Mice model differences shows inbred. Medical search. Frequent questions

The original genetic background used for the K18-hACE2 mice (C57Bl/6J) proved to be among the most susceptible, while the F1 crosses from a strain known as PWK were highly resistant to disease. (omniaeducation.com)
We aimed to study mitotic chromosome preparations from NIH, C57BL/6 and Razi strains of mice, which are outbred, inbred and partially inbred laboratory mice respectively. (ac.ir)
Karyotype of NIH, C57BL/6 and Razi strains of laboratory mice (Mus musculus)', Iranian Journal of Veterinary Medicine , 5(2), pp. 80-83. (ac.ir)
When we examined both male and female BTBR mice in comparison to C57BL/6J (C57) controls, we noted that both sexes of BTBR mice showed motor coordination deficits characteristic of cerebellar dysfunction, but only the male mice showed differences in delay eyeblink conditioning, a cerebellum-dependent learning task that is known to be disrupted in ASD patients. (mdpi.com)
For instance, C57BL/6J mice are resistant to hepatic, renal and cardiac fibrosis but susceptible to pulmonary and intestinal fibrosis. (biomedcentral.com)
Phenotypically, we found that mice from these strains exhibit significant differences in body mass and body fat as compared with both C57BL/6J control mice and each other. (jax.org)
In this study, the inbred mouse strains A/J and C57BL/6J were used to determine whether their specific strain differences correlate with differences in susceptibility to respiratory depression and constipation. (pacific.edu)
C57BL/6J mice showed a greater degree of change in several respiratory parameters, resulting in more pronounced respiratory depression. (pacific.edu)
This study demonstrates that the strain differences between A/J and C57BL/6J mice have a major effect on opioid-induced constipation and respiratory depression. (pacific.edu)
Past studies have mapped four susceptibility loci (Pas1-4) for pulmonary adenoma in which A/J and C57BL/6J (B6) mice have different alleles that affect incidence and multiplicity of tumours. (bmj.com)
6 Inbred mouse strains vary in their susceptibility to cancer and two extreme strains are A/J (susceptible) and C57BL/6J (B6, resistant). (bmj.com)
Mouse pulmoary adenoma susceptibility loci (Pas) as mapped in crosses of strains A/J and C57BL/6. (bmj.com)

Methods and Materials: We recently showed that differential susceptibility to PQ neurotoxicity in four inbred mouse strains from the family of BXD recombinant inbred strains is associated with the increase in iron concentration in the ventral midbrain - the area containing both the SNc and ventral tegmentum. (cdc.gov)
Initially, the founder strains, which include five common laboratory and three wild-derived strains, were selected to establish the Collaborative Cross (CC), a panel of high diversity recombinant inbred strains. (jax.org)

Iron: key to individual differences in susceptibility to pesticide neurotoxicity? (cdc.gov)
It is the first however, to show that individual differences in susceptibility to PQ and probably other neurotoxicants are related to genetic differences in toxicant-based influx of iron into the ventral midbrain, especially in the SNc. (cdc.gov)
Developing a preclinical platform for linking disease outcome to patient genetic features promises to bridge the knowledge gap in our understanding of the underlying differences in COVID-19 susceptibility, facilitating the development of precise models for rapid diagnoses, mechanistic studies and therapeutic intervention strategies. (omniaeducation.com)
In other autoimmune diseases such as Crohn's disease, specific genetic loci associated with disease susceptibility have been shown to influence the gut environment and lead to shifts in the resident microbial populations [ 11 ]. (biomedcentral.com)
There is mounting evidence suggesting that inbred mouse strains with different genetic backgrounds demonstrate variable susceptibility to a fibrotic injury. (biomedcentral.com)
There is evidence that mouse strain differences influence susceptibility to fibrosis and this appears to be organ specific. (biomedcentral.com)
The majority of genomic studies used to identify susceptibility pathways involved in disease pathologies have been performed in the mouse. (biomedcentral.com)
Mice are also easy to breed with a short generation time and a short life span allowing direct study of disease development and can accurately eludicidate how genetic sequences may vary in different strains and result in susceptibility to fibrotic pathologies. (biomedcentral.com)
Mouse model demonstrates strain differences in susceptibility to opioi" by Andrew L. Young, Archana Viswanath et al. (pacific.edu)
The mice were then evaluated for their susceptibility for seizures, their brain activity, and ASD-like behaviors. (belmarrahealth.com)
1, 2 Moreover, susceptibility is largely intrinsic to the lung itself as shown by the classical experiments involving lung explants from sensitive and resistant mice. (bmj.com)
4, 5 Four QTLs identified as pulmonary adenoma susceptibility (Pas) loci 1-4 have been mapped, respectively, to mouse chromosomes 6, 17, 19, and 9. (bmj.com)
The original development and use of inbred mice for probing the genetic determinants of resistance and susceptibility to infections and tumors was documented from research by Clara J. Lynch (Morse 1978). (experts.com)

A growing body of work now effectively models this "twins raised apart" situation in genetically identical strains of inbred mice or genetically similar rats. (edge.org)
Rats and mice that have been subjected to greater early life stress tend to be less cognitively flexible (stubbornly applying old rules in a laboratory task after new rules are introduced) and they may also be more repetitive or forgetful. (edge.org)
Rodents (mice or rats) are placed in the center compartment and allowed to explore the arms in search of this reward. (noldus.com)
For instance, using a rat model of depression known as congenital helplessness (cLH), researchers have shown that rats with depression-like symptomatology perform poorly in this task [6]. (noldus.com)
A total of 337 F344 rats,20 Sprague Dawley rats, and 40 OF1 mice were all given initiating dose(s) of colon carcinogen, and were randomly allocated to experimental groups 7 d later. (aacrjournals.org)
PEG was active in F344 rats, in Sprague Dawley rats ( P =0.0005), and in OF1 mice ( P = 0.001). (aacrjournals.org)
A number of studies have indicated that CR can increase the lifespan (50-300%) and reduce the onset of age-related diseases in a variety of organisms (e.g. rats, mice, flies, worms, and yeast). (longevitywiki.org)
In the EPM, female rats showed lower anxiety-like behavior than males, whereas CHF rats were more anxious than CLF rats. (bvsalud.org)
Such differences in emotionality responses in the 10th generation of selected rats further indicate a possible use of this model to study correlations between trait anxiety and defen- sive reactions. (bvsalud.org)

However, BALB/c mice are resistant to pulmonary fibrosis but susceptible to hepatic fibrosis. (biomedcentral.com)
CBi is an inbred mouse strain derived from an outbred population generated by crossing BALB/c, Rockland, NIH and Swiss mice. (biomedcentral.com)
In longevity experiments, 16 female 11-mon-old BALB/c mice and both genders of 12-mon-old ICR mice were daily fed with BPSP supplemented diets at doses of 0, 0.1 and 0.5 g BPSP/kg bw for 750 and 762 days, respectively. (scirp.org)

Mouse ADSC (mADSC) isolated from C57 male mice were expanded for CS formation (10 6 cells per CS). (biomedcentral.com)
Tissue content of monoamines, volumetric brain abnormalities, dendritic spine density in the hippocampus, and various domains of the mouse behavior repertoire were evaluated in adult male mice. (researchgate.net)
[13] Male mice that experienced long periods of fasting between meals were found to live longer and healthier lifespans, regardless of the types of food they ate. (longevitywiki.org)

When fear and tension rise across racial and ethnic divisions, as they have in recent years, genetic arguments to explain behavioral differences can quickly become popular. (edge.org)
Here, we add to the literature on the cerebellum in mouse models of autism with the characterization of the cerebellum in the idiopathic BTBR T + Itpr3 tf /J (BTBR) inbred mouse strain, which has behavioral phenotypes that are reminiscent of ASD in patients. (mdpi.com)
Mice that displayed behavioral characteristics of ASD were inbred, and researchers provoked an immune response in the offspring. (belmarrahealth.com)
The radial arm maze has also been used to investigate behavioral deficits in a plethora of animal models of cognitive dysfunction known to impact memory, such as anxiety and depression. (noldus.com)
The degree of functional interaction between avPFC and Nacc further predicted behavioral success during pursuit of the distal goal, when confronted with a proximal reward option, and scaled with interindividual differences in trait impulsivity. (blogspot.com)

Inbred mice--who were alike in all genes but MHC--could detect a difference in the scent of a relative that harbored an ever-so-slightly different MHC gene. (discovermagazine.com)
Young mice tend to prefer the odor of their nest mates, but when they hit puberty, it's vive la différence: they prefer to mate with mice whose MHC genes are unlike their own. (discovermagazine.com)
In this adaptive calibration model, animals that are genetically identical might express different set of genes in their brain and develop different neural circuits in an attempt to prepare their brain for success in the kind of environment in which they find themselves. (edge.org)
13 ] have shown that housekeeping genes cluster more readily than do other gene classes (as measured by breadth of representation in serial analysis of gene expression (SAGE) experiments), but clustering patterns that are more specific have also been reported. (biomedcentral.com)
In humans, the wide variety of carcinogens and varying degrees of exposure make identifying the predisposing genes difficult, but in a mouse model, such confounding variables can be controlled. (bmj.com)
Identification of the genes predisposing to mouse lung cancer could have considerable implications for diagnosis, treatment, or chemoprevention of lung cancer in humans. (bmj.com)
Xlr genes are the mouse orthologues of the human FAM9 gene family and are implicated in the regulation of dendritic branching, dendritic spine number and morphology. (researchsquare.com)
We show here that this reflects up-regulation of a profibrotic process in the airways but loss of the response in the same genes in the parenchyma. (atsjournals.org)

While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
New genetically diverse mouse populations mirror human genetic variation, providing a powerful new experimental platform to complement human data insights, particularly for complex trait and complex disease research. (jax.org)
For this reason, researchers are increasingly focusing on mouse populations with high genetic diversity. (jax.org)
The JAX Genetic Diversity Initiative is a strategic effort to increase the awareness and availability of diversity mouse populations and associated tools across the research community. (jax.org)
These populations are powering a revolution in model organism research that will enable major advancements in the understanding of complex genetic traits. (jax.org)
When investigated within diverse mouse populations, traits show a range similar to those observed in human populations, and they can be genetically mapped with high precision. (jax.org)
Although progress with research methods has only recently made work with DO mouse populations readily feasible, DO studies have already successfully mapped complex traits related to cardiovascular function, addiction, metabolic syndrome, cancer, behavior and more. (jax.org)
Since mouse strains are used as a model for diverse human populations, current inbred strain panels may fail to model the full breadth of human diversity, limiting the implications of biomedical research findings to only a subset of human individuals. (jax.org)

Laboratory mice have been at the center of biomedical research for almost a century. (jax.org)
The genetic makeup of mice largely corresponds to that of humans, which is why they are irreplaceable model organisms in both the pharmaceutical industry and biomedical research. (ut.ee)
Currently, most biomedical research is conducted on classical inbred mouse strains. (jax.org)

The Innovative Medicines Initiative-funded "Collaboration for prevention and treatment of MDR bacterial infections" (COMBINE) consortium is establishing a validated and globally harmonized preclinical model to increase reproducibility and more reliably translate results from animals to humans. (frontiersin.org)
Since the mouse studies were done, researchers have found that humans, too, can detect MHC-dependent odors. (discovermagazine.com)
We used humans just as a model species to get an idea about a very basic question in evolutionary biology. (discovermagazine.com)
But the extent of the similarity between mice and humans surprised even Wedekind. (discovermagazine.com)
Nonetheless, inbred mouse strains have limitations, and findings in them often don't translate well to humans or for clinical applications. (jax.org)
Translating discoveries to humans and leveraging them for therapeutic development will remain difficult, however, and modeling genetic diversity is essential. (jax.org)
Alternatively, humans and rodents may show positive adaptation to adversity. (edge.org)
The empirical difference between programed and nonprogramed senescence becomes evident when comparing the stereotypical steps leading to death in salmon contrasted with the lack of such stereotypy in most organisms such as humans and mice. (fightaging.org)
To better understand the pathophysiological role of the cerebellum in ASD, it is necessary to have a variety of mouse models that have face validity for cerebellar disruption in humans. (mdpi.com)
Such mouse strain studies may prove useful in elucidating the genetic as well as epigenetic factors in humans that could help determine why some people are more susceptible to the development of certain organ specific fibrosis than others. (biomedcentral.com)
Dietary polyunsaturated fatty acids (PUFA), in particular the long chain marine fatty acids docosahexaenoic (DHA) and eicosapentaenoic (EPA), are linked to many health benefits in humans and in animal models. (biomedcentral.com)
Diets rich in polyunsaturated fatty acids (PUFA) of n-3 series show many beneficial health effects, both in animal models and humans. (biomedcentral.com)
While the AID/APOBEC deaminase specificity repertoire in dogs is likely to be less than in humans, it will be far greater than in the mouse and thus more likely to better mimic dysregulated Ig like somatic hypermutation responses during cancer progression in humans. (sciencerepository.org)
Although in vivo models of pathologic processes are useful only if they provide information that can be extrapolated to other species of interest, particularly to humans, and it is known that no model behaves ideally, it is also true that they allow not only to replicate but also, in some cases, to anticipate the genetic architecture of complex human phenotypes as is the case of cancer disease. (biomedcentral.com)
Finally, ECs developed for one species have been shown to predict age accurately in closely related taxa (e.g., humans and chimps 14 ), and therefore can be developed for a less threatened species with the intent of using them in threatened sister species. (nature.com)
Fascinating" ( Richmond Times-Dispatch ) and "lighthearted" ( The Seattle Times ), Tucker shows how these tiny felines have used their relationship with humans to become one of the most powerful animals on the planet. (simonandschuster.com)
2003). These so-called nude mice have a marked ability to engraft many different types of tumor cells from other animals, including humans. (experts.com)
The face validity of the model and its use to experimentally simulate generalized anxiety disorder in humans are also discussed. (bvsalud.org)

Note: UGB is itself progesterone induced gene in the endometrium in Lagomorphs) Inhibits phospholipase A2 in vitro Binds phosphatidylcholine, phosphatidylinositol Binds to fibronectin: The uteroglobulin knockout mice on the inbred C57Bl6 strain develop Goodpasture's syndrome like glomerulopathy due to fibronectin binding of IgA which might potentially be prevented by uteroglobin replacement. (wikipedia.org)
However contrary to the animal model claims, human genetic data might suggest that the effect may be indirect Uteroglobin knockout mice on the inbred 129 strain appear to have healthy phenotype (no glomerulopathy development), but show physiological differences in their responses to respiratory challenges. (wikipedia.org)

The phenotype of the L1 mutant mouse indicates that it is a potentially valuable model for the human CRASH syndrome. (jneurosci.org)
Surgical removal of interscapular BAT did not impact the behavioural phenotype of USF1 KO mice. (researchsquare.com)

These oligomers were introduced into neocortical pyramidal cells during whole-cell recording and, using a combination of experimentation and modelling, electrophysiological parameters were extracted. (nih.gov)

Mice are often used as model organisms for human diseases to understand the causes and nature of disease. (ut.ee)
Succesful cloning from a cancer cell, succesful cloning from old adult organisms, repeated cloning of old adult organisms without compromising health(that is clones from clones from clones, second and third generation clones), and the like have shown, unless I missed some news, that IMHO it seems no permanent or at least significantly impairing damage at a genetic level seems to be occuring with aging. (fightaging.org)
A series of recent papers has taken a complementary approach by examining the sources of variation in expression profiles between strains of model organisms. (biomedcentral.com)
Similar survival experiments have shown that DR can increase the median and maximum lifespan of a variety of other organisms. (longevitywiki.org)

Researchers at The Jackson Laboratory have created a panel of genetically diverse mice that accurately model the highly variable human response to SARS-CoV-2 infection. (omniaeducation.com)

However, different inbred lines carry different fixed alleles and therefore exhibit different phenotypic characteristics, which affects experimental results. (ut.ee)
The specific goal of this project was to characterize genotypic and phenotypic diversity in these new inbred mouse strain lines. (jax.org)
In summary, we have performed an initial genomic and phenotypic characterization of a new wild-derived inbred mouse strain resource We show that these strains harbor a significant number of novel variants that are not captured in existing panels of classical inbred strains, many of which could be useful in the context of disease-modeling and complex trait genetics. (jax.org)

Data were collected from studies that were deemed eligible for analysis based on set inclusion criteria, and findings were assessed in relation to strain of mouse, type of injury and organ of investigation. (biomedcentral.com)
The findings of this project showed that the genomes of these new inbred strains deviated significantly from the reference genome and other classical inbred strains. (jax.org)

This phantom mouse design is unique, simple, reproducible, and therefore recommended as a standard approach to dosimetry for radiobiological mouse studies by means of any of the detectors used in this study. (experts.com)

Here, we investigated the capacity of N-cad in supporting epithelial integrity in the mammary gland of adult mice. (biomedcentral.com)
The present study was designed to characterize the interaction between mammary adenocarcinoma M-406 and CBi, CBi − and CBi/L inbred mice lines. (biomedcentral.com)
The mammary adenocarcinoma M-406 developed spontaneously in a CBi mouse. (biomedcentral.com)

Mice provide a suitable model for the study of human genetics because more than 95% of the genome is identical. (biomedcentral.com)
To date, the Mouse Genome Database through The Jackson Laboratory, lists 24 QTL in mice associated with fibrosis of which all but 3 are phenotypes in the lung. (biomedcentral.com)
This project used Illumina short read whole genome sequencing data processed with established bioinformatic tools (Fastp, BWA, GATK, and snpEff) to characterize the genotypic diversity of these a new inbred mouse strain resource established from a cohort of wild-caught mice from across the Americas. (jax.org)
To examine this, we performed gene expression analysis of the mouse small intestine and colon, using whole genome oligonucleotide arrays and validation experiments using quantitative real time PCR (qRT-PCR). (biomedcentral.com)
Here I review recent work in yeast, flies, mice and primates that examines the influences of naturally occurring sequence variation, chromosomal order and speciation on genome-wide expression profiles of both RNA and protein. (biomedcentral.com)

To see whether the variable human response could be replicated in mice, a team of researchers led by The Jackson Laboratory (JAX) Scientific Director and Professor Nadia Rosenthal , Ph.D., F.Med.Sci. (omniaeducation.com)
Interestingly, researchers have noted significant differences in performance in the radial arm maze between different strains of mouse, specifically regarding which areas of the brain are used in completing the task. (noldus.com)
For instance, when comparing the inbred strains C57 and DBA, researchers discovered that dependence on either the hippocampus, amygdala or frontal cortex are differentially important between the strains [4]. (noldus.com)

Choosing the right inbred strain for a particular experiment is an important consideration when working with laboratory mice and thus it is important to thoroughly map the functional differences between mouse lines. (ut.ee)

Here we summarize the factors of variability that we identified in murine lung infection models used for antimicrobial efficacy testing, as well as the workshop presentations, panel discussions and the survey results for the harmonization of key experimental parameters. (frontiersin.org)
Using a combined experimental and modelling approach, neuronal parameters were extracted to measure, for the first time in the neocortex, specific changes in neuronal electrophysiology. (nih.gov)
experimental models, including potential limitations and data gaps. (cdc.gov)
1977). This may be true, but the experimental work in by 40 mg/m3 TMA developed specific IgE, EAR, and LAR to one animal models suggests dermal exposure as a viable route of or more of the challenges to 40 mg/m3 TMA. (cdc.gov)

In comparing the effect of PQ on gene expression in the ventral midbrain, one PQ-susceptible strain showed changes in more than 300 transcripts whereas one resistant strain showed changes in fewer than one dozen transcripts. (cdc.gov)
We also show the importance of accounting for the gene linear dependence structure of the testing set, which is linked to the loss of effective signature size. (bvsalud.org)
Major histocompatibility complex products and endogenous retroviral gene products have both been shown to exert powerful influences on the frequency distribution of T-cell receptor β-chain variable region families in the mouse. (diabetesjournals.org)
Quantitative real time PCR, and -in a second animal experiment- intestinal fatty acid oxidation measurements confirmed significant gene expression differences and showed in a dose-dependent manner significant changes at biological functional level. (biomedcentral.com)
We show that marine n-3 fatty acids regulate small intestinal gene expression and increase fatty acid oxidation. (biomedcentral.com)
Study lead Dr. Patrick Cossette said, "The results show for the first time the role of the SYN1 gene in autism, in addition to epilepsy, and strengthen the hypothesis that a deregulation of the function of synapse because of this mutation is the cause of both diseases. (belmarrahealth.com)
[ 19 ] showed that a mutated Rab27a gene, not the MYO5A gene, causes the pathology of the ashen mouse. (medscape.com)
We generated mice that possess a heterozygous deletion of the PTG gene. (jci.org)

C57BL6J mice also showed significantly more constipation than A/J mice with 40 and 60 mg/kg morphine doses. (pacific.edu)
Inbred mice have shown to benefit significantly less from CR interventions than non-inbred mice, with some inbred mice strains not benefiting at all from CR. (longevitywiki.org)

Several mice studies have shown that different genetic backgrounds may substantially influence the response to CR. (longevitywiki.org)

In contrast, 129Sv mice are more sensitive to immune activation and more susceptible to metabolic syndrome, both important features of psychiatric disorders. (ut.ee)
Through the analysis of five separate colonies of T1D susceptible NOD mice, we identified similarities in NOD microbiome that were independent of animal facility. (biomedcentral.com)
In the inbred non-obese diabetic (NOD) mouse model of T1D, susceptible NOD mice were shown to harbor a distinct gut microbiota to a variety of T1D-protected inbred strains [ 8 ]. (biomedcentral.com)

The brains of the mice that experienced adversity may be dysfunctional, in line with evidence of atrophy of frontal neurons after stress. (edge.org)
Oligomeric and monomeric αSyn were injected directly into the soma of pyramidal neurons in mouse neocortical brain slices during whole-cell patch clamp recording. (nih.gov)
In the motor, somatosensory, and visual cortex, many pyramidal neurons in layer V exhibited undulating apical dendrites that did not reach layer I. The hippocampus of L1 mutant mice was smaller than normal, with fewer pyramidal and granule cells. (jneurosci.org)
Immunoperoxidase staining showed that L1 was abundant in developing neurons at embryonic day 18 (E18) in wild-type cerebral cortex, hippocampus, and corpus callosum and then declined to low levels with maturation. (jneurosci.org)

Preclinical animal models play a crucial role in assessing the efficacy of novel drugs, informing human dosing regimens and progressing drug candidates into the clinic. (frontiersin.org)
In this work we report on therapeutic efficacy of CS from mouse ADSC transduced to express human vascular endothelial growth factor 165 a/a isoform (VEGF165), which showed potency to restore perfusion and protect tissue in a model of limb ischemia. (biomedcentral.com)
Research with one mouse strain is analogous to research in one human-what you discover is important within that context, but it may not apply to other strains (or people). (jax.org)
The CC, DO and founder mice as well as associated analysis tools will greatly improve mouse-based research into complex traits and disease and complement human genetic analyses. (jax.org)
Rodents get us away from our cultural biases and can be raised in conditions that model human experience of adversity and scarcity in infancy and childhood. (edge.org)
In "Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19," a paper published in Nature Communications , the team shows that the resulting F1 (first generation crossed) mice indeed modeled human COVID-19 severity, ranging from asymptomatic to lethal. (omniaeducation.com)
With the mouse panel, the team was able to further investigate differences in the innate immune responses that had been implicated in human patient variability. (omniaeducation.com)
Increased T1D disease risk from IL-2 pathway loci in the TwinsUK cohort of human subjects resulted in some similar microbiota changes to those observed in the NOD mouse. (biomedcentral.com)
We hypothesized that these strains would capture a wide range of naturally existing mouse diversity, setting the stage for novel discoveries and broadening the impact of research outcomes to a wider range of human individuals. (jax.org)
These developments lead us to reappraise the likely impact of AID/APOBEC and ADAR deaminases in human cancer progression with their expected lesser impact on somatic mutagenesis in mouse cancer model systems. (sciencerepository.org)
Both GIMAP4 and GIMAP7 from human Jurkat cells [ 3 ] localize to the endoplasmic reticulum and Golgi apparatus while mouse Gimap3 from murine IL-3-dependent 32D myeloid precursor cells was expressed at the outer mitochondrial membrane [ 15 ]. (hindawi.com)
lymphoid tissue, and digestive tract), which the animal model captures the It can be difficult to parse out concordance has often been ob- range of potential human response reasons for lack of tumour site con- served among different species after to the particular agent tested. (who.int)
An cordance (i.e. lack of response or exposure to a given IARC Group 1 integral consideration for the devel- common responses between spe- human carcinogen (see Chapter 21, opment and use of these models is cies). (who.int)

The research team found that the highly resistant PWK F1 mice exhibited early control of virus replication in the lungs, with phased amplification and resolution of pro-inflammatory responses and prevention of virus dissemination to other organs. (omniaeducation.com)

In other words, bioethics should examine the prejudices that are "based on species difference" and "species membership," and hence take up the central issue of "our obligations to nonhuman animals. (erudit.org)
Epigenetic aging models are promising developments because they estimate individual age with high accuracy, accurately predict age in related species, and do not require invasive sampling or intensive long-term studies. (nature.com)
The development and use of epigenetic models in other species are still limited but are becoming increasingly common 6 . (nature.com)

DO mice have profound trait differences between individual mice, providing a powerful genetic mapping platform to identify associations between the traits and specific genomic regions. (jax.org)
Quantitative trait locus (QTL) analysis is a common genetic approach that has been used in the past two decades to identify loci involved in differences in fibrotic response between inbred strains of mice [ 9 ]. (biomedcentral.com)
Quantitative trait loci analysis can be time consuming and can only analyse two different mouse strains at a time. (biomedcentral.com)
Recent years have seen growing interest in the development of genetic animal models to investigate the bidirectional relationship between trait anxiety and defensive reactions. (bvsalud.org)

The resulting recommendations for standard design parameters are presented in this document and will provide the basis for the development of a harmonized and bench-marked efficacy studies in preclinical murine pneumonia model. (frontiersin.org)
The results obtained support the conclusion that the system M-406 plus the inbred mouse lines CBi, CBi − and CBi/L, is a good murine model to study the process of tumor immunoediting. (biomedcentral.com)

Research using inbred (genetically nearly identical) mice has provided countless biological insights and has been vital for medical progress, but translation to clinical application has been difficult and inconsistent. (jax.org)
Research with inbred mouse strains-that is, mice inbred for generations until their genetics are identical, or as nearly so as possible-has yielded countless biological discoveries and led to significant medical progress. (jax.org)
An interaction between chronological age and inbreeding is associated with age acceleration estimated by the EPM, suggesting a cumulative effect of inbreeding on biological aging throughout life. (nature.com)

Together with collaborators at NIH's Rocky Mountain Laboratories, the team uncovered differences in the innate immune and regulated proinflammatory responses, the timing and strength of which are associated with disease severity. (omniaeducation.com)
Moving forward, the diverse mouse strains will allow scientists to model patient variation in COVID-19 outcome and provide a platform for discovering biomarkers of disease severity, characterizing antiviral immune responses and evaluating countermeasures. (omniaeducation.com)
Individual differences have been observed in responses to opioid drugs, including common side effects. (pacific.edu)
Xenografting is a common technique used by radiobiologists to test the characteristics of disease growth, inhibiting drugs, and tumor responses to drugs and radiation by the injection of tumors and drugs into nude mice. (experts.com)

When mice are pregnant, their preferences revert, and they prefer the familiar odor of MHC-similar males, says Wedekind. (discovermagazine.com)
Research has shown that epilepsy and autism are linked by immune activation within pregnant mice, triggering immune molecules in the offspring. (belmarrahealth.com)
Pregnant mice were treated with saline or polyinosinic:polycytidylic acid at gestation day 9. (researchgate.net)
Another study had similar results when assessing the effects of the ketogenic diet on pregnant mice and their offspring (Wojciech et al. (illuminatenrhc.com)
2021). The brain mass of the female mice who were pregnant and fed a ketogenic diet, decreased compared to the controls who were fed a standard diet. (illuminatenrhc.com)

No differences were found between lines or sexes in the FST. (bvsalud.org)

Here, we have performed an analysis of associations between the gut microbiota and T1D genetic risk using the non-obese diabetic (NOD) mouse model of T1D and the TwinsUK cohort. (biomedcentral.com)
Similarly, a cross-sectional study from a US-based cohort found differences in the bacterial composition between new-onset patients, high- and low-risk first-degree relatives, and healthy, unrelated subjects [ 7 ]. (biomedcentral.com)

Insulin resistance in older PTG heterozygous mice correlates with a significant increase in muscle triglyceride content, with a corresponding attenuation of insulin receptor signaling. (jci.org)

Concordantly, 55% of Ncadk.i. mice harboring a heterozygous p53 deletion developed malignant and invasive tumors. (biomedcentral.com)
Although young PTG heterozygous mice initially demonstrate normal glucose tolerance, progressive glucose intolerance, hyperinsulinemia, and insulin resistance develop with aging. (jci.org)

Few studies have assessed the effect of the same injury stimulus in different organ systems using the same strains of mouse. (biomedcentral.com)

Abstract -- In order to determine a mouse's dose accurately and prior to engaging in live mouse radiobiological research , a tissue-equivalent tumor-bearing phantom mouse was constructed and bored to accommodate detectors. (experts.com)

and Rocky Mountain National Laboratories Chief of Innate Immunity and Pathogenesis Sonja Best, Ph.D., crossed the original K18-hACE2 line with other mouse strains that represent broad genetic diversity. (omniaeducation.com)
Classical inbred mouse strains are a very narrow representation of the genetic diversity that exists across mice. (jax.org)

Based on the resultant survival curves and average lifespans of both mouse models, basal diets supplemented with BPSP are effective to extend mouse longevity by a dose dependent manner. (scirp.org)

United States has shown identical 16S rRNA sequences. (cdc.gov)

An animal model would help illuminate the normal function of L1 and facilitate progress in defining the molecular basis of CRASH syndrome. (jneurosci.org)
Animal models are useful tools for studying diseases such as cancer. (biomedcentral.com)
We tested this concept in a well-established animal neuroma model. (researchgate.net)
It is of merit to demonstrate that peanut kernels as a potent producer could be bio-elicited to biosynthesize a broad spectrum of bioactive stilbenes to prepare BPSP which is effective to extend mouse longevity as science-evidenced by the two long-term animal experiments. (scirp.org)
Caenorhabditis elegans is a roundworm nematode widely used as an aging animal model. (longevitywiki.org)
2010). Radiobiologists have valued this animal model for sustained grafted tumor growth, which permits fractionation considerations in therapeutic models, even for radiation therapy (Allam et al. (experts.com)
Genetic animal model, contextual fear conditioning, anxiety. (bvsalud.org)

Prenatal immune activation interacted with mhDISC1 to produce the neurobehavioral phenotypes that were not seen in untreated mhDISC1 mice and that resemble aspects of major mental illnesses. (researchgate.net)

Laboratory studies soon proved Thomas right in the case of mice. (discovermagazine.com)
Anaplasma sites and suggest that AP-Variant 1 is common in nature phagocytophilum (4,5).The white-footed mouse serves as a natural reservoir in White-tailed Deer for AP-ha, and laboratory studies have shown that numer- ous inbred strains of mice (e.g. (cdc.gov)
These studies indicate that in the steady state, NOD mice harbor a "diabetes-permissive" microbiota, and major perturbations in the microbiota can both reduce and accelerate disease. (biomedcentral.com)
A total of 44 studies were included covering 21 mouse strains and focusing on fibrosis in the lung, liver, kidney, intestine and heart. (biomedcentral.com)
Studies have shown that epileptic seizures impair the neural pathways required for socialization, but the details of this process are unknown. (belmarrahealth.com)
Previously, classical genetic studies involving cross breeding of mouse strains with differing susceptibilities have identified chromosomal areas associated with predisposition to developing spontaneous and chemically induced lung adenomas. (bmj.com)
Past research studies have assessed the brain volume and metabolic difference in juvenile mice when given a ketogenic diet (KD) (Mayengbam et al. (illuminatenrhc.com)
MICE HAVE been used in radiobiological research studies for many years. (experts.com)
It is from these studies that novel techniques seen to reduce the size of prostate tumor xenografts have had recent success using drugs injected into mice (Greco et al. (experts.com)

Differences in oligomer secondary structure appeared to produce only subtle differences in the activity of the oligomers. (nih.gov)
The cause of DCD is not well understood, but our research has shown that children with DCD use their brain differently and show subtle differences in their brain pathways compared to typically-developing children. (bcchr.ca)

It was generated to be used as a base population of broad genetic basis and as the control line of an experiment of artificial body-conformation selection which gave rise, among others, to CBi − and CBi/L mice lines [ 7 , 8 ]. (biomedcentral.com)
A caloric-restriction experiment was conducted on wild mice to see if they would experience similar results as genetically bred lab mice. (longevitywiki.org)

Thus, we provide a new mouse model to investigate the molecular mechanisms of fibrocystic mastopathy and the transition from benign to malignant tumors. (biomedcentral.com)

Lastly, the fourth study used mice models of ASD and epilepsy to explore underlying processes. (belmarrahealth.com)

Karyotyping of the samples showed that there was no difference in chromosomal numbers among the three mice strains, also the metaphase preparations of their diploid cells contained 40 chromosomes (2n = 40) and all chromosomes were telocentric. (ac.ir)

It has also been used to characterize basic functions of the brain's various centers of memory function and individual differences in cognition between animals. (noldus.com)

To explore functional differences between the two cadherins in vivo , we recently generated a knock-in line in which N-cad is expressed from the E-cad locus. (biomedcentral.com)

Prenatal interaction modulated secretion of inflammatory cytokines in fetal brains, levels of mhDISC1, endogenous mouse DISC1, and glycogen synthase kinase-3beta. (researchgate.net)

In this dissertation, two mouse lines, Bl6 and 129Sv, were compared with particular emphasis on inflammation and metabolic syndrome. (ut.ee)
Collectively these data suggest that the metabolic regulator USF1 is involved in the control of affective behaviour in mice and that this modulation of mood states is unrelated to USF1-dependent BAT activation, but instead reflected in structural changes in the brain. (researchsquare.com)
There were various metabolic differences noted between the two groups, as there was a lower level of amino acids in the brain such as methionine. (illuminatenrhc.com)

In NOD mice, an inbred mouse model of type I diabetes, puberty in males coincides with a β-chain variable region-specific T-cell expansion that mimics the results of exposure to exogenous superantigens in immunologically mature animals. (diabetesjournals.org)
Our results show that Bl6 mice are better able to cope with the negative effects of inflammation and a high-fat diet. (ut.ee)
Similar to the year 2000 tick results, a showed the variant to be the predominant strain at 2 of 3 higher percentage of female ticks (50 [38.8%] of 129) than male ticks (13 [20%] of 65) were positive for A. phagocy- tophilum . (cdc.gov)
Results of this study showed that reduced faceseal leakage for N95 FFRs and SMs improves source control. (cdc.gov)
Results further revealed age differences between three expectancy dimensions and alcohol consumption. (blogspot.com)
Each detector system demonstrated results similar to the dose computed by the treatment planning system, although some differences were noted. (experts.com)

E-cad and N-cad have been shown to be able to interact with the receptors of different growth factors, which suggests that cadherins are involved in the modulation of signaling pathways. (biomedcentral.com)
Recent evidence suggests that inbreeding avoidance is one of the less appreciated functions of the MHC. (tripod.com)

In most mouse strains, these repertoire modifiers appear to be fully functional early in mouse development and shape a repertoire of antigen specificities that remains essentially unchanged from the first weeks of life until old age. (diabetesjournals.org)
Moreover, we show that these lesions precede the development of malignant tumors. (biomedcentral.com)
The first epithelial cell layer in the development of mouse embryos, the trophectoderm of blastocysts, requires E-cad for proper function. (biomedcentral.com)

Anatomy37

Organisms24

Diseases45

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Psychiatry and Psychology7

Phenomena and Processes49

Disciplines and Occupations1

Information Science3

Health Care4

C57BL12

Recombinant inbred strains2

Susceptibility13

Rats9

BALB3

Male mice3

Behavioral5

Genes8

Populations8

Biomedical research3

Humans18

Knockout mice2

Phenotype2

Experimentation1

Organisms4

Genetically diverse mice1

Phenotypic3

Findings2

Reproducible1

Mammary3

Genome5

Researchers3

Laboratory mice1

Experimental4

Gene8

Significantly2

Different genetic backgrounds1

Susceptible3

Neurons4

Human13

Resistant1

Species3

Trait4

Murine2

Biological3

Responses4

Pregnant5

Sexes1

Cohort2

Correlates1

Heterozygous2

Strains of mouse1

Abstract1

Genetic diversity2

Lifespans1

Identical1

Animal7

Phenotypes1

Studies9

Subtle differences2

Experiment2

Investigate1

Lastly1

Chromosomal1

Individual differences1

Functional differences1

Brains1

Metabolic3

Results6

Suggests2

Development3