• tumour
  • Control sera were obtained from nu/nu and adult +/+ mice inoculated with tumour cells only, and from nu/nu mice protected with normal +/+ spleen cells. (springer.com)
  • In all the mice studied, CIC and blocking appeared to be mutually independent parameters throughout the MSV tumour course. (springer.com)
  • On the other hand, in immune protected mice considered alone or together with the control groups, CIC and time after tumour cell inoculation, but not tumour size, were significantly correlated. (springer.com)
  • A significant relationship between blocking and tumour size was also established, although this only applied to immune protected mice. (springer.com)
  • However, analysis of the combined data from sequentially bled immune protected mice in relation to different phases of tumour behaviour, did not support the notion that blocking, and more particularly the persistence of CIC, contribute to tumour regrowth and dissemination. (springer.com)
  • C57BL
  • Transplantation of 8 x 10(6) C57BL/6-Nu+/Nu+ (nude) bone marrow cells into C3H/HeJ recipients after conditioning with 8 Gy of total body irradiation has resulted in a markedly higher rate of graft rejection or graft failure compared to that found in recipients of normal C57BL/6 or C57BL/6-Bg+/Bg+ (beige) T-cell-depleted bone marrow. (osti.gov)
  • NMRI
  • In vivo, HepG2 cells were xenografted to male NMRI mice (n/group = 8) and treated with daily intraperitoneal injections of 10 mg/kg Panobinostat. (aacrjournals.org)
  • immune
  • In seven separate experiments, nude (nu/nu) mice carrying established murine sarcoma virus (MSV) tumours were reconstituted with syngeneic (+/+) immune splenic T cells. (springer.com)
  • These immune protected mice were randomly divided to provide smaller groups for serial exsanguination. (springer.com)
  • interferon
  • Interferon gamma is involved in the recovery of athymic nude mice from recombinant vaccinia virus/interleukin 2 infection. (rupress.org)
  • Administration of a mAb against interferon gamma (IFN-gamma) to mice infected with the IL-2-encoding virus completely prevented the IL-2-induced mechanisms of recovery. (rupress.org)
  • experiments
  • Mixing experiments using different numbers of nude bone marrow cells with or without mature thymocytes (unagglutinated by peanut agglutinin) revealed that engraftment of allogeneic T-cell-depleted bone marrow is T-cell dependent. (osti.gov)
  • recombinant
  • Athymic nude mice recover from an infection with recombinant vaccinia virus (VV) encoding murine interleukin 2 (IL-2), but treatment with a mAb to IL-2 accentuated infection. (rupress.org)
  • Both asialo-GM1+ (NK) and asialo-GM1- (non-NK) cells were participants in the IFN-gamma-mediated recovery of nude mice from infection with the IL-2-encoding VV recombinant. (rupress.org)
  • dose
  • To ensure engraftment, a large inoculum of nude bone marrow must be supplemented with a trace number of donor T cells, whereas a small bone marrow dose from nude donors requires a much larger number of T cells for engraftment. (osti.gov)
  • transplantation
  • The transplantation of tilapia Brockmann bodies into a diabetic mice model has been shown to promote long-term normal blood glucose level. (wikipedia.org)
  • cells
  • Marked enhancement of donor type chimerism was also found when F1 thymocytes were added to nude bone marrow cells, indicating that the enhancement of bone marrow engraftment by T cells is not only mediated by alloreactivity against residual host cells but may rather be generated by growth factors, the release of which may require specific interactions between T cells and stem cells or between T cells and bone marrow stroma cells. (osti.gov)
  • liver
  • We aimed at reviewing the various uses of Nude mouse for the development of liver deficiency models and evaluation of efficacy of hepatic cell xenotransplantation. (hindawi.com)
  • The first part records the large range of liver deficiency models that can be developed in Nude mice: surgical partial hepatectomy, acute toxic liver deficiency, chronic cirrhosis, and transgenic liver injury. (hindawi.com)
  • Altogether, these results show that Nude mouse appears to be a suitable small animal model to expand our insight into liver cell engraftment and regeneration. (hindawi.com)
  • Hypoglycemia in OCL-1-bearing nude mice was considered to be caused by abnormal redistribution of glycogen, i.e. , marked accumulation of glycogen in tumor tissues and depletion of glycogen in the host liver. (aacrjournals.org)
  • normal
  • In controlled, germ free environments and with antibiotic treatments found in many laboratories that routinely use nude mice, they can live almost as long as normal mice (18 months to two years). (wikipedia.org)
  • main
  • The phenotype (main outward appearance) of the mouse is a lack of body hair, which gives it the "nude" nickname. (wikipedia.org)
  • various
  • At various time points mice were individually bled and CIC concentration and blocking activity of each individual serum was determined. (springer.com)
  • Study
  • This study used intragastric administration of astaxanthin to detect its role on tumor proliferation, apoptosis, microRNA (miRNA) overexpression, and microbacteria composition change by establishing androgen-independent PCa cell PC-3 xenograft nude mice. (mdpi.com)