• nmol
  • At a substrate concentration of 20 μM, propofol hydroxylase activity was significantly lower ( p = .032) in greyhound microsomes (1.7 ± 0.4 nmol/mg/min) compared with beagle microsomes (5.1 ± 1.3 nmol/mg/min) but was not statistically different ( p = .42) compared with mixed-breed microsomes (3.1 ± 1.2 nmol/mg/min). (aspetjournals.org)
  • 3) Kinetic analysis of tirilazad hydroxylase activity in three human livers resulted in an apparent Km of 2.12, 1.68 and 1.66 microM, and Vmax = 0.85, 0.44 and 3.45 (nmol/mg protein/min) for HL14, HL17 and HL21, respectively. (aspetjournals.org)
  • beagle
  • Life Technologies provides liver subcellular fractions from a variety of tox species, including human, nonhuman primates (Cynomolgus Monkey and Rhesus Monkey), dog (Beagle), rat (Sprague-Dawley), mouse (CD-1), and trout (Oncorhynchus mykiss). (thermofisher.com)
  • drug
  • Biotransformation of propofol to 2,6-diisopropyl-1,4-quinol (4-hydroxypropofol) by cytochrome P-450 in the liver is proposed as a critical initial step in the elimination of this drug in dogs. (aspetjournals.org)
  • protein
  • The introduction of the double bond in lathosterol at C-5 to form 7-dehydrocholesterol that is catalyzed by lathosterol-5-dehydrogenase was equally rapid in controls and homozygotes liver microsomes (120 +/- 8 vs 100 +/- 7 pmol/mg protein per min, P = NS). (jci.org)
  • In other words, the test is used to determine if elevated protein levels are due to skeletal damage or liver damage. (wikipedia.org)
  • kidney
  • Use by those with significant kidney problems, liver problems, or who are pregnant is not recommended. (wikipedia.org)