AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
CollectinsPulmonary SurfactantsPulmonary Surfactant-Associated Protein DPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsSerum GlobulinsProteolipidsSurface-Active AgentsMannose-Binding LectinSurface TensionPulmonary Surfactant-Associated Protein BLungPulmonary Surfactant-Associated Protein CMannansLectinsMacrophages, AlveolarComplement C1qOpsonin ProteinsGlycoproteinsHemagglutinationInfluenza A virusCarbohydratesMonosaccharidesHemagglutination Inhibition TestsPhagocytosis1,2-DipalmitoylphosphatidylcholineRespiratory Distress Syndrome, NewbornPulmonary AlveoliMycobacterium aviumBiological ProductsRespiratory MucosaImmunity, InnateCarrier ProteinsPhosphatidylglycerolsCetrimonium CompoundsRecombinant ProteinsPhospholipidsSurface Plasmon ResonanceGlycosylationMicellesProtein BindingBronchoalveolar Lavage FluidAdsorptionSurface PropertiesCattle
Family of proteinsLectins called collectinsAlveolarLipoproteinLipidsHomeostasisPulmonary surfactantSFTPA1PathogensHydrophobic proteinsELISAInnateImmunityAntimicrobialAntibodyImmunogenLungsImmuneSurface tensionBacterialRespiratoryCompositionDependentFunctionalCellsResponseFunctionHumanMember
Family of proteins2
  • This item detects porcine surfactant protein D (pSP-D), a 138kD member of the collectin family of proteins. (labome.cn)
  • It belongs to a family of proteins called collectins, which consists of collagenous region and a carbohydrate recognition domain (Taylor et al. (springeropen.com)
Lectins called collectins3
  • SP-A1 is a member of a subfamily of C-type lectins called collectins. (wikipedia.org)
  • SFTPA1 / Surfactant Protein A is a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. (lsbio.com)
  • Surfactant proteins, SP-A and SP-D, are collagen-containing C-type (calcium dependent) lectins called collectins, which contribute significantly to surfactant homeostasis and pulmonary immunity. (ox.ac.uk)
Alveolar5
  • SP-A1 is primarily synthesised in type II alveolar cells in the lung, as part of a complex of lipids and proteins known as pulmonary surfactant. (wikipedia.org)
  • Using specific monoclonal antibodies for Surfactant protein A, the protein can be detected in lung alveolar type II pneumocytes, club cells, and alveolar macrophages, but no extrapulmonary SP-A immunoreactivity was observed. (wikipedia.org)
  • Binding of pathogens, allergens, and other molecules Increasing phagocytosis and chemotaxis of alveolar macrophages Induction of proliferation of immune cells Stimulation of proinflammatory cytokine production Modulation of the generation of reactive oxygen species Serving as a hormone in parturition Maintaining the structure of tubular myelin (an extracellular form of surfactant) The role of SFTPA1 in innate immunity has been extensively studied. (wikipedia.org)
  • We provide evidence here that agricultur al organic dusts can inhibit mRNA and protein expression of SP-D in a human alveolar epithelial cell line, and an in vivo mouse model. (cdc.gov)
  • Surfactant recovered by alveolar wash from most mammals contains 70-80% phospholipids, 8-10% protein, and 10% neutral lipids, primarily cholesterol. (medscape.com)
Lipoprotein1
Lipids2
  • In preterm infants, surfactant replacement therapies that include lipids and the hydrophobic surfactant proteins are highly efficacious in improving lung function. (fz-borstel.de)
  • SP-D is a multifunctional protein which binds selectively to saccharides and lipids on microbial surfaces promoting antimicrobial responses and regulating surfactant lipid homeostasis. (labome.cn)
Homeostasis2
  • Surfactant homeostasis is critical for breathing (and thus survival) in the prematurely born infant, but also for maintaining lung health, and normal lung function throughout life. (wikipedia.org)
  • This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. (lsbio.com)
Pulmonary surfactant3
  • Surfactant protein A1 (SP-A1), also known as Pulmonary surfactant-associated protein A1 (PSP-A) is a protein that in humans is encoded by the SFTPA1 gene. (wikipedia.org)
  • Together with SP-A2, they are the most abundant proteins of pulmonary surfactant. (wikipedia.org)
  • Dipalmitoylphosphatidylcholine is a phospholipid consisting of two palmitic acids and is the major constituent of pulmonary surfactant. (absoluteastronomy.com)
SFTPA11
  • Surfactant Protein A antibody LS-C699595 is a Cy3-conjugated rabbit polyclonal antibody to Surfactant Protein A (SFTPA1) (aa21-248) from mouse. (lsbio.com)
Pathogens1
  • SP-A-deficient mice have an enhanced susceptibility to infection to pulmonary infection with bacterial and fungal pathogens and collectin replacement in these animals corrects defects in dysregulated cellular functions and microbial clearance. (fz-borstel.de)
Hydrophobic proteins1
  • Among the four surfactant apoproteins identified, surfactant protein B (SP-B) and SP-C are two small hydrophobic proteins that make up 2-4% of the surfactant mass and are present in commercially available surfactant preparations. (medscape.com)
ELISA3
  • Description: A sandwich quantitative ELISA assay kit for detection of Mouse Visfatin (VF) in samples from serum, plasma or other biological fluids. (2sars.com)
  • Description: A competitive Inhibition ELISA kit for detection of Visfatin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (2sars.com)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Surfactant Associated Protein D (SPD) in samples from serum, plasma, tissue homogenates, cell lysates, lung lavage fluid, cell culture supernates or other biological fluids. (2sars.com)
Innate3
  • The protein component of surfactant helps in the modulation of the innate immune response, and inflammatory processes. (wikipedia.org)
  • The immune surfactant or collectin surfactant protein D (SP-D) is a crucial multifunctional innate immune receptor. (cdc.gov)
  • Surfactant protein D is thought to play a significant role in the innate immune response against microorganisms within the lungs and at other mucosal surfaces. (labome.cn)
Immunity1
  • A better understanding of collectin-mediated lung immunity will contribute to the identification of disease states in which the therapeutic administration of pulmonary collectins may be beneficial. (fz-borstel.de)
Antimicrobial1
  • It is currently discussed that adult and infant patients suffering from diseases associated with lung infection may benefit from the anti-inflammatory and antimicrobial properties of the pulmonary collectins. (fz-borstel.de)
Antibody3
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Visfatin (VF) in serum, plasma and other biological fluids. (2sars.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Visfatin (VF) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (2sars.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Surfactant Associated Protein D (SPD) in serum, plasma, lung lavage fluid and other biological fluids. (2sars.com)
Immunogen1
  • Immunogen: Purified porcine surfactant protein D. Histology Positive Control Tissue: Porcine lung tissue. (labome.cn)
Lungs1
  • Surfactant development - allows lung inflation and decreases the work of breathing and also related to immunology of the lungs. (edu.au)
Immune2
  • The data on the role of lung collectins in immunomodulation are compelling, but the intracellular events by which they exert anti-inflammatory effects on activated immune cells are only partially understood. (fz-borstel.de)
  • Our group is investigating the functions and mechanisms of immune cells that are involved in the specific ability of pulmonary collectins to carry out immunomodulations that are important for preventing infection and inflammation. (fz-borstel.de)
Surface tension2
Bacterial1
  • SP-D expression is induced in lung surfactant in response to aerogenous bacterial infection, and upon binding to bacteria, promotes phagocytosis and antigen presentation by dendritic cells. (labome.cn)
Respiratory2
  • Changes in the amount or composition of surfactant can alter its function and are associated with respiratory diseases. (wikipedia.org)
  • Chest radiographs in a premature infant with respiratory distress syndrome before and after surfactant treatment. (medscape.com)
Composition1
Dependent1
  • Organic barn dust inhibits surfactant protein D production through protein kinase-c alpha dependent increase of GPR116. (cdc.gov)
Functional2
  • Disruption of the structural and functional features of surfactant protein A by acrolein in cigarette smoke. (lsbio.com)
  • Studies involving gene knock-out mice, murine models of lung hypersensitivity and infection, and functional characterization of cell surface receptors have revealed the diverse roles of SP-A and SP-D in the control of lung inflammation. (ox.ac.uk)
Cells1
  • Fusion Partners: Spleen cells from immunised Balb/c mice were fused with cells of theP3X63Ag.8.653 myeloma cell line. (labome.cn)
Response1
  • Little work to date has examined the effect of such collectins in response to organic dusts. (cdc.gov)
Function1
  • Surfactant proteins SP-A and SP-D: structure, function and receptors. (ox.ac.uk)
Human1
  • Deficiencies and inactivation of surfactant have been associated with a variety of human lung diseases in both infants and adults. (fz-borstel.de)
Member1
  • Surfactant pulmonary-associated protein D, also known as SFTPD and SP-D, is a member of the collectin family of C-type l. (targetmol.com)