AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Templates, GeneticRibonuclease IIIBase Sequence3' Untranslated RegionsGene Expression ProfilingMolecular Sequence DataTranscription, GeneticArgonaute ProteinsGene Expression RegulationSequence Analysis, RNARNA, MessengerOligonucleotide Array Sequence AnalysisDNA-Directed RNA PolymerasesNucleic Acid ConformationDNA-Directed DNA PolymeraseDNA ReplicationRNA, ViralDNARNAComputational BiologyGene Expression Regulation, NeoplasticRNA InterferenceRNA Processing, Post-TranscriptionalBinding SitesDEAD-box RNA HelicasesReverse Transcriptase Polymerase Chain ReactionBase PairingRNA ReplicaseMutationReal-Time Polymerase Chain ReactionCell Line, TumorRNA-Directed DNA PolymeraseRNA, PlantOligonucleotidesCell LineRNA-Induced Silencing ComplexPolymerase Chain ReactionDNA, ViralModels, MolecularAlgorithmsEscherichia coliHeLa CellsDown-RegulationMicroarray AnalysisDatabases, Nucleic AcidRNA StabilityKineticsPromoter Regions, GeneticTranscriptomeTranscription FactorsDNA, Single-StrandedReproducibility of ResultsSequence AlignmentDNA Polymerase IGene Regulatory NetworksSoftwareCluster AnalysisGene SilencingModels, GeneticRNA Polymerase IIRNA NucleotidyltransferasesDeoxyribonucleotidesNucleotidesAmino Acid SequencePlasmidsHEK293 CellsVirus ReplicationConserved SequenceProtein BindingRNA PrecursorsGene Expression Regulation, DevelopmentalHigh-Throughput Nucleotide SequencingViral ProteinsRNA, Small InterferingThymine NucleotidesHIV Reverse TranscriptaseRNA-Binding ProteinsDNA-Binding ProteinsDNA PrimaseCell ProliferationModels, BiologicalSignal TransductionChromatinExosomesProtein BiosynthesisEukaryotic Initiation FactorsProteinsSequence Analysis, DNARNA, NeoplasmArabidopsisRibonuclease HCell DifferentiationCaenorhabditis elegansAvian myeloblastosis virusSubstrate SpecificityGene ExpressionCloning, MolecularGene Expression Regulation, PlantDNA Polymerase IICells, Cultured
MiRNAGene expressionVariationMiRNAsRegulateSequencesGenesMRNAProteinsMammalianLiving organismsClustersTherapeuticTranscriptionGenomeCellMoleculeEnzymeMutationsMolecularSmallMeiosisCarries geneticProtein synthesisDifferentiationDiseasesAmplificationMaterialViralFlowsStrandBehaviorDiversityPolymeraseProcessStudiesTranslationTraitsLongFunctionEnhanceCellsCodeReproductionShowComplex
MiRNA4
  • The paralogous miRNA gene clusters that give rise to miR-17 family microRNAs (miR-17~92, miR-106a~363, and miR-106b~25) have been implicated in a wide variety of malignancies and are sometimes referred to as oncomirs. (wikipedia.org)
  • The most common types of RNA are messenger RNA (mRNA), transfer RNA (tRNA), ribosomal RNA (rRNA), small nuclear RNA (snRNA), small nucleolar RNA (snoRNA), microRNA (miRNA), Piwi-interacting RNA (piRNA), and long non-coding RNA (lncRNA). (business2money.com)
  • MicroRNA (miRNA) is a type of small non-coding RNA molecule. (business2money.com)
  • Small RNA molecules, such as microRNA (miRNA) and small interfering RNA (siRNA), bind to mRNA and can either promote its degradation or inhibit its translation into protein. (facts.net)
Gene expression4
Variation3
  • A genetic variation in the CpG island of pseudogene GBAP1 promoter is associated with gastric cancer susceptibility. (nih.gov)
  • The analysis showed that, despite individual environmental and genetic variation, a combination of three unrelated metabolites (C22:1-CoA, C2-carnitine and C16-ceramide) together formed an accurate signature for predicting insulin resistance. (asbmb.org)
  • Due to the uncertainty of the deletion sizes, probing for this type of genetic variation is typically performed with long-range PCR and requires a high-fidelity polymerase that can accurately and reliably amplify both small and large genomic regions. (takarabio.com)
MiRNAs1
  • It is generally recognized that most of the mammalian genome is transcribed into ncRNAs, including microRNAs (miRNAs) and long ncRNAs (lncRNAs). (biomedcentral.com)
Regulate3
  • The mature microRNA products are thought to regulate expression levels of other genes through complementarity to the 3' UTR of specific target messenger RNA. (wikipedia.org)
  • Careful analysis of the deletions revealed that they were most commonly found in two microRNA clusters that regulate the switch from latent infection to reactivation through a lytic-cycle cascade. (takarabio.com)
  • Various factors, such as microRNAs and RNA-binding proteins, can modulate the activity of translation factors, which bind to the ribosome and regulate protein synthesis. (vikipedi.org)
Sequences3
  • At the time, the RNA molecule was seen as a mere messenger which decodes (transcribes) information from genetic sequences of DNA, in the form of a messenger RNA, which is then used as a template when the protein molecules are combined (translation). (lu.se)
  • The RNA polymerase reads the DNA template, recognizes specific sequences known as promoter regions, and then initiates transcription. (scienceaplus.com)
  • miRBase: microRNA sequences, targets and gene nomenclature. (jax.org)
Genes1
  • They identified deletions in microRNA clusters and viral particle production genes which could be linked to the malignancies. (takarabio.com)
MRNA4
  • Messenger RNA (mRNA) is a type of RNA that carries genetic information from the DNA in the nucleus to the ribosomes in the cytoplasm, where it is used to create proteins. (business2money.com)
  • mRNA molecules are single-stranded, and are synthesized from the template strand of DNA. (business2money.com)
  • Messenger RNA (mRNA) carries the genetic information from DNA to the ribosomes, where it serves as a template for protein synthesis. (facts.net)
  • The resulting RNA molecule is known as messenger RNA (mRNA) and carries the genetic information from the DNA to the ribosome. (vikipedi.org)
Proteins3
  • Ribonucleic acid (RNA) is a molecule which is present in cells and made of genetic material to help build proteins necessary for cell function. (lifeboat.com)
  • RNA provides a template for the construction of proteins and is essential for cell and organism life. (lifeboat.com)
  • DNA contains the genetic information needed to direct the synthesis of proteins, which are the workhorses of the cell, performing a variety of functions such as structural, catalytic, regulatory, and others. (scienceaplus.com)
Mammalian2
  • This Precis provides an overview of the book " The Scent of Eros: Mysteries of Odor in Human Sexuality ," which details for a general audience a five-step biological pathway that allows the social environment to influence the genetic nature of mammalian behavior. (microrna.pro)
  • The upshot is that microRNA with origin in rice have been found in mammalian bloodstreams and can be shown to influence cells. (thestranger.com)
Living organisms3
  • DNA is the molecule that stores the genetic code for all living organisms. (nativeoaksplayersclub.com)
  • The DNA molecule carries the genetic information for all living organisms. (nativeoaksplayersclub.com)
  • DNA is the genetic material found in all living organisms, ranging from single-celled bacteria to multicellular mammals. (libretexts.org)
Clusters3
  • With the exception of miR-93, these microRNAs are produced from several microRNA gene clusters, which apparently arose from a series of ancient evolutionary genetic duplication events, and also include members of the miR-19, and miR-25 families. (wikipedia.org)
  • These clusters are transcribed as long non-coding RNA transcripts that are processed to form ~70 nucleotide microRNA precursors, that are subsequently processed by the Dicer enzyme to give a ~22 nucleotide products. (wikipedia.org)
  • In other studies, deletions in these microRNA clusters have been shown to lead to lymphomagenesis (Lin et al. (takarabio.com)
Therapeutic2
  • Understanding functional genomics is critical to advance genetic research and therapeutic discovery. (horizondiscovery.com)
  • Dharmacon Reagents have you covered with a complete range of genomic solutions from single-gene experiments to whole genome screens facilitating advancements in genetic research and therapeutic discovery. (horizondiscovery.com)
Transcription6
  • Transcription is the process by which RNA is synthesized from a DNA template. (nativeoaksplayersclub.com)
  • In a process known as transcription, RNA is synthesized from a DNA template and acts as a messenger between the DNA and the protein synthesis machinery. (scienceaplus.com)
  • Transcription is the process of converting the genetic information stored in DNA to RNA. (scienceaplus.com)
  • A primary transcript is an RNA molecule produced during transcription that is a copy of the genetic information stored in the DNA. (scienceaplus.com)
  • When a signal is sent to express a specific gene, the DNA sequence encoding that gene is used as a template to produce single-stranded RNA in a process called transcription. (ernolaszlo.com)
  • During transcription, the DNA double helix is unwound, and RNA polymerase binds to the DNA template strand. (vikipedi.org)
Genome3
  • The US holds a dominant share of the North American dPCR and qPCR market due to factors such as the high incidence of chronic and genetic diseases (coupled with the rising geriatric population), growing adoption of qPCR and dPCR techniques in research and academia, significant public-private funding in the field of genome analysis, and the strong presence of major pharmaceutical and biotechnology companies in the country. (contrivedatuminsights.com)
  • Targeted genome editing using CRISPR-Cas9 has been widely adopted as a genetic engineering tool in various biological systems. (mdpi.com)
  • The entire genetic content of a cell is known as its genome, and the study of genomes is genomics. (libretexts.org)
Cell8
  • I could go on about the facts about cell type differentiation for hours or refer you to MicroRNA.pro or one of my other domains. (microrna.pro)
  • It ensures that each daughter cell inherits an identical copy of the genetic material from the parent cell. (nativeoaksplayersclub.com)
  • RNA is necessary to act as a messenger because it serves as a bridge between the genetic information stored in DNA and the protein synthesis machinery of the cell. (scienceaplus.com)
  • DNA (deoxyribonucleic acid) is the cell's genetic material, contained in chromosomes within the cell nucleus and mitochondria. (msdmanuals.com)
  • They carry the genetic blueprint of a cell and carry instructions for the functioning of the cell. (libretexts.org)
  • We start with DNA, the genetic information in every cell that is copied and passed from generation to generation. (rainis.pics)
  • Considerable effort over the last decade has been directed towards developing integrated and scalable single cell genetic analysis on chip (7, 8). (justia.com)
  • Although these systems provide a high-throughput qPCR readout, they do not address the front end sample preparation and require single cell isolation by FACS or micropipette followed by off-chip processing and pre-amplification of starting template prior to analysis. (justia.com)
Molecule3
  • RNA is the molecule that transfers the genetic information from DNA to protein. (nativeoaksplayersclub.com)
  • The RNA molecule transports a copy of the genetic information from the DNA to the ribosomes, which are the cellular structures responsible for protein synthesis. (scienceaplus.com)
  • The RNA polymerase then moves along the template strand and synthesizes a complementary RNA molecule. (vikipedi.org)
Enzyme1
  • In 1965, Jacob won the Nobel Prize in Physiology or Medicine with Andre M. Lwoff and Jacques L. Monod for their work on the genetic control of enzyme synthesis. (asu.edu)
Mutations1
  • In cancer treatment this phenomenon can be exploited to selectively kill tumour cells that have specific genetic mutations. (hrb.ie)
Molecular2
  • Genetic, environmental, and lifestyle factors interact to result in the accumulation of macromolecular damage and molecular deficits that manifest as aging. (ernolaszlo.com)
  • This white paper will first provide a brief refresher on the central paradigm of molecular biology, the rigorously controlled process by which genetic information flows within cells and biological systems. (ernolaszlo.com)
Small2
  • Pobezinsky and colleagues found that a small piece of microRNA that has been present throughout evolution is expressed in memory cells. (lifeboat.com)
  • The gene was very short and only coded for a small piece of RNA - what is now known as a microRNA. (lu.se)
Meiosis1
  • In meiosis, the genetic information inherited from a person's mother and father is recombined through crossing over (exchange between homologous chromosomes). (msdmanuals.com)
Carries genetic1
  • A copy of the DNA gene that carries genetic information from the nucleus to the ribosome, where it serves as a template for protein synthesis. (scienceaplus.com)
Protein synthesis1
  • When RNA reaches the ribosomes, it acts as a template for protein synthesis. (scienceaplus.com)
Differentiation1
  • Differentiation of the glucocerebrosidase gene from pseudogene by long-template PCR: implications for Gaucher disease. (nih.gov)
Diseases2
  • MicroRNAs can thus affect the occurrence of diseases such as cancer and could provide us with new possibilities for cancer treatment. (lu.se)
  • Genetic and Rare Diseases Information Center 2017). (takarabio.com)
Amplification1
  • More recently, another group of researchers reported that they had developed a process for optimizing low- abundance RNA, by combining aRNA amplification with template- switching. (genomicglossaries.com)
Material4
  • Many viruses, such as the flu virus and HIV, rely on RNA as their genetic material. (facts.net)
  • RNA played a pivotal role in the early stages of life on Earth and is believed to have preceded DNA as the genetic material. (facts.net)
  • Stray genetic material from all over is in our food, and always has been. (thestranger.com)
  • DNA was discovered by Friedrich Miescher in 1869 and identified as genetic material in experiments conducted by Oswald Avery, Colin MacLeod, and Maclyn McCarty in the 1940s. (rainis.pics)
Viral1
  • Next-generation sequencing has revolutionized our understanding of the genetic elements of viral pathogenesis. (takarabio.com)
Flows1
Strand1
Behavior1
  • Thus, human pheromones may fulfill the biological criteria required to link at least one aspect of a sensory-based, nurturing, social environment: olfaction, to the genetic nature of human behavior through a five-step pathway common to all terrestrial mammals and to many other vertebrates. (microrna.pro)
Diversity1
  • Genetic Diversity among Lathyrus ssp. (mdpi.com)
Polymerase1
Process3
  • Translation is the process by which protein is synthesized from an RNA template. (nativeoaksplayersclub.com)
  • Here, the AUs present a method for converting commercial, customizable DNA microarrays into RNA microarrays using an accessible three-step process involving primer photocrosslinking, extension, and template degradation. (nature.com)
  • What is the process called that converts the genetic information stored in DNA to an RNA copy? (scienceaplus.com)
Studies1
  • Victor Ambros has been awarded "The 2015 Breakthrough Prize" for his fundamental studies of the function of microRNAs. (lu.se)
Translation1
  • CircRNAs have essential functions as microRNA sponges, RNA-binding protein- and transcriptional regulators, and protein translation templates. (biomedcentral.com)
Traits1
  • BayesR3 samples the polymorphisms affecting complex traits at reduced computational cost to predict the genetic value, breeding value, or individual risk of genotypes. (nature.com)
Long1
  • Since PrimeSTAR GXL is optimized to excel with long amplicons and challenging genomic templates, it was more than up to the task. (takarabio.com)
Function1
  • The RNA polymerase's main function is to synthesize RNA from a DNA template by adding ribonucleotides (the building blocks of RNA) to the growing RNA chain. (scienceaplus.com)
Enhance2
  • The report published in Nature Communications identified that the microRNA, let-7, may enhance memory of T cells. (lifeboat.com)
  • Taking advantage of the associations between MSCs with M2 macrophages and microRNA, methods to enhance the immunomodulatory capacity of MSCs have shown success. (biomedcentral.com)
Cells1
  • All the cells within an organism carry the same coded genetic information, but different tissues and organs express only part of it. (biotopics.co.uk)
Code1
  • Our genetic code, which we inherit from our parents, is gathered in our DNA. (lu.se)
Reproduction1
  • The synthesis of RNA also is light-activated in the context of microRNA biogenesis, which biophysically constrains the physiology of reproduction in species from microbes to humans. (microrna.pro)
Show1
  • There is no reason to suppose microRNA is more likely to show up from GM foods than any other food, so their existence is no more a warning about GM food than organic kale. (thestranger.com)
Complex1
  • Insulin resistance leading to high blood sugar, a hallmark of pre-diabetes, is a complex condition with many genetic and environmental determinants. (asbmb.org)