• lymphocytes
  • Their key experiment involved harvesting of splenocytes containing LCMV-specific cytotoxic T lymphocytes(CTL) from an infected mouse strain A. These were then mixed in vitro with virus infected fibroblasts or macrophages from two different mouse strains, A and B. By the method of Cr-release cytotoxicity assay, thereby tagging the CTL with chromium-51 (Cr-51), the CTL destruction of infected cells was quantified by release of Cr-51. (wikipedia.org)
  • grown
  • Early work using nude mice for studying T-cell differentiation and the role of T cells in antibody- and cell-mediated responses was soon overwhelmed by oncologic studies when it was established that many human tumors could be grown in nude mice and that the tumors showed only minor changes in their growth patterns and morphology. (springer.com)
  • Brunner N, Spang-Thomsen M, Vindelov L, Wolff J, Engelholm SA (1985) Effect of tamoxifen on the receptor-positive T61 and the receptor-negative T60 human breast carcinomas grown in nude mice. (springer.com)
  • In this study, we examined the anti-cancer effect of mimosine on human H226 lung cancer cells grown in nude mice. (spandidos-publications.com)
  • tumour
  • Control sera were obtained from nu/nu and adult +/+ mice inoculated with tumour cells only, and from nu/nu mice protected with normal +/+ spleen cells. (springer.com)
  • In all the mice studied, CIC and blocking appeared to be mutually independent parameters throughout the MSV tumour course. (springer.com)
  • On the other hand, in immune protected mice considered alone or together with the control groups, CIC and time after tumour cell inoculation, but not tumour size, were significantly correlated. (springer.com)
  • A significant relationship between blocking and tumour size was also established, although this only applied to immune protected mice. (springer.com)
  • However, analysis of the combined data from sequentially bled immune protected mice in relation to different phases of tumour behaviour, did not support the notion that blocking, and more particularly the persistence of CIC, contribute to tumour regrowth and dissemination. (springer.com)
  • C57BL
  • Transplantation of 8 x 10(6) C57BL/6-Nu+/Nu+ (nude) bone marrow cells into C3H/HeJ recipients after conditioning with 8 Gy of total body irradiation has resulted in a markedly higher rate of graft rejection or graft failure compared to that found in recipients of normal C57BL/6 or C57BL/6-Bg+/Bg+ (beige) T-cell-depleted bone marrow. (osti.gov)
  • NMRI
  • In vivo, HepG2 cells were xenografted to male NMRI mice (n/group = 8) and treated with daily intraperitoneal injections of 10 mg/kg Panobinostat. (aacrjournals.org)
  • experiments
  • In seven separate experiments, nude (nu/nu) mice carrying established murine sarcoma virus (MSV) tumours were reconstituted with syngeneic (+/+) immune splenic T cells. (springer.com)
  • Mixing experiments using different numbers of nude bone marrow cells with or without mature thymocytes (unagglutinated by peanut agglutinin) revealed that engraftment of allogeneic T-cell-depleted bone marrow is T-cell dependent. (osti.gov)
  • human
  • The second part tackles the outcome of rat hepatocyte as well as human cell transplantation, both mature hepatocyte and hepatic progenitor, into Nude mouse submitted to liver injury. (hindawi.com)
  • The athymic (nude) mouse is a useful model for studying the biology and response to therapies of human tumors in vivo. (springer.com)
  • Bullard DE, Schold SC, Bigner SH, Bigner DD (1981) Growth and chemotherapeutic response in athymic mice of tumors arising from human glioma-derived cell lines. (springer.com)
  • Busuttil A, O'Conor GT, Foster ME, Gurtsevitch V, Morten JE, Steel CM (1986) The gross pathology and histological features of tumours produced by inoculation of human cell lines into immune-deprived mice. (springer.com)
  • Aldehyde dehydrogenase activity in xenografted human brain tumor in nude mice. (springer.com)
  • ALDH activity measured fluorimetrically using a high concentration of aliphatic aldehyde as substrate was studied in human glioblastomas grafted in nude mice. (springer.com)
  • Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. (semanticscholar.org)
  • Cetuximab is a chimeric (mouse/human) monoclonal antibody given by intravenous infusion that is distributed under the trade name Erbitux in the U.S. and Canada by the drug company Bristol-Myers Squibb and outside the U.S. and Canada by the drug company Merck KGaA. (wikipedia.org)
  • Cetuximab is a chimeric (mouse/human) monoclonal antibody which binds to and inhibits EGFR. (wikipedia.org)
  • cells
  • To ensure engraftment, a large inoculum of nude bone marrow must be supplemented with a trace number of donor T cells, whereas a small bone marrow dose from nude donors requires a much larger number of T cells for engraftment. (osti.gov)
  • Marked enhancement of donor type chimerism was also found when F1 thymocytes were added to nude bone marrow cells, indicating that the enhancement of bone marrow engraftment by T cells is not only mediated by alloreactivity against residual host cells but may rather be generated by growth factors, the release of which may require specific interactions between T cells and stem cells or between T cells and bone marrow stroma cells. (osti.gov)
  • 1978
  • Auerbach R, Morrissey LW, Sidky YA (1978) Regional differences in the incidence and growth of mouse tumors following intradermal or subcutaneous inoculation. (springer.com)
  • infections
  • Taking this into consideration, Doherty and Zinkernagel were working on the response of mice to virus infections. (wikipedia.org)
  • transplantation
  • The transplantation of tilapia Brockmann bodies into a diabetic mice model has been shown to promote long-term normal blood glucose level. (wikipedia.org)
  • model
  • Altogether, these results show that Nude mouse appears to be a suitable small animal model to expand our insight into liver cell engraftment and regeneration. (hindawi.com)
  • liver
  • We aimed at reviewing the various uses of Nude mouse for the development of liver deficiency models and evaluation of efficacy of hepatic cell xenotransplantation. (hindawi.com)
  • The first part records the large range of liver deficiency models that can be developed in Nude mice: surgical partial hepatectomy, acute toxic liver deficiency, chronic cirrhosis, and transgenic liver injury. (hindawi.com)
  • Hypoglycemia in OCL-1-bearing nude mice was considered to be caused by abnormal redistribution of glycogen, i.e. , marked accumulation of glycogen in tumor tissues and depletion of glycogen in the host liver. (aacrjournals.org)
  • main
  • The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the "nude" nickname. (wikipedia.org)
  • normal
  • In controlled, germ free environments and with antibiotic treatments found in many laboratories that routinely use nude mice, they can live almost as long as normal mice (18 months to two years). (wikipedia.org)
  • various
  • At various time points mice were individually bled and CIC concentration and blocking activity of each individual serum was determined. (springer.com)