• In a rat model of myocardial infarction, intracoronary S100A1 adenoviral gene transfer restored sarcoplasmic reticular calcium transients and load, normalized intracellular sodium concentrations, reversed the pathologic expression of the fetal gene program, restored energy supply, normalized contractile function, preserved inotropic reserve, and reduced cardiac hypertrophy 1 week post-myocardial infarction. (wikipedia.org)
  • Schisandra chinensis is a commonly used traditional Chinese medicine, which has been widely used in the treatment of acute myocardial infarction in China. (frontiersin.org)
  • Cardiovascular disease, including atherosclerosis, myocardial infarction, heart failure and stroke, is the leading cause of morbidity and mortality in developed nations. (frontiersin.org)
  • Rapid and correct diagnosis of acute myocardial infarction (AMI) plays a crucial role in saving patients' life. (hindawi.com)
  • Acute myocardial infarction (AMI) is one of the leading causes for death worldwide, and it is the single largest cause of death in the United States, responsible for 1 out of every 6 deaths [ 1 , 2 ]. (hindawi.com)
  • Tissue sections of hearts after myocardial infarction. (mpg.de)
  • In addition, we found that these animals developed a much smaller scar on the heart muscle after experimentally induced myocardial infarction. (mpg.de)
  • Cardioprotective effects of Hmox1 were demonstrated in experimental models of myocardial infarction (MI). (springer.com)
  • Upon myocardial infarction (MI) immune system becomes activated by extensive necrosis of cardiomyocytes and release of damage-associated molecular patterns [ 16 ]. (springer.com)
  • New data from the laboratory indicates that increasing glycolytic rate in cardiomyocytes markedly protects the heart from myocardial infarction. (einsteinmed.edu)
  • In collaboration with the laboratory of Gaetano Santulli, we are examining the mechanistic basis for this novel observation as a means to specifcally prevent heart damage and failure that progressively occurs following myocardial infarction. (einsteinmed.edu)
  • Excessive inflammation after myocardial infarction (MI) can promote infarct expansion and adverse left ventricular (LV) remodeling. (wustl.edu)
  • however, whether L-4F imparts beneficial effects after myocardial infarction (MI) is unknown. (wustl.edu)
  • Thus, endothelial cell dysfunction can lead to a reduction in the blood supply to the heart muscle by coronary arteries, thus increasing the risk of a heart attack or myocardial infarction. (medicalnewstoday.com)
  • Formally known as "beta-adrenergic blocking agents," beta blockers came to prominence in the 1960s, when deaths from myocardial infarction (MI), the clinical term for heart attack , were very common. (medicalxpress.com)
  • Muscular damage to the heart sustained during infarction may cause the organ to be less effective in pumping blood to the rest of the body, a condition that can eventually lead to heart failure and death. (medicalxpress.com)
  • Both treatments provide comparable results and similar long-term benefits, including improved function in the left ventricle, an area often damaged during heart attack, as well as reduced infarction size and improved vessel function," said Gerdes, who has studied the cardiovascular benefits and effects of thyroid hormone treatment for more than a decade. (medicalxpress.com)
  • Kuo Zhang et al, Comparison of therapeutic triiodothyronine versus metoprolol in treatment of myocardial infarction in rats, Thyroid (2018). (medicalxpress.com)
  • On the other hand, the number of circulating hEPC is increased in hypoxia or acute myocardial infarction (AMI). (intechopen.com)
  • We hypothesized that changes in cardiac macrophage glucose metabolism would reflect polarization status after myocardial infarction (MI), ranging from the early inflammatory phase to the later wound healing phase. (biomed.news)
  • Compounds that target tissue-specific transcription factors could overcome non-specific effects of small molecules and lead to the regeneration of heart muscle following myocardial infarction. (biomedcentral.com)
  • Myocardial infarction results in the loss of ventricular heart tissue which is not efficiently replaced [ 1 ]. (biomedcentral.com)
  • However, S100A1-/- did not show the eventual cardiac hypertrophy or chamber dilation in aged mice. (wikipedia.org)
  • S100A1 has been demonstrated as a regulator of the genetic program underlying cardiac hypertrophy, in that S100A1 inhibits alpha1 adrenergic stimulation of hypertrophic genes, including MYH7, ACTA1 and S100B. (wikipedia.org)
  • The Margulies lab has a longstanding focus on load-dependent myocardial remodeling with current studies focusing on mechanisms of load-dependent maturation, mechanical memory and pathological myocardial hypertrophy. (upenn.edu)
  • In this format, application of our tunable elastomers allow control of in vitro afterload to study processes of load-dependent myocardial maturation, pathologic hypertrophy during sustained biomechanical stress, hypertrophy regression and the molecular dynamics transducing these processes. (upenn.edu)
  • Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. (duke.edu)
  • Dysregulation of Ca 2+ /calmodulin-dependent protein kinase (CaMK)II is closely linked with myocardial hypertrophy and heart failure. (korea.ac.kr)
  • Mice null for cardiac PRMT1 exhibit a rapid progression to dilated cardiomyopathy and heart failure within 2 months, accompanied by cardiomyocyte hypertrophy and fibrosis. (korea.ac.kr)
  • The thickening of the left ventricle, known as left ventricular hypertrophy , can result in complications such as heart failure, which is the inability of the heart to pump sufficient quantities of blood to the body. (medicalnewstoday.com)
  • This study was undertaken to investigate whether Res can protect the heart suffering from hypertrophy injuries induced by isoproterenol (ISO), and whether the protective effect is mediated by endoplasmic reticulum (ER) stress. (karger.com)
  • Hypertrophy was estimated by measuring the cell surface area and the atrial natriuretic peptide (ANP) gene expression. (karger.com)
  • Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
  • In summary, Res treatment effectively suppressed myocardial hypertrophy and apoptosis at least partially via inhibiting ER stress. (karger.com)
  • Although the cardiac hypertrophy is an adaptive response of the heart that responds to a variety of extrinsic and intrinsic stimuli, prolonged hypertrophy typically culminates in chronic heart failure or sudden cardiac death. (karger.com)
  • Interestingly, the neurodegeneration is fully rescued in hEGFR KI/KI mice, however, they develop a severe heart hypertrophy with semilunar valve abnormalities. (silverchair.com)
  • Development of novel therapeutic approaches to bolster kinin activity in the vascular wall and in specific compartments in the kidney might be a highly effective strategy for the treatment of hypertension and its complications, including cardiac hypertrophy and renal failure. (nature.com)
  • deficiency accelerates the transition to heart failure in pressure overload hypertrophy. (omicsdi.org)
  • Pressure overload cardiac hypertrophy, a risk factor for heart failure, is associated with reduced mitochondrial fatty acid oxidation (FAO) and oxidative phosphorylation (OXPHOS) proteins that correlate in rodents with reduced PGC-1? (omicsdi.org)
  • expression following pressure overload-induced cardiac hypertrophy preserves angiogenesis but not contractile or mitochondrial function. (omicsdi.org)
  • Pathological cardiac hypertrophy was induced using 4 wk of transverse aortic constriction (TAC) in mice overexpressing the human PGC-1? (omicsdi.org)
  • Hypertrophic cardiomyopathy (HCM) is a primary disease involving myocardial fiber hypertrophy, disarrangement, and myocardial hypertrophy, especially asymmetric left ventricular hypertrophy. (biomedcentral.com)
  • S100A1 has shown to be a regulator of myocardial contractility. (wikipedia.org)
  • Through the network analysis, reduction of cardiac preload and myocardial contractility was shown to be the major effect of Schisandra components, which was further experimentally validated. (frontiersin.org)
  • In addition, the expression of NCOR2 and NFAT in myocyte were experimentally confirmed to be associated with Schisandra in the treatment of AMI, which may be responsible for the preservation effect of myocardial contractility. (frontiersin.org)
  • In addition, the lab is actively engaged in studies examining regulation of contractility by microtubules and other cytoskeletal elements, cardiotoxicity associated with VEGF-anti-angiogenic tyrosine kinase inhibitors, disease-associated shifts in cardiac metabolism, mechanisms of inherited cardiomyopathies, advanced myocardial phenotyping using digital pathology and machine learning techniques, and integrated genomic inquiries designed to identify molecular mechanisms of myocardial pathology. (upenn.edu)
  • 3) Do interventions that decrease dT/T improve contractility without increasing myocardial oxygen consumption and/or ATP utilization? (upenn.edu)
  • S100A1 has shown promise as an effective candidate for gene therapy to treat post-myocardially infarcted cardiac tissue. (wikipedia.org)
  • In the last few years, the dysregulation of tissue expression levels of miRNAs has been directly linked to cardiac disease. (hindawi.com)
  • In these analyses we isolated a variety of inflammatory specific cell types within adipose tissue and have taken extensive use of RNAseq technology to characterize the expression profiles of these various cell subsets. (einsteinmed.edu)
  • Tissue or organ-specific genes were predicted by BioGPS. (researchsquare.com)
  • Non-ischemic cardiomyopathy (NICM) can cause left ventricular dysfunction through interstitial fibrosis, which corresponds to the failure of cardiac tissue remodeling. (nature.com)
  • During MI, increased adrenaline raises pressure in the arteries and increases heart rate to compensate for the sudden loss of contractile tissue. (medicalxpress.com)
  • However, the regional microstructural tissue effects of these molecular mechanisms in the heart have yet to be spatially linked and further elucidated. (researchgate.net)
  • Concordantly in this same region, the heart's local microstructural tissue helicity is also selectively increased in exercised mice. (researchgate.net)
  • Quantification of CITED4 expression and microstructural tissue helicity reveals a significant correlation across both sedentary and exercise mouse cohorts. (researchgate.net)
  • Taken together, CITED4 expression is necessary for exercise-induced regional remodeling of the heart's microstructural helicity revealing how a key molecular regulator of cardiac remodeling manifests into downstream local tissue-level changes. (researchgate.net)
  • Expression of transcription factor CITED4 is necessary for exercise-induced regional remodeling of the heart's microstructural helicity, revealing how a key molecular regulator of cardiac remodeling mediates local tissue-level changes. (researchgate.net)
  • Our results demonstrate that miR-146a transcript levels were sharply increased in cardiac ventricular tissue of transgenic mice with specific overexpression of TNF-α in the heart, and also in a cardiomyocyte cell line of human origin (AC16) exposed to TNF-α. (jefferson.edu)
  • Here, following pulmonary immunization with a Salmonella vaccine strain, mouse MAIT cells expanded as separate CD127-Klrg1+ and CD127+Klrg1- antigen-adapted populations that differed in terms of their transcriptome, function and localization in lung tissue. (biomed.news)
  • Decrease in miR-24 has been observed in heart tissue after MI while miR-325, miR-21, miR-16, miR-375 have shown to increase [ 19 ]. (biomedcentral.com)
  • However, whether the determinants of ECM composition, such as the balance between ECM proteases (matrix metalloproteinases [MMPs]) and their tissue inhibitors [TIMPs]), are altered in hypertensive heart disease is unknown. (indexindex.com)
  • Tissue-specific remodeling of the mitochondrial proteome in type 1 diabetic akita mice. (omicsdi.org)
  • TNFα levels were also inhibited in the alcohol and HDE-exposed mouse lung tissue as compared to the HDE only exposed group. (cdc.gov)
  • Splenectomy decreased the numbers of circulating inflammatory Ly6C hi monocytes in blood, reduced the numbers of proinflammatory cardiac macrophages and significantly improved the post-MI LV function in Hmox1 −/− mice. (springer.com)
  • Afterwards, however, the hearts of Hmox1-deficient mice undergo adverse late LV remodeling due to overactive and prolonged post-ischemic inflammatory response. (springer.com)
  • Then, 3-4 days later inflammatory monocytes are recruited into ischemic area of the heart. (springer.com)
  • Pathogen-associated molecular patterns released by infecting organisms not only bind immune receptors on inflammatory cells but also bind receptors on cells in the heart ( 8 ). (frontiersin.org)
  • Here we demonstrate that L-4F suppresses the expansion of blood, splenic, and myocardial pro-inflammatory monocytes and macrophages in a mouse model of reperfused MI. (wustl.edu)
  • In vitro, L-4F also inhibited pro-inflammatory and glycolytic gene expression in macrophages. (wustl.edu)
  • miR-146a is a microRNA whose transcript levels are induced in the heart upon activation of NF-κB, a transcription factor induced by pro-inflammatory molecules (such as TNF-α) that is strongly related to the pathogenesis of cardiac disorders. (jefferson.edu)
  • Inflammatory cytokine activation and up-regulation of TLR expression have been reported in experimental as well as human heart failure regardless of etiology. (vin.com)
  • Because alcohol blocks airway epithelial cell release of IL-6 in vitro , we hypothesized that alcohol exposure would alter mouse lung inflammatory responses to HDE. (cdc.gov)
  • Based on the differentially expressed genes (DEGs), weighted gene co-expression network analysis (WGCNA) was used to construct a gene network, detect co-expression modules, and explore their relation to clinical traits. (biomedcentral.com)
  • Microarray datasets of HF were downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were selected by using R software. (researchsquare.com)
  • Serious' effects are those that evoke failure in a biological system and can lead to morbidity or mortality (e.g., acute respiratory distress or death). (cdc.gov)
  • Protein expression of ER stress and apoptosis factors was analyzed using Western Blot analysis. (karger.com)
  • Conversely, capillary density was preserved, in concert with increased VEGF expression, while apoptosis and fibrosis were reduced in TG relative to Cont mice after TAC. (omicsdi.org)
  • Importance of the filamin A-Sav1 interaction in organ size control: evidence from transgenic mice. (nih.gov)
  • Here we show that transgenic mice expressing a dominant-negative form of the CREB transcription factor (CREBA133) under the control of the cardiac myocyte-specific alpha-MHC promoter develop dilated cardiomyopathy that closely resembles many of the anatomical, physiological, and clinical features of human IDC. (nih.gov)
  • Myocyte-restricted Hmox1 transgenic mice exposed to MI exhibited significantly improved survival and LV function, lower interstitial fibrosis and oxidative stress. (springer.com)
  • Histologically, the CREBA133 hearts demonstrated both atrophic and hypertrophied fibers as well as significant interstitial fibrosis. (nih.gov)
  • In today's paper, first author Dr Valiente-Alandi, corresponding author Dr Blaxall from University of Cincinnati College of Medicine and Heart Institute, and their colleagues hypothesized that interfering with fibronectin polymerization, or its genetic ablation and fibroblasts, would attenuate myocardial fibrosis and improve cardiac function following ischemia reperfusion injury. (libsyn.com)
  • Inhibiting fibronectin matrix deposition by pUR4 treatment or by deleting fibronectin gene expression in cardiac fibroblasts confirmed cardioprotection against ischemia reperfusion-induced injury by attenuating at first left ventricular remodeling and cardiac fibrosis, thus preserving cardiac function. (libsyn.com)
  • In summary, interfering with fibronectin polymerization may be a new therapeutic strategy for treating cardiac fibrosis and heart failure. (libsyn.com)
  • In this paper from co-first authors Dr Park and Ranjbarvaziri, corresponding author Dr Ardehali, from David Geffen School of Medicine, University of California, Los Angeles, the authors utilized a novel multiple-strain approach known as the Hybrid Mouse Diversity Panel to characterize the contributions of cardiac fibroblasts to the formation of isoproterenol-induced cardiac fibrosis in three strains of mice. (libsyn.com)
  • We identify a pro-fibrogenic macrophage subtype in non-ischemic cardiomyopathy, and demonstrate that WWP2 is a key regulator of IRF7-mediated Ccl5/Ly6c high monocyte axis in heart fibrosis. (nature.com)
  • Fibrosis account for a significant proportion of the annual death rate worldwide and include myocardial fibrosis, a global health issue related to nearly all forms of heart disease 2 . (nature.com)
  • Inflammation can promote coronary atherosclerosis and induce coronary microvascular dysfunction in patients with RA, leading to an inadequate supply of myocardial oxygen, with the primary incipient procedures for the two changes being endothelial dysfunction and immune system dysregulation [ 15 , 16 ]. (biomedcentral.com)
  • The pathophysiology of sepsis includes inflammation, immune dysfunction, and dysfunction of coagulation, while sepsis-induced cardiomyopathy ( SIC ), defined as a global but reversible dysfunction of both sides of the heart induced by sepsis, plays a significant role in all of the aspects above in the pathogenesis of sepsis. (frontiersin.org)
  • The endotoxin-induced myocardial dysfunction probably depends on the toll-like receptor (TLR) 4-induced cytokines release as a delay in onset of myocardial depression after endotoxin administration ( 10 ). (frontiersin.org)
  • Other TLR-related genes (TLR2, 3, and 9) were demonstrated to be involved in sepsis-induced cardiac dysfunction from recent studies. (frontiersin.org)
  • Another change associated with aging involves the dysfunction of endothelial cells , which form the inner lining of blood vessels and the heart. (medicalnewstoday.com)
  • Gene expression of PGC-1α was 2.5-fold higher in GAMT-/- hearts while downstream genes were not activated, implicating a dysfunction in mitochondrial biogenesis signaling. (ox.ac.uk)
  • Given that MMP-9 is an AP-1 target gene involved in cardiac remodeling, myocardial dysfunction and progression of heart failure, these findings suggest that miR-146a might be a new and promising therapeutic tool for treating cardiac disorders associated with enhanced inflammation in the heart. (jefferson.edu)
  • Following TAC, KO mice progressed more rapidly to heart failure and developed more severe mitochondrial dysfunction, despite a similar overall pattern of repression of OXPHOS and FAO genes as WT-TAC. (omicsdi.org)
  • expression following POH, while preserving myocardial vascularity, does not prevent mitochondrial and contractile dysfunction. (omicsdi.org)
  • DHEA supplements are used for aging skin, depression, infertility, muscle strength, heart disease, erectile dysfunction (ED), and many other conditions, but there is no good scientific evidence to support many of these other uses. (medlineplus.gov)
  • A research from TLR4-deficient mice confirmed the essential role of TLR4 in mediating neutrophil migratory phagocytic functions, attenuating inflammation, reducing reactive oxygen species generation, and enhancing bacterial clearance ( 13 ). (frontiersin.org)
  • These data suggest that L-4F could be a used as a therapeutic adjunct in humans with MI to limit inflammation and alleviate the progression to heart failure. (wustl.edu)
  • The aim of this study was to determine the role of Hmox1 in the monocyte/macrophage-mediated cardiac remodeling in a mouse model of MI. (springer.com)
  • Consequently, a greater post-MI monocyte-derived myocardial macrophage infiltration was noted in Hmox1-deficient individuals. (springer.com)
  • During the past two years, we have developed a robust research team, several key mouse genetic models, human liver biopsy speciments and cell based approaches to investigate the regulation of liver gluconeogenesis abd lipogenesis in normal and pathophysiologic states of insulin resistance, obesity and non-alcoholic fatty liver disease (NFALD). (einsteinmed.edu)
  • The study indicates that inducing the expression of LAV-BPIFB4 in aged mice improved cardiac function and regulation of blood flow to the heart. (medicalnewstoday.com)
  • They are encoded by separate but linked genes termed regulation of complement activation (RCA) genes, located on the q32 region of chromosome 1. (medscape.com)
  • MicroRNAs (miRNAs) are an abundant class of small (approximately 22 nt) endogenous non-coding RNAs that direct post-transcriptional regulation of gene expression. (biomedcentral.com)
  • PRMT1 depletion in isolated cardiomyocytes evokes hypertrophic responses with elevated remodeling gene expression, while PRMT1 overexpression protects against pathological responses to neurohormones. (korea.ac.kr)
  • Using mouse and human cardiac myofibroblasts, authors found that the fibronectin polymerization inhibitor pUR4 attenuated the pathological phenotype exhibited by mouse and human myofibroblasts by decreasing fibronectin polymerization and collagen deposition into the extracellular matrix as well as by myofibroblast proliferation and migration. (libsyn.com)
  • Collectively, these results indicate the potential for therapeutic alteration of cell fate decisions and pathological gene regulatory networks by GATA4-targeted compounds modulating chamber-specific transcriptional programs in multipotent cardiac progenitor cells and cardiomyocytes. (biomedcentral.com)
  • It actively contributes to the pathological processes of these diseases by influencing the expression of various genes. (biomedcentral.com)
  • Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were used to conduct enrichment analysis. (researchsquare.com)
  • Single-gene enrichment analysis and expression validation of key genes were then performed. (biomedcentral.com)
  • S100A1 overexpression via adenoviral gene transfer in adult rabbit cardiomyocytes or a cardiac-restricted S100A1 murine transgenic enhanced cardiac contractile performance by increasing sarcoplasmic reticular calcium transients and uptake, altering the calcium sensitivity and cooperativity of myofibrils, enhancing SERCA2A activity and enhancing calcium-induced calcium release. (wikipedia.org)
  • Among all the in silico predicted miR-146a target genes, Fos mRNA and protein levels notably decreased after TNF-α treatment or miR-146a overexpression. (jefferson.edu)
  • Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with serious adverse outcomes, including heart failure, arrhythmias, and sudden cardiac death. (rupress.org)
  • We identified spleen as an important source of these cardiovascular complications in Hmox1 −/− mice. (springer.com)
  • Studies have shown that the longevity-associated variant (LAV) of the BPIFB4 gene is associated with a longer lifespan in humans and has protective effects in rodent models of cardiovascular disease. (medicalnewstoday.com)
  • A recent study published in Cardiovascular Research suggests that LAV-BPIFB4 , a gene variant that previous research ha shown to be highly expressed by individuals with an exceptionally long lifespan, could also protect cardiac and vascular function in old age. (medicalnewstoday.com)
  • Aging is associated with an increase in the risk of cardiovascular conditions, including heart attack , heart failure , and coronary artery disease . (medicalnewstoday.com)
  • These cardiovascular conditions are caused by alterations in the structure and function of the heart and blood vessels, including the coronary arteries. (medicalnewstoday.com)
  • Heart failure (HF) is the end pathophysiological process of many cardiovascular diseases. (researchsquare.com)
  • Heart failure (HF) is the most common final pathophysiological process of many cardiovascular diseases, and it poses a serious threat to human life and health. (researchsquare.com)
  • Hypertension is the most common disease among many cardiovascular diseases, and HF caused by hypertension is one of the main causes of myocardial remodeling. (researchsquare.com)
  • To investigate this option, Gerdes' team, which included experts from China's top cardiovascular center, FuWai Heart Hospital, compared the effectiveness of T3 and metoprolol, a commonly prescribed beta blocker, in female laboratory rats. (medicalxpress.com)
  • Vascular calcification in patients with ESKD is closely related to rapid progression of ischemic heart disease, peripheral artery disease, and aortic stenosis (AS), which become leading causes of morbidity and mortality. (biomedcentral.com)
  • The Margulies Lab examines mechanisms of myocardial remodeling to identify targets for therapeutic interventions. (upenn.edu)
  • Neutrophil activation-related genes of S100A8 and S100A12 are under investigation as therapeutic targets for both RA and CAD, hinting at the common pathogenic mechanisms of CAD&RA [ 17 ]. (biomedcentral.com)
  • in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease. (cusabio.com)
  • Expression of LTBP2 was elevated and specifically localized in the fibrotic regions of the myocardium after injury in mice and in human heart failure, suggesting that it may be a potential therapeutic target. (libsyn.com)
  • miRNAs are endogenous, small (~22 nucleotides), single-stranded, noncoding RNAs that regulate gene expression at the posttranscriptional level by binding to the 3′ untranslated regions (UTRs) of their target mRNAs [ 10 ]. (hindawi.com)
  • Expression of genes that regulate mitochondrial biogenesis, substrate utilization, and oxidative phosphorylation (OXPHOS) were determined. (omicsdi.org)
  • In the new study, inducing the expression of LAV-BPIFB4 in aged mice led to improvements in cardiac function that, translated to the human context, would be equivalent to a reduction in the heart's biological age by 10 years. (medicalnewstoday.com)
  • Age-Dependent Decline in Cardiac Function in Guanidinoacetate-N-Methyltransferase Knockout Mice. (ox.ac.uk)
  • Chronic hypertension may cause left ventricular (LV) remodeling, alterations in cardiac function, and the development of chronic heart failure (CHF). (indexindex.com)
  • As development progresses up to embryonic day 17.5, S100A1 expression shifts to a lower levels in atria and higher levels in ventricular myocardium. (wikipedia.org)
  • The level of active CaMKII is significantly elevated in PRMT1-deficient hearts or cardiomyocytes. (korea.ac.kr)
  • NF- κ B and AP-1 are chronically activated in cardiomyocytes in human heart failure. (vin.com)
  • Chronic kidney disease and anaemia are common in heart failure (HF) and are associated with a worse prognosis in these patients. (revistanefrologia.com)
  • It is unclear whether this process is independent or somehow coordinated with primary pathogenic sarcomere gene mutations, thus interfering with the clinical HCM course and its prognosis. (biomedcentral.com)
  • Development and Validation of a Novel Nomogram to Predict the Impact of the Polymorphisms of the Variants of ICAM-1 Gene on the Prognosis of Ischemic Cardiomyopathy. (cdc.gov)
  • In their studies on genetically modified mice, the Bad Nauheim researchers also found that in animals in which miR-1/133a was switched off, the heart muscle cells coped much better with hypoxia conditions (oxygen depletion), such as those that exist after a heart attack. (mpg.de)
  • In the experiment, the heart muscle cells from miR-1/133a knockout animals showed higher viability and survival in hypoxia,' Valussi said. (mpg.de)
  • However, the role of hypoxia- and immune-related genes in HCM have not been reported. (biomedcentral.com)
  • Next, hypoxia- and immune-related genes were screened by the LASSO + support vector machine recursive feature elimination (SVM-RFE) and weighted gene co-expression network analysis (WGCNA). (biomedcentral.com)
  • In this study, 35 differentially expressed hypoxia genes were found. (biomedcentral.com)
  • By using LASSO + SVM-RFE analysis, 10 more targets with differentially expressed hypoxia genes were identified. (biomedcentral.com)
  • When hypoxia and immune genes were combined for cross-tabulation analysis, three hypoxia- and immune-related genes ( ATP2A2 , DDAH1 , and OMA1 ) were identified. (biomedcentral.com)
  • Based on hypoxia characteristic genes, three key genes were identified. (biomedcentral.com)
  • Many of our inquiries are initiated by multilevel examinations of explanted human heart tissues obtained at the time of transplantation or organ donation to permit insights into both the heterogeneity of myocardial adaptations to disease and identification of dominant mechanisms and responses. (upenn.edu)
  • Due to cellular heterogeneity in the heart, the activation of gene programs representing specific atrial and ventricular cardiomyocyte subtypes would be highly desirable. (biomedcentral.com)
  • The functioning of the heart itself requires oxygen and nutrients that are supplied by the coronary arteries. (medicalnewstoday.com)
  • The discovery that mutations in sarcomere protein genes cause HCM has enabled the development of mouse models that recapitulate clinical manifestations of disease. (rupress.org)
  • New disease genes and pathogenic mutations often seem far afield from the overt manifestations of human pathology, in particular when the gene is expressed life long, but the disease emerges only after years or decades. (rupress.org)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • Research with animals, particularly mice with specifically targeted mutations, has allowed better comprehension of the specific mechanisms involved in deficiency states and the resulting clinical manifestations and/or associated diseases. (medscape.com)
  • The development of HCM depends not only on primary sarcomere damage caused by mutations but also on secondary disease-related alterations in the heart [ 3 ]. (biomedcentral.com)
  • In conclusion, the three-mode gene ontology network can be an effective network analysis workflow to evaluate the pharmacological effects of a multi-drug complex system. (frontiersin.org)
  • CONCLUSION: Long-term Cr deficiency in GAMT-/- mice reduces mitochondrial volume without affecting respiratory function, most likely due to impaired biogenesis. (ox.ac.uk)
  • Accordingly, in contrast to organs with a high regenerative capacity, no divisible, regenerative stem cells are found in the heart. (mpg.de)
  • The compound scaffolds described within this study could be used to develop regenerative strategies for myocardial regeneration. (biomedcentral.com)
  • Hmox1 knockout (Hmox1 −/− ) and wild-type (WT, Hmox1 +/+ ) mice were subjected to a permanent ligation of the left anterior descending coronary artery. (springer.com)
  • MI was induced by permanent ligation of the left coronary artery in adult male C57BL/6J mice for 1 (D1), 3 (D3), or 7 (D7) days. (biomed.news)
  • Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (bvsalud.org)
  • In mice with ablation of the S100A1 gene (S100A1-/-), cardiac reserve upon beta adrenergic stimulation was impaired, showing reduced contraction rate and relaxation rate, as well as reduced calcium sensitivity. (wikipedia.org)
  • Here, we aimed to identify the risk genes for the comorbid presence of these two complex diseases using a network modularization approach, to offer insights into clinical therapy and drug development for these diseases. (biomedcentral.com)
  • According to Dr. Marcusson, an important aspect of these studies was the demonstration of miR-21 knockdown using genome-wide mRNA expression studies. (genengnews.com)
  • β-defensin-1 mRNA expression has been identified in the heart of mice (murine beta-defensin-1, mBD1), pig (porcine beta-defensin-1, pBD1), and horse (equine beta-defensin-1, eBD1). (vin.com)
  • Both exercise-induced molecular mechanisms and physiological cardiac remodeling have been previously studied on a whole heart level. (researchgate.net)
  • Moreover, hEGFR KI/KI mice display accelerated chondrocyte and osteoblast differentiation, a phenotype that is also present in Egfr -/- mice and has not been previously described. (silverchair.com)
  • To understand the role of pyruvate dehydrogenase complex in T cell differentiation, we generated mice deficient in T cell pyruvate dehydrogenase E1A ( Pdha ) subunit using a CD4-cre recombinase-based strategy. (biomed.news)
  • Importantly, these are unique to human beta cell/islet maturation: they are not expressed in adult mouse islet cells or β-like cells from renewable sources. (einsteinmed.edu)
  • The severity of the phenotypes correlates with the expression levels of the hEGFR KI allele, which is not efficiently expressed in epithelial and bone cells, but is expressed at similar and even higher levels as the endogenous Egfr in brain and heart. (silverchair.com)
  • We found that miR-1/133a suppresses two receptors on heart muscle cells. (mpg.de)
  • This process is one of several that is required to maintain nuclear SREBP1-c at very low levels thereby suppresses lipogenic gene expression and lipogenesis. (einsteinmed.edu)
  • Heart, as the pump organ, plays a key role in the pathology of septic shock. (frontiersin.org)
  • Furthermore, myocardial energy stores and key ATP homeostatic enzymes were barely altered, while pathology was unrelated to oxidative stress since superoxide production and protein carbonylation were unaffected. (ox.ac.uk)
  • Previously, we have shown in a mouse model that exposure to hog dust extract (HDE) collected from a CAFO results in the activation of protein kinase C (PKC), elevated lavage fluid cytokines/chemokines including interleukin-6 (IL-6), and the development of significant lung pathology. (cdc.gov)
  • The heart contains a functionally intact local innate immune system that can be activated in response to different types of injury. (vin.com)
  • The immune system is involved in maintaining the normal physiological function of the heart and may play a crucial role in HCM. (biomedcentral.com)
  • Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. (duke.edu)
  • We performed long-term treatment of mice with an antimiR-21 inhibitor (a single-stranded oligonucleotide) as well as a mismatched antimiR control. (genengnews.com)
  • Records: Tumor-bearing mice had been treated with (A) an individual iv dosage of 10 mg/kg of either RL71 or SMA-RL71 and euthanized 6 h afterwards or (B) intravenously implemented 10 mg/kg of RL71 or SMA-RL71 LGK-974 kinase inhibitor on times 4, 7, 11, and 14 and euthanized 3 times afterwards. (insulin-receptor.info)
  • There is an unmet clinical need for agents that safely improve impaired contraction and relaxation observed in most patients with heart failure (HF). (upenn.edu)
  • Thirteen characteristic modules and 49 susceptibility hub genes were identified, and their corresponding molecular functions may reflect the underlying mechanism of CAD&RA, hence providing insights into the development of clinical therapies against these diseases. (biomedcentral.com)
  • Although these findings should be confirmed in a larger prospective study, these data do suggest that changes in the MMP/TIMP balance may play an important role in the structural, functional, and clinical manifestations of hypertensive heart disease. (indexindex.com)
  • Hypozincemia contributes to phosphate-induced vascular calcification in model animals of renal failure, but the association between hypozincemia and aortic stenosis (AS) prevalence in patients with end-stage kidney disease remains unreported in clinical settings. (biomedcentral.com)
  • Significantly lower incidence of left ventricle (LV) free wall rupture was noted between 3rd and 5th day after MI in Hmox1 −/− mice resulting in their better overall survival. (springer.com)
  • Furthermore, it is unknown whether endogenous progenitors/stromal cells in the adult human heart could be chemically induced to generate functional atrial or ventricular heart muscle to treat adult heart diseases. (biomedcentral.com)
  • Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
  • The use of cardiac myocytes derived from human induced pluripotent stem cells (Hu-iPSC-CM), molecular reporters and advances in gene editing provides diverse unprecedented opportunities to rigorously study these fundamental processes in human cardiac cells. (upenn.edu)
  • Idiopathic-dilated cardiomyopathy (IDC) is a common primary myocardial disease of unknown etiology characterized by progressive biventricular failure, cardiac dilatation, and premature mortality. (nih.gov)
  • Predicted Deleterious Variants in Cardiomyopathy Genes Prognosticate Mortality and Composite Outcomes in UK Biobank. (cdc.gov)
  • Statistically significant weight reductions and 20% mortality were also observed in the mice co-exposed to HDE and alcohol. (cdc.gov)
  • In contrast to protein interaction networks, enriched gene ontology (GO) terms of AMI related genes were used to construct a gene ontology interaction (GOI) network, which can be used to simulate the functional interactions between differential expressed genes of disease. (frontiersin.org)
  • GATA4-targeted compounds 3i-1000 and 3i-1103 were identified as differential modulators of atrial and ventricular gene expression. (biomedcentral.com)
  • Firstly, we obtained four HCM-related datasets from the Gene Expression Omnibus (GEO) database for differential expression analysis. (biomedcentral.com)
  • Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR) function, which includes loss of betaAR density and functional uncoupling of remaining receptors. (duke.edu)
  • In this case, the heart muscle cells lost the ability to contract due to the unchecked activity of the two receptors and the animals suffered heart failure. (mpg.de)
  • The drugs work by blocking the neurotransmitters norepinephrine and epinephrine, also known as adrenaline, from binding to receptors in the heart. (medicalxpress.com)
  • Both beta-defensins and their signaling molecules, Toll-Like Receptors, have been identified in the heart of various species. (vin.com)
  • Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
  • Protein S100-A1, also known as S100 calcium-binding protein A1 is a protein which in humans is encoded by the S100A1 gene. (wikipedia.org)
  • Mice develop tumors resembling those seen in humans, including expression of high levels of miR-21. (genengnews.com)
  • HGNC ID, HGNC:9605), also known as cyclooxygenase-2 or COX-2, is an enzyme that in humans is encoded by the PTGS2 gene. (wikipedia.org)
  • Following a more extensive analysis, I have now identified multiple additional human transcription factors (including RXRG, NR0B1, MXI1, ONECUT2 and ESR1) that, like SIX2 and SIX3, increase their expression with age in humans. (einsteinmed.edu)
  • Clearly, the absence of miR-1/133a had a positive effect on myocardial cell survival and regeneration. (mpg.de)
  • Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway. (nih.gov)
  • La enfermedad renal crónica y la anemia son frecuentes en la insuficiencia cardíaca (IC) y su presencia se asocia con un peor pronóstico en estos pacientes. (revistanefrologia.com)
  • Además, en un análisis post hoc de un ensayo clínico, la ferroterapia mejoró la función renal en pacientes con IC y ferropenia. (revistanefrologia.com)
  • Although brain natriuretic peptide (BNP) and N-terminal pro B type natriuretic peptide, (NT-proBNP) have been widely used to diagnose HF, their expression levels are easily affected by age, weight, obesity, and renal function. (researchsquare.com)
  • The medical treatment of chronic heart failure has undergone a dramatic transition in the past decade. (duke.edu)
  • The MCP-count algorithm yielded five differentially expressed immune cells, and after assessing them for WGCNA characteristics, 612 immune genes were discovered. (biomedcentral.com)
  • Accordingly, pharmacological inhibition of CaMKII restores contractile function in PRMT1-deficient mice. (korea.ac.kr)
  • deficient mice exhibited greater degrees of oxidative stress, decreased cardiac efficiency, lower rates of glucose metabolism, and repression of hexokinase II protein.PGC-1? (omicsdi.org)
  • Exosomal EVs have also been used as biomarkers for ischemic heart disease and studied in the context of cardio-repair [ 12 ]. (biomedcentral.com)
  • Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)
  • Targets of Schisandra ingredients were further screened to enrich and construct the "component-gene ontology" network, which was a component for the integration of a three-mode network. (frontiersin.org)
  • miR-146a targets Fos expression in human cardiac cells. (jefferson.edu)
  • Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now discovered that the two micro RNA molecules miR-1 and miR-133 in the adult heart inactivate two genes that normally force cell division. (mpg.de)
  • The two molecules, oncostatin M receptor and FGF receptor 1, control the division activity of heart muscle cells in the adult heart,' says Thomas Böttger, one of the lead authors of the study. (mpg.de)
  • Recent studies have revealed numerous potential regulators of adult islet function, many of which are not expressed in mouse or immature human β-like cells. (einsteinmed.edu)
  • In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)
  • The individual cells are interconnected via cell-cell contacts so that the electrical excitation conduction necessary for heart contraction can take place in a controlled manner. (mpg.de)
  • At the end of that period, thyroid hormone proved to be as good, if not better, than metoprolol at improving heart function and reversing expression of detrimental genes linked to heart failure , providing all the benefits of the beta blocker plus some additional benefits unique to thyroid hormones, such as improved expression of genes related to better contraction and relaxation of the heart. (medicalxpress.com)
  • Between 2 and 20 wk of age, these mice develop four chamber cardiac dilatation, decreased systolic and diastolic left ventricular function, and attenuated contractile responses to the beta-adrenergic agonist, isoproterenol. (nih.gov)
  • Transcription factor GATA4-targeted compounds that have previously shown in vivo efficacy in cardiac injury models were tested for stage-specific activation of atrial and ventricular reporter genes in differentiating pluripotent stem cells using a dual reporter assay. (biomedcentral.com)
  • Contractile function was also equally impaired in Cont and TG mice following TAC, as demonstrated by decreased +dP/dt and ejection fraction and increased left ventricular developed pressure and end diastolic pressure. (omicsdi.org)