Elastic fibers19
- Studies have shown that abnormalities of elastic fibers found in floppy mitral valves are related to genetic variants in fibrillin, one of the components of the microfibrils, as well as elastin and collagen I and II. (medscape.com)
- Stabilizes and organizes elastic fibers in the skin, lung and vasculature. (thermofisher.com)
- Elastin is a major component of elastic fibers in the skin. (skintypesolutions.com)
- Elastic fibers are like little coils or springs that give skin its stretchiness. (skintypesolutions.com)
- These tropoelastin molecules join together and attach to microfibrils to form elastic fibers. (skintypesolutions.com)
- The elastin and elastic fibers made in youth have to last a lifetime. (skintypesolutions.com)
- Elastic fibers are found throughout the dermis, running parallel and perpendicular to the skin surface. (skintypesolutions.com)
- This web-like arrangement of elastic fibers maintains elasticity in all directions. (skintypesolutions.com)
- The papillary dermis near the surface contains fine elastic fibers called oxytalan fibers extending perpendicular to connect to the epidermis. (skintypesolutions.com)
- The deeper reticular dermis houses thicker elastic fibers composed of both elastin and fibrillin called elaunin fibers running parallel to the surface. (skintypesolutions.com)
- This intricate network of oxytalan and elaunin elastic fibers is critical for healthy, youthful skin that does not sag. (skintypesolutions.com)
- The elastic fibers made in youth are pretty much expected to last a lifetime. (skintypesolutions.com)
- Sun exposure in particular causes dramatic changes and breakdown of elastic fibers. (skintypesolutions.com)
- Any structural anomaly of the elastic fibers of the skin. (nih.gov)
- Elastic fibers are the essential extracellular matrix macromolecules comprising an elastin core surrounded by a mantle of fibrillin-rich microfibrils. (nih.gov)
- Fibrillin is important for the assembly of elastin into elastic fibers. (github.io)
- Elastic fibers are predominantly composed of elastin, a highly hydrophobic protein (≈750 amino acids long). (github.io)
- Elastic fibers were observed at the insertion point of the anterior cruciate ligament to bone in the ovine stifle joint where they colocalized with perlecan. (cardiff.ac.uk)
- SD are characterized by erythematous or atrophic bands and are histologically atrophic epidermis, homogenized collagen and hardly elastic fibers. (suisselle.com)
Extracellular6
- A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. (lookformedical.com)
- Soluble tropoelastin is secreted into the extracellular space, where it forms lysine cross-links to other tropoelastin molecules to generate a large network of elastin fibers and sheets. (github.io)
- FBN1 Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. (affbiotech.com)
- e have colocalized elastin and fibrillin-1 with perlecan in extracellular matrix of tensional and weight-bearing connective tissues. (cardiff.ac.uk)
- The cells that form them are separated from each other by collagen, reticulin and elastin fibers and by an extracellular matrix, these three elements being the components of these tissues. (agrocorrn.com)
- The pathogenesis is unknown but relates to changes in the components of extracellular matrix, including fibrillating, elastin and collagen. (suisselle.com)
Fibrillin6
- Oxytalan fibers contain the microfibrillar protein fibrillin but no elastin. (skintypesolutions.com)
- 2022). Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development. (mcgill.ca)
- Co-localization of microfibrils and elastin fibres was examined by dual immunostaining of fibrillin-1 and elastin. (ox.ac.uk)
- Fibrillin-1- containing microfibrils provide long-term force bearing structural support. (affbiotech.com)
- Elastin and fibrillin-1 were identified as prominent components of paraspinal blood vessels, and posterior longitudinal ligament in the human fetal spine and outer annulus fibrosus of the fetal intervertebral disc. (cardiff.ac.uk)
- Elastin, fibrillin-1 and perlecan were co-localized in the intima and media of small blood vessels in the synovium and in human fetal paraspinal blood vessels. (cardiff.ac.uk)
Muscle Fibers2
- When the signal stops, the muscle fibers rearrange and the contraction stops, the muscle relaxes. (vitalscend.com)
- It has a mesodermal origin and is formed by elongated cells called muscle fibers, which contain actin and myosin and whose functional characteristics are excitability, conductivity and contractility. (agrocorrn.com)
Protein fibers1
- Made up of many smaller protein fibers, a muscle can contract and produce force. (vitalscend.com)
Predominantly1
- In the inner annulus fibrosus, the microfibrils were predominantly visible as a filamentous mesh network, both in the interterritorial matrix and also around the cells. (ox.ac.uk)
CONNECTIVE TISSUE1
- Elastin is a resilient connective tissue protein found in the ECM of most vertebrate tissues, and it is an important part in the interstitium of tissues that undergo repeated physical deformations in the human body (Swee et al. (github.io)
Molecules1
- Water also plays a role, allowing the coiled elastin molecules to extend and contract. (skintypesolutions.com)
Synthesis2
- New elastin synthesis shuts down after puberty. (skintypesolutions.com)
- Detailed clinical evaluation and histological studies of skin biopsies (revealing a moth-eaten appearance, abnormal elastin fiber branching and lose microfibrils associated with reduced elastin synthesis) are usually diagnostic in ARCL1. (rareguru.com)
Bundles2
- In the outer annulus fibrosus (OAF), abundant microfibrils organized in bundles were mainly distributed in the interterritorial matrix. (ox.ac.uk)
- In addition, the microfibril bundles were orientated parallel to each other and co-localized highly with elastin fibres. (ox.ac.uk)
Blood vessels1
Collagen fiber1
- Elevation of the dermal-epidermal junction maybe functionally related to the positive effect of the HA to the collagen fiber alignment. (suisselle.com)
Occur2
- This may help us to understand the interactions which are expected to occur in vivo between the tropoelastin and perlecan to facilitate the deposition of elastin and formation of elastic microfibrils in situ and would be consistent with the observed distributions of these components in a number of connective tissues. (cardiff.ac.uk)
- Stretch marks occur when the skin's collagen and elastin fibers are stretched, like when a person grows or gains weight rapidly. (healthline.com)
Fibroblasts1
- FBN2 silencing recapitulates hypoxic conditions and induces elastic fiber impairment in human dermal fibroblasts. (mcgill.ca)
Structural1
- Not only do microfibrils provide structural integrity of specific organ systems, but they also provide a scaffold for elastogenesis in elastic tissues. (github.io)
Network1
Skin10
- Elastin is a protein that gives skin its snap and elasticity. (skintypesolutions.com)
- Treatments for sagging skin need to focus on replacing collagen, not elastin. (skintypesolutions.com)
- Elastin allows the skin to stretch and then snap back into shape. (skintypesolutions.com)
- As we age, elastin levels decline leading to loose, sagging skin. (skintypesolutions.com)
- The important role water plays is why moisturizing and hydrating the skin is important to help prevent damage of elastin fibers. (skintypesolutions.com)
- Elastin has extremely low turnover in adult skin. (skintypesolutions.com)
- This means that not very much new elastin can be made in adult skin. (skintypesolutions.com)
- Skin tightening treatments can shrink and tighten collagen, but no treatments work on elastin although many claim they do. (skintypesolutions.com)
- To understand how companies can make this claim, you need to understand how elastin in skin is measured. (skintypesolutions.com)
- Also known as collagen induction therapy, microneedling makes tiny punctures in the top layer of skin to trigger elastin and collagen production. (healthline.com)
Human2
- Microfibrils, elastin fibres and collagen fibres in the human intervertebral disc and bovine tail disc. (ox.ac.uk)
- The distribution of microfibrils was studied immunohistochemically in intervertebral discs taken from young normal human surgical cases and from the bovine tail. (ox.ac.uk)
Abstract1
- abstract = "Elastic fiber fragmentation (EFF) is a hallmark of aortic valve disease (AVD), and neovascularization has been identified as a late finding related to inflammation. (elsevierpure.com)
Matrix1
- By contrast, sparse elastin fibres, with a few of microfibrils, were visible in the interterritorial matrix. (ox.ac.uk)
Stretch1
- Elastin has a coiled structure that allows it to stretch and recoil. (skintypesolutions.com)
Components1
- A distinct pattern of elastic fiber components surrounded early-onset AVD neovessels, including increased emilin-1 and decreased fibulin-5. (elsevierpure.com)
Essential1
- Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. (thermofisher.com)
Production1
- After puberty, elastin production decreases dramatically. (skintypesolutions.com)
Important1
- Electrostatic interactions through the heparan sulfate chains of perlecan and core protein mediated the interactions with tropoelastin, and were both important in the coacervation of tropoelastin and deposition of elastin onto perlecan immobilized on the chip surface. (cardiff.ac.uk)