Micrornas gene expression regulation. Medical search. Frequent questions

MicroRNAs (miRNAs) are small non-coding RNA molecules of about 22 nucleotides which function to silence the expression of their target genes. (biomedcentral.com)
Only a few studies have examined the expression profiles of miRNAs in luminal B breast cancer, and their regulatory roles in cancer progression have yet to be investigated. (biomedcentral.com)
We considered the expression of both miRNAs and messenger RNAs (mRNAs) at these time points to improve the identification of regulatory targets of miRNAs. (biomedcentral.com)
Among 82 newly discovered breast-cancer-related miRNAs, 35 can potentially regulate 271 protein-coding genes based on their sequence complementarity and expression profiles. (biomedcentral.com)
In this study we profiled the expression of miRNAs during breast cancer progression in the PyMT mouse model. (biomedcentral.com)
By integrating miRNA and mRNA expression profiles, we identified differentially expressed miRNAs and their target genes involved in several hallmarks of cancer. (biomedcentral.com)
In addition to numerous protein-coding genes, many microRNAs (miRNAs) also play important roles in breast cancer. (biomedcentral.com)
These miRNAs are around 22 nucleotides in size that are central and negative regulators of gene expression. (mbpinc.net)
Moreover, the block expression at the post-transcriptional levels and transcriptional levels, on the basis of perfect or imperfect match in sequences among miRNAs and target genes is also there. (mbpinc.net)
These miRNAs are known to be the "epigenetic controllers" since they impact gene expression without brining any changes in the genomic sequence. (mbpinc.net)
Changed and manipulated expression of miRNAs is commonly seen in several pathological conditions like cancer. (mbpinc.net)
Just like the protein coding genes, miRNAs are also influenced to epigenetic changes and regulation by DNA methylation in their respective promoter regions. (mbpinc.net)
The DNA methylation of miRNAs has an indirect impact on the regulation of the miRNA target genes. (mbpinc.net)
That being said, the DNA methylation of miRNAs also is a big factor that leads to overexpression in the target genes. (mbpinc.net)
Also, miRNAs have the ability to influence the expression of several targets. (mbpinc.net)
As a result, the gene targets can be regulated with the help of a plethora of different miRNAs, simultaneously. (mbpinc.net)
This creates a great network of miRNAs-targets that greatly enhances the complexity of gene regulation. (mbpinc.net)
Scientists further worked showed that despite of the differences between cell lines in the gene expression level, the miRNAs-gene network is very slightly influenced or disrupted in these pathways. (mbpinc.net)
This also showed that there is an inverse correlation between methylation statuses of the above mentioned miRNAs along with the expression of their gene targets. (mbpinc.net)
On the other hand, the miRNAs examined in this study can also be used to target other genes and pathways. (mbpinc.net)
Moreover, other literature and studies have demonstrated that many genes are directly silenced by methylation, and not by miRNAs. (mbpinc.net)
A new study shows that increased levels of reactive oxygen species in cancer induce widespread, sequence-specific modifications of guanines in the seed regions of microRNAs, altering the targets of those miRNAs and influencing tumorigenesis. (nature.com)
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (nih.gov)
This study aimed to identify the role of AA in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cell (VSMC) behaviours and to explore the effects of microRNAs (miRNAs). (hindawi.com)
MicroRNAs (miRNAs) are small noncoding sequences involved in the negative regulation of gene expression. (hindawi.com)
Individual miRNAs are capable of regulating gene networks by interacting with multiple targets or by suppressing transcriptional controllers [ 6 , 8 ]. (researchsquare.com)
Expression of various miRNAs is dysregulated in experimental models of status epilepticus and in resected brain tissue from patients with drug-resistant temporal lobe epilepsy [ 11-13 ]. (researchsquare.com)
Analysis of miRNAs involved in the regulation of MMP9 and its consequences to cell. (usp.br)
miRNAs are a large family of non-coding RNAs which play important roles in translational and post-transcriptional regulation of gene expression and biological processes. (unboundmedicine.com)
Abnormal expression of miRNAs is related to the initiation and progression of different diseases which make them be promising candidates for early medical diagnostics. (unboundmedicine.com)
This chapter describe the possibilities of MicroRNAs (miRNAs) in crop plants gene expression regulation in different metabolic pathways. (intechopen.com)
Several current researches have shown different environmental stresses induce abnormal expression of miRNA, thus signifying that miRNAs may be an appropriate tool for genetical improvement in plant for stress tolerance. (intechopen.com)
These miRNAs mainly control gene expression through translational inhibition. (intechopen.com)
Furthermore, we discuss recent findings on EBV associated gastric carcinogenesis by focusing on the roles of latent genes, epigenetic abnormalities, genomic alterations, and post-transcriptional regulation by cellular and viral microRNAs (miRNAs). (spandidos-publications.com)
Recently, much attention has focused on the impact of microRNAs (miRNAs) on tumorigenesis and cancer progression. (sarcomahelp.org)
miRNAs are approximately 22-nucleotide non-coding RNAs that participate in post transcriptional gene expression regulation through mRNA degradation, translational inhibition or chromatin-based silencing mechanisms. (sarcomahelp.org)
miRNA deregulation has been identified in a variety of epithelial origin cancers, where changes in specific miRNAs expression possibly contribute to tumor growth, progression, metastasis, and chemoresistance. (sarcomahelp.org)
Pharmacologic manipulation of microRNA expression has been undertaken in the form of in vivo miRNA delivery of downregulated miRNAs and "antagomirs" targeting upregulated miRNAs. (sarcomahelp.org)
MicroRNAs (miRNAs) are small non-coding RNA molecules (containing ~22 nucleotides) that function in RNA silencing and post-transcriptional regulation of gene expression. (spandidos-publications.com)
miRNAs normally cleave mRNA by base-pairing to the 3′-untranslated region (UTR) of the target genes ( 9 ). (spandidos-publications.com)
miRNAs are a family of small non-coding RNAs that emerged as significant and versatile regulators involved in regulation of immune responses. (frontiersin.org)
MicroRNAs (miRNAs) are highly conserved, single-stranded, small non-coding RNAs that have been shown to act as essential regulators of gene expression at the posttranscriptional level. (frontiersin.org)
miRNAs induce gene degradation and suppression of translation, or both, mainly by imperfect binding to miRNA recognition elements (MREs) within the 3′-untranslated region (UTR) of target mRNAs ( 1 ). (frontiersin.org)
Growing evidence show that miRNAs play an important role in the regulation of immunity and inflammation. (frontiersin.org)
However, the principles that determine if a gene is regulated by miRNAs are poorly understood. (frontiersin.org)
MicroRNAs (miRNAs) post-transcriptionally regulate genes across all animals and plants. (frontiersin.org)
MicroRNAs (miRNAs) are noncoding RNAs that target a network of molecules. (duke.edu)
MicroRNAs are short, noncoding RNAs that are known to regulate expression of many genes, though the existence and significance of miRNAs has been realised only recently. (helsinki.fi)
MicroRNAs (miRNAs) are small non-coding RNAs responsible for posttranscriptional regulation of gene expression. (lu.se)
that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)
As binding of miRNAs to a target mRNA may result in an airway inflammatory disease closely correlates with either mRNA degradation or inhibition of protein immune regulation, more and more evidences suggest translation.1 More than 2000 miRNAs have been discovered in humans. (cdc.gov)
DC demonstrated that miRNAs participate in airway maturation, while downregulation of let-7i significantly inflammatory regulation in asthma. (cdc.gov)
MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)
SNPs in 6 miRNA processing genes and in 78 miRNAs which target genes known to be important in breast cancer among 906 African American (AA) and 653 European American (EA) cases and Author Manuscript controls enrolled in the Women's Circle of Health Study (WCHS). (cdc.gov)
We found a number of SNPs in miRNAs and processing genes in association with breast cancer overall or stratified by estrogen receptor (ER) status. (cdc.gov)

Because malignant cells show dependence on the dysregulated expression of miRNA genes, which in turn control or are controlled by the dysregulation of multiple protein-coding oncogenes or tumour suppressor genes, these small RNAs provide important opportunities for the development of future miRNA-based therapies. (nih.gov)
Here the authors identify chromatin-bound RNAs and their binding sites in human embryonic stem cells suggesting that most chromatin-associated RNAs act proximal to their encoding loci and single RNAs are unlikely to alter gene expression. (nature.com)
MicroRNAs (miRs) are endogenous non-coding RNAs of ∼ 23-mer, which have important roles in regulation of gene expression. (nature.com)
Small noncoding RNAs called microRNAs (miRNA) negatively regulate gene expression by sequence-specific targeting of protein-coding transcripts [ 6 ]. (researchsquare.com)
MicroRNAs are short non-coding RNAs with important functions in the regulation of gene expression in healthy and diseased tissues. (lu.se)
MicroRNAs, as their name implies, are small RNAs that provide an essential regulation of gene expression by controlling translation of protein expressing messenger RNAs. (rvc.ac.uk)
Individual small RNAs are responsible for controlling the expression of gonadoliberin or GnRH (Gonadotropin-Releasing Hormone), a neurohormone that controls sexual maturation, the appearance of puberty, and fertility in adults, new research shows. (sciencedaily.com)
MicroRNAs are small non-coding RNAs transcribed from our DNA. (sciencedaily.com)
Scientists at one of the world's top mesothelioma research centers, the Asbestos Diseases Research institute in Sydney, Australia, say that restoring the expression of certain micro RNAs in the cells of mesothelioma patients may offer a new way to fight the disease. (survivingmesothelioma.com)
The objective of this study is to identify microRNAs-small, non-coding RNAs that help control gene expression-that contribute to the regulation of new blood vessel formation. (ca.gov)
MicroRNAs are small noncoding RNAs, 18 to 25 nucleotides in length, that negatively regulate gene expression," she said. (uga.edu)

Therefore, it is important to describe their mechanisms of actions, expression patterns and possible target genes and cellular pathways with which they interact. (mdpi.com)
This Special Issue of "Genes" seeks reviews and original papers covering a wide range of topics related to microRNA biology, such as regulation of expression in various disorders (cancer, metabolism, autoimmunity to mention but a few), genetics of microRNAs and their target sites, functional analysis of microRNA function and studies of interactions between microRNAs and target genes. (mdpi.com)
In terms of diagnosis, the study carried out by Vincent Prévot's team in Lille shows the interest of analysing DNA segments from which microRNAs are transcribed, as well as the genome segments that encode their binding sites on the target genes. (sciencedaily.com)

We can help researchers identify SNPs, indels, gene copy numbers, and genomic rearrangements from the various types of DNA-sequencing and microarray data and provide tailored downstream analysis of variants and mutations. (nottingham.ac.uk)
CRISPR/Cas9 genomic editing to evaluate the role of MMP9 and microRNA-21 in metastatic. (usp.br)
This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. (origene.com)
The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to MicroRNA-484. (helsinki.fi)

Global CpG island hypermethylation, which induces epigenetic silencing of tumor suppressor genes, is also a unique feature of EBVaGC and is considered to be crucial for its carcinogenesis. (spandidos-publications.com)
Regulation of gene expression, e.g. expression of the GnRH gene, by microRNAs is therefore considered "epigenetic" regulation. (sciencedaily.com)
The mere existence of microRNA in biological systems reveals complex layers of epigenetic regulation that govern the outcome of cellular signaling. (uga.edu)
Our current focus is to study the role of epigenetic mechanisms and microRNAs. (lu.se)
To understand the role of the epigenetic co-repressor protein TRIM28 in the control of transposable elements (TEs) and how TEs control gene regulation in the developing and adult brain. (lu.se)
If these microRNAs are over or under expressed (increase or decrease in quantity) - for example owing to epigenetic changes to the DNA - this will have an impact on many other regulatory processes. (lu.se)
It has proved difficult to develop drugs that act directly on epigenetic changes in DNA, but now it is possible instead to intervene later in the cell metabolism and regulate the level of specific microRNA molecules. (lu.se)

In molecular biology mir-384 microRNA is a short RNA molecule. (wikipedia.org)
In many mice that developed liver cancer, the AAV vector targeted a region of the mouse genome called Rian, near a gene called Mir341 that codes for a microRNA molecule. (nih.gov)
A microRNA is a small RNA molecule which is involved in the regulation of gene expression. (survivingmesothelioma.com)
MicroRNA is a type of RNA, a chemical cousin of DNA, that attaches to a protein's blueprint (a molecule called messenger RNA) and blocks the production of proteins from it. (medlineplus.gov)
A gene, the basic unit of heredity, is a segment of DNA containing all the information necessary to synthesize a polypeptide (protein) or a functional RNA molecule. (msdmanuals.com)
A gene is a segment of DNA that provides the code to construct a protein or RNA molecule. (msdmanuals.com)

MicroRNAs function to regulate the expression levels of other genes by several mechanisms. (wikipedia.org)
The mRNA levels in a cell are fine tuned by different mechanisms, one of which is driven by microRNA molecules. (sciencedaily.com)
Our experience in working with RNA-sequencing or expression microarray data can enable researchers to pinpoint the molecular mechanisms that create associations between genotypes and phenotypes. (nottingham.ac.uk)
A number of post-transcriptional mechanisms fine-tune the gene expression landscape. (researchsquare.com)

Over the past several years it has become clear that alterations in the expression of microRNA (miRNA) genes contribute to the pathogenesis of most--if not all--human malignancies. (nih.gov)
Their ability to maintain cell and tissue homeostasis is critical, with many miRNA genes implicated in human diseases such as metabolic, inflammatory, and neurodegenerative diseases ( Vishnoi and Rani, 2017 ). (frontiersin.org)
Without appropriate regulation by miRNA, genes are likely expressed abnormally, which could cause cells to grow and divide uncontrollably and lead to tumor formation. (medlineplus.gov)

They conducted research on mice with a rare disease similar to one in humans, hoping their findings may eventually help improve gene therapy for humans. (nih.gov)
Analysis of the GnRH gene in humans shows that analogous phenomena might occur in our own species. (sciencedaily.com)
Humans have about 20,000 to 23,000 genes depending on how a gene is defined. (msdmanuals.com)

A team from the US and Korea documents rare variants with apparent ties to gene expression regulation across dozens of human tissue types for another paper in PLOS Genetics . (genomeweb.com)

and positive regulation of cell differentiation. (mcw.edu)
MicroRNAs constitute a pervasive post-transcriptional filter on protein or mRNA expression levels that are likely to control developmental timing, cellular differentiation, stress responses, metabolism and proliferation. (mdpi.com)
However, the role of microRNA in mammalian tissue development and differentiation is still quite uncharacterized. (mdpi.com)
Through this role in regulating the activity (expression) of genes, the Dicer protein is involved in many processes, including cell growth and division (proliferation) and the maturation of cells to take on specialized functions (differentiation). (medlineplus.gov)
the smaller Y chromosome carries genes that initiate male sex differentiation, as well as a few other genes. (msdmanuals.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
Therefore, the entire oligodendroglial differentiation, diffuse astrocytomas, oligoastrocytomas, coding sequence of the LATS1 gene in IDH1 Mutation, and 1P/19q loSS and oligodendrogliomas. (who.int)

MicroRNAs are tiny ribonucleic acid (RNA) molecules (~22 nucleotides long) that recently have been found to play important roles in regulating gene expression in eukaryotic organisms, including plants and animals. (sciencedaily.com)
MicroRNAs perform important roles in the post-transcriptional regulation of gene expression. (researchsquare.com)
Sequencing as well as functional studies using antisense oligonucleotides, indicate important roles for microRNAs during the development of epilepsy through targeting transcripts involved in neuronal structure, gliosis and inflammation. (researchsquare.com)
Initially, researchers were mainly focused on miRNA identification, appropriate to specific or multiple environmental condition, expression profiling and recognize their roles in stress tolerance. (intechopen.com)
MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)

Methods and Results: We show that the highly conserved microRNA family encoding miR-10 regulates the behavior of endothelial cells during angiogenesis by positively titrating pro-angiogenic signaling. (ca.gov)

MicroRNAs are small, non-coding RNA molecules involved in the regulation of gene expression. (nih.gov)
Messenger RNA (mRNA) molecules are encoded by genes and are themselves templates for the proteins that carry the main metabolic functions in a cell. (sciencedaily.com)
MicroRNAs are ~22 nucleotide long RNA molecules that provide substrate specificity to a protein complex known as the RNA-induced silencing complex. (sciencedaily.com)
Within the complex, microRNAs are thought to bind to mRNA molecules containing a complementary stretch of RNA sequence. (sciencedaily.com)
Sofia Elmroth and her research team primarily study microRNAs, which are molecules that influence protein levels in the cells of the body indirectly by binding to messenger RNA. (lu.se)
There are many different types of microRNAs involved in the regulation of different proteins and of other RNA molecules. (lu.se)

A-to-I editing can further diversify the microRNA pool by altering individual nucleotides. (lu.se)

mRNAs corresponding to several regulatory genes that mediate auxin responses contain short stretches of sequence that are complementary to microRNAs, and therefore have been considered potential targets of microRNA-mediated regulation. (sciencedaily.com)
One of these targets is the transcription factor AUXIN RESPONSE FACTOR17 (ARF17), which is thought to repress the expression of a number of other genes involved in auxin responses. (sciencedaily.com)
miR-128-5p targets the tissue inhibitor of metalloproteinases (TIMPs), silent information regulator 2 (SIRT2), peroxisome proliferator-activated receptor (PPAR), and p21 genes, which are linked to the behaviours of VSMCs. (hindawi.com)
Over-expression of miR-22 has been reported to protect in models of brain injury and additional targets of miR-22 have been identified [ 17 , 18 ]. (researchsquare.com)
Alterations in expression of confirmed miR-210 transcription factor target foxp3 were observed in the dLN and ears and decreases in predicted targets' (foxp3, runx1, runx3, and smad4) mRNA expression were observed in the dLN of TDI-exposed mice. (cdc.gov)
8 The results demonstrated that miRNA expression signatures were clearly distinct among the tumor types studied, suggesting their possible role in sarcomagenesis, and their potential as diagnostic markers or even therapeutic targets. (sarcomahelp.org)
Since a significant number of the genes with altered expression were shown to be predicted targets of this particular microRNA-484, the researchers concluded that the effects are driven through it. (helsinki.fi)
Furthermore, microRNAs are also shown to be targets for asthma therapy in the future. (cdc.gov)

Overexpression of this gene is associated with tumor cell proliferation and metastasis. (cancerindex.org)
These abnormalities result in significant alterations in gene expression related to cell proliferation, apoptosis, migration and immune signaling pathways. (spandidos-publications.com)
In conclusion, the present study demonstrated that TMZ inhibits GBM cell proliferation by inhibiting the expression of miR‑223, which leads to increased expression of tumor suppressor PAX6. (spandidos-publications.com)

Auxin influences development by affecting the expression of numerous genes that control the processes of cell division and cell expansion in specific plant tissues at specific stages during the plant life cycle - e.g. for leaves, roots, and floral organs to develop in the correct patterns and correct time sequence. (sciencedaily.com)
We have specific expertise in studying fusion genes, epigenomics modification, lncRNAs, microRNAs and alternative splice patterns. (nottingham.ac.uk)
6 Following the initial demonstration of the important role for miR in human cancer, such as downregulation of miR-15a-miR-16-1 in chronic lymphocytic leukemia, 7 a number of cancers have been shown to exhibit distinct miR expression patterns related to various phenotypes with remarkable cytogenetic abnormalities. (nature.com)
With the help of an analytical approach called a "likelihood ratio test for quantitative traits" (LRT-q), the investigators analyzed whole-genome sequence and RNA sequence data spanning samples from 49 tissue types in nearly 700 Genotype-Tissue Expression (GTEx) project participants of European ancestry, highlighting genes with particularly pronounced expression patterns or disease associations that appeared to be regulated by rare rather than common variants. (genomeweb.com)
Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)

Research reported in The Plant Cell shows that microRNAs control the accumulation of transcription factor proteins that regulate the expression of genes in the auxin response pathway. (sciencedaily.com)
There are many AGO1-like proteins in animals and other eukaryotes as well, indicating that the RNA-induced silencing complex is of ancient evolutionary origin, and that microRNA-mediated regulation of gene expression is shared among many eukaryotes. (sciencedaily.com)
Metabolomics and proteomics - Working closely with experts in data analytics our team can assist researchers investigating the global expression of proteins and metabolites, thus enabling the unbiased discovery of biomarker that can be used for further targeted studies. (nottingham.ac.uk)
Western blotting confirmed the expression of DRAM2, p53, and the other involved proteins. (cancerindex.org)
DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)
This modification of the microRNA expression profile is essential to the inhibition of the expression of transcription factors (proteins that activate or inhibit gene expression) that have a repressive effect on GnRH expression. (sciencedaily.com)
In this work, we present a different paradigm for predicting miRNA-regulated genes based on the encoded proteins. (frontiersin.org)
Research has long focused on transcription from our genes that uses RNA messengers to code for the formation of proteins, the building blocks of the body. (lu.se)

Although glucocorticoid receptors (GRs) in the hippocampus play a vital role in the regulation of physiological and behavioural responses to stress, the regulation of receptor expression remains unclear. (karger.com)

These results demonstrate the functional effects of rare variants, especially on gene expression," they report, "which provides important biological insights in understanding the genetic mechanism of rare variants in complex traits and diseases. (genomeweb.com)
Based on these data, the multinational research team noticed that variants within the NDE1 gene both change the level of expression of a large number of genes, and correlate with the likelihood that a patient is to cease using specific psychoactive medications. (helsinki.fi)
The results demonstrate a means by which genetic variation in the DISC1 network can not only increase risk to major mental illnesses, but also how those same variants can alter treatment response to specific psychoactive medications through the regulation of their metabolizing enzyme, said William Hennah , a group leader at the Institute for Molecular Medicine Finland (FIMM), HiLIFE , University of Helsinki. (helsinki.fi)
Although the variants we studied are common to many populations, their specific biological consequences associated with schizophrenia and gene expression changes may be unique to this Finnish family cohort. (helsinki.fi)

The 3′UTR-binding sequence site of miR-128-5p on the p21 gene was predicted and assessed by luciferase assays. (hindawi.com)
Interestingly, the non-coding parts of the NDE1 gene were shown to contain sequence coding for a microRNA. (helsinki.fi)

miR-128-5p directly targeted the 3′UTR-binding sequences of the p21 gene, negatively regulated p21 expression, and supported the proliferation of VSMCs. (hindawi.com)

microRNA (miRNA) expression level alterations between endometrial tissue and endometriotic lesions indicate their involvement in endometriosis pathogenesis. (mdpi.com)

Furthermore, post-transcriptional gene expression regulation by cellular and/or EBV-derived microRNAs has attracted considerable attention. (spandidos-publications.com)
Post-transcriptional regulation in multicellular organisms is mediated by microRNAs. (frontiersin.org)
We conclude that protein function is informative across species in predicting post-transcriptional miRNA regulation in living cells. (frontiersin.org)

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. (cancerindex.org)

In cancer, they act as tumor suppressor genes and sometimes as oncogenes. (mbpinc.net)

The corrected gene delivered by AAV is the most effective therapy we have developed so far to treat MMA," said Charles Venditti, M.D., Ph.D., senior author and investigator in NHGRI's Genetic and Molecular Biology Branch. (nih.gov)
A recent study focusing on familial schizophrenia in Finland demonstrates that genetic variation in a known risk gene called NDE1 can affect both gene expression levels and medication usage of psychoactive drugs used to treat major mental illnesses. (helsinki.fi)
Researchers have previously shown that genetic variation in the NDE1 gene and the related DISC1 network increases risk for schizophrenia in a Finnish family cohort. (helsinki.fi)

Indeed, in the absence of microRNAs, the expression of transcription factors that inhibit GnRH expression increases, and leads to the extinction of GnRH synthesis in the brain, leading to the arrest of sexual maturation, absence of puberty, and complete sterility in adult individuals. (sciencedaily.com)
Activation of NF-κB result in the transcription of various inflammatory genes, including TNF-α and IL-6, to sense microbial pathogens ( 7 - 9 ). (frontiersin.org)
The identified transcription factors influence both the global and specific gene expression of the BCLs and have possible implications for diagnosis and treat- ment. (lu.se)
Translocation carcinoma is a renal cell carcinoma (RCC) subtype that harbors a translocation involving a member of the microphthalmia transcription factor gene family. (medscape.com)

By combining gene functional and pathway annotation with miRNA-mRNA interactions, we created a PyMT-specific tripartite miRNA-mRNA-pathway network and identified novel functional regulatory programs (FRPs). (biomedcentral.com)
In order to investigate the functional role of miR-210 during TDI sensitization, BALBc mice were dermally exposed to TDI (0.5-4% v/v) and gene and protein expression were evaluated in the draining lymph nodes (dLN) and ears using RT-PCR and Western blot/ flow cytometry, respectively. (cdc.gov)
The 23rd pair, the sex chromosomes (X and Y), determines a person's sex as well as containing other functional genes. (msdmanuals.com)

Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha. (biomedcentral.com)
Dr. Bonnie Bartel at Rice University in Houston, TX together with Drs. David Bartel and Allison Mallory at the Massachusetts Institute of Technology and the Whitehead Institute for Biomedical Research in Cambridge, MA report experiments using transgenic Arabidopsis plants that produce a version of ARF17 mRNA that resists microRNA-mediated cleavage. (sciencedaily.com)
Mature form of miRs silence gene expression by binding to the 3′-UTR of target mRNAs and initiate translational repression or cleavage of cognate mRNAs. (nature.com)

FSS also caused a time-dependent increase in the expression of miR-124a, a microRNA known to reduce GR mRNA expression, which was inversely correlated with a reduction in GR mRNA levels 30 min after FSS. (karger.com)
Acute stress results in decreased GR mRNA expression specifically in the dentate gyrus. (karger.com)

In a widely used mouse model of breast cancer, mammary gland-specific expression of the polyoma middle T (PyMT) oncoprotein under the control of the MMTV promoter/enhancer in transgenic mice (MMTV-PyMT) results in widespread transformation of the mammary epithelium and subsequent development of multifocal mammary adenocarcinomas and metastatic lesions in the lymph nodes and in the lungs [ 2 ]. (biomedcentral.com)

Gene expression programmes drive many of the changes underlying network reorganisation in epileptogenesis, including neurodegeneration, astrogliosis, microgliosis, aberrant neurogenesis and restructured local and distant neuronal contacts, among other changes [ 3-5 ]. (researchsquare.com)

DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53. (cancerindex.org)
Pobezinsky and colleagues found that a small piece of microRNA that has been present throughout evolution is expressed in memory cells. (lifeboat.com)

Evaluation of the therapeutic role of microRNA-29b in a preclinical model of Peyronie's. (usp.br)
The discovery of the involvement of microRNAs opens up considerable prospects for the medical management of these patients, from both a diagnostic and therapeutic point of view. (sciencedaily.com)
To develop vector-based strategies of CRISPR/Cas9-mediated gene editing in the brain for experimental and therapeutic purposes. (lu.se)

RhoC over-expression has been reported in ductal pancreatic adenosarcoma (Suwa, 1998) and in inflammatory breast cancers (van Golen, 1999). (cancerindex.org)
TPT suppressed the expression of miR-155 and up-regulated the release of SHIP-1, thus inhibiting the inflammatory response in the LPS-stimulated monocytes of RA patients. (curehunter.com)
Upregulated miR-21 suppresses LPS-induced inflammatory cytokine expression by targeting IL-1 receptor-associated kinase 4 (IRAK4), thereby avoiding excessive inflammatory responses. (frontiersin.org)

In this study, using polyoma middle T antigen (PyMT) mice, a widely used luminal B breast cancer model, we profiled microRNA (miRNA) expression at four time points that represent different key developmental stages of cancer progression. (biomedcentral.com)
In prior MMA gene therapy studies, researchers showed that mice bred to develop the condition could be restored to health by AAV gene therapy injection shortly after birth. (nih.gov)
When the AAV was inserted near Mir341, the vector caused elevated expression of the gene, which the researchers believe contributed to the occurrence of liver cancer in the mice. (nih.gov)
When the researchers used an alternate AAV vector to deliver the corrected gene in a study of just 10 mice, that vector did not insert where it would elevate the expression of nearby genes and it did not cause liver cancer. (nih.gov)
Research conducted in mice by Vincent Prévot's team shows that birth induces a radical change in the expression of microRNAs in the hypothalamic GnRH neurons. (sciencedaily.com)
In her research, Murph is specifically looking at fragments of microRNA material in the obese mice involved in the regulation of cancer gene expression. (uga.edu)

Previously it was known that microRNAs were important for the development of a subset of helper T cells called regulatory T cells, which are required to regulate the immune response and prevent attacks against host tissue that lead to autoimmunity. (rvc.ac.uk)

To optimally utilize the biological and clinical information that is contained in microRNA expression levels, tools for their accurate and cost-effective quantification are needed. (lu.se)

The plants showed increased accumulation of ARF17 mRNA and altered levels of mRNAs corresponding to several genes that may be regulated by ARF17. (sciencedaily.com)
Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)

This reveals that DNA methylation regulates gene expression on a rich profusion of levels, and regulates cell homeostasis along with cancer progression. (mbpinc.net)

We investigated the mechanism of chemoresistance by analysis of microRNAs using the ovarian cancer cell line KFr13 and its PTX-resistant derivative (KFr13Tx). (nature.com)
In addition, lower levels of miR31 and higher expression of MET in human ovarian cancer specimens were significantly correlated with PTX chemoresistance and poor prognosis. (nature.com)
This study demonstrated miR31-dependent regulation of MET for chemoresistance of ovarian cancer, raising the possibility that combination therapy with a MET inhibitor and PTX will increase PTX efficacy. (nature.com)
For a paper appearing in PLOS One , a team from Denmark explores microRNA expression profiles in epithelial ovarian cancer, in an effort to find potential miRNA markers of disease stage, treatment response, or patient outcomes. (genomeweb.com)

Here, we describe a protocol to quantify microRNA editing isoforms using two-tailed RT-qPCR, with either SYBR Green or hydrolysis probes. (lu.se)
In this article the researchers describe their identification of important individual microRNAs and relevant genes they regulate to control regulatory T cell development. (rvc.ac.uk)

Depending on the expression status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), it can be classified into four molecular subtypes: luminal A, luminal B, HER2-positive, and basal-like (or triple-negative) breast cancer. (biomedcentral.com)
Our studies, supported by the Liddy Shriver Sarcoma Initiative, aimed to identify unique miRNA expression profiles of WDLPS and DDLPS with the hope that such signatures could provide insights into our understanding of the molecular determinants driving these two entities. (sarcomahelp.org)

The complex then cleaves the mRNA into smaller pieces, thereby preventing translation of the protein it encodes, and thus inhibiting or "silencing" gene expression. (sciencedaily.com)
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. (origene.com)

Twenty-two of the pairs, chromosome numbers 1 to 22, the autosomes, are normally homologous (identical in size, shape, and position and number of genes). (msdmanuals.com)
The genes that occupy the same locus on each chromosome of a pair (one inherited from the mother and one from the father) are called alleles. (msdmanuals.com)
A chromosome contains many genes. (msdmanuals.com)

National Institutes of Health researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. (nih.gov)
The research team performed additional experiments to detect where in the mouse genome the AAV vector delivered the corrected gene and how that related to any cancer development. (nih.gov)
Most of the AAV integrations that caused liver cancer landed in a gene that is not found in the human genome, which suggests that the cancers we observed after AAV gene therapy may have been a mouse-specific phenomenon. (nih.gov)
A recent study of the disparity in breast cancer mortality between AA and EA women concluded that differences in mortality are driven by higher hazard rates of breast cancer death in AA women, irrespective of ER expression [9]. (cdc.gov)
We are interested in microRNAs, which we think have a role in the development of cancer", says Sofi Elmroth. (lu.se)
The quantity of microRNAs in different types of cancer varies and each type of cancer appears to display a specific pattern. (lu.se)

Expression of metalloproteinases and their tissue inhibitors in the detrusor muscle. (usp.br)
miR-21-5p mimics was topically applied to C57/BL6 mouse eyes, which significantly increased miR-21-5p expression in the conventional outflow tissue and reduced IOP by a maximum of 17.77% at 24 h after treatment. (duke.edu)

Some genes occur in multiple copies that may be next to each other or in different locations in the same or different chromosomes. (msdmanuals.com)
Today there are many companies that can quickly produce exact copies of the microRNAs that occur naturally in the body. (lu.se)

Toxic side effects actually are rarely observed by researchers who have designed gene therapies using an adeno-associated virus (AAV) as a vector to deliver the corrected gene to a specific point in the cell's DNA. (nih.gov)
For 10 years, NHGRI researchers have worked toward a gene therapy to treat MMA. (nih.gov)
The researchers found that this modification was a safer gene therapy. (nih.gov)
Our expertise in dealing with both shotgun and high throughput sequencing data can empower researchers with accurate gene prediction and precise species categorisation. (nottingham.ac.uk)
In this work, RVC researchers set about to understand microRNA regulation of helper T cells development. (rvc.ac.uk)
A team lead by researchers from the University of Helsinki took advantage of data on gene expression levels determined in 64 individuals. (helsinki.fi)

Effective and safe gene therapies have the potential to dramatically reverse diseases that are life-threatening for affected children," said NHGRI Scientific Director Dan Kastner, M.D., Ph.D. "This study is an important step in developing gene therapies that can be safely used to benefit patients. (nih.gov)
However, we have identified an important safety parameter related to the AAV gene therapy in our mouse models that is critical to understand before we move to human patient trials. (nih.gov)
This is predicted to exert an important influence on the gene expression landscape. (researchsquare.com)
In alpha-cells, CFTR is important for regulation of alpha-cell electrical activity and the generation of action potentials. (lu.se)

Anatomy20

Organisms10

Diseases5

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes73

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science9

Health Care3

MiRNAs55

RNAs11

Target genes3

Genomic4

Epigenetic7

Molecule6

Mechanisms4

MiRNA genes3

Humans3

Genetics1

Differentiation8

Roles6

Highly conserved1

Molecules6

Nucleotides1

Targets8

Cell Proliferation3

Patterns5

Proteins8

Hippocampus1

Variants4

Sequence2

Negatively1

Alterations1

Transcriptional3

Signal transduction1

Tumor suppr1

Genetic3

Transcription4

Functional3

Cleavage3

MRNA expression2

Metastatic1

Neuronal1

Small2

Therapeutic3

Inflammatory3

Mice6

Previously1

Biological1

MRNAs2

Reveals1

Ovarian4

Describe2

Molecular2

Encodes2

Chromosome3

Cancer6

Tissue2

Occur2

Researchers6

Important4