• Lipid
  • The integral membrane enzyme diacylglycerol kinase (DAGK) has long been thought to require the presence of lipid as an obligate 'cofactor' in order to be catalytically viable in micelles. (mendeley.com)
  • These results highlight the fact that some integral membrane proteins can maintain native-like properties in lipid-free detergent micelles and also suggest that C(14)-based detergents may be worthy of more widespread use in studies of membrane proteins. (mendeley.com)
  • Why is it that things like phosphlipids and glycosphingolipids (like sphingomyelin and glycosphingolipids) form lipid bilayers when theyre exposed to water, whereas some things form micelles instead? (biology-online.org)
  • Controlling lipid micelle stability using oligonucleotide headgroups. (nih.gov)
  • We have engineered serum stabilized micelles using short quadruplex forming oligonucleotide extensions as the lipid headgroup. (nih.gov)
  • The difficulty filling all the volume of the interior of a bilayer, while accommodating the area per head group forced on the molecule by the hydration of the lipid head group, leads to the formation of the micelle. (wikipedia.org)
  • surfactants
  • Micelles composed of ionic surfactants have an electrostatic attraction to the ions that surround them in solution, the latter known as counterions. (wikipedia.org)
  • Subsequently, when the surface coverage by the surfactants increases, the surface free energy (surface tension) decreases and the surfactants start aggregating into micelles, thus again decreasing the system's free energy by decreasing the contact area of hydrophobic parts of the surfactant with water. (wikipedia.org)
  • Upon reaching CMC, any further addition of surfactants will just increase the number of micelles (in the ideal case). (wikipedia.org)
  • One well-known definition is that CMC is the total concentration of surfactants under the conditions: if C = CMC, (d3F/dCt3) = 0 F = a[micelle] + b[monomer]: function of surfactant solution Ct: total concentration a, b: proportional constants The CMC generally depends on the method of measuring the samples, since a and b depend on the properties of the solution such as conductance and photochemical characteristics. (wikipedia.org)
  • The CMC is the concentration of surfactants in the bulk at which micelles start forming. (wikipedia.org)
  • What can isothermal titration microcalorimetry experiments tell us about the self‐organization of surfactants into micelles? (wikipedia.org)
  • equilibrium
  • Their use, however, has been challenged by the fact that these particles are inherently unstable in serum becaue of interactions with protein components, which drives the micelle equilibrium to the monomeric state. (nih.gov)
  • One initially starts off with concentrations greater than CMC in water and on adding fabric with large interfacial area and waiting for equilibrium, the surfactant concentration goes below CMC and no micelles are left. (wikipedia.org)
  • SAXS
  • B) Experimental SAXS profiles of DSPE-PEG, diC18-UGGGU, and diC18-UUUUU micelles each at 2 mg/mL, from top to bottom, and fitted profiles from ellipsoid model fits (red lines). (nih.gov)
  • Typical time evolution of absolute SAXS intensities upon rapid mixing of SDS micelles (weight 1%) and 2 M NaCl solution. (esrf.eu)
  • Quantitative analysis of the SAXS data in terms of a core-shell model yields the shape as well as the average size parameters of the micelles. (esrf.eu)
  • At higher salt concentration (1 M), the SAXS data are best described by a linear combination of ellipsoidal and worm-like micelles. (esrf.eu)
  • Concomitantly, the contour length of worm-like micelles ( L ave ) increases linearly as indicated in (c) and finally exceeds the resolution limit of the SAXS configuration. (esrf.eu)
  • particle
  • The particle-size distribution obtained from DLS measurements for polymer micelle indicates that the structure of polymer micelle synthesized from GSM is quite uniform. (nsti.org)
  • When encapsulating hydrophobes in this way it is important to ensure the particle size is appropriate for the PEG backbone being utilized, as the number of PEG mer units (generally with a MW of 6K or 10K Daltons) determines the maximum particle size that can be successfully contained at the core of the micelle. (wikipedia.org)
  • nanometers
  • Through a combination of crystallization-driven self-assembly of crystalline-coil BCPs in solution and selective micelle corona cross-linking, we have created short (about 130 nanometers), monodisperse cylindrical seed micelles that grow unidirectionally. (sciencemag.org)
  • temperature
  • Theradiusoftheganglioside micelles has previously been determined as about 54 using fluorescence experiments and with Stoke-Einstein relation the reorientation correlation time becomes τR= 120-165 ns depending on the temperature dependence of the water viscosity. (diva-portal.org)
  • The shape and size of these micelles depend on the type of surfactant and thermodynamic conditions such as temperature, solvent composition and salinity. (esrf.eu)
  • Micelles only form above critical micelle temperature. (wikipedia.org)
  • concentrations
  • The field dependent spin-lattice relaxation rates were measured for Larmor frequencies ranging from 0.1 to 40 MHz and for two micelle concentrations at three temperatures (T=10,15,20oC). (diva-portal.org)
  • concentration
  • The results show that upon rapid change in salt concentration, "worm-like" micelles are formed by the fusion of globular and transient elongated micelles on a millisecond time scale in a similar fashion to a step-like polymerisation process. (esrf.eu)
  • At lower salt concentration (c.a. 0.5 M), micelles become more elongated but do not form worm-like chains. (esrf.eu)
  • At low salt concentration (0.5 M), the aspect ratio increases roughly as an exponential function but the micelles remain globular as shown in (a). (esrf.eu)
  • The critical micelle concentration of the Rf-PEG depends on the length of the PEG portion of the polymer. (wikipedia.org)
  • form
  • Block copolymers, in which two dissimilar polymers are covalently joined together, can be designed to form micelles in solution and can be used as self-assembling injectable gels for tissue engineering or wound healing. (sciencemag.org)
  • i know that the structure of these is rectangular, but what exactly causes them to form the linear side-by-side bilayers, instead of just curling up circularly like a micelle? (biology-online.org)
  • solvent
  • Although the closest counterions partially mask a charged micelle (by up to 90%), the effects of micelle charge affect the structure of the surrounding solvent at appreciable distances from the micelle. (wikipedia.org)
  • oligonucleotides
  • Using antisense oligonucleotides we demonstrated that disruption of the quadruplex leads to micelle destabilization and cargo release. (nih.gov)
  • Micelle destabilization using antisense oligonucleotides. (nih.gov)
  • Addition of antisense oligonucleotides that disrupt G-quadruplex formation results in micelle destabilization and cargo release. (nih.gov)
  • disruption
  • Chapter 2 introduces a pH-responsive, diblock copolymer micelle platform with a tunable mode of endosomal disruption to facilitate intracellular delivery of DNA. (washington.edu)
  • properties
  • Here, we report that near-optimal catalytic properties are observed for DAGK in micelles composed of lysomyristoylphosphatidylcholine (LMPC), with significant activity also being observed in micelles composed of lysomyristoylphosphatidylglycerol and tetradecylphosphocholine. (mendeley.com)
  • Luisi P., Meyer P., Wolf R. (1980) Properties of Enzymes Solubilized in Hydrocarbons Via Reversed Micelles. (springer.com)
  • I don't know what a micelle is (we haven't covered that in class) but we did go over properties of phospholipids. (biology-online.org)
  • Ionic micelles influence many properties of the mixture, including its electrical conductivity. (wikipedia.org)
  • example
  • Block copolymer micelles are an example of a complex architecture achievable by the RAFT process, adopting a core-shell morphology under physiological conditions. (washington.edu)
  • delivery
  • Verrier, B. Micelle-Based Adjuvants for Subunit Vaccine Delivery. (mdpi.com)
  • Chapter 6 integrates the findings of these previous chapters into the development of glycopolymer micelles and determines their efficacy for in vivo DNA delivery. (washington.edu)