTECs) that home in the inner part of the thymus- medulla, present on their MHC molecules self-peptides, generated mostly by protein Autoimmune regulator, to eliminate T cells with self-reactive TCRs via processes of central tolerance e.g. negative selection and protect the body against development of autoimmunity. (wikipedia.org)
Extensive research on thymic epithelial cells (TEC) within the cortex and medulla has defined their essential roles during T-cell development. (frontiersin.org)
Arguably, the most recognized and well-studied stromal populations in thymus biology are thymic epithelial cells (TEC) within the cortical and medullary areas, which are defined by their anatomical separation and function. (frontiersin.org)
For example, mouse thymic epithelial cells react with antibodies for keratin 5, keratin 8, and keratin 14. (wikipedia.org)
These antibodies are used as fluorescent markers to distinguish subsets of mouse thymic epithelial cells in genetic studies of the thymus . (wikipedia.org)

Using RNA-Seq, we identified a total of 163 and 568 differentially expressed genes in primary normal human bronchial epithelial (NHBE) cells that were exposed to diacetyl and 2,3-pentanedione, respectively. (nature.com)
In this study, we utilized primary normal human bronchial epithelial (NHBE) cells that are cultured at an air-liquid interface (ALI) to mimic the in vivo airway characteristics 30 . (nature.com)
Further, blocking nitric oxide (NO) production in bronchial epithelial cells prevents PKA activation. (cdc.gov)
This pulmonary exposure to alcohol can damage the bronchial epithelial layer of the lung [ 6 , 7 ], while impairing the lung's ability to repair epithelial wounding via inhibition of the PKA pathway [ 8 ]. (cdc.gov)

1. Describe the regulation of key cellular processes such as the formation and maintenance of epithelial cell polarity and the regulation of cell migration. (bath.ac.uk)

Reconstitution of eroded or injured EPITHELIUM by proliferation and migration of EPITHELIAL CELLS from below or adjacent to the damaged site. (bvsalud.org)

We have shown that AUF1 induces EMT and stemness in breast epithelial cells via stabilization of the SNAIL1 and TWIST1 mRNAs, and their consequent upregulation. (nature.com)
We show that the force distribution and magnitude differ between MCF7 breast cancer cells and MCF10A normal-like breast epithelial cells, and that monitoring traction forces can be used to investigate the effects of anticancer drugs. (lu.se)

In an in vitro model system of transepithelial migration, human PMN's were stimulated by 0.1 micrometer fMet-Leu-Phe to traverse confluent, polarized canine kidney epithelial monolayers of varying permeabilities. (rupress.org)
So far, most of the in vivo and in vitro approaches to study leukocyte migration across the tissue parenchyma have addressed the role of each single tissue barrier that immune cells encounter in their journey to the inflammatory focus. (hindawi.com)
Results: Wound closure in epithelial cells from WT mice occurred within 24 h in vitro. (cdc.gov)
Rat primary astrocytes were isolated from different brain regions (cortex, cerebellum, and hippocampus) and grown in vitro to demonstrate the utilization of live-cell analysis for monitoring and comparing the diversity of cultured astroglia phenotypes. (news-medical.net)
Because alcohol blocks airway epithelial cell release of IL-6 in vitro , we hypothesized that alcohol exposure would alter mouse lung inflammatory responses to HDE. (cdc.gov)

We observed that direct stimulation with LT D4, induced intestinal epithelial cell migration, through activation of the CysLT1 receptor, phosphotidylinositol-3 kinase, Vav2 and Rac localisation to membrane ruffles. (lu.se)

Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
Sesquiterpene lactones containing a 3-methylenedihydrofuran-2(3H)-one (or α-methylene-γ-lactone) moiety, for example damsin (1), are Michael acceptors that affect biological processes such as cell proliferation, death/apoptosis, and cell migration, by interfering with cell signalling pathways. (lu.se)

Ectopic expression of AUF1 also promoted stemness in mammary epithelial cells, and thereby increased the proportion of cancer stem cells. (nature.com)
These data prompted us to ask whether AUF1 upregulation could promote EMT as well as stemness in mammary epithelial cells. (nature.com)

Materials/methods: We cultured primary tracheal epithelial cells in monolayers from both wild-type (WT) and dimethylarginine dimethylaminohydrolase overexpressing C57Bl/6 (DDAH1 transgenic) mice and measured wound repair using the electric cell impedance sensing system. (cdc.gov)
In contrast, treatment of the WT cell monolayers with 5% hog dust extract prevented significant NO-stimulated wound closure. (cdc.gov)

As epithelial permeability increased, the number of PMN invasion sites as well as the number of PMN's that traversed the monolayer increased. (rupress.org)
These results indicated that, in the absence of serum and connective tissue factors, (a) the number of PMN invasion sites and the number of PMN's that traversed an epithelium were a function of the conductance of the epithelium and (b) PMN's in the process of transepithelial migration maintained close cell-cell contacts and prevented the leakage of particles (greater than 5 nm in diameter) across the invasion site. (rupress.org)
EMT is associated with enhanced migration and invasion. (cipsm.de)
Our data showed that knockdown of HuR in pancreatic cancer cells significantly inhibited cell migration, invasion, and stem-like features. (ku.edu)
As an HuR/mRNA disruptor, KH-3 treatment successfully mimicked the effects of HuR knockdown in pancreatic cancer cell lines: KH-3 significantly inhibited pancreatic cancer cell migration, invasion, tumor sphere formation and EMT. (ku.edu)
Wound healing assay was used to determine Caov-3 cell migration while cell invasion was evaluated using Transwell assay. (ajol.info)
The results demonstrate that zerumbone inhibits cell proliferation, migration and invasion, but represses the EMT process via inactivation of Wnt/β-catenin signaling pathway. (ajol.info)
The aim of our study was to investigate the role of SNHG3 in the proliferation, migration, and invasion of GC cell lines. (hindawi.com)
CCK-8 and Transwell assays were performed to detect cell proliferation, invasion, and migration abilities. (hindawi.com)
Moreover, lncRNA SNHG3 knockdown or miR-326 overexpression significantly inhibited cell proliferation, migration, and invasion of GC cell lines. (hindawi.com)
In addition, TWIST overexpression can reverse the inhibition of lncRNA SNHG3 knockdown or miR-326 overexpression on cell proliferation, migration, and invasion. (hindawi.com)

On this edition of "Ask Dr. J", Dr. Jaffe is asked to comment on Vitamin A's importance on health, epithelial and mucosa lining, T-cell migration and inhibition of IL6. (elisaact.com)
The data demonstrated that inhibition of HuR destabilized SNAI1 mRNA, and subsequently reduced Snail protein levels, resulting in the EMT and CSCs inhibition in pancreatic cancer cells. (ku.edu)
Inhibition of release of inflammatory mediators in rat peritoneal mast cells and murine macrophages by a Chinese herbal medicine formula (RCM-102). (wikidata.org)
Inhibition of COX-2 expression or specifically inhibiting COX-2 activity, resulted in cell adhesion being favoured over cell migration in a CD47 dependent manner. (lu.se)

Indeed, a common feature of epithelial dysfunction is the loss of polarity. (hindawi.com)
Here we review evidence showing that apicobasal polarity regulates the inflammatory response: various polarized epithelia asymmetrically secrete chemotactic mediators and polarize adhesion receptors that dictate the route of leukocyte migration within the parenchyma. (hindawi.com)
We also discuss recent findings showing that the loss of apicobasal polarity increases leukocyte adhesion to epithelial cells and the consequences that this could have for the inflammatory response towards damaged, infected or transformed epithelial cells. (hindawi.com)

Thus, the study of the biological effects of US on cancer cells is important to understand the consequences of these changes on the malignant phenotype. (unicatt.it)
This study aimed to investigate the effects of low-intensity ultrasound (LIPUS) on the phenotype of colorectal cancer cell lines. (unicatt.it)

2009). However, previous work recognized two transmembrane proteins that are excellent candidates to mediate planar signaling at the basal surface and thus promote migration of this tissue: the atypical cadherin Excess fat2 and the receptor tyrosine phosphatase Leukocyte antigen related (Lar) (Bateman et al. (brain-tumor-cancer-information.com)
RT-PCR analysis indicated that the predominant receptor expressed on RPE cells was CXCR4. (elsevierpure.com)

Medullary epithelial cells (mTEC), in conjunction with dendritic cells, then take over control of developing thymocytes. (frontiersin.org)
In addition to intrathymic selection, and during this medullary residency period, CD4 + and CD8 + single positive (CD4SP, CD8SP) thymocytes acquire the ability to proliferate in response to TCR stimulation, and undergo licensing for cytokine production, prior to exiting the thymus to join the peripheral T-cell pool as Recent Thymus Emigrants (RTE) ( 5 , 6 ). (frontiersin.org)

On the other hand, these barriers contain damaged or infected cells that are part of the inflammatory focus and the endpoint of the leukocyte migratory journey, so some sort of footprint, which is not completely understood, must exist in these cells to promote a preferential adhesion with infiltrated leukocytes. (hindawi.com)
The parenchymal three-dimensional organization contributes to establish an haptotactic and chemotactic gradient (1) Leukocyte adhesion and transendothelial migration or diapedesis. (hindawi.com)
The LAP [leucine-rich and postsynaptic density-95/Discs large/zona occludens-1 (PDZ)] protein erbin and δ-catenin, a component of the cadherin-catenin cell adhesion complex, are highly expressed in neurons and associate through PDZ-mediated interaction, but have incompletely characterized neuronal functions. (jneurosci.org)
implying that this complex has functional roles that extend beyond its ability to regulate cell adhesion. (jneurosci.org)
CD44 has functional roles in cell migration, lymphocyte homing and adhesion during hematopoiesis and lymphocyte activation. (bdbiosciences.com)
Little is known about molecular mecha- desmosomal glycoproteins, resulting in the nisms affecting mast cell and T lympho- loss of keratinocyte cell-cell adhesion [ 1 ]. (who.int)

Precursors of T cells originate in the bone marrow from which they migrate via bloodstream into thymic cortex, where they encounter stromal cells including cTECs, which form the microenvironment crucial for proliferation and development of T cells by expression of DLL4 (delta-like notch ligand 4), cytokines IL-7, TGFβ or stem cell factor and chemokines CCL25, CXCL12 or CCRL1 etc. (wikipedia.org)
CXCR4 protein could be detected on the surface of 16% of the RPE cells using flow cytometry, Calcium mobilization in response to the CXCR4 ligand stromal cell-derived factor 1 alpha (SDF-1 alpha) indicated that the CXCR4 receptors were functional, Incubation with SDF-1 alpha resulted in secretion of monocyte chemoattractant protein-1, IL-8, and growth-related oncogene iv, RPE cells also migrated in response to SDF-1 alpha. (elsevierpure.com)
These microenvironments are classically defined as distinct cortex and medulla regions that each contain specialized subsets of stromal cells. (frontiersin.org)
While adult lymphoid progenitor cells are produced by the bone marrow, their lineage commitment and development into mature T-cells is dependent on their migration into the thymus, where essential interactions with heterogeneous thymic stromal cells take place ( 1 ). (frontiersin.org)
While many studies have demonstrated the importance of cTEC and mTEC during T-cell development, thymic stromal microenvironments also contain heterogenous non-epithelial stromal (NES) populations in a similar manner to that seen in peripheral lymphoid tissues. (frontiersin.org)
Leukocyte recruitment into the inflamed parenchyma requires successive interactions with cellular and stromal barriers that establish mechanical, chemotactic and haptotactic gradients to guide immune cells towards the inflammatory focus. (hindawi.com)

In these operational systems, specific models of transmembrane proteins localize to opposing sides from the same cell and mediate intercellular conversation by getting together with each other across cell-cell limitations. (brain-tumor-cancer-information.com)
Integrin trafficking may also guide mRNA to ribosomes associated with the protrusive regions of metastatic cells, and thus localise the synthesis of pro-migratory proteins. (gla.ac.uk)
A major aim of our research is to characterise the mechanisms by which integrin-associated proteins command mRNA transport and translation during the invasive migration of cancer cells. (gla.ac.uk)

The Rho GTPases Rac, Rho and Cdc42 regulate cytoskeletal dynamics spatially and therefore control cell shape and the direction of cell migration. (abdn.ac.uk)

Cell proliferation was evaluated by viability test and by evaluation of pERK expression, while cell motility using the scratch test. (unicatt.it)
LIPUS-induced increase in cell motility was likely due to a Rho GTPase-dependent mechanism. (unicatt.it)
This article discusses how a combination of live-cell analysis methods deliver the required flexibility to allow these highly dynamic astrocytic models to be characterized, via quantification of their growth, motility, morphology, and functional analysis. (news-medical.net)
The Incucyte ® Live-Cell Analysis System delivers flexible kinetic quantification of biological phenotypes to monitor growth, motility, morphology, and cellular function. (news-medical.net)
CD117 by immunohistochemical methods sion molecules, involved in cell-cell and in order to clarify the role of the infiltrating cell matrix interactions and thought to take inflammatory cells in the pathomechanisms part in cell motility [ 2,3 ]. (who.int)

Thymus tissue is compartmentalized into cortex and medulla and each of these two compartments comprises its specific thymic epithelial cell subset. (wikipedia.org)

Although polymorphonuclear leukocytes (PMN's) can migrate through every epithelium in the body regardless of its permeability, very little is known about the effect of epithelial permeability on PMN migration and the effect of emigrating PMN's on the permeability of the epithelium. (rupress.org)
Open up in another window Shape 1 The developmental framework for the migration from the follicular epithelium(A and B) Illustrations displaying a migrating epithelium from basal (A) and part (B) sights. (brain-tumor-cancer-information.com)
A germ is had by them cell cluster that's encircled with a somatic epithelium called the follicle cells. (brain-tumor-cancer-information.com)
The Fz/Vang and Foot/Ds PCP pathways aren't necessary for the migration of the follicular epithelium (Viktorinova DCN et al. (brain-tumor-cancer-information.com)
Using these methods, it could be established that the proliferating cells in Bowman's space, which are characteristically found in RPGN, are derived almost exclusively from the glomerular epithelium - primarily PECs. (scienceopen.com)

Targeting α5β1 integrins might not only prevent metastasis of HNSCC but also delay the development of the primary tumor by reducing tumor cell viability. (cipsm.de)
reported that miR-326 is abnormally expressed in metastasis and nonmetastasis tissues in non-small-cell lung cancer, providing an experimental basis for exploring the mechanism of non-small cell lung cancer metastasis and molecular diagnosis and treatment [ 16 ]. (hindawi.com)

Rao, MV & Zaidel-Bar, R 2015, ' Actin Polymerization by the Formin Fmnl3 Supports Epithelial Cell-Cell Junction Integrity during Collective Cell Migration ', Molecular Biology of the Cell , vol. 26. (tau.ac.il)
Journal of Cell Biology , 220(12), e202006049. (gla.ac.uk)
Journal of Cell Biology , 219(6), e20190620. (gla.ac.uk)
Also covered in detail was the basic cell biology of EMT and its role in cancer and fibrosis, as well as the identification of new markers to facilitate the observation of EMT in vivo. (rupress.org)
The use of real-time, live-cell analysis provides new possibilities and cell biology workflows. (news-medical.net)

On the one hand, similar to endothelial cells, parenchymal epithelia must guide leukocytes to traverse them in order to reach a localized inflammatory focus, for example, in the lung or intestinal mucosa. (hindawi.com)
Endothelial and epithelial barriers determine the different stages of leukocyte migration in its journey towards the inflammatory focus in complex tissues. (hindawi.com)
OVDs can create and preserve surgical space, pressurize the anterior chamber in the presence of an open wound, partition spaces, protect the corneal endothelial cells from fluid turbulence, and facilitate surgery. (lww.com)

Background: Vestigial like family member 3 (VGLL3) is associated with the prognosis of epithelial ovarian cancer and soft tissue sarcoma, but its role in gastric cancer (GC) is unclear. (researchgate.net)

Retinal pigment epithelial (RPE) cells form part of the blood-retina barrier and have recently been shown to produce various chemokines in response to proinflammatory cytokines, As the scope of chemokine action has been shown to extend beyond the regulation of leukocyte migration, we have investigated the expression of chemokine receptors on RPE cells to determine whether they could be a target for chemokine signaling. (elsevierpure.com)
Results showed that in cultured human-derived retinal pigment epithelial ARPE-19 cells , the extract of Chlorella zofingiensis and its nutritional ingredient astaxanthin exhibited significant inhibitory effects on the formation of endogenous N ε -carboxymethyllysine (CML), a key AGE representative, through the suppression of intracellular oxidative stress. (rsc.org)

During more recent years, his reseach has been conducted in the field of regenerative medicine, focussed on antigen expression and immune recognition of human embryonic stem cells and bioartificial heart valves, the latter tissues being of animal origin. (gu.se)
The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)

Cell proliferation , superoxide levels, nitric oxide (NO) levels, and arginase activity were estimated using Cell Counting Kit-8 assays, a superoxide assay kit, an NO assay kit, and an arginase activity kit. (bvsalud.org)

Here we show that expression of the EMT master inducer Snail in primary adult Drosophila intestinal tumors leads to the dissemination of tumor cells and formation of macrometastases. (whiterose.ac.uk)
The clinical differential diagnosis of a fibroma depends on its clinical presentation and location and includes giant cell fibroma, neurofibroma , peripheral giant cell granuloma , schwannoma, granular cell tumor, mucocele , and benign and malignant salivary gland tumors (eg, see Salivary Gland Neoplasms ). (medscape.com)

As SDF-1 alpha expression by RPE cells was detected constitutively, we postulate that SDP-1-CXCR4 interactions may modulate the affects of chronic inflammation and subretinal neovascularization at the RPE site of the blood-retina barrier. (elsevierpure.com)
8 Astrocytes interact with blood vessels, pericytes, and epithelial cells to organize CNS flow and modulate the blood-brain barrier (BBB). (news-medical.net)

Following PMN emigration, epithelial junctional membranes reapproximated and were impermeable to the tracers. (rupress.org)

Epithelial permeability and the transepithelial migration of human neutrophils. (rupress.org)
Epithelial permeability was determined by both conductance measurement and horseradish peroxidase (HRP) tracer studies. (rupress.org)
The effect of PMN migration on epithelial permeability was examined using the ultrastructural tracers HRP and lanthanum nitrate. (rupress.org)
It changes the permeability of the fungal cell membrane after binding to cell membrane sterols, causing cellular contents to leak. (medscape.com)
Clotrimazole is a broad-spectrum antifungal agent that inhibits yeast growth by altering cell membrane permeability, causing death of fungal cells. (medscape.com)

Cell differentiation was evaluated assessing alkaline phosphatase activity. (unicatt.it)
Cell Death and Differentiation , 29(10), pp. 2089-2104. (gla.ac.uk)
Recent advances in live imaging and genetics of mammalian division, movement and cell differentiation leading to development which integrate observations of biochemical tissue formation [14 ]. (lu.se)

The events that follow leukocyte extravasation are perhaps less well characterized, although significant advances have been made with the advent of high-resolution intravital microscopy and the development of more sophisticated culture systems to investigate leukocyte migration and interactions in three dimensions. (hindawi.com)

In this review, we cover how the non-epithelial compartment of thymic stroma represent essential cell populations in regulating thymus function. (frontiersin.org)
During the inflammatory response, immune cells egress from the circulation and follow a chemotactic and haptotactic gradient within the tissue, interacting with matrix components in the stroma and with parenchymal cells, which guide them towards the sites of inflammation. (hindawi.com)
Particular attention has been paid to elucidating how leukocytes can migrate through the stroma, the way these cells remodel their morphology and sense cues that guide them towards dysfunctional tissue areas. (hindawi.com)
We believe that successfully combining our current knowledge about leukocyte extravasation, three-dimensional migration through the stroma and the sequential interactions with parenchymal cell barriers, which include adopting unified experimental models, will help shed light on the entire migratory route of each immune cell type and on the specificity of the innate inflammatory responses in each type of tissue. (hindawi.com)

Snail drives an EMT in tumor cells, which, although retaining some epithelial markers, subsequently break through the basal lamina of the midgut, undergo a collective migration and seed polyclonal metastases. (whiterose.ac.uk)
The tumor cells are CD34 and vimentin positive. (medscape.com)

Vitamin A: The Importance in Health, Epithelial & Mucosa Lining, T-Cell Migration etc. (elisaact.com)
TFFs are rapidly and coordinately secreted from mucus-secreting cells when the gastrointestinal mucosa suffers mechanical and/or chemical damage, and they respond to the mucosal injury ( 4 , 5 ). (spandidos-publications.com)

Consistent with this, qRT-PCR confirmed that the expression of multiple genes involved in cilia biogenesis was significantly downregulated by diacetyl and 2,3-pentanedione in NHBE cells. (nature.com)
Furthermore, immunofluorescence staining showed that the number of ciliated cells was significantly decreased by the flavoring chemicals. (nature.com)
The number, diversity, and complexity of astroglia cells have increased significantly with evolution, and research from several groups implies that gender differences exist. (news-medical.net)
Fibronectin and collagen type I alpha1 chain ( collagen 1A1) expression increased, and cell migration increased significantly in ARG1-overexpressing HLECs compared with those transfected with an empty vector after TGF-ß2 treatment . (bvsalud.org)

Our work aims for a full description of the molecular machinery that coordinates integrin traffic during cell migration as these may represent novel targets for anti-metastatic drugs. (gla.ac.uk)
To describe how defects in the regulation of these process contribute to the metastatic behaviour of cancer cells. (bath.ac.uk)
Pancreatic cancer is enriched with cancer stem cells (CSCs), which contribute to its high metastatic tendency and resistance to treatments. (ku.edu)
SW620-V- or SW620-B-transfected (pooled) cells were injected into the splenic capsule ( B ) PET imaging (GB = Gallbladder, arrows indicate metastatic foci). (jci.org)

One way that leading and trailing edge dynamics could possibly be coordinated between migrating epithelial cells is certainly by using a planar signaling program. (brain-tumor-cancer-information.com)

Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
ARG1 is highly expressed in various tumour cells . (bvsalud.org)

1983) and the multipotent progenitor cells from fetal disease (Bjorklund and Lindvall, 2000). (lu.se)

The physical shape of the extracellular environment is usually not considered in the context of directional cell migration. (abdn.ac.uk)

C57BL/6 mice , a human lens epithelial cell line (HLEC-SRA01/04), and human lens capsule samples were used in this study. (bvsalud.org)
Human lens epithelial cells (HLECs) were transfected with ARG1-targeted (siARG1) or negative control siRNA (siNC). (bvsalud.org)
CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)

Previous work shows that activating cAMP-dependent protein kinase (PKA) enhances airway epithelial wound repair while activating protein kinase C (PKC) inhibits wound repair. (cdc.gov)
Hog barn dust extracts slow cell migration and wound repair via a PKC-dependent mechanism. (cdc.gov)
A significant enhancement of wound repair was observed in DDAH cells compared to WT cells treated with hog dust extract for 24 h. (cdc.gov)
I am interested in the process by which cells use environmental conditions as guidance cues during development, wound healing and regeneration. (abdn.ac.uk)
Transwell assays and wound healing assays were used to determine cell migration . (bvsalud.org)

The egg chamber offers a effective model to research the mechanisms managing epithelial AR-C69931 tyrosianse inhibitor migration (Statistics 1CC1G). (brain-tumor-cancer-information.com)
Compared to the endothelium, the molecular mechanisms involved in the interaction of infiltrated or tissue-resident immune cells with parenchymal barriers have not been so extensively studied. (hindawi.com)
Since electric fields and variation in substratum shape co-exist in vivo another interest is to determine the hierarchy of directional cues and the mechanisms that allow the cues to be selected/integrated by individual cells. (abdn.ac.uk)
Thus understanding cellular mechanisms leading to cell migration may reveal novel targets and lead to new therapeutic strategies in treating IBD and CC. (lu.se)
of the most critical events which lead to tissue patterning involves mechanisms going beyond single cells. (lu.se)

The thymus supports T-cell development via specialized microenvironments that ensure a diverse, functional and self-tolerant T-cell population. (frontiersin.org)
However, experimental evidence suggests these cells are important for thymus function by either directly influencing T-cell development, or by indirectly regulating TEC development and/or function. (frontiersin.org)

I am interested in the process by which individual cells sense very small substratum features and how they translate the cues subsequently into directed migration. (abdn.ac.uk)
and, in response to antigen, are subsequently secreted by plasma cells. (msdmanuals.com)

From the proper period an egg chamber forms until stage 8 of oogenesis, the follicle cells collectively migrate along their cellar membrane (Cetera et al. (brain-tumor-cancer-information.com)
However, cells migrate along parallel substratum features on the scale of tens to hundreds of nanometers, which mimic the size of naturally ocurring features (such as individual collagen fibrils or oriented neuronal fibers). (abdn.ac.uk)

Once T cell precursors enter the thymic cortex, they start their transformation from double negative stages (T cell without surface expression of CD4 and CD8 co-receptors) to a double positive stage (T cell with surface expression of both co-receptors) that expresses fully recombined TCR. (wikipedia.org)
Interaction between TCR of double positive T cell and MHC I molecule leads to loss of CD4 expression and double positive T cell becomes CD8 single positive T cell, conversely, engagement of MHC II molecule leads to the development into CD4 single positive T cell. (wikipedia.org)
It was also described that CD8/CD4 restriction is influenced by transcription factors Runx3, in the case of CD8 restriction, and Th-POK which directs the development into CD4 T cell lineage and represses the expression of Runx3. (wikipedia.org)
The level of CXCR4 mRNA expression, but not cell surface expression, increased on stimulation,vith It-lp or TNF-alpha. (elsevierpure.com)
In addition, mTEC screen thymocytes for their expression of high affinity αβ-TCRs, with negative selection limiting the release of these reactive T-cells into the peripheral pool ( 4 ). (frontiersin.org)
Similarly, the majority of CRC cell lines tested exhibited decreased BVES expression and promoter DNA hypermethylation, a modification associated with transcriptional silencing. (jci.org)
Treatment with a DNA-demethylating agent restored BVES expression in CRC cell lines, indicating that methylation represses BVES expression. (jci.org)
Numidargistat (CB-1158) dihydrochloride (CB-1158), an ARG1 inhibitor, suppressed TGF-ß2-induced anterior subcapsular cataract (ASC) by reducing the proliferation of lens epithelial cells (LECs) and decreasing fibronectin , α-SMA, collagen 1A1, and vimentin expression. (bvsalud.org)

Importantly, breast cancer cells that ectopically express AUF1 were more efficient in forming orthotopic tumor xenografts in nude mice than their corresponding controls with limiting cell inocula. (nature.com)
In cells from DDAH1 transgenic mice, control wounds were repaired up to 8 h earlier than seen in WT mice. (cdc.gov)
Likewise, cells from DDAH1 transgenic mice demonstrated increased NO and PKA activity and decreased hog dust extract-stimulated PKC. (cdc.gov)
A ) 2.5 × 106 LIM2405-P ( n = 3), LIM2405-V ( n = 6), Caco-2-V, Caco-2-dnBVES, or LIM2405-BVES-expressing cell lines LIM-9 ( n = 6), LIM-32 ( n = 3), LIM-15 ( n = 3) were implanted in the dorsal flank of 8-week-old athymic nude mice. (jci.org)

Distant metastases arise in 20-30% of patients with squamous cell carcinoma of the head and neck (HNSCC) in the 2 years following treatment. (cipsm.de)
Other types include squamous cell carcinoma (see the image below) and adenocarcinomas. (medscape.com)
Cross-section through the bladder, uterus, and vagina with squamous cell carcinoma of the bladder infiltrating through the bladder wall into the vaginal wall. (medscape.com)

The production of a diverse αβ-T-cell pool is vital to establishing and maintaining a functional adaptive immune system. (frontiersin.org)
Cortical epithelial cells (cTEC) support the earliest thymocyte progenitor populations, guiding them through the cortex, directing them to a T-cell lineage fate and ensuring their functional qualities as self-MHC restricted cells through the process of positive selection ( 2 ). (frontiersin.org)
Astrocytes are a heterogeneous population of cells with distinguishing functional and morphological characteristics and are specialized to their different brain regions and locations. (news-medical.net)

No alterations in vitality and clonogenicity were observed when the intermediate (0.4 MPa) and the lowest (0.035 MPa) acoustic intensities were administered while the treatment with high intensity (1 MPa) induced a reduction of both cell viability and clonogenicity in both cell lines in a frequency-dependent manner. (unicatt.it)
Data demonstrated that Pao and Rau preferentially inhibited the viability of pancreatic CSC population, compared with the whole cancer cell population. (ku.edu)

During migration, the actin cytoskeleton can be planar polarized, with tension fibers oriented in direction of motion and industry leading protrusions oriented orthogonally (arrows). (brain-tumor-cancer-information.com)

Each cell also produces these adhesions at its back to permit the trailing advantage to retract and cell AR-C69931 tyrosianse inhibitor body to progress. (brain-tumor-cancer-information.com)
Axelrod and Matis, 2013), whereas the cell migration equipment reaches the basal surface AR-C69931 tyrosianse inhibitor area. (brain-tumor-cancer-information.com)
We hypothesized that blocking an endogenous NO inhibitor, asymmetric dimethylarginine, by overexpressing dimethylarginine dimethylaminohydrolase mitigates the effects of hog dust extract on airway epithelial would repair. (cdc.gov)

These carbonic anhydrases are a class of metalloenzymes that catalyze the reversible hydration of carbon dioxide and are differentially expressed in a number of cell types. (nih.gov)

Anatomy73

Organisms10

Diseases7

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Psychiatry and Psychology1

Phenomena and Processes44

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Information Science5

Health Care2

Mesenchymal22

Transition1

Airway epithelial cells1

Thymic epithelial cells7

Bronchial epithelial4

Maintenance of epithelial cell polarity1

Proliferation and Migration1

Breast epithelial cells2

Vitro5

Intestinal epithelial1

Apoptosis3

Mammary2

Monolayers2

Invasion11

Inhibition4

Polarity3

Phenotype2

Receptor2

Medullary2

Adhesion6

Stromal6

Proteins3

Cytoskeletal Dynamics1

Motility5

Cortex and medulla1

Epithelium5

Metastasis2

Biology5

Endothelial3

Ovarian1

Retinal2

Embryonic3

Nitric oxide1

Tumors2

Modulate2

Junctional1

Permeability5

Differentiation3

Leukocyte migration1

Stroma4

Tumor cells2

Mucosa2

Significantly4

Metastatic4

Dynamics1

Tumour2

Progenitor cells1

Directional cell migration1

Human3

Wound5

Mechanisms5

Thymus2

Subsequently2

Migrate2

Expression8

Mice4

Squamous cell carc3

Functional3

Viability2

Actin cytoskeleton1

Inhibitor3

Differentially expressed1