• As noted previously, MSCs are self-renewable multipotent progenitor cells that have the potential to differentiate into various lineages. (medscape.com)
  • [ 9 ] Whereas bone marrow MSCs represent a rare population of cells that make up only 0.001 to 0.01% of total nucleated cells and are 10-fold less abundant than hematopoietic stem cells, they can be readily grown and expanded in culture. (medscape.com)
  • However, the source tissue for studies of MSCs has recently been expanded to cells deriving from virtually all tissues including muscle, adipose tissue, and umbilical cord blood. (medscape.com)
  • MSCs generally lack specific cell surface markers of hematopoietic cells (CD14, CD34, CD11a/LFA-1, and CD45), erythrocytes (glycophorin A), and platelet and endothelial cell adhesion molecules (CD31). (medscape.com)
  • [ 16 ] Additionally, reports exist proposing negative selection to exclude hematopoietic stem cells, or using positive selections for some of the MSC markers for the purpose of enriching MSCs. (medscape.com)
  • The transplantation of mesenchymal stem cells (MSCs) in patients with premature ovarian failure (POF) could lead to clinical improvement. (nih.gov)
  • Mesenchymal stem cells (MSCs) also known as mesenchymal stromal cells or medicinal signaling cells are multipotent stromal cells that can differentiate into a variety of cell types, including osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells) and adipocytes (fat cells which give rise to marrow adipose tissue). (wikipedia.org)
  • While the terms mesenchymal stem cell (MSC) and marrow stromal cell have been used interchangeably for many years, neither term is sufficiently descriptive: Mesenchyme is embryonic connective tissue that is derived from the mesoderm and that differentiates into hematopoietic and connective tissue, whereas MSCs do not differentiate into hematopoietic cells. (wikipedia.org)
  • Mesenchymal stem cells (MSCs), a term first coined by Arnold I. Caplan in 1991, are characterized morphologically by a small cell body with a few cell processes that are long and thin. (wikipedia.org)
  • However, MSCs are found in much higher concentration in the Wharton's jelly compared to cord blood, which is a rich source of hematopoietic stem cells. (wikipedia.org)
  • These cells have several advantages over bone-marrow-derived MSCs. (wikipedia.org)
  • MSCs have been seen to even differentiate into neuron-like cells, but doubt remains about whether the MSC-derived neurons are functional. (wikipedia.org)
  • Mesenchymal stem cells (MSCs) have been demonstrated to have a therapeutic effect on many central nervous system (CNS) diseases by regulating inflammation and other mechanisms. (biomedcentral.com)
  • In vivo, 8- to 10-week-old mice were infected intraperitoneally with JEV and syngeneic bone marrow MSCs were administered through the caudal vein at 1 and 3 days post-infection. (biomedcentral.com)
  • Additionally, the VL was decreased in Neuro2a cells in the presence of MSCs accompanied by increased expression of interferon-α/β. (biomedcentral.com)
  • MSCs have the capacity for immunoregulation, the potential to migrate to the injury site, and the ability to differentiate into multiple cell types such as adipocytes, osteocytes, chondrocytes, and neuron-like cells. (biomedcentral.com)
  • It has been reported that transplantation of MSCs can upregulate the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), and can improve neurological recovery in many CNS diseases [ 20 - 23 ]. (biomedcentral.com)
  • Mesenchymal stem cells (MSCs) are multipotent stem cells with abundant source, active proliferation, and multidirectional differentiation potential. (hindawi.com)
  • MSCs play a role through cell homing, secretion of active factors, and participation in immune regulation. (hindawi.com)
  • Another advantage is that, compared with embryonic stem cells, there are fewer ethical factors involved in the application of MSCs. (hindawi.com)
  • Mesenchymal stem cells (MSCs) have shown promising potential to regenerate periodontal tissue in various preclinical and clinical studies. (biomedcentral.com)
  • The poor survival rate of MSCs during in vivo transplantation and host immunogenic reaction towards MSCs are the main drawbacks of direct use of MSCs in periodontal tissue regeneration. (biomedcentral.com)
  • Different cell types such as bone marrow MSCs (BMSCs), periodontal ligament stem cells (PDLSCs), dental pulp stem cells (DPSC) are key stem cells used in stem cell-based periodontal regeneration [ 19 ]. (biomedcentral.com)
  • There are emerging evidences linking osteoporosis and stem cell defects, including osteoblast-progenitors (mesenchymal stem cells, MSCs) residing in the bone marrow [ 9 ], so it has been hypothesized that such cells from in vitro culture might be infused back to osteopenic subjects in order to replenish their stem cell pool, which would result in a positive bone balance and ultimately the regeneration of the osteopenic skeleton. (biomedcentral.com)
  • The main benefits of ADSCs in therapeutic applications, as compared with bone marrow-derived MSCs, are that adipose tissue is readily accessible and relatively abundant, and the stem cell population can be easily harvested by simple methods, such as lipoaspiration or surgical resection, and can be rapidly expanded ex vivo [ 14 ]. (biomedcentral.com)
  • Mesenchymal stem cells (MSCs) were derived from mouse bone marrow or human umbilical cord blood and subsequently differentiated into insulin-producing cells. (vinastemcelllab.com)
  • Mesenchymal stem cells (MSCs) are a promising cell source for the treatment of ischemic stroke. (molcells.org)
  • Mesenchymal stem cells (MSCs) are one of the most commonly used types of stem cells in therapy. (transhumanist-party.org)
  • The cells into which MSCs can transform (differentiate) include osteoblasts (bone cells), chondrocytes (cartilage cells), myocytes (muscle cells), and adipocytes (fat cells). (transhumanist-party.org)
  • MSCs are of great interest to aging researchers and are arguably one of the most well studied and understood types of stem cells. (transhumanist-party.org)
  • While MSCs are considered immune privileged and can evade immune surveillance, they do not engraft into host tissue and die within 3-10 days post-transplantation. (nih.gov)
  • AFS cells and bone marrow-derived mesenchymal stem cells (MSCs) were resuspended in fibrin-collagen gel and "printed" over the wound site. (indexindex.com)
  • However, tracking of fluorescently labeled AFS cells and MSCs revealed that the cells remained transiently and did not permanently integrate in the tissue. (indexindex.com)
  • Accordingly, we performed proteomic analysis, which showed that AFS cells secreted a number of growth factors at concentrations higher than those of MSCs. (indexindex.com)
  • Dr. Mezey is interested in the biology of bone marrow stromal cells (MSCs). (nih.gov)
  • In addition, they are studying how MSCs might regulate red cell production in the bone marrow of patients with anemia. (nih.gov)
  • Dr. Mezey's group collaborates with clinicians to find out the best ways to use the unique properties of these cells in patients, and to prime MSCs for targeted use. (nih.gov)
  • At NIDCR, Dr. Mezey established the Adult Stem Cell Section to study the biology of bone marrow derived stem cells (MSCs). (nih.gov)
  • OBJECTIVE: Mesenchymal stem cells (MSCs) are known to be capable of suppressing immune responses, but the molecular mechanisms involved and the therapeutic potential of MSCs remain to be clarified. (ox.ac.uk)
  • RESULTS: Our results demonstrate that matrix metalloproteinases (MMPs) secreted by MSCs, in particular MMP-2 and MMP-9, play an important role in the suppressive activity of MSCs by reducing surface expression of CD25 on responding T-cells. (ox.ac.uk)
  • Blocking the activity of MMP-2 and MMP-9 in vitro completely abolished the suppression of T-cell proliferation by MSCs and restored T-cell expression of CD25 as well as responsiveness to interleukin-2. (ox.ac.uk)
  • In addition, we provide a novel insight into the mechanism underlying the suppressive effects of MSCs on T-cell responses to alloantigen. (ox.ac.uk)
  • These dental stem cells are considered mesenchymal stem cells (MSCs) and possess different levels of capacities to become specific tissue forming cells. (bvsalud.org)
  • MSCs are often utilized for cell transplantation directly into tissues, or seeded in biomaterial scaffolds to repair tissues, such as bone or cartilage defects. (nih.gov)
  • This session will discuss the current state of the science in stem cell research, including the biology of ESCs, iPSCs, and ASCs (with the emphasis on MSCs), their potential applications, as well as advantages and disadvantages, and opportunities for future NIAMS-funded research. (nih.gov)
  • The standard test to confirm multipotency is differentiation of the cells into osteoblasts, adipocytes and chondrocytes as well as myocytes. (wikipedia.org)
  • In this study, a comparative analysis of gene expression profiling using cDNA microarray and realtime-PCR indicated that Zinc finger protein 467 (Zfp467) involved in adipocyte and osteoblast differentiation of cultured adipose derived stem cells (ADSCs). (biomedcentral.com)
  • Initially, Dick and colleagues identified the leukemia-initiating cluster of differentiation (CD)-34 + CD38 - cells from acute myeloid leukemia (AML) and showed that these cell fractions have differentiation and self-renewal capacities using serial transplantation in immunodeficient mice ( 1 ). (frontiersin.org)
  • CSCs share several common characteristics with normal stem cells, including self-renewal capacity, asymmetric division, and differentiation potential ( 2 - 4 ). (frontiersin.org)
  • Cell-biology-related research on preadipocyte (adiposal-mesenchymal cell) differentiation laid the foundation for discoveries of adipose-derived cells (both in stromal vascular fraction, or SVF, and adipose-derived stromal/stem cells, or ASCs), which had become an increasing interest to both stem cell biologists and clinicians because of their potential for angiogenesis and suppression of inflammation for tissue engineering and treatments. (scirp.org)
  • Evaluation of APP695 Transgenic Mice Bone Marrow Mesenchymal Stem Cells Neural Differentiation for Transplantation. (en-journal.org)
  • Inhibitory effects of growth differentiation factor 11 on autophagy deficiency-induced dedifferentiation of arterial smooth muscle cells. (en-journal.org)
  • Interleukin-17 ( IL-17 ) is characteristic cytokines of CD4 + cells and the group of Th17 cells secrete, the lack of estrogen will lead to increased Th17 cell differentiation, showed that IL-17 plays an important role in the formation of osteoclast [ 8 ]. (biomedres.info)
  • Stem cells obtained from amniotic fluid show high proliferative capacity in culture and multilineage differentiation potential. (indexindex.com)
  • A session at the 2006 NIAMS Scientific Retreat focused on the biology of stem cells in muscle and skin, with an emphasis on identification and characterization of the stem cell populations, regulation of stem cell maintenance within the stem cell niche, control of differentiation of stem cell progeny to more mature cell types, and the roles that the stem cells play in tissue homeostasis and the repair of tissue injury. (nih.gov)
  • The NIAMS investment in human iPSCs is currently limited to a very small number of projects studying the reprogramming process, creating safer and more efficient ways to generate patient-specific iPSCs for gene and cell-based therapies, investigating disease pathogenesis and studying differentiation of stem cell progeny. (nih.gov)
  • Transcriptomics confirm the establishment of a liver-immune dual-humanized mouse model after transplantation of a single type of human bone marrow mesenchymal stem cell. (harvard.edu)
  • Furthermore, we demonstrated in vitro that UMSCs inhibit the adhesion and invasion of inflammatory cells and also the polarization of M1 macrophages. (nih.gov)
  • These stem cells are capable of differentiating into chondrocytes, cardiomyocytes, melanocytes, and hepatocyte‐like cells in vitro. (wikipedia.org)
  • 1. Long-term health in recipients of transplanted in vitro propagated spermatogonial stem cells. (nih.gov)
  • 11. Propagation of human spermatogonial stem cells in vitro. (nih.gov)
  • Eldad Melamed at Tel Aviv University, Israel, described how his team converted mesenchymal stem cells to astrocytes in vitro. (alzforum.org)
  • The most significant result was however seen with Rac1 silencing, which demonstrated decreased expression of apoptotic proteins, enhanced in vitro survival ratio, reduction in TBI lesional volume and significant improvement in neurological function post shRac1-BMMSCs transplantation. (aging-us.com)
  • We continuously exposed the human prostate epithelial stem/progenitor cell line WPE-stem to an environmentally relevant level of arsenic (5 μM) in vitro and determined the acquired cancer phenotype. (nih.gov)
  • The burgeoning preclinical and clinical experience with human adult adipose-derived cells appears to be promising but interpretation of the current literature with in vitro studies, translational research and FDA-registered investigations emphasizes the need for standardized methods to advance basic science knowledge and beneficial safe clinical outcomes. (scirp.org)
  • Characterization of these cells were carried out by using in vitro two- and three-dimensional cultures and in vivo reconstitution of mice after orthotopic or intravenous injection, in conjunction with quantitative reverse transcription polymerase chain reaction, Western blotting, immunohisto(cyto)chemistry/immunofluorescence, and RNA seq analysis. (nih.gov)
  • In parallel, we showed that AFS cell-conditioned media induced endothelial cell migration in vitro. (indexindex.com)
  • Cardiomyogenic potential of human adult bone marrow mesenchymal stem cells in vitro. (geneticsmr.com)
  • Cardiomyocytes can be generated from marrow stromal cells in vitro. (geneticsmr.com)
  • By advances in understanding phenotype and function of dendritic cells, several protocols have been described for in-vitro generation of tolerogenic dendritic cells (tolDCs). (ac.ir)
  • Important insight gain from in-vitro studies and animal models have led to the development of clinical use of tolerogenic dendritic cells for treating autoimmune diseases. (ac.ir)
  • Rahavi H, Hashemi SM, Soleimani M, Mohammadi J, Tajik N. Adipose tissue-derived mesenchymal stem cells exert in vitro immunomodulatory and beta cell protective functions in streptozotocin-induced diabetic mice model. (ac.ir)
  • This soluble decoy receptor showed anti-tumor effects in vitro and in vivo using mouse MM1.R and INA-6 tumor models. (ancell.com)
  • 1.63 m in diameter) were used as the date, single cells have been imaged in vitro in culture superparamagnetic label. (nih.gov)
  • This method was recently extended to that these particles are efficiently endocytosed by a wide visualizing single cells and single particles in in vitro variety of cell types, with labeling capacity as high as embryo samples by MRI (7). (nih.gov)
  • Mesenchymal stem cells are heterogenous adult multipotent stromal cells that can be isolated from various sources including: bone marrow, peripheral blood, umbilical cord blood, dental pulp, and adipose tissue. (intechopen.com)
  • Previous clinical trials of muscle progenitor cell transplantation for the treatment of muscular dystrophy were not successful, due to the poor survival of the transplanted cells. (nih.gov)
  • [ 1 ] By low-density culturing of bone marrow on plastic culture dishes, Friedenstein and colleagues were able to discard nonadherent hematopoietic stem cells and identify plastic-adherent cells or colony-forming unit fibroblasts, which were later introduced largely by Owen [ 5 ] as mesenchymal stromal cells. (medscape.com)
  • CRISPR-Cas9-AAV versus lentivector transduction for genome modification of X-linked severe combined immunodeficiency hematopoietic stem cells. (harvard.edu)
  • Decreased expression of ITGB1 correlates with acquiring multidrug resistance of tumor cells in the presence of anti-tumor drug. (thermofisher.com)
  • Consistent with tumor-derived CSCs, As-CSCs formed abundant free-floating spheres enriched in CSC-like cells, as confirmed by molecular analysis and the fact that only these floating cells formed xenograft tumors. (nih.gov)
  • Cancer stem cell (CSC) is a subpopulation of tumor cells, which is known to account for 1-2% of tumors. (frontiersin.org)
  • To obtain clinical insight on its function in lung cancer, microarray data from lung tumor tissues (LTTs) and matched lung normal tissues (mLNTs) of primary non-small cell lung cancer (NSCLC) patients (n = 37) were utilized. (bvsalud.org)
  • Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. (thermofisher.com)
  • Tumor-Associated Macrophages promote cancer stem cell-like properties via transforming growth factor-beta1-induced epithelial-mesenchymal transition in hepatocellular carcinoma. (stembook.org)
  • Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies" doi: 10.1136/jitc-2022-005018. (ancell.com)
  • Role of inositol phospholipid signaling in natural killer cell biology. (utah.edu)
  • The cell biology of adipocytes has led to a number of promising concepts in the last century, especially in the areas of obesity and associated diseases, lipid homeostasis and endocrine functions. (scirp.org)
  • Since the specialty of Plastic Surgery with its position statement on stem cells and fat grafting is committed to advancing evidence-base preclinical and clinical studies in compliance with FDA-regulations, an updated review of cell biology provides insights to achieve these goals. (scirp.org)
  • In 1989, after 15 years of research in the N. K. Koltzov Institute of Developmental Biology, Dr. Tomarev joined NEI, where he leads the Section on Retinal Ganglion Cell Biology. (nih.gov)
  • Mesenchymal stem cells: biology and potential clinical uses. (geneticsmr.com)
  • Dr. Mezey came to NIH as a postdoctoral fellow in the Laboratory of Cell Biology at NIMH and later at NINDS. (nih.gov)
  • These grants were funded as a result of a Request for Applications, "Basic and Applied Stem Cell Research for Arthritis and Musculoskeletal Diseases," which resulted from the conference, Stem Cell Biology: Potential and Promise, in June 2000. (nih.gov)
  • Much of the NIAMS investment in stem cells has focused on the biology and application of adult stem cells, including bone marrow derived mesenchymal stem cells (MSC), stem cells and satellite cells obtained from skeletal muscle, and keratinocyte and other multipotent stem cells obtained from skin. (nih.gov)
  • There have been rapid advances in the biology and understanding of stem cells in the last three years. (nih.gov)
  • Although more success has been achieved in preclinical trials on the use of mesenchymal stem cells in animal models than in human clinical trials, particularly in septic shock and Chagas disease, more progress has been made in both disorders after the recent use of specific sources and certain doses of mesenchymal stem cells. (intechopen.com)
  • The results from recent preclinical studies regarding stem cell-based therapies are promising. (hindawi.com)
  • Impact of timing and dose of mesenchymal stromal cell therapy in a preclinical model of acute myocardial infarction. (geneticsmr.com)
  • Preclinical studies have shown that ST266 reduces eye inflammation in damaged corneas and enhances re-epithelialization by cells that form the cornea. (noveome.com)
  • In preclinical studies, ST266 has been shown to be neuroprotective and to resuscitate damaged and diseased retinal ganglion cells, offering the possibility of a novel treatment for glaucoma. (noveome.com)
  • [ 14 ] In other tissues, upon receiving appropriate biological signals during tissue injury or inflammation, they may differentiate into specialized cells and play a pivotal role in tissue repair and/or control of inflammation in situ. (medscape.com)
  • Stromal cells are connective tissue cells that form the supportive structure in which the functional cells of the tissue reside. (wikipedia.org)
  • The term encompasses multipotent cells derived from other non-marrow tissues, such as placenta, umbilical cord blood, adipose tissue, adult muscle, corneal stroma, or the dental pulp of deciduous (baby) teeth. (wikipedia.org)
  • 14. Evaluation of apoptotic- and autophagic-related protein expressions before and after IVM of fresh, slow-frozen and vitrified pre-pubertal mouse testicular tissue. (nih.gov)
  • The results of the present study demonstrated that nicergoline ameliorated apoptosis in hippocampal cells and hippocampus tissue in 3xTg‑AD mice with Alzheimer's disease. (spandidos-publications.com)
  • Because of their biological characteristics, mesenchymal stem cells can regulate immunologic mechanisms and repair the uterus, ovaries, and oviductal tissue. (hindawi.com)
  • ITGB1 is up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue. (thermofisher.com)
  • This suggests the role of stem cell-released signaling molecules and factors on tissue regeneration. (biomedcentral.com)
  • This has relevance to therapeutic interventions in osteoporosis, including si-Zfp467-based therapies currently available, and may be of relevance for the use of adipose-derived stem cells for tissue engineering. (biomedcentral.com)
  • Ensuing specialists later determined that this multifunctional organ contained a number of valuable resident cells, other worthy non-indigenous cellular populations and a quantity of distinct structural elements, which possessed the potential to optimize fat graft survival and eventually further tissue engineering applications in regenerative medicine. (scirp.org)
  • Studies of thyroid stem/progenitor cells have been hampered due to the small organ size and lack of tissue, which limits the yield of these cells. (nih.gov)
  • There is an urgent critical need for the development of clinically relevant tissue-engineered large bone substitutes that can promote early vascularization after transplantation. (desktopmetal.com)
  • To promote rapid blood vessel growth in the engineered tissue, we preincubated aortic fragments, as well as, co-cultures of aortic fragments and osteoblast-like cells in matrigel-filled PLGA scaffolds before implantation into the dorsal skinfold chambers of balb/c mice. (desktopmetal.com)
  • In an attempt to accelerate the vascularization of tissue engineering constructs we compared the usage of bone marrow mesenchymal stem cells (bmMSCs) and fragments derived from the aorta in vivo. (desktopmetal.com)
  • Comparison of in vivo immunomodulatory effects of intravenous and intraperitoneal administration of adipose-tissue mesenchymal stem cells in experimental autoimmune encephalomyelitis (EAE). (ac.ir)
  • therefore, cellular grafts such as basal cell layer-enriched epidermal suspension are preferred over tissue grafts when a large area is to be treated. (e-ijd.org)
  • Ancell CD166/FITC used as a Mesenchymal marker to characterize Adipose Tissue-Derived Multilineage Progenitor cells (ADMPC) used for Periodontal transplant. (ancell.com)
  • Periodontal Regeneration by Allogeneic Transplantation of Adipose Tissue Derived Multi-Lineage Progenitor Stem Cells in vivo. (ancell.com)
  • This study examines how musculoskeletal stem cells contribute to the repair and remodeling of connective tissue. (nih.gov)
  • to tissue, following cell labeling and transplantation. (nih.gov)
  • Some specific applications in- Primary mouse hepatocytes were labeled with both su- clude stem cell tracking to damaged myocardium (1), early perparamagnetic and fluorescent agents, and transplanted detection of tissue rejection (2), early detection of cancer into the spleens of recipient mice. (nih.gov)
  • The key elements of tissue engineering are stem cells, morphogen, and a scaffold of extracellular matrix. (bvsalud.org)
  • Postnatal stem cells have been sourced from umbilical cord blood, umbilical cord, bone marrow, peripheral blood, body fat, and almost all body tissues, including the pulp tissue of teeth 8 . (bvsalud.org)
  • Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
  • In adult tissues, somatic stem cells are essential for normal homeostasis and tissue repair. (nih.gov)
  • There is currently considerable enthusiasm for the potential use of stem cells for tissue engineering and regenerative medicine. (nih.gov)
  • Stem cell-based therapies cast a new hope for infertility treatment as a replacement or regeneration strategy. (hindawi.com)
  • Stem cell-based periodontal regeneration is currently at the center of attention [ 18 ]. (biomedcentral.com)
  • Because of the lack of significant immunogenicity and the ability of the amniotic fluid-derived stem (AFS) cells to modulate the inflammatory response, we investigated whether they could augment wound healing in a mouse model of skin regeneration. (indexindex.com)
  • Stem cells are sometimes used in the body for regeneration. (nih.gov)
  • This project uses a mouse model of osteogenesis imperfecta (brittle bone disease) to evaluate possibilities of regeneration or repair of bone marrow using mouse stem cells. (nih.gov)
  • There are limited numbers of publications about ES cells in pulp regeneration, due to the restricted policies regarding ES cell research over the past few years. (bvsalud.org)
  • [ 8 ] While the acronym MSC has become the predominant term used within the literature, no matter what terminology one chooses to use, the field investigating these cells has grown rapidly because of the marked potential in terms of therapeutic exploitation. (medscape.com)
  • They have certain immunomodulatory, immunosuppressive, and antimicrobial properties that enable them to have several therapeutic and clinical applications including: treatment of autoimmune disorders, role in hematopoietic stem cell transplantation and regenerative medicine, as well as treatment of various infections and their associated complications such as septic shock and acute respiratory distress syndrome. (intechopen.com)
  • Intravenous administration of mesenchymal stem cells (IV-MSC) protects the ischemic rat brain in a stroke model, but the molecular mechanism underlying its therapeutic effect is unclear. (molcells.org)
  • Mesenchymal stem cells (MSC) present remarkable immunomodulatory ability, and these cells are potential therapeutic agents for autoimmune disorders. (biomedcentral.com)
  • This had the dual effect of prolong MSC lifetimes (as they are succeptible to death by cytotoxic T-cells), but also essentially potentiating therapeutic MSC effects as they are used primarily for anti-inflammatory purposes. (nih.gov)
  • For instance, in bone marrow, they are reported to represent the precursor cell for stromal tissues that support hematopoiesis. (medscape.com)
  • He is also investigating the ability of a cell therapy approach to treating GVHD with mesenchymal stromal cell (MSC) infusions, which can both suppress the harmful immune reaction and help repair tissues damaged by GVHD. (nih.gov)
  • To accelerate the microvascular development in engineered tissues, we preincubated osteoblast-like cells as well as mesenchymal stem cells or a combination of both cell types in Matrigel-filled PLGA scaffolds before transplantation into the dorsal skinfold chambers of balb/c mice. (desktopmetal.com)
  • Scientists are also looking at how stem cells may regenerate or repair these tissues. (nih.gov)
  • All tissues originate from stem cells. (bvsalud.org)
  • A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)
  • The NIAMS has made a significant investment in stem cell research, as it pertains to NIAMS relevant tissues. (nih.gov)
  • Corticosterone mediates the inhibitory effect of restraint stress on the migration of mesenchymal stem cell to carbon tetrachloride-induced fibrotic liver by down-regulating CXCR4/7 expression. (stembook.org)
  • WPE-stem cells rapidly acquired a malignant CSC-like phenotype by 18 weeks of exposure, becoming highly invasive, losing contact inhibition, and hypersecreting matrix metalloproteinase-9. (nih.gov)
  • Mesenchymal stem cells prevent the rejection of fully allogenic islet grafts by the immunosuppressive activity of matrix metalloproteinase-2 and -9. (ox.ac.uk)
  • Therefore, in this article, we summarize the current status of mesenchymal stem cell therapies in infertility pathophysiology and discuss potential areas of further research in regenerative medicine. (hindawi.com)
  • Stem-cell therapy holds tremendous potential and promises to enhance treatment efficiency by overcoming the limitations of traditional therapies. (vinastemcelllab.com)
  • Mesenchymal stem cells (MSC) are used to treat some autoimmune diseases and are considered a safer agent when patients are resistant to these conventional therapies mentioned above [ 3 ]. (biomedcentral.com)
  • Aging research has made significant progress in the last few years, with senescent-cell-clearing therapies entering human trials this year, DNA repair in human trials, and a number of other exciting therapies nearing human testing. (transhumanist-party.org)
  • In the latest development, EHFORSCS, which is an enriched source of follicular inactive melanocyte (melanocyte stem cells), seems to be a good addition to the prevailing cell-based therapies for vitiligo. (e-ijd.org)
  • This study investigates the growth factors and hormones that influence how stem cells develop, which should guide the development of therapies in bone diseases. (nih.gov)
  • Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies. (bvsalud.org)
  • This explains why researchers are now focusing attention on developing stem cell therapies using postnatal stem cells donated by the patients themselves or their close relatives. (bvsalud.org)
  • Developing new technologies to isolate, characterize, cultivate, and manipulate stem cells of the digestive system may provide new approaches to understand the pathogenesis and develop new therapies for digestive diseases. (nih.gov)
  • Patient-specific iPS cell lines have now been reported for several diseases, providing the tools for studies of disease pathogenesis, for screening of drugs, and for the combined gene and cell-based therapies for genetic defects. (nih.gov)
  • however, there are persistent concerns that ex vivo-expanded CD34 cells may lose pluripotency and the ability to contribute meaningfully to long-term engraftment. (nih.gov)
  • To address this issue, we transduced CD34-selected UCB cells with a lentiviral construct expressing luciferase, and determined homing and engraftment patterns in vivo by noninvasive bioluminescent imaging in sublethally irradiated NOD/SCID/IL-2Rgamma(-/-) (NSG) mice. (nih.gov)
  • The results suggest that multipotent stem cells can be expanded ex vivo and can contribute meaningfully to long-term hematopoietic engraftment. (nih.gov)
  • Methods We therefore investigated the in vivo incorporation of collagen-coated and cell-seeded poly-L-lactide-co-glycolide scaffolds in diabetic B6.BKS(D)-Leprdb/J mice using repetitive intravital fluorescence microscopy over a time period of two weeks. (desktopmetal.com)
  • In vivo immunomodulatory effects of adipose-derived mesenchymal stem cells conditioned medium in experimental autoimmune encephalomyelitis. (ac.ir)
  • For in vivo studies, 200 μl of CM from the ALS iPSCs (CS07 and CS053) was injected subcutaneously into the ALS model mice (transgenic for the human SOD1 G93A mutation). (springer.com)
  • to macrophages (2), and some initial reports have described labeled hepatocyte phantoms in combination with histological in vivo labeling of peripheral T cells (16) and neural stem evaluation confirmed the presence of dispersed single hepato- cells (17). (nih.gov)
  • In this study we used a well developed model for liver determine whether the observed contrast could have been due cell transplantation to demonstrate that single-cell detec- to dead cells or free particles, and the results confirmed that tion in vivo can be achieved with MRI. (nih.gov)
  • MSC treatment alleviated JEV-induced inflammation and mortality in mice. (biomedcentral.com)
  • We aimed to investigate the role of microRNA-146a (miR-146a) in regulating corneal inflammation in a mouse model of benzalkonium chloride (BAC)-induced dry eye and the TNF-α-induced NF-κB signaling pathway in human corneal epithelial cells (HCECs). (bvsalud.org)
  • Predicted pathway analysis revealed that cerebral ischemia activated 10 signaling pathways mainly related to inflammation and cell cycle. (molcells.org)
  • Amelioration of dysregulated inflammation- and cell cycle-related gene expression in the host brain is one of the molecular mechanisms of IV-MSC therapy for cerebral ischemia. (molcells.org)
  • Intratracheal transplantation of bone marrow-derived mesenchymal stem cells reduced airway inflammation and up-regulated CD4 + CD25 + regulatory T cells in asthmatic mouse. (geneticsmr.com)
  • Aged regulatory T cells protect from autoimmune inflammation despite reduced STAT3 activation and decreased constraint of IL-17 producing T cells. (ac.ir)
  • Over time, relapses of this inflammation can lead to vision loss and potentially permanent blindness due to damaged optic nerve cells. (noveome.com)
  • Kupffer cells-dependent inflammation in the injured liver increases recruitment of mesenchymal stem cells in aging mice. (stembook.org)
  • 2. Co-transplantation of mesenchymal stem cells improves spermatogonial stem cell transplantation efficiency in mice. (nih.gov)
  • Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival. (utah.edu)
  • Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. (geneticsmr.com)
  • CD133 specific CAR-macrophages created in situ using NanoPorter hydrogel in combination with CD47 checkpoint blocking antibody improves post operative Glioblastoma survival in a humanized mouse model "Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy" Chen Chen, Xinyi Jiang, et al. (ancell.com)
  • Our results showed that silencing these proteins significantly reduced oxidative stress and cell death/apoptosis, and promoted implanted BMMSCs proliferation after TBI. (aging-us.com)
  • Notably, ARRB2-knockout (ARRB2KO) lung cancer cells exhibited marked enhancements of cancer migration, invasion, colony formation, and proliferation in response to TLR3 and TLR4 stimulation. (bvsalud.org)
  • Autophagy alleviates the decrease in proliferation of amyloid β1‑42‑treated bone marrow mesenchymal stem cells via the AKT/mTOR signaling pathway. (en-journal.org)
  • The immunosuppressive effects of human bone marrow-derived mesenchymal stem cells target T cell proliferation but not its effector function. (geneticsmr.com)
  • 3), and tracking neural stem cell response to stroke (4). (nih.gov)
  • He applies these tools to generate a mechanistic description of how the brain carries out its functions through mapping functional connections and monitoring the activity of individual cells and neural circuits. (nih.gov)
  • When hetero-transplanted, these cells (designated As-CSC) formed highly pleomorphic, aggressive tumors with immature epithelial- and mesenchymal-like cells, suggesting a highly pluripotent cell of origin. (nih.gov)
  • Arsenite transforms prostate epithelial stem/progenitor cells into CSC-like cells, indicating that it can produce CSCs from a model NSC population. (nih.gov)
  • Although assumed, proof of the direct emergence of epithelial CSCs from an NSC population is not available, and the identity of the cells that acquire the molecular lesions initiating chemical carcinogenesis remains undefined ( Perez-Losada and Balmain 2003 ). (nih.gov)
  • Cigarette Smoking Condensate Disrupts Endoplasmic Reticulum-Golgi Network Homeostasis Through GOLPH3 Expression in Normal Lung Epithelial Cells. (en-journal.org)
  • Because ST266 is made from selected and cultured amnion epithelial cells, it may provide many of the same benefits as amniotic fluid. (noveome.com)
  • Mesenchymal stem cells (MSC) have recently attracted interest as a potential basis for a cell-based therapy of AD. (nih.gov)
  • Umbilical cord mesenchymal stem cells (UMSCs) have unique immunosuppressive properties enabling them to evade host rejection and making them valuable tools for cell therapy. (nih.gov)
  • Possible role of combined therapy targeting MET and pro-HGF activation for renal cell carcinoma: analysis by human HGF-producing SCID mice. (harvard.edu)
  • Researchers are exploring diverse strategies, from cell replacement (see Part 1 of this series), to gene therapy, to small molecules that could counteract pathological processes. (alzforum.org)
  • Bone marrow mesenchymal stem cells (BMMSCs)-based therapy has emerged as a promising novel therapy for Traumatic Brain Injury (TBI). (aging-us.com)
  • 1 Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. (nih.gov)
  • Cancer stem cells (CSCs) exhibit intrinsic therapy/stress resistance, which often cause cancer recurrence after therapy. (frontiersin.org)
  • Trang chủ Công trình KHCN Bài báo ngoài nước Improving the efficacy of type 1 diabetes therapy by transplantation of immunoisolated. (vinastemcelllab.com)
  • Improving the efficacy of type 1 diabetes therapy by transplantation of immunoisolated insulin-producing cells. (vinastemcelllab.com)
  • Pancreas- or islet-grafting therapy offers highly efficient treatment but is limited by inadequate donor islets or pancreases for transplantation. (vinastemcelllab.com)
  • In this study, we included studies on mice to assess the efficacy of MSC in the therapy of lupus nephritis in mice, in order to draw a more robust result for the effectiveness of MSC treatment for lupus nephritis. (biomedcentral.com)
  • In this article, Mr. Steve Hill discusses two very promising human clinical trials using stem cell therapy for age-related frailty. (transhumanist-party.org)
  • The first results of two human clinical trials using stem cell therapy for age-related frailty have been published, and the results are very impressive indeed. (transhumanist-party.org)
  • Stem cell therapy for pediatric dilated cardiomyopathy. (geneticsmr.com)
  • Current research in Stem Cell Transplantation (SCT) focuses on improving transplant outcome through immune manipulations using cell therapy and lymphocyte growth factors. (nih.gov)
  • At the end of this review, we discuss the challenge faced in further developing of tolerogenic dendritic cell therapy in autoimmunity. (ac.ir)
  • Stem Cell Therapy for Diseases of Bone in a Mouse Model , Christopher Niyibizi, Ph.D., University of Pittsburgh, Pa. (nih.gov)
  • The specific medications administered depend on the choice of therapy and whether it is supportive care only, immunosuppressive therapy, or hematopoietic cell transplantation. (medscape.com)
  • The accomplishments have sparked renewed interest in exploring cell therapy clinical trials for the dystrophies. (nih.gov)
  • Bioluminescent Monitoring of Graft Survival in an Adoptive Transfer Model of Autoimmune Diabetes in Mice. (harvard.edu)
  • Evidence suggests that nicergoline serves an important role in the apoptosis of hippocampal cells, memory recovery, cognitive function and neuronal survival. (spandidos-publications.com)
  • Additionally, two RNA-seq hub genes ( VEGFA and MMP-2 ) were identified to play critical roles in shRac1-mediated cell survival. (aging-us.com)
  • In summary, we propose that knockdown of Rac1 gene could significantly boost cell survival and promote the recovery of neurological functions after BMMSCs transplantation in TBI mice. (aging-us.com)
  • The benefits of organ transplantation, as evidenced by prolonged survival and/or improved quality of life, have been clearly demonstrated for children and adults suffering from a wide range of congenital and acquired diseases. (nih.gov)
  • Although 1-year survival after organ transplantation has improved markedly over the last 15 years, the prevalence of morbidities such as systemic hypertension, diabetes mellitus, renal insufficiency, and malignancy remain high in transplant recipients as compared with the general population. (nih.gov)
  • MiR146a represents one of the best characterized regulators of the immune response, as well as cellular survival through the negative feedback inhibition of nuclear factor-kappa B (NF-ĸB) signaling in myeloid cells. (bvsalud.org)
  • Mesenchymal Stem Cells Enhance Angiogenesis and Follicle Survival in Human Cryopreserved Ovarian Cortex Transplantation. (stembook.org)
  • [ 15 ] Finally, their ability to differentiate into several mesenchymal lineages has also been used as an identity marker. (medscape.com)
  • Stem cells are characterized by both the ability to renew themselves, as well as to generate progeny that differentiate into more specialized cells. (nih.gov)
  • We find that transplantation of young mesenchymal stem cells significantly slows the loss of bone density and, surprisingly, prolongs the life span of old mice. (foreverlabs.com)
  • A disadvantage to the use of UCB for HSCT is that immune reconstitution may be significantly delayed because of the low stem cell dose available in the graft. (nih.gov)
  • Area stained for CD45 significantly increased in rTg4510 mice at 9 months of age in the anterior cortex and hippocampus compared with nontransgenic littermates or with younger mice. (bio-rad-antibodies.com)
  • At days 0, 7, and 14, AFS cell- and MSC-driven wound closure and re-epithelialization were significantly greater than closure and re-epithelialization in wounds treated by fibrin-collagen gel only. (indexindex.com)
  • By the use of preincubated mesenchymal stem cells, a significantly accelerated angiogenesis was achieved. (desktopmetal.com)
  • 5. Does co-transplantation of mesenchymal and spermatogonial stem cells improve reproductive efficiency and safety in mice? (nih.gov)
  • 7. Spermatogonial stem cell preservation and transplantation: from research to clinic. (nih.gov)
  • 8. Efficient and safe recipient preparation for transplantation of mouse spermatogonial stem cells: pretreating testes with heat shock. (nih.gov)
  • 10. Testicular Busulfan Injection in Mice to Prepare Recipients for Spermatogonial Stem Cell Transplantation Is Safe and Non-Toxic. (nih.gov)
  • 15. Spermatogonial stem cell autotransplantation and germline genomic editing: a future cure for spermatogenic failure and prevention of transmission of genomic diseases. (nih.gov)
  • 16. Testicular injection of busulfan for recipient preparation in transplantation of spermatogonial stem cells in mice. (nih.gov)
  • 19. Establishment of recipient model for spermatogonial stem cells transplantation in Kunming mice. (nih.gov)
  • These findings support the hypothesis that MSC-transplants may affect AD pathology via an immune-modulatory function that includes an effect on microglial cells. (nih.gov)
  • SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice. (harvard.edu)
  • Immune reactions after transplantation were monitored by counting total white blood cells. (vinastemcelllab.com)
  • Here, we describe an optimized lipid nanoparticle (LNP) strategy for the delivery of miRNA mimics to myeloid immune cells and provide detailed protocols for characterization of LNP complexes and their biological activity. (bvsalud.org)
  • Stem cell transplantation offers the chance of cure for leukemia patients through a unique graft-versus-leukemia GVL effect conferred by an immune reaction of the donor graft against the patient's leukemia. (nih.gov)
  • Dr Barrett's approach to improve SCT outcome is to generate in the laboratory immune cells from the donor that are capable of fighting viruses and leukemia without causing GVHD. (nih.gov)
  • An emerging concept from this work is that leukemia cells develop multiple ways to switch off the immune response that might otherwise successfully eradicate the leukemia. (nih.gov)
  • Furthermore the group plans to develop a comprehensive knowledge of the antigens on leukemia cells that render them targets for immune attack. (nih.gov)
  • These cells are able to suppress the immune system and have been tested in autoimmune diseases. (nih.gov)
  • Her group studies ways in which to improve the efficiency of these cells in fighting auto-immune diseases. (nih.gov)
  • Dendritic cells (DCs) are special antigen-presenting cells that are important for activation of immune response and tolerance. (ac.ir)
  • However, there have been significant advances in animal models using improved stem cell preparations, vascular delivery, and strategies to suppress the immune response or to induce tolerance to the transplanted cells. (nih.gov)
  • Multiple myeloma cells induce lipolysis in adipocytes and uptake fatty acids through fatty acid transporter proteins. (harvard.edu)
  • Recent advances in adipogenesis had provided insights into understanding of the complex cues for influencing the cytoarchitecture, epigenomic remodeling, signaling pathways and transcription regulators on gene actions for both white and brown adipogenic progression from mesenchymal stem cells to matured committed adipocytes. (scirp.org)
  • Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma. (harvard.edu)
  • SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging. (utah.edu)
  • The use of umbilical cord blood (UCB) grafts for hematopoietic stem cell transplantation (HSCT) is a promising technique that permits a degree of human leukocyte antigen mismatch between the graft and the host without the concomitant higher rate of graft-versus-host disease that would be observed between an adult marrow graft and a mismatched host. (nih.gov)
  • These studies focus on using adult stem cells to treat bone and muscle that may have been altered by disease. (nih.gov)
  • Development of a GFP Sensitive Apoptosis Marker Gene , David W. Rowe, M.D., University of Connecticut School of Medicine, Farmington, Conn. This investigation will follow programmed cell activity-specifically, the life and death of a cell-and show how that activity generates a form of stem cells that are a factor in maintaining adult bone mass. (nih.gov)
  • The most valuable cells for regenerative endodontics are postnatal or adult stem cells. (bvsalud.org)
  • Photomicrograph showing expression of the Lgr5-lacZ reporter gene in the base of small intestinal crypts in adult mice. (nih.gov)
  • Through this type of research, scientists have been able to identify stem cells within the adult intestine that are capable of forming the cell types needed to continually renew this organ throughout life. (nih.gov)
  • This study investigated the putative immunemodulatory effects in neuroinflammation of systemic transplantation of MSC into APP/PS1 transgenic mice. (nih.gov)
  • Impaired function of bone marrow stromal cells in systemic mastocytosis. (nih.gov)
  • These observations suggest that the increased wound closure rates and angiogenesis may be due to delivery of secreted trophic factors, rather than direct cell-cell interactions. (indexindex.com)
  • They express variable levels of CD105 (SH2), CD73 (SH3/4), CD44, stromal antigen 1, and a group of other adhesion molecules and receptors including CD166 (vascular cell adhesion molecule), CD54/CD102 (intracellular adhesion molecule), and CD49 (very late antigen). (medscape.com)
  • This 90 kDa disulfide-linked homodimer is expressed by vascular endothelial cells. (thermofisher.com)
  • CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. (thermofisher.com)
  • The approach has been approved for clinical trials with ALS patients in Israel, Melamed said, and an upcoming small Phase 1/2 trial will be conducted in collaboration with startup company Brainstorm Cell Therapeutics in Petach Tikva, Israel. (alzforum.org)
  • The Clinical Trials in Organ Transplantation (CTOT) program will support a cooperative, multi-institutional consortium for the conduct of interventional trials (Phase 1, 2, or 3) or observational clinical studies in organ or vascularized composite allotransplantation (VCA). (nih.gov)
  • The Barrett group has carried out clinical trials in stem cell transplantation (SCT) as a treatment for leukemia for over 23 years at NIH. (nih.gov)
  • In this review, we describe the different agents and mechanisms for generating tolerogenic dendritic cells, and applying them for induction of specific tolerance and suppressing autoimmune response in animal models and clinical trials. (ac.ir)
  • Outer root sheath cell suspension transfer is a novel, minimally invasive technique in its nascent stage in the surgical management of vitiligo which requires further larger clinical trials for evaluation of its efficacy. (e-ijd.org)
  • Regenerative endodontic procedures can be defined as biologically based procedures designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex. (bvsalud.org)
  • The major areas of research that might have application in the development of regenerative endodontic techniques are (a) postnatal stem cells, (b) scaffold materials, (c) morphogen/growth factors, (d) implantation. (bvsalud.org)
  • Hepatic stellate cells secreted hepatocyte growth factor contributes to the chemoresistance of hepatocellular carcinoma. (stembook.org)
  • These findings suggested that the apoptosis of hippocampal cells is associated with the progression of cognitive impairment, and thus with the onset and development of Alzheimer's disease. (spandidos-publications.com)
  • Hashemi SM, Hassan ZM, Pourfathollah AA, Soudi S, Shafiee A, Soleimani M. Comparative immunomodulatory properties of adipose-derived mesenchymal stem cells conditioned media from BALB/c, C57BL/6, and DBA mouse strains. (ac.ir)
  • ITGB1 is a cell adhesion molecule appearing on platelets, as the common Beta subunit of the very late activation antigen (VLA), and as a component of various protein complexes binding to extracellular matrix proteins. (thermofisher.com)
  • A meta-analysis was performed to assess whether MSC can achieve good efficacy in the treatment of lupus nephritis in mice. (biomedcentral.com)
  • The cells do not have the capacity to reconstitute an entire organ. (wikipedia.org)
  • However, normal life expectancy and health-related quality of life are rarely, if ever, restored by organ transplantation. (nih.gov)
  • Noninvasive imaging of single cells in intact, live organ- sue damage is present in the liver. (nih.gov)
  • As a result, a battery of negative and positive markers is generally used to phenotypically characterize these cells. (medscape.com)
  • Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2. (geneticsmr.com)
  • The phosphatidylinositol 3‑kinase (PI3K)/RAC‑α serine/threonine‑protein kinase (AKT) signaling pathway was additionally analyzed in hippocampal cells following treatment with nicergoline. (spandidos-publications.com)
  • Additionally, amyloid precursor protein accumulation was cleared in the hippocampal area in nicergoline‑treated mice. (spandidos-publications.com)
  • It was additionally demonstrated in the present study that nicergoline improved motor attention impairment and cognitive competence in hippocampal cells by acting on the PI3K/AKT signaling pathway. (spandidos-publications.com)
  • Additionally, because of increased cytokines from stromal cells and osteoblasts that regulated osteoclast generation due to estrogen loss, the number of osteoclasts increased and caused the elevated bone resorption [ 13 ]. (biomedcentral.com)
  • Additionally, NRF2 -silenced HCT116 cells showed attenuated sphere formation capacity and reduced CSC markers expression, indicating the critical role of the NRF2 pathway in the development of CSC-like properties. (frontiersin.org)
  • Immunosuppressive properties of mesenchymal stem cells: advances and applications. (geneticsmr.com)
  • ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells. (harvard.edu)
  • In humans, arsenic is carcinogenic in the urogenital system (UGS), including the bladder and potentially the prostate, whereas in mice arsenic induces multiorgan UGS cancers, indicating that UGS NSCs may represent targets for carcinogenic initiation. (nih.gov)
  • Corticosterone induces neurotoxicity in PC12 cells via disrupting autophagy flux mediated by AMPK/mTOR signaling. (en-journal.org)
  • Overexpression of Nodal induces a metastatic phenotype in pancreatic cancer cells via the Smad2/3 pathway. (stembook.org)
  • The apoptosis rates of hippocampal cells were studied in mice with Alzheimer's disease treated with nicergoline compared with the negative control. (spandidos-publications.com)
  • Apoptosis‑associated gene expression levels in hippocampal cells, and hippocampus area, were analyzed in the experimental mice. (spandidos-publications.com)
  • The data indicated that apoptosis‑associated genes, including caspase‑3, BCL2 associated X, BH3 interacting domain death agonist and caspase‑9, were downregulated in hippocampal cells isolated from nicergoline-treated experimental mice. (spandidos-publications.com)
  • Absalon et al ( 15 ) suggested that the activation of cell cycle entry, MAPT-phosphorylation and the inhibition of apoptosis in post-mitotic neurons through microRNA-regulated gene expression may contribute to the recovery of mice with Alzheimer's disease. (spandidos-publications.com)
  • This study was performed to determine the effects of LIPUS on granulosa cells (GCs) apoptosis and protein expression of B-cell lymphoma-2 (Bcl-2) and BCL2-Associated X (Bax) in 4-vinylcyclohexene diepoxide (VCD)-induced POF mice and investigate the mechanisms of LIPUS on ovarian function and reserve capacity. (biomedcentral.com)
  • The results showed that VCD can induce estrus cycle disorder, follicular atresia, sex hormone secretion decreased and GCs apoptosis in mice to establish POF model successfully. (biomedcentral.com)
  • Apoptosis of oocyte and granulosa cells (GCs) has been identified as one possible underlying mechanism for VCD-induced POF, which leads primordial and primary follicles to be destroyed [ 13 , 14 ]. (biomedcentral.com)
  • B-cell lymphoma-2 (Bcl-2) and BCL2-Associated X (Bax) are regulators of primordial follicle initiation and apoptosis, and the ratio of Bcl-2 /Bax determines whether cell apoptosis occurs when stimulated by apoptosis signal [ 15 , 16 ]. (biomedcentral.com)
  • Our experiments were originally aimed at testing the idea that, in the specific case of age-related osteoporosis, declining function of osteogenic precursor cells might be at least partially responsible. (foreverlabs.com)
  • Briefly, RNA polymerase II transcribes miRNA genes, leading to the formation of long precursor transcripts named primary miRNAs (pri-miRNAs), which have stem-loop structures consisting of hundreds of nucleotides. (biomedcentral.com)
  • [ 3 ] this method for isolation has largely remained the "standard of practice," being the adherence of fibroblast-like cells (when isolating cells recovered from bone marrow) to the plastic substrate of a cell culture plate, together with a concurrent lack of adherence of marrow-derived hematopoietic cells. (medscape.com)
  • Khosrowpour Z, Hashemi SM, Mohammadi-Yeganeh S, Soudi S. Pretreatment of Mesenchymal Stem Cells With Leishmania major Soluble Antigens Induce Anti-Inflammatory Properties in Mouse Peritoneal Macrophages. (ac.ir)