Mice skin abnormalities. Medical search. Frequent questions

In addition to increased schizophrenia susceptibility, 22q11.2DS is also associated with over 100 different malformations and clinical presentations including heart defects, immune dysfunction, hypocalcaemia, and craniofacial abnormalities such as cleft palate ( Paylor and Lindsay, 2006 ). (biorxiv.org)
LEOPARD syndrome affects approximately 200 individuals worldwide and is clinically distinguished by multiple lentigines (freckle-like spots on the skin), as well as craniofacial defects, deafness, and blood abnormalities which can give rise to pediatric leukemias. (scienceblog.com)
BACKGROUND: Cardio-facio-cutaneous (CFC) syndrome is a RASopathy subtype that presents with unique craniofacial dysmorphology, congenital heart disease, dermatologic abnormalities, growth retardation, and intellectual disability. (bvsalud.org)

Without a known genetic mutation, researchers had not been able to create a genetically altered mouse with which to study the condition. (medindia.net)
Dietz's group delved deeper into the question by creating mice that had both the SSS mutation and artificially low levels of integrin, and found that the mice never developed fibrosis or an abnormal immune response. (medindia.net)
The team next tried waiting until mice with the SSS mutation had developed fibrosis, then treating them with a compound known to block a key molecule with known connections to both fibrosis and the immune response. (medindia.net)
Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5. (taconic.com)
7] Each SPINK5 mutation leads to a different length of LEKTI protein, resulting in genotype/phenotype correlations in cutaneous severity, susceptibility to atopic dermatitis,[8] growth retardation, skin infection, increased stratum corneum protease activities,[9, 10] and elevated kallikrein levels in the stratum corneum. (medscape.com)
Myelencephalic blebs (my) is a recessively inherited mutation on mouse Chr 3. (ucl.ac.uk)
Most of these patients have a genetic abnormality - mutation - in a portion of the DNA called the RET gene which predisposes them to develop MTC. (btf-thyroid.org)
Bidirectional, non-necrotizing glomerular crescents are the critical pathology in X-linked Alport syndrome mouse model harboring nonsense mutation of human COL4A5. (omicsdi.org)
We analyzed sequential pathology in a mouse model of XLAS harboring a human nonsense mutation of COL4A5. (omicsdi.org)

Mice with genetic disruption of the DGAT1 or DGAT2 genes have been made by the Farese laboratory at UCSF. (wikipedia.org)
In the current study, M.D./Ph.D. student Elizabeth Gerber created a line of mice with a genetic variant similar to that found in SSS patients. (medindia.net)
X-linked Alport syndrome (XLAS) is a progressive kidney disease caused by genetic abnormalities of COL4A5. (omicsdi.org)
We made significant breakthrough and successfully modeled sick ARVD/C heart muscles in cell cultures using versatile stem cells derived from ARVD/C patients' skin cells with genetic mutations in desmosomal proteins (a specific type of cell-cell junctions in hearts), e.g. plakophilin-2 (Pkp2), desmoplakin (Dsp), etc. (ca.gov)

7,8 One of the reasons of delayed healing is connective tissue abnormalities. (ivsajournals.com)

We hypothesized that mice lacking TG storage in adipocytes would result in excess TG storage in cell types other than adipocytes and severe lipotoxicity accompanied by metabolic disease. (elifesciences.org)
However, ADGAT DKO mice were unexpectedly otherwise metabolically healthy and did not accumulate TGs ectopically or develop associated metabolic perturbations, even when fed a high-fat diet. (elifesciences.org)
Thus, the ADGAT DKO mice provide a fascinating new model to study the coupling of metabolic energy storage to energy expenditure. (elifesciences.org)
Moreover, we hypothesized that these mice would have accumulation of TGs in other tissues, such as the liver or skeletal muscle, resulting in lipotoxicity and metabolic derangements, such as insulin resistance or fatty liver disease. (elifesciences.org)
But after taking a closer look and conducting a series of experiments, it became clear that there was some other factor involved in this metabolic abnormality. (naturalnews.com)

This reversed the mice's skin fibrosis and immunologic abnormalities. (medindia.net)
Concerning the mice's skin, ultrasound therapy also stopped it from wearing out. (naturalcures.news)

Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. (research.com)
Embryonic subepidermal blebs cause abnormalities of the feet, eyes, skin and hair. (ucl.ac.uk)

A commercial preparation of amitrole induces chromosomal abnormalities in plants. (inchem.org)

Other abnormalities include preaxial polydactyly, syndactyly of the middle digits, acrania, pseudencephaly and renal agenesis. (ucl.ac.uk)
Bone abnormalities in short-rib polydactyly type 5 include extremely short ribs, short arms and legs, and extra fingers or toes (polydactyly). (medlineplus.gov)

Netherton syndrome is a rare autosomal recessive genodermatosis characterized by congenital ichthyosiform erythroderma, an atopic diathesis, and a characteristic hair-shaft abnormality known as trichorrhexis invaginata. (medscape.com)
Trichorrhexis invaginata, or bamboo hair, is a hair shaft abnormality that occurs as a result of an intermittent keratinizing defect of the hair cortex. (medscape.com)

Tumor hypoxia is a consequence of inadequate oxygen supply caused by extensive abnormalities in the vascular network [ 2 ]. (biomedcentral.com)
Studies of macroscopic experimental tumors have shown that the severity of the vascular abnormalities increases during tumor growth, resulting in reduced blood supply and increased extent of hypoxia [ 8 ]. (biomedcentral.com)
The mice were injected with either MCF-7 cells, mammary tumor cells from C3H donor, or NaCl 0.9% (placebo) subcutaneously into the axilla area and exposed by external electrostatic in each cage for 12 hours in 2 weeks before necropsied. (uai.ac.id)
After 2 weeks of exposure, placebo mice were physically normal, whereas the tumor undergone significant shrinkage of more than 67% in size. (uai.ac.id)

Df1 /+ mice have a multi-gene deletion analogous to the chromosomal microdeletion that causes human 22q11.2DS, and like human 22q11.2DS patients exhibit high rates of hearing loss arising primarily from susceptibility to middle ear inflammation. (biorxiv.org)

As the team expected, both groups of mice developed patches of stiff skin, along with elevated levels of proteins and cells involved in the immune response much like humans with SSS or systemic sclerosis. (medindia.net)
R . akari is transmitted among house mice ( Mus musculus ) and to humans by the house mouse mite ( Liponyssoides sanguineus ) 2 . (cdc.gov)
Jak3 mediates growth signals through cytokine receptors such as interleukin-2 (IL-2), IL-4, and IL-7, and its deficiency results in autosomal recessive SCID in mice and humans. (rupress.org)
kidney lesions associated with experimental exposures to carbaryl and It can produce adverse effects in humans by skin contact, inhalation or ingestion. (onsettelemarketing.com)
These infected ticks spread infection to other mice and animals as well as to humans. (cdc.gov)
Abolished InsP3R2 function inhibits sweat secretion in both humans and mice. (msdmanuals.com)
The deer (or bear) tick, which normally feeds on the white-footed mouse, the white-tailed deer, other mammals, and birds, is responsible for transmitting Lyme disease bacteria to humans in the northeastern and north-central United States. (cdc.gov)

Now a new study showing that the mTOR inhibitor drug rapamycin can reverse cardiac muscle damage in a mouse model of the congenital disease LEOPARD syndrome not only identifies the first possible medical treatment for this rare condition, but also demonstrates the importance of targeted therapies in managing congenital diseases. (scienceblog.com)
Ectodermal dysplasias comprise a large group of congenital developmental disorders of at least two ectoderm-derived structures: eccrine sweat glands, teeth, hair, skin, and/or nails. (springer.com)

They've done it before with mouse embryos. (interestingengineering.com)
A year ago, Hanna first showed off a 'mechanical womb' in which he managed to grow natural mouse embryos outside of a female mouse for several days. (interestingengineering.com)
However, Hanna added these synthetic mouse embryos to his mechanical womb, growing them further than ever before - to a point where the hearts started beating, blood began moving, and 'there was the start of a brain and a tail. (interestingengineering.com)
Even the model embryos eventually suffered abnormalities. (interestingengineering.com)
In the next stage, Hanna is using his blood or skin cells, including those of a few other volunteers, as the starting point for making synthetic human embryos. (interestingengineering.com)
To answer my first question, I used genetically modified mouse embryos carrying a TCF/Lef-dependent reporter to visualize the areas with active Wnt signalling. (biologists.com)

The most characteristic symptom of early Lyme disease is the skin rash which occurs at the site of the tick bite from 5 to 40 or more days after the bite. (cdc.gov)

To generate mice lacking TGs in adipose tissue (ADGAT DKO), we crossed adipose tissue-specific Dgat1 knockout mice (Cre-transgene expressed under control of the mouse adiponectin promoter 3 ) with Dgat2 flox mice 4 . (elifesciences.org)
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. (mousephenotype.org)

Wound healing is a process in skin or other organs that occurs after injury. (ivsajournals.com)
Acute Lyme disease, except for the peculiar skin rash it produces in 60 to 80% of the patients in which it occurs, is a summer 'flu-like' illness without a cough. (cdc.gov)

We report here that Ptch +/- mice develop primordial follicular neoplasms resembling human trichoblastomas, and that exposure to ultraviolet radiation or ionizing radiation results in an increase in the number and size of these tumors and a shift in their histologic features so that they more closely resemble human basal cell carcinoma. (nature.com)
Dermal exposure to the liquid can cause burns and irritation, but absorption across intact skin is slow. (cdc.gov)
Amitrole was tested in mice by oral administration, skin application and transplacental exposure, in rats by oral and subcutaneous administration, and in hamsters by oral administration. (inchem.org)
Atopic dermatitis (AD) is a common chronic inflammatory skin disease associated with various factors, including immunological abnormalities and exposure to allergens. (positivehealth.com)
Thermal exposure to the body surface causes damage to the skin by membrane destabilization, protein coagulation, associated energy depletion and hypoxia at the cellular level which leads to extensive tissue necrosis. (ivsajournals.com)

Based on these novel findings, we identified and tested two potential clinically safe drugs in their efficacy of treating an established ARVD/C mouse model. (ca.gov)
Given that HF cycling abnormalities underlie many human hair growth disorders, the accurate classification of individual cycle stages within skin biopsies is clinically important and essential for hair research. (amsterdamumc.org)
Hypohidrosis due to skin abnormalities is rarely clinically significant. (msdmanuals.com)

In addition to a behavioral evaluation, the effects of AST on the AD were determined by the clinical skin severity score, serum IgE level, histological analyses of skin, and by reverse transcription-PCR and Western blotting analyses for the expression of inflammation-related factors. (positivehealth.com)
When compared with vehicle-treated group, the administration of AST significantly reduced the clinical skin severity score. (positivehealth.com)

Recently, we have characterized the role of calcium-permeable AMPA receptors in nociception and chronic inflammatory pain using transgenic mouse models. (uni-heidelberg.de)

NaturalNews) Skin: It is your body's largest organ, and groundbreaking new research out of Denmark has found that the proper function of your other vital organs is dependent upon its integrity. (naturalnews.com)
A collaborative research project out of the University of Southern Denmark (USD) recently discovered that human skin directly communicates and interacts with the rest of the body, meaning that, when it is not in good health, there is a good chance that the same is true about other vital organs. (naturalnews.com)
While working with Nils Faergeman's research group at USD's Department of Biochemistry and Molecular Biology, Mandrup and her team observed that human skin literally "talks" to other vital organs, including the liver, which is responsible for filtering out toxins and processing carbohydrates and fats. (naturalnews.com)
For example, we have generated a mouse line which enables deletion of genes specifically in all nociceptive neurons of the dorsal root ganglia (DRG) and trigeminal ganglia without affecting gene expression in non-nociceptive neurons, the spinal cord, the brain or any other organs in the body (Agarwal et al. (uni-heidelberg.de)

We expected to generate a mouse model similar to those of classic lipodystrophy due to defects of TG storage in adipose tissue. (elifesciences.org)
Mice lacking the epidermal growth factor receptor (EGFR) develop epithelial defects and a neurodegenerative disease and die within the first month of birth. (silverchair.com)
However, these mice are growth retarded and show skin and hair defects similar to Egfr -/- mutants. (silverchair.com)

A positional cloning strategy was thus undertaken using an intersubspecific backcross between the mutant mouse and the wild-derived Mus musculus castaneus. (ucl.ac.uk)
For in vivo, we used female mice (Mus musculus) strain C3H as animal model. (uai.ac.id)

To test this hypothesis, we selectively deleted both TG-synthesis enzymes, DGAT1 and DGAT2, in adipocytes (ADGAT DKO mice). (elifesciences.org)
We generated mice lacking both known TG synthesis enzymes, DGAT1 and DGAT2 1 , 2 , in adipocytes. (elifesciences.org)
In diabetes, as a result of reduced synthesis and enhanced degradation of collagen the collagen content is reduced and this may be one of the abnormalities contributed to poor wound healing seen in diabetes. (ivsajournals.com)

Scleroderma or CREST syndrome is a chronic, auto immune disease which manifests as thick, dry, fibrous skin. (medindia.net)
Disease usually begins with a slowly expanding skin lesion - erythema migrans (EM) - at the site of the tick bite (early localized disease). (logicalimages.com)
Atopic dermatitis (AD) is an allergic, inflammatory skin disease caused by immune dysregulation. (researchgate.net)
In nature, the Lyme disease bacteria exist in a cycle involving ticks and small animals, most specifically the wild white-footed mouse. (cdc.gov)
For Lyme disease to exist in an area, at least three closely interrelated elements must be present in nature: the Lyme disease bacteria, ticks that can transmit them, and mammals (such as mice and deer) to provide food for the ticks in their various life stages. (cdc.gov)

Here, we used the Df1 /+ mouse model of 22q11.2DS to investigate the relationship between hearing loss and susceptibility to schizophrenia-relevant brain and behavioral abnormalities. (biorxiv.org)
We found that hearing loss in Df1 /+ mice affected schizophrenia-relevant endophenotypes, including electrophysiological measures of central auditory gain and behavioral measures of auditory sensorimotor gating. (biorxiv.org)
These results reveal bottom-up neurobiological mechanisms through which peripheral hearing loss arising from the 22q11.2 deletion may promote the emergence of schizophrenia-relevant auditory brain and behavioral abnormalities, and also suggest a link between conductive hearing loss and reduced PV+ interneuron density in the auditory cortex. (biorxiv.org)
These results suggest mechanisms through which hearing loss associated with the 22q11.2 deletion may promote emergence of schizophrenia-relevant auditory brain and behavioral abnormalities and indicate that conductive hearing loss may influence PV+ interneuron density in the auditory cortex. (biorxiv.org)

We found that these two drugs are effective in reducing deterioration of cardiac function in ARVD/C mice, which will be the foundation for future clinical therapeutic testing in human patients with ARVD/C. This is the first time that a patient-specific stem cell based in-vitro model leads to novel pathogenic insights and to permit the development of novel ARVD/C-specific therapies in vivo. (ca.gov)
In this study, we investigated anti-atopic and anti-inflammatory activities of Sanguisorba hakusanensis ethanol extract (SHE) both in vivo using NC/Nga mice and in vitro using human HaCaT keratinocytes. (researchgate.net)
For preclinical human hair research purposes, human scalp skin can bexenografted onto immunocompromised mice tostudy human HF cyclingandmanipulate long-lasting anagen in vivo. (amsterdamumc.org)
Although available for mice, a comprehensive guide on how to recognize different human hair cycle stages in vivo is lacking. (amsterdamumc.org)

Erythroderma and hair abnormality persist. (medscape.com)
These proteins are involved in signal transduction from ectoderm to mesenchyme during development of the fetus and are indispensable for the differentiation of ectoderm-derived structures such as eccrine sweat glands, teeth, hair, skin, and/or nails. (springer.com)
The patient had normal nails with dry skin, sparse hair, everted lower lip vermilion, hyperpigmented eyelids, and abnormal nasal bridge morphology around the eyes. (bvsalud.org)
Detailed schematic drawings and representative micrographs provide examples of how best to identify human HF stages, even in suboptimally sectioned tissue, and practical recommendations are given for designing human-on-mouse hair cycle experiments. (amsterdamumc.org)

DGAT2 is mainly located in fat, liver and skin cells. (wikipedia.org)
In contrast, DGAT2−/− mice have reduced triglyceride levels but are lipopenic, suffer from skin barrier abnormalities (including the inability to retain moisture), and die shortly after birth. (wikipedia.org)

Seizures and other nervous system abnormalities have been reported in patients treated with Flagyl. (drugs.com)
causes inadequate sweating but is a central nervous system disorder rather than a skin disorder. (msdmanuals.com)

In certain types of tissues, including skin, fibrillin-1 helps make up the scaffolding for cells. (medindia.net)
The mice move energy from the tissues to the liver. (naturalnews.com)

Basal cell carcinomas, the commonest human skin cancers, consistently have abnormalities of the hedgehog signaling pathway and often have PTCH gene mutations. (nature.com)
In animal studies (mice and rats), this medicine caused certain types of cancers or tumors. (drugs.com)

The role of passenger leukocytes in the anomalous survival of neonatal skin grafts in mice. (whonamedit.com)

To compare the heterogeneities of human umbilical cord mesenchymal stem cells (HUCMSCs) derived from different donors and test their therapeutic variations in mouse liver fibrosis model. (researchsquare.com)
Then the HUCMSCs with distinct immunomodulatory effects were tested for treating liver fibrosis in mice and then therapeutic effects were observed. (researchsquare.com)
In addition, three HUCMSC lines applied to mice liver fibrosis model had different therapeutic outcomes, in line with individual immune regulation capability. (researchsquare.com)
The HUCMSCs derived different donors have individual heterogeneity, which potentially lead to distinct therapeutic outcomes in mouse liver fibrosis, indicating we could make use of the donor-variation of MSCs to screen out guaranteed general indicators of MSCs for specific diseases in further stem cell therapy. (researchsquare.com)
Since these same mice were having difficulties processing fat through their livers, instead accumulating it over time, the team initially assumed that this probably had something to do with their missing liver genes. (naturalnews.com)
At first we thought that the fat accumulation in the liver was linked with the fact that the gene was missing in the liver of the knock-out mice ," stated Ditte Neess, one of the researchers. (naturalnews.com)
We therefore asked ourselves whether this water and heat loss could be the reason why the mice accumulated fat in the liver and became weak when weaned from their mother. (naturalnews.com)
We have showed that the skin affects the metabolism in the liver, and that is quite a surprise," stated the team. (naturalnews.com)

The Ptch mutant mice provide the first mouse model, to our knowledge, of ultraviolet and ionizing radiation-induced basal cell carcinoma-like tumors, and also demonstrate that Ptch inactivation and hedgehog target gene activation are essential for basal cell carcinoma tumorigenesis. (nature.com)
Finally, for my third question, we bred RAPGEF5 mutant mice and inspected them at stages E9.5, E10.5, E14.5 and 6 weeks after birth. (biologists.com)
In mutant mice, nephropathy commenced from focal GBM irregularity by EM at 6 weeks of age, prior to exclusive crescents at 13 weeks of age. (omicsdi.org)

This single rash in untreated patients can become quite large and/or may be accompanied by one or more scattered rashes on other areas of the skin. (cdc.gov)
His temperature was 38.4 C. No swollen joints, rash or neurological abnormalities were noted on physical examination. (cdc.gov)

but only stem cells taken from the skin. (interestingengineering.com)
Sperm DNA methylation is predominantly stable in mice offspring bornafter transplantation of long-term cultured spermatogonial stem cells. (diagenode.com)
Using heart cells derived from ARVD/C-specific stem cells, we discover specific abnormalities in energy consumption of ARVD/C heart muscles that lead to their dysfunction and death. (ca.gov)

She had area of loss of scalp skin and skull bone with seen brain tissue and sagittal sinus were exposed that was measure 6 by 5 cm in size. (bvsalud.org)

These mice are also lean and resistant to diet-induced obesity, consequently generating interest in DGAT1 inhibitors for the treatment of obesity. (wikipedia.org)

Functional annotation of a full-length mouse cDNA collection. (taconic.com)
By employing a conditional knock-in approach using the human EGFR cDNA mice humanised for EGFR ( hEGFR KI/KI )were generated. (silverchair.com)

The team also tested the compounds on lab-grown human skin cells with systemic sclerosis, with the same results. (medindia.net)
In the Df1 /+ mouse model of human 22q11.2 Deletion Syndrome, we find that hearing loss shapes measures that are considered schizophrenia-relevant endophenotypes, such as central auditory gain and auditory sensorimotor gating. (biorxiv.org)
The mouse basal cell carcinomas and trichoblastoma-like tumors resemble human basal cell carcinomas in their loss of normal hemidesmosomal components, presence of p53 mutations, frequent loss of the normal remaining Ptch allele, and activation of hedgehog target gene transcription. (nature.com)
Patched (ptch)-associated preferential expression of smoothened (smoh) in human basal cell carcinoma of the skin. (nature.com)
By creating an LS mouse model that reproduced features of the human disorder, the Kontaridis group found that the mutations in PTPN11 that cause LEOPARD syndrome are distinct, and lead to a loss of phosphatase activity and hyperactivation of the AKT/mTOR pathway - which leads to the development of hypertrophic cardiomyopathy. (scienceblog.com)
While human skin cells usually start to wear out after about 15 divisions, ultrasound therapy helped the mice reach 24 divisions with no signs of abnormality. (naturalcures.news)

Johns Hopkins researchers have greatly increased understanding of the causes of systemic sclerosis, using mice, lab-grown cells and clues from a related disorder. (medindia.net)
Patients with systemic sclerosis, also known as systemic scleroderma, experience a sudden hardening, or fibrosis, of the skin. (medindia.net)
But Dietz's group was struck by the similarities between systemic sclerosis and a less severe, much rarer condition called stiff skin syndrome (SSS), which does run in families, and they suspected that learning more about SSS would also shed light on systemic sclerosis. (medindia.net)
A number of the compounds that proved effective in SSS mice and systemic sclerosis cells are currently being explored by drug companies for the treatment of other conditions, prominently including cancer. (medindia.net)
Thus, systemic toxicity is unlikely unless liquid on the skin is prevented from evaporating by heavy clothing or other impermeable covering. (cdc.gov)
Multiple widespread skin lesions represent dissemination of the infection with or without systemic symptoms. (logicalimages.com)

However, these mice also fail to lactate, showing a complete lack of milk production due to their inability to produce milk lipid droplets. (wikipedia.org)
Something else we found was that both types of mice had high levels of integrin in their skin, which made us think their cells were trying to compensate for the lack of fibrillin-integrin interaction by making more and more integrin. (medindia.net)
According to Science Daily , the team had been conducting research on so-called "knock-out" mice, or mice that lack a special fat-binding protein known as acyl-CoA-binding protein, when they made the discovery. (naturalnews.com)

Chronic skin inflammation results in scaling and exfoliation, predisposing these patients to life-threatening infections, sepsis, and dehydration. (medscape.com)
BJIKT can regulate AhR activation and may help reduce inflammation in AD by regulating the expression of skin barrier genes and immune responses. (biomedcentral.com)
1,2 It is a body's natural process of regenerating dermal and epidermal tissue in skin and is a complex process involving inflammation, cellular proliferation, and tissue remodeling which is regulated by a cascade of inflammatory mediators, including cytokines and growth factors. (ivsajournals.com)

In situ detection of hedgehog target genes and immunohistology of Ptch +/- mouse BCC differentiation markers, hemidesmosomal proteins and Bcl2 protein. (nature.com)
In consequence, the process of initiation, formation, and differentiation of skin appendages is disturbed. (springer.com)
With the exception of EDA1 and NEMO , both localized on the X chromosome, all other genes encoding components of the TNFα-related signaling pathway involved in differentiation of skin appendages, are localized on the autosomes (Table 1 ). (springer.com)
The signaling via the TNFα-related pathway, which is critical for differentiation of skin appendages, has been elucidated mainly due to the investigations performed in mice (Mikkola 2009 ). (springer.com)

Skin manifestations and associated symptoms may vary considerably among individuals with Netherton syndrome. (medscape.com)
A related study in today's on-line issue of the JCI, by a team of scientists at the University Health Network, Toronto, found that in a mouse model of Noonan syndrome, excessive activity of an enzyme called ERK (a downstream target of the RAS pathway) led to the development of hypertrophic cardiomyopathy, and that treatment with an ERK inhibitor currently being tested as an anti-cancer agent, reversed the cardiomyopathy. (scienceblog.com)
Bitoun et al[22] showed that in contrast to normal skin, LEKTI precursors and proteolytic fragments were not detected in differentiated primary keratinocytes from patients with Netherton syndrome. (medscape.com)

Micronuclei are not induced in mouse bone marrow. (inchem.org)

Surprisingly, DGAT1−/− mice are healthy and fertile and have no changes in triglyceride levels. (wikipedia.org)

A Survey of Attitudes about Maternal Serum Screening for Fetal Chromosome Abnormalities in Women 35 Years of Age and Older. (whonamedit.com)

We have made these mice widely available to the pain community to enable nociceptor-specific deletion of a variety of pain-related genes. (uni-heidelberg.de)
Serum IgE, splenocyte IL-4, and IFN-γ levels, skin barrier genes, and AhR target gene expressions were analyzed using RNA-sequencing analysis. (biomedcentral.com)
A correlation analysis was conducted to analyze the correlation between immune markers and skin barrier genes and AhR target genes. (biomedcentral.com)
Additionally, BJIKT significantly reduced epithelial skin thickness and transepidermal water loss (TEWL) values and reversed the decreased expression of skin barrier genes. (biomedcentral.com)

We will inject these mutated cells under the skin of mice to study their growth and how they respond to medications aimed at treating MTC. (btf-thyroid.org)

Since the leaky skin mice appeared to be losing more water than the other mice, making them colder, researchers hypothesized that this, and not the missing gene, was somehow responsible for a corresponding fat accumulation in the mice's livers. (naturalnews.com)
The knock-out mice with the skin and fur problems were more prone to fat accumulation in their livers, and this was the result of their unhealthy skin. (naturalnews.com)
After applying a petroleum-based jelly to the coats of the mice in question, and later liquid latex, both of which stopped the heat loss in the mice, their fat accumulation issues also stopped. (naturalnews.com)

The authors investigated whether AST could improve the dermatitis and pruritus in a murine model of AD using NC/Nga mice. (positivehealth.com)
In addition, the spontaneous scratching in AD model mice was reduced by AST administration. (positivehealth.com)

A growing body of scientific evidence shows that berry polyphenols' antioxidant capacity powerfully targets numerous degenerative diseases, from cancer and atherosclerosis to impaired glucose control and blood lipid abnormalities. (lifeextension.com)
BJIKT effectively improved AD symptoms in AD mice fed a low AhR ligand diet by reducing neutrophil and eosinophil counts, lowering IgE levels in the blood, and decreasing IL-4 and IFN-γ levels in the splenocytes. (biomedcentral.com)
These morphological abnormalities collectively increase the geometric resistance to blood flow and impair vascular function [ 7 ]. (biomedcentral.com)
Ticks feed on blood by inserting their mouth parts (not their whole bodies) into the skin of a host animal. (cdc.gov)

The results raised another big question for the team: Which of the several types of skin cells were responsible for the runaway immune response and fibrosis? (medindia.net)
Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. (shengsci.com)
In mice, nuage that is prominent in postnatal male germ cells is also called intermitochondrial cement or chromatoid bodies. (shengsci.com)
The number of eosinophils, total and degranulated mast cells all significantly decreased in the skin of AST-treated mice compared with vehicle-treated mice. (positivehealth.com)
Additionally, SHE treatment reduced the infiltration of immune cells such as mast cells and macrophages in AD skin lesions. (researchgate.net)
Prof. Michael Sheetz from the University of Texas conducted experiments on mice, the cells of which became "reinvigorated" when exposed to low-frequency sound waves. (naturalcures.news)

At this time, patients may develop multiple widespread skin lesions of disseminated EM along with acute neurologic abnormalities, atrioventricular (AV) block, or myocarditis. (logicalimages.com)

The aryl hydrocarbon receptor (AhR) is a transcription factor that plays a crucial role in regulating the immune system and maintaining skin barrier function. (biomedcentral.com)
Therefore, our study aimed to investigate the impact of a low AhR ligand diet on impaired skin barrier function and immune regulation in AD mice. (biomedcentral.com)

Anatomy3

Organisms1

Diseases4

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Information Science1

Craniofacial3

Mutation9

Genetic4

Connective tissue1

Metabolic5

Mice's skin2

Embryonic2

Induces1

Polydactyly2

Trichorrhexis2

Tumor4

Chromosomal1

Humans7

Congenital2

Embryos6

Characteristic1

Knockout mice2

Occurs2

Exposure5

Clinically3

Severity2

Transgenic mouse1

Organs4

Defects3

Musculus2

Synthesis3

Disease5

Behavioral4

Vivo4

Hair4

DGAT22

Nervous system2

Tissues2

Cancers2

Neonatal1

Liver8

Mutant3

Rash2

Stem cells3

Scalp skin1

Resistant to diet-induced obesity1

CDNA2

Human6

Systemic6

Lack3

Inflammation3

Differentiation4

Syndrome3

Bone marrow1

DGAT11

Chromosome1

Genes4

Growth1

Accumulation3

Model2

Blood4

Cells6

Lesions1

Barrier function2