Microorganisms virulence factors. Medical search. Frequent questions

It is quite resistant to antimicrobials and has several virulence factors that contribute to its high pathogenicity. (usp.br)
A cluster of virulence genes encoded on a pathogenicity island is responsible for the pathogenicity of L. monocytogenes . (pressbooks.pub)
Virulence Virulence The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. (lecturio.com)
Often their pathogenicity arises not only from the formation of special virulence factors, but rather results from complex interactions of the pathogen with the immune system of the infected host. (leibniz-hki.de)
A significant part of the breast microbiota includes lactic acid bacteria, whose cell-free supernatant (LAB-CFS) may prevent bacteria from secreting virulence factors and lessen their pathogenicity ( 12 , 13 ). (frontiersin.org)

Unlike antibacterials that aim to inhibit cell growth, antivirulence therapies are based on the inhibition of bacterial virulence. (nature.com)
An important factor of bacterial virulence is the formation of biofilms which are aggregates of microorganisms incorporated into an extracellular matrix that protects bacteria from hostile environments. (usp.br)
My primary research focus is on investigating disordered bacterial virulence factors and their interactions with the host's innate immune system. (lu.se)

This is due to the unique virulence factor s produced by individual pathogens, which determine the extent and severity of disease they may cause. (pressbooks.pub)
Environmental pathogens are defined as microorganisms that normally spend a substantial part of their lifecycle outside human hosts, but when introduced to humans cause disease with measurable frequency. (asm.org)
To achieve this understanding, surveillance of the environment to determine the numbers and distribution of environmental pathogens is needed, as is research into the microbial virulence and host factors that enable microbes to invade and damage human hosts. (asm.org)
Whilst many bacterial pathogens are intracellular in nature, others do not need to invade the host cell, but instead use various secretion processes which effect the delivery of toxins and other virulence factors into the host cell. (immunology.org)
The oral cavity acts as a major route of exposure to exogenous factors including pathogens, and processes therein may affect the communities in the subsequent compartments of the gastrointestinal tract. (uni.lu)
Pathogens, such as bacteria, viruses and parasites, that cause disease in humans and animals may depend partially or entirely for their existence on other physical, chemical, or biological factors. (who.int)
My main research interest is to explore structural and molecular level mechanism of host-pathogen interactions during an infection, and how pathogens use defined virulence determinants to target central components of the host's immune system. (lu.se)

They concluded that almost half (47 per cent) of the virulence factors identified are not currently well known as molecules that help bacteria to infect a host at the cellular level. (eco-business.com)
To sustain their virulence mechanisms, many bacteria can sequester free iron in the mammalian host, through the elaboration of iron-binding siderophores. (immunology.org)
ii) to evaluate the virulence factors expressed by these cariogenic bacteria in the presence of Terpinen-4-ol by real-time PCR. (fapesp.br)
The discovery of bacteria as an etiological factor for a wide range of medical conditions in the late 19th century promoted the development and usage of appropriate therapeutic treatments. (phytogenius.com)
Current research is especially investigating the possibilities on influencing quorum sensing (QS), which is an important mechanism to regulate virulence gene expression in many pathogenic bacteria (Boyen et al. (phytogenius.com)

When a pathogenic microorganism ( bacterium , viru s or protozoal parasite ) infects the human body, a battle ensues between the host's innate & adaptive immune systems and the pathogen's assorted virulence mechanisms and factors . (immunology.org)
Additionally, transcriptomics can be used to monitor the gene expression of virulence factors in microorganisms, aiding scientists in better understanding pathogenic processes from this viewpoint. (americascupmagazine.com)
It is hoped that the pathogenic correlation of spirochaetal virulence to temperature and heat shock proteins (HSP) might encourage a new direction of research in molecular epidemiology. (biomedcentral.com)

The main virulence factor of C. albicans is the ability to transform from planktonic yeast-form cells into a filamentous form (hyphae or pseudohyphae), with the subsequent formation of biofilm. (lu.se)
Cholera toxin is the main virulence factor. (cdc.gov)

This finding has raised an intriguing question: Does C. jejuni sense, inject and secrete putative virulence factors into host cells? (assignster.com)

All of these multiple virulence factors could raise BSIs of Candida species by escape mechanism which is part of the defence system in order to impair the host tissue. (microbiologyjournal.org)

The Micro-14 (Characterizing the Effects of Spaceflight on the Candida albicans Adaptation Responses) life science research mission will investigate and evaluate the responses of the Candida albicans microorganism to microgravity conditions and, in particular, to assess changes at the physiological, cellular, and molecular level and to characterize virulence factors. (nasa.gov)
12 The manifestation of virulence factors of Candida species can be differentiated based on species, type of infection, geographical region, host reaction and stage, and the site of infection. (microbiologyjournal.org)

The aims of this research work were to determine the patterns of antibiotic resistance in Escherichia coli isolates from the meat of wild or domestically reared pigeons from Spain, to detect the presence of virulence and antibiotic resistance genes, and to carry out a phylogenetic classification of the isolates. (mdpi.com)
Another extremely important topic which is discussed is the resistance of these microorganisms to antimicrobial agents. (novapublishers.com)
The interpretation of various virulence factors and antifungal drug resistance were seen mostly among NAC species, thus hence signifying its pivotal role in immunocompromised individual treatment. (microbiologyjournal.org)
RESULTS: We found a striking increase in the overall abundance and expression of both virulence factors and antimicrobial resistance genes in COVID-19. (uni.lu)
We found that different MAC species encode distinct suites of biomedically relevant genes, including antibiotic resistance genes and virulence factors, which may influence their distinct clinical manifestations. (cdc.gov)
We found that different MAC species and M. avium isolates from different sources encode distinct suites of clinically relevant genes, including those for virulence and antibiotic resistance. (cdc.gov)
Resistance to the lytic effects of serum complement confers virulence. (msdmanuals.com)

Heatmap and PCoA analysis confirmed this unique virulence profile associated with MDR-PA strains. (springeropen.com)
Diarrheagenic strains of E. coli can be classified into 5 key "pathotypes," each of which has unique virulence factors Virulence factors Those components of an organism that determine its capacity to cause disease but are not required for its viability per se. (lecturio.com)

RAM also publishes articles on microbial ecology and diversity, zoo- and phytopathogens and microorganisms of value for food, agronomic, industrial and environmental applications. (elsevier.es)
The aim of this project is to study of species composition of biofilm communities by cultivation and molecular methods and assessment of the differences in poly-microbial communities in relation to therapy failure, length of insertion of catheter, its type and other factors including predominating microbial species. (muni.cz)
Mammalian host cells have also evolved an array of pattern recognition receptors for microbes or microbial factors, such as the Toll-like receptors (TLRs), which when bound, trigger intracellular signalling cascade(s) with antimicrobial effects. (immunology.org)
Many factors have contributed to the persistence and increase in the occurrence of infectious diseases, such as societal changes, health care, food production, human behaviour, environmental change, public health infrastructure and microbial adaptation [2]. (who.int)

Microorganisms , 2020, 8: 1328. (plus.ac.at)

These factors include membrane-active toxins, called cytotoxins, and a group of pyrogenic toxin superantigens. (novapublishers.com)
Several current aspects related to the virulence of S. aureus and CoNS are discussed, including isolates of different origins, phenotypic and genotypic techniques for the detection of these toxins, and the gene regulation mechanism involved in the expression of these toxins. (novapublishers.com)
Two classes have been characterized: toxins, biological and surface adhesion molecules that affect the ability of the microorganism to invade and colonize a host. (lecturio.com)
Microorganisms may produce toxins that facilitate infection. (medscape.com)

The aim of our present study was to screen P. aeruginosa strains isolated from ocular infections, for their potential to produce various phenotypic virulence factors and correlating them with biofilm formation and their antibiotic susceptibility profile. (springeropen.com)

Analysis of virulence related gene expression and computational simulations of pivotal proteins involved in pathogenesis demonstrate that myricetin downregulates the saeR global regulator and interacts with sortase A and α-hemolysin. (nature.com)

We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several S. aureus virulence factors, including adhesion, biofilm formation, hemolysis and staphyloxanthin production, without interfering with growth. (nature.com)
is related to a combination of factors contributing to their virulence, such as their ability to grow at 37 °C, their phenotypic variability (switching), their transition from budding-to-hyphae or pseudo-hyphae and biofilm formation. (biomedcentral.com)
Virulence factors like hemolysin production, coagulase activity, phospholipase activity, and biofilm formation were studied and antifungal susceptibility testing was and Minimum Inhibitory Concentration (MIC) values were interpreted. (microbiologyjournal.org)

Our aim was to characterize the virulence determinants of MDR P. aeruginosa causing ocular infections. (springeropen.com)

A pathogen's virulence factors are encoded by genes that can be identified using molecular Koch's postulates. (pressbooks.pub)

Genomic analysis of pasteurella atlantica provides insight on its virulence factors and phylogeny and highlights the potential of reverse vaccinology in aquaculture. (uib.no)

In this section, we examine various types and specific examples of virulence factors and how they contribute to each step of pathogenesis. (pressbooks.pub)
Proteases is said to contribute to pathogenesis through destruction of connective tissue and degradation of host immunological factors [ 20 ] in patients with keratitis. (springeropen.com)

Mycetoma is an infection that affects the subcutaneous tissue by the inoculation of microorganisms on the skin after minor traumas. (rbac.org.br)

Those microorganisms that are potential indicators of contamination in a dental environment include Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus mutans, Streptococcus mitis, Streptococcus salivarius, Corynebacterium diphtheriae, Bacteroides fragilis and Peptoestreptococus. (bvsalud.org)

Wallaby encompasses about 250 predicted genes, some of which are probably involved in competition with microorganisms. (nature.com)
When genes encoding virulence factors are inactivated, virulence in the pathogen is diminished. (pressbooks.pub)
These genes are regulated by a transcriptional factor known as peptide chain release factor 1 (PrfA). (pressbooks.pub)
We observed that M. avium isolates from different sources-human pulmonary infections, human disseminated infections, animals, and natural environments-are readily distinguished by their core and accessory genomes, by their patterns of horizontal gene transfer, and by numerous specific genes, including virulence factors. (cdc.gov)

Any microorganism which is able to cause disease in a host organism is termed a pathogen . (immunology.org)
Another serious human pathogen, Bacillus anthracis, causative of anthrax , has well-developed virulence mechanisms involving the secretion of three proteins, one of which, protective antigen (PA), binds host cell receptors to effect entry of either lethal factor (LF) or edema factor (EF). (immunology.org)

Comparative assessment of Vibrio virulence in marine fish larvae. (uib.no)
This paper examines such factors, giving particular attention to a newly recognized serotype of Vibrio cholerae, which has caused epidemics in India and Bangladesh. (who.int)
Le présent article examine ces facteurs, en s'attachant plus particulièrement au sérotype nouvellement identifié de Vibrio cholerae qui a provoqué des épidémies en Inde et au Bangladesh. (who.int)
J. Glenn Morris] Well, actually Vibrio cholerae are free-living environmental microorganisms, and the who genus Vibrio are, again, free-living environmental microorganisms. (cdc.gov)

Understanding these virulence factors is crucial to know the pathophysiology, and also assists researchers to discover novel antifungal targets for more effective therapeutic regimens. (microbiologyjournal.org)

Virulence generally involves the employment of various mechanisms to destroy, or cause the malfunction of, host cells. (immunology.org)
A more detailed description of the various mechanisms employed by specific microorganisms can be found on other Bite-sized pages. (immunology.org)
Thus to protect itself from such virulence mechanisms, the host cell fights back by synthesising siderocalin receptors which competitively bind iron. (immunology.org)
Many microorganisms have mechanisms that impair antibody production by inducing suppressor cells, blocking antigen processing, and inhibiting lymphocyte mitogenesis. (msdmanuals.com)

Inroads have been made to understand the persistence of these organisms in the environment, the reservoirs they inhabit, the ways they exchange virulence factors and their diversity, but a great deal more research is needed. (asm.org)
Research covers the detection of such micro-organisms and factors that govern their transmissibility, virulence, ecology, epidemic behaviour and distribution. (nicd.ac.za)

The presence of microorganisms is ubiquitous and Aeromonas species is one great example. (preventit.in)

Various inflammatory cascades are discussed in more detail to provide in-depth knowledge of the connection of the symptoms to both the virulence factors in microorganisms and to the immunological defence in humans. (uu.se)
A large number of infections in humans and animals is caused by microorganisms that are actually considered to be harmless soil dwellers. (leibniz-hki.de)
Background The Concept of Emergence Emerging infectious diseases are diseases of infectious origin whose incidence in humans has increased within the past two decades or threatens to increase in the near future.1 Many factors, or combinations of factors, can contribute to disease emergence (Table1). (cdc.gov)

In general, it is impossible to separate environmental factors from biological factors, as can be seen from interrelationships in nature that play a significant role in the emergence of infectious diseases. (who.int)

The book also focuses on the identification of CoNS, virulence factors responsible for the symptoms and severity of infections caused by Staphylococcus spp. (novapublishers.com)

If caused by an infectious agent [ 12 ] as presupposed by Marie in 1884 [ 13 ], what kind of transmission or virulence would lie at its root? (biomedcentral.com)
Emerging infectious diseases such as acquired immunodeficiency syndrome (AIDS) and TB vividly illustrate that no nation can be complacent regarding human vulnerability to the microorganisms with which we share our environment. (cdc.gov)

The control Microbiology Laboratory, located in the Department of of microorganism growth aims to obtain healthier food Food Science and Technology of the Federal University of products, resulting on the elimination or reduction of Santa Catarina in isothermal boxes containing ice. (bvsalud.org)

causative of melioidosis or glanders ) have multiple secretion processes through which they deliver virulence factors into the host cell. (immunology.org)

Methanogens are microorganisms that produce methane as a byproduct of metabolism, and are mostly found in environments that lack oxygen. (eco-business.com)

For cancer patients, in addition to the intrinsic factors related to treatment such as placement of central venous catheters and receipt of parenteral nutrition, there are additional risk factors for candidemia. (biomedcentral.com)

Some studies consider periodontitis as an independent risk factor for preterm birth, growth restriction, low birth-weight and pre-eclampsia. (intechopen.com)
Enterococcus faecalis is most frequently isolated from persistent apical periodontitis [2] and has many virulence factors. (ijdr.in)

Identify the structure and function of microorganisms, their habitats and growth requirements as well as the methods used for diagnosis of bacterial and viral diseases all based on available evidence. (edu.au)
Different microorganisms can interact mechanistically by actively participating in these habitats, through direct and indirect exchanges of both a physical and chemical character. (frontiersin.org)

Des échantillons de muqueuse ont été prélevés grâce à une biopsie antrale sur 136 patients dyspeptiques consécutifs pour lesquels un diagnostic d'ulcère gastro-duodénal avait été établi par endoscopie à l'hôpital général de Bassora (Basra) en Iraq. (who.int)

Although the clinical importance of these microorganisms continues to expand, our understanding of their genomic diversity is limited, hampering basic and translational studies alike. (cdc.gov)

According to experts, microorganisms have the capability to present danger spanning centuries. (eco-business.com)

How such microorganisms could have acquired properties to colonize or persist in the host is poorly understood. (leibniz-hki.de)
7 ), "live microorganisms that, when administered in adequate amounts, confer a health benefit on the host" are probiotics. (frontiersin.org)

However, nutritional factors, interactions with the microbiota, and the presence of salivary antibodies have been suggested as possible influencing factors in the incidence of these yeasts, which are usually controlled by local factors, such as competition with bacterial cells of the resident microbiota [ 3 - 6 ]. (biomedcentral.com)

Many serious diseases related to environmental factors have recently emerged worldwide. (who.int)
Many diseases related to environmental factors have recently emerged worldwide and are of a degree to raise serious concerns. (who.int)
The focus of this paper is on the environmental factors associated with emergence of disease. (who.int)

Irrigation is complementary to instrumentation in facilitating the removal of pulp tissue and/or microorganisms. (ijdr.in)

Anatomy15

Organisms64

Diseases31

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes58

Disciplines and Occupations6

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science4

Health Care7

Pathogenicity5

Bacterial virulence3

Pathogens7

Bacteria5

Pathogenic3

Main virulence factor2

Putative virulence factors1

Multiple virulence factors1

Candida2

Resistance7

Unique virulence2

Microbial4

20201

Toxins4

Antibiotic1

Gene expression1

Biofilm3

Determinants1

Pathogen's1

Phylogeny1

Pathogenesis2

Infection1

Aureus1

Genes4

Pathogen2

Vibrio4

Antifungal1

Mechanisms4

Organisms2

Species1

Humans3

Biological factors1

Symptoms1

Infectious2

Microbiology1

Secretion1

Produce1

Candidemia1

Periodontitis2

Habitats2

Patients1

Diversity1

Capability1

Host2

Interactions1

Environmental3

Tissue1