Mice ovariectomy. Medical search. Frequent questions

We conclude that AAT mitigates ovariectomy-induced bone loss in mice possibly through inhibiting osteoclast activity and bone resorption and AAT can be a potential agent to prevent bone loss in humans. (usda.gov)

however, none of the treadmill training regimens prevented ovariectomy induced bone loss. (frontiersin.org)

In this study, 50 mice ranging from 25 to 35 g were divided into five experimental groups as follows: Control, VAC, Estrogen, Tamoxifen, and Tamoxifen-VAC. (ac.ir)
To determine whether AAT mitigates bone loss induced by estrogen deficiency, thirty-eight female C57BL/6J mice (7-wk-old), were either ovariectomized or sham-operated. (usda.gov)
Furthermore, we generated a mouse model of FSH elevation by intraperitoneally injecting exogenous FSH into ovariectomized (OVX) mice, in which a normal level of estrogen (E2) was maintained by exogenous supplementation. (nature.com)
Consistently, the results indicate that FSH, independent of estrogen, increases the serum cholesterol level in this mouse model. (nature.com)
To investigate the endometrial transcriptome profile and the associated molecular pathway alterations, we established an ovariectomized C57BL/6 mouse model treated with subcutaneous implantation of 17-β estradiol (E2) pellet and/or high-fat diet (HFD) for 12 weeks to mimic sustained estrogen stimulation and insulin resistance. (scienceopen.com)
We sought to determine the effect of gender and estrogen status on the severity of choroidal neovascularization (CNV) in a mouse model for experimental choroidal neovascularization. (duke.edu)
Laser-induced CNV was performed in mice with or without estrogen supplementation. (duke.edu)
Ovariectomy in adult mice did not increase severity, but paradoxically estrogen supplementation after ovariectomy did increase CNV severity. (duke.edu)
Splenic macrophages from estrogen supplemented mice showed a significant increased in TNF-alpha mRNA expression (eight fold difference compared to the control) but only a mild change in iNOS mRNA levels (2-3 fold difference). (duke.edu)
Endometrial tumorigenesis in Pten(+/-) mice is independent of coexistence of estrogen and estrogen receptor a. (jefferson.edu)

Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)

We, therefore, turned to ovariectomized (OVX) C57BL/6 mice and directly compared a low intensity endurance training on the treadmill to medium and high intensity interval trainings tailored to the individual performance limits. (frontiersin.org)
C57BL/6J mice are resistant to audiogenic seizures, have a relatively low bone density, and develop age related hearing loss. (mmpc.org)
Diet-induced obesity in C57BL/6 mice triggers common features of human metabolic syndrome (MetS). (scienceopen.com)

We recently showed that skin inflammation induces bone loss in mice and humans. (bone-abstracts.org)
Studies have shown that ovariectomy induces bone loss in the whole mandible, including its condyle 7-11 . (bvsalud.org)

5. Zhang J, Lapato A, Bodhankar S, Vandenbark AA, Offner H. Treatment with IL-10 producing B cells in combination with E2 ameliorates EAE severity and decreases CNS inflammation in B cell-deficient mice. (ac.ir)
The evidence supporting the claims of the authors is solid, although inclusion of the analysis of cell type-specific GLI1-deficient mice would have strengthened the study. (elifesciences.org)
Here, we examined the role of MCs in the inflammatory and repair phase during fracture healing.Male 12-week old MC deficient mice (Mcpt5-Cre R-DTA). (bone-abstracts.org)
deficient mice does not lead to bone loss 14. (creativepanzee.com)

AAT injection (2 mg/mouse, every 3 days for 30 days) increased tibial trabecular bone volume/total volume and trabecular thickness compared to phosphate buffered saline (PBS) injection in ovariectomized mice. (usda.gov)
Additionally, MDK-deficiency protected mice from a loss of trabecular bone mass after ovariectomy (OVX). (bone-abstracts.org)

1990. Subchronic toxicity of tetrahydrofuran vapors in rats and mice. (nih.gov)

To circumvent the slow progress of human osteoporosis and the manifold confounding factors associated with human studies, we here turned to a mouse model in order to compare various treadmill training regimens for their propensity to prevent osteoporosis-associated bone loss. (frontiersin.org)
Effect of Astragalus polysaccharides on ovariectomy-induced osteoporosis in mice. (geneticsmr.com)
Olive oil effectively mitigated ovariectomy-induced osteoporosis in rats, and is a promising candidate for the treatment of postmenopausal osteoporosis. (biomedcentral.com)

In all experiments OVX mice were treated during 21 days and divided in four groups: control group, Yellow Maca, Red Maca and Black Maca. (biomedcentral.com)

We found that ovariectomy decreased wet uterus weight, caused significant bone loss, and increased serum leptin concentrations in mice compared to sham. (usda.gov)
In our work we explored, for the first time, the role of IFN-γ encoding plasmid (pIFN-γ) in a mouse model of osteopenia induced by ovariectomy and in the sham-operated counterpart to estimate its effects in skeletal homeostasis. (slub-dresden.de)
As similar effects were observed both in sham-operated and in ovariectomized mice, our studies proved that an increased IFN-γ synthesis in bone marrow might be sufficient to induce inflammatory and catabolic responses even in the absence of pathologic predisposing substrates. (slub-dresden.de)
Methods: Fifty-four female rats were first divided equally into two groups: ovariectomized (Ovx) and simulated ovariectomy (Sham). (bvsalud.org)

In this study, we observed increased 11β-HSD1 expression in osteoclasts within an osteoporotic mice model (ovariectomized mice). (ijbs.com)
Therefore, we hypothesized that MDK may also be involved in the pathogenesis of delayed, osteoporotic fracture healing after OVX in mice. (bone-abstracts.org)

Dose-finding studies in nude mice demonstrate that F10 administered i.c. using an Alzet osmotic mini-pump at doses up to 200 mg/kg administered over 7 days are well-tolerated and do not cause damage to normal brain (Fig. 2b). (alzet.com)
Using ovariectomized nude mice, peritonitis carcinomatosa consisting of OVCAR-3 cells with the strongest ERα expression or DISS cells with weaker ERα expression was prepared. (biomedcentral.com)

Adrenal 20α-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone. (nih.gov)

It is known for causing temporary vission issues and is a It also reduced inflammation and tissue scarring in mice, andarine s4 vs cardarine. (pnlrealestategroup.com)

The weakly estrogenic organochlorine pesticide chlordecone can accelerate the development of systemic lupus erythematosus (SLE) in ovariectomized (NZBxNZW)F1 mice, with a shortened time to appearance of autoantibodies and disease similar to that produced by treatment with the sex hormone 17beta-estradiol (E2). (nih.gov)
Weight gain is a hallmark of decreased estradiol (E2) levels because of menopause or following surgical ovariectomy (OVX) at younger ages. (cam.ac.uk)

We used loss- and gain-of-function approaches including genetic manipulation of the lipolytic enzyme Pnpla2 , change in environmental temperature, and lifestyle interventions to comprehensively test the premise that a thermogenic-like BAT phenotype is coupled with enhanced glucose tolerance in female mice. (diabetesjournals.org)
Three-month-old female mice from the Swiss strain obtained from the animal house of the Universidad Peruana Cayetano Heredia were used for the study. (biomedcentral.com)
Our result showed that aged female mice had significantly larger CNV than age-matched males. (duke.edu)
In conclusion, aged female mice developed more severe CNV than do males. (duke.edu)
For example, gonadectomy prolongs the persistence of the X-zone in female mice and prepubertal male mice and can cause the reappearance of the X-zone in postpubertal males. (nih.gov)
Administration of androgens like testosterone is followed by rapid disappearance of the X-zone in female mice. (nih.gov)

Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)
Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
Mouse, rat, and human IL-17A can induce IL-6 secretion in mouse stromal cells, indicating that all homologs can recognize the mouse IL-17A receptor. (thermofisher.com)

Therefore, we investigated the effect of VAC extract on ovariectomized mice after the induction of permanent middle cerebral artery occlusion (PMCAO) model. (ac.ir)
High doses of orally administered simvastatin has previously been shown to improve fracture healing in a mouse femur fracture model. (biomedcentral.com)
Our studies demonstrate that prolactin can promote diverse carcinomas in mice, many of which resemble luminal breast cancers, providing a novel experimental model to examine the pathogenesis, progression and treatment responsiveness of this tumor subtype. (biomedcentral.com)

Femur fractures were produced in 70 mature male Balb-C mice and stabilized with marrow-nailing. (biomedcentral.com)

Under such background, we have supplemented Ovariectomized (OVX) - rats with olive oil four weeks before ovariectomy with an aim to evaluate the efficacy of olive oil supplementation starting before menopause. (biomedcentral.com)

In conclusion, CLA increases bone mass in both cancellous and cortical bones, and the effects of CLA on bone is not further improved by EX in pure cortical bone of young male mice. (biomedcentral.com)

However, chlordecone treatment did not alter the composition of splenic B-cell subsets in marked contrast to the decrease in transitional B cells and increase in marginal zone B cells seen in E2-treated mice. (nih.gov)
These effects were also observed following central pharmacological blockade of the k-OR system using the k-OR-selective antagonist PF-04455242 in wild type mice, in which we also observed a decrease in OVX-induced weight gain associated with increased UCP1 positive immunostaining in brown adipose tissue (BAT) and browning of white adipose tissue (WAT). (cam.ac.uk)
Then, 11β-HSD1 global knock-out or knock-in mice were employed to demonstrate its function in manipulating bone metabolism, showing significant bone volume decrease in 11β-HSD1 knock-in mice. (ijbs.com)
Ovariectomy produced a dramatic decrease of bone mineral density (BMD). (slub-dresden.de)

Mesenchymal stem tissues avoid ovariectomy-induced weakening of bones enhancement inside mice via intraosseous vascular redecorating. (aktinhibitor.com)
The classical three-point bending and impact tests were carried out for three rat bone groups: control (SHO), the humerus of animals under the conditions of established osteopenia (OVX), and bones of rats receiving nesfatin-1 after ovariectomy (NES). (mdpi.com)

In this paper, we report the beneficial effects of CLA and EX on bone, in four different groups of Balb-C young, male mice. (biomedcentral.com)

In 2002, the authors reported on a dramatic improvement of fracture repair in mice by simvastatin mixed in the feed[ 14 ]. (biomedcentral.com)

Firstly, 20 mice received subcutaneous injections of either simvastatin (20 mg) or vehicle. (biomedcentral.com)
Secondly, 30 mice were divided into three groups of 10 mice receiving continuous subcutaneous delivery of the vehicle substance, the vehicle with 5 mg or with 10 mg of simvastatin per kg bodyweight per day. (biomedcentral.com)

post-menopausal women with a higher serum FSH (≥78.3 IU/L) had higher serum TC and LDL-C levels than those with relatively lower FSH levels (40-78.3 IU/L), and ovariectomized mice had higher serum FSH and lipid levels and reduced hepatic LDL receptor expression. (nature.com)

1970. Normal and pathologic anatomy of the adrenal gland of the mouse, including neoplasms. (nih.gov)

Finally, CNV severity was significantly more severe in iNOS -/- mice, compared to iNOS +/+ mice after laser treatment. (duke.edu)

Ovariectomized mice with AAT treatment had higher uterus weight, lower serum osteocalcin levels, fewer bone marrow TRAP-positive osteoclasts and less expression of calcitonin receptor in bone than that in PBS-injected mice. (usda.gov)

Ovariectomy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)

Differences in the Lung Tumor Incidence and Survival Rate for CD-1 Mice Between 78-Week and 104-Week Studies in the Historical Control Data, Lewis CM, Koshlukova SE. (ca.gov)

Two months old mice, under their respective treatment regimens were followed for 14 weeks. (biomedcentral.com)

These tumors were distinct from mouse mammary tumor virus (MMTV)-neu tumors, and contained elevated transcripts for factors associated with luminal/alveolar expansion and differentiation, suggesting that they arose from physiologic targets of prolactin. (biomedcentral.com)

the encoded protein exhibits 72 percent amino acid identity with HVS13 , an open reading frame from a T lymphotropic Herpesvirus saimiri, and 63 percent with mouse CTLA-8 (cytotoxic T-lymphocyte associated antigen-8). (thermofisher.com)

The Jackson Laboratory offers several hands-on workshops for those wishing to obtain training in surgical techniques for the laboratory mouse. (jax.org)
This four-day intensive hands-on workshop is for those wishing to obtain advanced training in surgical techniques for the laboratory mouse. (jax.org)
Mice were provided with Purina laboratory chow and tap water ad libitum . (biomedcentral.com)

By pharmacological inhibition of GLI1, the proportion of proinflammatory macrophages and the number of osteoclasts were significantly reduced, and the joint inflammatory response and bone destruction in CIA mice were alleviated. (elifesciences.org)

In male mice, the X-zone regresses at puberty (by about 5 weeks of age). (nih.gov)

This is a NEW one-of-a-kind workshop on mouse stereotaxic surgery. (jax.org)

The study aimed to elucidate the effect of Yellow, Red and Black Maca on cognitive function and depression in ovariectomized (OVX) mice. (biomedcentral.com)

Description: The eBio17B7 antibody reacts with mouse and rat IL-17A with no recognition of IL-17F. (thermofisher.com)
Applications Tested: This eBio17B7 antibody has been tested by intracellular staining and flow cytometric analysis of restimulated, Th17-polarized mouse splenocytes using the Intracellular Fixation and Permeabilization Buffer Set (cat. (thermofisher.com)

Anatomy15

Organisms8

Diseases9

Chemicals and Drugs28

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes23

Information Science1

Health Care1

Mitigates ovariectomy-induced1

Prevented ovariectomy induced1

Estrogen10

Castration1

C57BL3

Induces2

Deficient mice4

Trabecular bone2

Rats and mice1

Osteoporosis3

Experiments1

Sham4

Osteoporotic2

Nude mice2

Progesterone1

Inflammation1

Estradiol2

Female6

Stromal cells3

Model3

Femur1

Olive oil1

Increases1

Decrease4

Bones2

Effects1

Dramatic1

Subcutaneous2

Lipid levels1

Pathologic1

Severity1

Serum1

MeSH1

Studies1

Regimens1

Differentiation1

Protein1

Laboratory3

Inflammatory response1

Male1

Surgery1

Effect1

Antibody2