Microrna precursor cell lymphoblastic leukemia lymphoma. Medical search. Frequent questions

R-split-CHOP chemotherapy for elderly patients with diffuse large B-cell lymphoma. (uksh.de)
Large deletions of the viral genome were frequent across three diseases (CAEBV, extranodal NK/T-cell lymphoma, diffuse large B-cell lymphoma). (yusukeokuno.com)
Among peripheral B-cell lymphomas, the major difficulty is to differentiate BL from diffuse large B-cell lymphoma (DLBCL) , lymphoblastic lymphoma , and blastic mantle cell lymphoma (MCL) . (medscape.com)
In the 2008 World Health Organization (WHO) classification system, these are referred to as "B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma. (medscape.com)

In fact, recent studies have shown the utility of microRNAs as cancer-related biomarkers. (biomedcentral.com)
In this review we discuss the current knowledge in the area of peripheral immune-based biomarkers, drawing information from the results of recent clinical studies of a number of different immunotherapy modalities in the treatment of cancer, including checkpoint inhibitors, bispecific antibodies, chimeric antigen receptor T cells, and anti-cancer vaccines. (biomedcentral.com)
Recently, the analysis of TMB and T-cell gene expression provided value in identifying patients most likely to respond to pembrolizumab, suggesting the potential value for these biomarkers in the selection of patients for checkpoint therapy [ 5 ]. (biomedcentral.com)

Mantle cell lymphoma can have a clinical presentation very similar to that of CLL, but it is more aggressive. (medscape.com)
Several features aid in the distinction of mantle cell lymphoma from CLL. (medscape.com)
Mantle cell lymphoma expresses CD5 and CD19 but not CD23 antigen, which is expressed in CLL. (medscape.com)
Mantle cell lymphoma typically expresses FMC-7. (medscape.com)
Importantly, expression of CD20 is bright in mantle cell lymphoma, whereas it is dim in CLL. (medscape.com)
Similarly, mantle cell lymphoma cases can be easily distinguished from Burkitt lymphoma (BL) by immunohistochemistry and flow cytometry as they typically stain strongly for CD5 and cyclin D1, unlike BL. (medscape.com)

The miR-17 microRNA precursor family are a group of related small non-coding RNA genes called microRNAs that regulate gene expression. (wikipedia.org)
The mature microRNA products are thought to regulate expression levels of other genes through complementarity to the 3' UTR of specific target messenger RNA. (wikipedia.org)
The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells. (oregonstate.edu)
Furthermore, single-cell-based proteomic and transcriptomic analysis of D4-IgG4H-CD28TM CAR T cells reveals specific genes (e.g. (nature.com)
They have the capacity to control the expression of many downstream genes which can affect several cell regulatory pathways, such as cell growth, differentiation, mobility and apoptosis. (biomedcentral.com)
Genes of Predisposition to Childhood Beta-Cell Acute Lymphoblastic Leukemia in the Kazakh Population. (cdc.gov)
to test this hypothesis, we analyzed expression of viral and cellular genes in brain-infiltrating immune cells. (liverpool.ac.uk)
SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. (medscape.com)
The genes that have been identified to date have been categorized into two broad categories, depending on their normal functions in the cell. (cancerquest.org)
Genes whose protein products stimulate or enhance the division and viability of cells. (cancerquest.org)
This first category also includes genes that contribute to tumor growth by inhibiting cell death. (cancerquest.org)
Genes whose protein products can directly or indirectly prevent cell division or lead to cell death. (cancerquest.org)
Many of these genes are responsible for providing the positive signals that lead to cell division. (cancerquest.org)
As stated in the introduction to this section, the defective versions of these genes, known as oncogenes, can cause a cell to divide in an unregulated manner. (cancerquest.org)
This is in contrast with tumor suppressor genes which must BOTH be defective to lead to abnormal cell division. (cancerquest.org)
Despite the differences in their normal roles, these genes all contribute to unregulated cell division if they are present in a mutant (oncogenic) form. (cancerquest.org)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)

Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia. (lu.se)

In the bone marrow, BL must be differentiated from B and T precursor and myeloid leukemias. (medscape.com)

Burkitt's lymphoma. (medscape.com)
Burkitt's lymphoma in a patient with adenosine deaminase deficiency-severe combined immunodeficiency treated with polyethylene glycol-adenosine deaminase. (medscape.com)
Burkitt's lymphoma: clinicopathologic features and differential diagnosis. (medscape.com)
Virus particles in cultured lymphoblasts from Burkitt's lymphoma. (medscape.com)
Best known for causing mononucleosis, or "the kissing disease," the virus has also been implicated in more serious conditions, including Hodgkin's, non-Hodgkin's and Burkitt's lymphomas. (news-medical.net)

This forms a hairpin precursor of approximately 60-70 nucleotides, termed pre-microRNA, which is exported to the cytoplasm and modified by another enzyme, the RNAseII endonuclease, Dicer, to form a duplex of mature microRNA. (biomedcentral.com)

MicroRNAs are small noncoding RNAs that function to control gene expression. (biomedcentral.com)
Gene expression-based prognostic signatures have a significant effect on predicting the survival of patients with malignant tumors, such as non-small cell lung cancer [ 7 ] and pediatric acute myeloid leukemia [ 8 ]. (aging-us.com)
Two different studies explored gene-expression profiling by microarray technology as a tool to accurately diagnose Burkitt lymphoma (BL) and differentiate it from DLBCL due to the significant difference in prognosis and treatment approaches for these diseases. (medscape.com)

Leuk Lymphoma. (wikipedia.org)

Genomic signatures and prognosis of advanced stage Chinese pediatric T cell lymphoblastic lymphoma by whole exome sequencing. (cdc.gov)
Cyclin D2 gene variance and expression level in pediatric acute lymphoblastic leukemia. (cdc.gov)
Pediatric acute lymphoblastic leukemia (ALL) originates from the malignant transformation of lymphocyte progenitor cells into leukemic cells in the B-cell and T-cell lineages. (biomedcentral.com)
In the present study we provide a comprehensive, genome-wide map of de novo DNA methylation changes in ALL cells at diagnosis and relapse by interrogating the methylation levels of 435,941 CpG sites distributed genome-wide in a large collection of pediatric ALL cells of diverse cytogenetic backgrounds. (biomedcentral.com)

Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)

Burkitt lymphoma (BL) must be distinguished from other primary abdominal tumors in childhood, including Wilms tumor , neuroblastoma , and peripheral neuroectodermal tumor . (medscape.com)
For evaluation of peripheral immune-cell function, several immune-related analytes may be measured, including cytokines, soluble plasma proteins, and immune cells, analyzed by surface marker expression, transcriptomic, or epigenetic profiles. (biomedcentral.com)
Mouse monoclonal to CD10.COCL reacts with CD10, 100 kDa common acute lymphoblastic leukemia antigen (CALLA), which is expressed on lymphoid precursors, germinal center B cells, and peripheral blood granulocytes. (antiviralbiologic.com)

Amgen today announced updated results from a Phase 2 study that showed treatment with blinatumomab (AMG 103) helped achieve a high-rate of complete response (CR) in 72 percent of adult patients with relapsed or refractory B-precursor acute lymphoblastic leukemia (ALL) treated in the study. (news-medical.net)

Integrated analysis of relapsed B-cell precursor Acute Lymphoblastic Leukemia identifies subtype-specific cytokine and metabolic signatures. (uksh.de)
Non-Coding RNA Signatures of B-Cell Acute Lymphoblastic Leukemia. (ucsf.edu)

Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. (oregonstate.edu)
Although aberrant DNA methylation has been observed previously in acute lymphoblastic leukemia (ALL), the patterns of differential methylation have not been comprehensively determined in all subtypes of ALL on a genome-wide scale. (biomedcentral.com)

Molecular alterations in bone marrow mesenchymal stromal cells derived from acute myeloid leukemia patients. (uksh.de)
Acute leukemias of ambiguous lineage in adults: molecular and clinical characterization. (uksh.de)
This effort gave rise to the development of guidelines, which now permit distinguishing between EVs according to their size, density, molecular cargo, or information regarding the cell of origin. (encyclopedia.pub)
In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
Molecular Cell , 82 (1), 190-208. (axonmedchem.com)
Molecular cell, 82(1), 106-122. (axonmedchem.com)
The University of Texas MD Anderson Cancer Center was awarded more than $5.7 million in grants from Break Through Cancer to support collaborative research teams working to discover novel molecular targets to eradicate minimal residual disease in AML, as well as treating clonal hematopoiesis which is a precursor to AML. (aggrego.news)
OBJECTIVE@#To investigate the effect of lactic acid-induced upregulation of PLEKHA4 expression on biological behaviors of glioma cells and the possible molecular mechanism. (bvsalud.org)

High level expression of miR-17 family members induces cell proliferation, whereas deletion of the miR-17~92 cluster, in mice, is lethal and causes lung and lymphoid cell developmental defects. (wikipedia.org)
latent infection can spread by b cell recirculation and proliferation, but whether this alone achieves systemic infection is unclear. (liverpool.ac.uk)
Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)
CD10 is a regulator of B cell growth and proliferation. (antiviralbiologic.com)
A specific PLEKHA4 siRNA was transfected in glioma U251 and T98G cells, and the changes in cell proliferation ability were assessed by real-time cell analysis technology and Edu experiment. (bvsalud.org)
Second, the rapid proliferation of these cells, along with a reduction in their ability to undergo programmed cell death (apoptosis), results in their accumulation in the bone marrow, the blood, and, frequently, the spleen and liver. (medscape.com)

Ikaros Regulates microRNA Networks in Acute Lymphoblastic Leukemia. (ucsf.edu)

The oncogenic communication with tumor cells and through the crosstalk of autocrine and paracrine components in almost all tumor types are responsible for this phenomenon. (biomedcentral.com)
We recently demonstrated that the Survival Associated Mitochondrial Melanoma Specific Oncogenic Non-coding RNA (SAMMSON) is essential for UM cell survi. (researchgate.net)

These small RNAs have been shown to contribute to the control of cell growth, differentiation and apoptosis, important features related to cancer development and progression. (biomedcentral.com)
The colony-forming ability of the cells was evaluated using plate cloning assay, and cell cycle changes and cell apoptosis were analyzed with flow cytometry. (bvsalud.org)

mRNA microarray analyses of A549, PC14, and PC14CDDP cells that were transiently transfected with either pre-miR-197 or LNA-miR-197 and their controls. (nih.gov)

MicroRNA profiling reveals aberrant microRNA expression in adult ETP-ALL and functional studies implicate a role for miR-222 in acute leukemia. (uksh.de)

This is due to the finding that microRNAs display altered expression profiles in cancers versus normal tissue. (biomedcentral.com)
adoptive transfer of genetically engineered t-cells to express antigen-specific t-cell receptor (tcr) is a feasible and effective therapeutic approach for numerous types of cancers, including epstein-barr virus (ebv)-associated malignancies. (liverpool.ac.uk)
See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)

One of the microRNA strands of the duplex is loaded onto the RNA-induced silencing complex (RISC) where it is then able to either cleave RNA targets or repress protein translation dependent upon its complementarity to the target mRNA. (biomedcentral.com)
Through their binding to target mRNA sequences, microRNAs have a large number of biologically diverse functions. (biomedcentral.com)
The mRNA expression of PLEKHA4 was detected by PCR in glioma samples and controls and in glioma cells treated with lactic acid and glucose. (bvsalud.org)

In particular, stem cells, including mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs), and induced pluripotent stem cells (iPSCs), and immune cells, such as T-cells and Natural Killer (NK) cells, have been favored candidates for regenerative medicine and cell-based cancer immunotherapy, respectively. (biomedcentral.com)

Clinical relevance of IDH1/2 mutant allele burden during follow-up in acute myeloid leukemia. (haematologica.org)
Moreover, the potential application of microRNAs in clinical settings will also be highlighted. (biomedcentral.com)
Finally, the challenges regarding the translation of research involving microRNAs to the clinical realm will be discussed. (biomedcentral.com)
The rows contain clinical information, data on EBV-infected cells, and the somatic and germline mutations found. (yusukeokuno.com)
Klepfish A, Gilles L, Ioannis K, Eliezer R, Ami S. Enhancing the action of rituximab in chronic lymphocytic leukemia by adding fresh frozen plasma: complement/rituximab interactions & clinical results in refractory CLL. (medscape.com)
The Cancer Genome Atlas (TCGA) LUAD data set was used to explore associations among B-cell infiltration, PD-L1 expression, clinical outcome, and gene landscape. (cancer-genetics.org)

Age-related clonal hematopoiesis and monoclonal B-cell lymphocytosis/chronic lymphocytic leukemia: a new association? (haematologica.org)
Chronic active EBV infection (CAEBV) is an intractable disease characterized by persistent and active EBV infection in T and/or NK cells. (yusukeokuno.com)
Chronic Lymphocytic Leukemia Treatment (PDQ®): Health Professional Version. (medscape.com)
A polymorphism and disease progression in chronic lymphocytic leukemia. (medscape.com)
Nicoloso MS, Kipps TJ, Croce CM, Calin GA. MicroRNAs in the pathogeny of chronic lymphocytic leukaemia. (medscape.com)
Investigating the targets of MIR-15a and MIR-16-1 in patients with chronic lymphocytic leukemia (CLL). (medscape.com)
Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. (medscape.com)
Familial Chronic Lymphocytic Leukemia: What Does it Mean to Me? (medscape.com)
Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. (medscape.com)
Improved survival in chronic lymphocytic leukemia in the past decade: a population-based study including 11,179 patients diagnosed between 1973-2003 in Sweden. (medscape.com)

Single-cell profiling of transcriptome and histone modifications with EpiDamID. (axonmedchem.com)

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

Targeting tumor cells or the tumor microenvironment (TME) are the two major fundamental principles for antitumor therapies. (biomedcentral.com)
The crosstalk between pro-tumorigenic immune cells, stromal cells, and cytokines helps to establish the pre-metastatic niche for disseminated circulatory tumor cells and facilitates metastasis. (biomedcentral.com)
The stromal component interacts with tumor cells in complex crosstalk to support tumor growth. (biomedcentral.com)
Specifically in cancer, EVs secreted by tumor cells promote the development of tumor-related features in recipient cells and the acquisition of the cancer hallmarks described in the literature [ 11 ] . (encyclopedia.pub)
Circulating tumor cells also demonstrate prognostic value as liquid biopsies in certain tumor types such as breast and prostate, with measurement of nuclear proteins such as prostate cancer androgen receptor splice variant-7, providing additional supportive information for prognosis and therapy selection [ 6 ]. (biomedcentral.com)

Another problem to be considered is splenic lymphoma with villous lymphocytes. (medscape.com)
DLBCL typically has larger cells, but some Burkitt lymphoma (BL) cases might have centroblast-like (large) cells intermixed with the more common medium-sized monoclonal lymphocytes, resulting in some degree of a diagnostic dilemma, especially when considering that up to 15% of DLBCL cases might test positive for the c- myc translocation. (medscape.com)
Although the efficacy of adoptive transfer of tumor infiltrating lymphocytes (TILs) was examined over several decades, genetically engineered T cells expressing chimeric antigen receptors (CARs) rapidly replaced the application of TILs due to their high specificity, non-MHC-restricted recognition of tumor antigen, superior potency, and improved in vivo persistency [ 9 , 13 , 14 ]. (biomedcentral.com)

Nonchromosomal birth defects and risk of childhood acute leukemia: An assessment in 15?000 leukemia cases and 46?000 controls from the Childhood Cancer and Leukemia International Consortium. (cdc.gov)

Abstract PO-62: Overcoming venetoclax resistance in B-cell malignancies by antagonism of stromal TGF-beta-mediated drug resistance. (ucsf.edu)

With the exception of miR-93, these microRNAs are produced from several microRNA gene clusters, which apparently arose from a series of ancient evolutionary genetic duplication events, and also include members of the miR-19, and miR-25 families. (wikipedia.org)
Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape. (uksh.de)
Gene-environment analyses reveal novel genetic candidates with prenatal tobacco exposure in relation to risk for childhood acute lymphoblastic leukemia. (cdc.gov)
Genetic alterations and MRD refine risk assessment within KMT2A-rearranged B-cell precursor ALL in adult: a GRAALL study. (cdc.gov)
Researchers have been able to define a specific genetic signature for Burkitt lymphoma (BL). (medscape.com)
Many innovative methods have been developed with genetic modification of cells being the most advanced cell surface engineering technique. (biomedcentral.com)
Although genetic modification is a powerful tool, it has a limited applicability due to the permanent modifications made on cells. (biomedcentral.com)

Epithelial cells derived from 46 human breast tissue samples of patients suffering from breast cancer have been cultivated. (shengsci.com)

Flow Cytometry MM1.S cells were treated with 0.5 M compound or 0.1% vehicle (DMSO) for 24 h. (antiviralbiologic.com)

In addition, mtDNA stress in TFAM-deficient mouse melanoma cells produces tumours that are more resistant to doxorubicin in vivo. (regenerativemedicine.net)

Identifying childhood leukemia with an excess of hematological malignancies in first-degree relatives in Brazil. (cdc.gov)

Heterogeneous antigen expression is a key barrier influencing the activity of chimeric antigen receptor (CAR) T cells in solid tumors. (nature.com)
a novel epstein-barr virus-latent membrane protein-1-specific t-cell receptor for tcr gene therapy. (liverpool.ac.uk)
This receptor is found in moderate levels on some normal cells and as the gene's name implies, it is involved in cellular responses to growth factors. (cancerquest.org)
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (cancer-genetics.org)

PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia. (uksh.de)

Biochem Cell Biol. (oregonstate.edu)

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies. (ucsf.edu)

Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

Some proto-oncogenes work to regulate cell death. (cancerquest.org)

In addition, microRNAs have been associated with cancer progression. (biomedcentral.com)
The EBV-infected cells in CAEBV acquired various driver mutations during the course of disease progression. (yusukeokuno.com)
Therefore, we investigated the role of infiltrating B cells in LUAD progression and its correlation with PD-L1 expression. (cancer-genetics.org)

In humans, the activating mutations of miR-17~92 have been identified in non-Hodgkin's lymphoma, whereas the miRNA constituents of the clusters are overexpressed in a multiple cancer types. (wikipedia.org)
FAT1 expression and mutations in adult acute lymphoblastic leukemia. (uksh.de)
20% of the patients carried somatic driver mutations such as DDX3X mutations in their EBV-infected cells. (yusukeokuno.com)

First, the production of normal blood cells markedly decreases, which results in varying degrees of anemia , thrombocytopenia , and neutropenia . (medscape.com)

Lymphoblastic lymphoma may be histologically similar to Burkitt lymphoma (BL), however, it is a T-cell lymphoma that expresses T-cell markers in addition to TdT, which are usually negative in BL cases. (medscape.com)

Adult Burkitt leukemia and lymphoma. (medscape.com)

Due to their secretory functions, differentiation capabilities, specific homing effects through chemotaxis, distinctive therapeutic potentials, and ex vivo expandability, cells have become an attractive reagent for advanced therapeutic strategies. (biomedcentral.com)
Stability of Imprinting and Differentiation Capacity in Naïve Human Cells Induced by Chemical Inhibition of CDK8 and CDK19. (axonmedchem.com)

In addition, techniques are available to detect microRNAs by in situ hybridization. (biomedcentral.com)
These limitations hamper each individual study's statistical power to detect the true effects of the stem cell implantation. (regenerativemedicine.net)

In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)

In this review, the mechanisms to alter microRNA expression and their relation to cancer will be addressed. (biomedcentral.com)
Recent studies have uncovered key intrinsic mechanisms by which TNF acts on osteoclast precursors to restrain osteoclastogenesis, including the mechanisms mediated by RBP-J signaling, RBP-J and ITAM (Immunoreceptor tyrosine-based activation motif) crosstalk, RBP-J mediated regulatory network, NF- κ B p100, IRF8, and Def6. (frontiersin.org)
The related coactivator complexes SAGA and ATAC control embryonic stem cell self-renewal through acetyltransferase-independent mechanisms. (axonmedchem.com)

This study revealed the malignant transformation of EBV-infected cells in CAEBV. (yusukeokuno.com)
The lytic reactivation caused by the deletions is suggested to drive the malignant transformation of infected cells. (yusukeokuno.com)

Tumor-infiltrating immune cells are an important component of the TIME and are a significant predictor of cancer patients' survival. (biomedcentral.com)
During metastasis, tumor-derived exosomes help in the requirement and arrangement of immunosuppressive immune cells for favorable premetastatic niche formation and growth of metastases. (biomedcentral.com)

These clusters are transcribed as long non-coding RNA transcripts that are processed to form ~70 nucleotide microRNA precursors, that are subsequently processed by the Dicer enzyme to give a ~22 nucleotide products. (wikipedia.org)

Anatomy11

Organisms4

Diseases36

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Phenomena and Processes18

Disciplines and Occupations1

Information Science4

Health Care3

Diffuse large B-4

Biomarkers3

Mantle cell lym6

Genes17

Acute lymphobla1

Myeloid leukemias1

Burkitt's5

Mature microRNA1

Gene expression3

Leuk Lymphoma1

Pediatric4

Neoplastic transformation1

Peripheral3

Patients with relapsed1

Signatures2

Methylation2

Molecular8

Proliferation6

Regulates1

Oncogenic2

Apoptosis2

Microarray1

Reveals1

Cancers3

MRNA3

Hematopoietic stem1

Clinical6

Chronic10

Histone modifications1

Hematopoiesis1

Tumor cells5

Lymphocytes3

Risk of childhood1

Abstract1

Genetic7

Epithelial cells1

Flow cytometry1

Tumours1

Childhood1

Receptor4

Genomic1

Biol1

Refractory B cell malignancies1

Pathogenesis1

Regulate1

Progression3

Mutations3

Thrombocytopenia1

Expresses1

Adult1

Differentiation2

Detect2

Fibroblasts1

Mechanisms3

Malignant transformation2

Immune cells2

Dicer1