Mice liver glycogen. Medical search. Frequent questions

Protein targeting to glycogen (PTG) is a scaffolding protein that targets protein phosphatase 1α (PP1α) to glycogen, and links it to enzymes involved in glycogen synthesis and degradation. (jci.org)
These mice have reduced glycogen stores in adipose tissue, liver, heart, and skeletal muscle, corresponding with decreased glycogen synthase activity and glycogen synthesis rate. (jci.org)
These data suggest that PTG plays a critical role in glycogen synthesis and is necessary to maintain the appropriate metabolic balance for the partitioning of fuel substrates between glycogen and lipid. (jci.org)
FGF15 is found in the absorptive cells of the mouse ileum and plays an important role in feedback inhibition of hepatic bile acid synthesis. (wikipedia.org)
FGF15 (and FGF19 in humans) function as hormones produced in response to bile acid absorption acting on the farnesoid X receptor FXR, are secreted into the portal venous circulation and bind onto the liver membrane receptor FGFR4/β-Klotho and repress bile acid synthesis by the Cyp7a1 gene. (wikipedia.org)
In a mouse model of chronic diarrhea due to bile acid malabsorption, FGF15 administration, or stimulation of its production, reduced the bile acid loss by inhibiting new synthesis. (wikipedia.org)
It was also demonstrated that PTPϵM suppressed insulin-induced glycogen synthesis and inhibited insulin-induced suppression of phosphoenol pyruvate carboxykinase (PEPCK) expression in primary hepatocytes. (bioone.org)
We show that TG liver developed a substantial transient steatosis, which reached a maximum at postnatal day 5 and is associated with increased expression of hepatic genes involved in fatty acid and triglyceride synthesis, lipid beta-oxidation, and amino acid biosynthesis. (duke.edu)
Insulin inhibits GSK3 by promoting phosphorylation of a serine residue (Ser-21 in GSK3α, Ser-9 in GSK3β), thereby relieving GSK3 inhibition of glycogen synthesis in muscle. (portlandpress.com)
Farnesoid X receptor (FXR) and its regulated target networks in both the liver and the intestines are critical in suppressing BA synthesis and promoting BA transport and enterohepatic circulation. (aspetjournals.org)
BA synthesis in the liver is the primary form of cholesterol catabolism ( Fig. 1 ). (aspetjournals.org)
In the liver, two major pathways carry out BA synthesis, the classic and the alternative pathway. (aspetjournals.org)
Hepatic anaplerotic outflow fluxes are redirected from gluconeogenesis to lactate synthesis in patients with Type 1a glycogen storage disease. (medscape.com)

Moreover, I3C exerts anti-obesity effects by reducing body weight and fat accumulation in epididymal adipose tissue in HFD-induced obese mice and thereby improves hyperglycemia and hyperinsulinemia [126]. (researchgate.net)
Interleukin-6 derived from cutaneous deficiency of stearoyl-CoA desaturase- 1 may mediate metabolic organ crosstalk among skin, adipose tissue and liver. (umassmed.edu)
It is typically expressed in glucocorticoid receptors-rich tissues, such as the liver, adipose tissue, lung and brain. (biomedcentral.com)

C) Necrotic foci in the liver stain periodic acid-Schiff (PAS)-positive (arrow), which suggests focal accumulation of glycogen (original magnification ×400). (cdc.gov)
At this time point, the mutant mice showed lowered blood glucose levels with enhanced accumulation of glycogen in the liver. (elsevierpure.com)

Adult TG mice exhibited reduced hepatic glycogen and progressive liver injury, but maintained normal serum levels of glucose, insulin, and glucagon. (duke.edu)

Wild type as well as substrate-trapping DA forms of PTPϵM suppressed phosphorylation of IR downstream enzymes such as Akt, extracellular regulated kinase (ERK) and glycogen synthase kinase 3 (GSK3). (bioone.org)
In a previous report, we identified the role of glycogen synthase kinase-3β (GSK-3β) in NF-κB activation by regulating IKKγ/NEMO. (mdpi.com)
Moreover, JNK and glycogen synthase kinase 3β activation was significantly attenuated, and Mcl-1 degradation was inhibited in APAP-treated MLK3-knockout mice. (aspetjournals.org)
GSK3 (glycogen synthase kinase-3) regulation is proposed to play a key role in the hormonal control of many cellular processes. (portlandpress.com)

We have shown that an endogenous peptide, catestatin, can directly suppress glucose production from hepatocytes and can indirectly suppress lipid accumulation in liver as well as macrophage-mediated inflammation in obese mice," said Sushil K. Mahata, PhD, professor of medicine at UC San Diego School of Medicine. (sciencedaily.com)
The liver also controls lipid production and metabolism. (sciencedaily.com)
Furthermore, transmission electron microscopy analysis of postnatal TG liver revealed extensive mitochondrial membrane damage, which is likely due to reactive oxygen species generated from lipid beta-oxidation. (duke.edu)
In conclusion, our model proposes that in response to reduction in hepatocyte glycogen storage, the TTR-Foxa2 TG mice survive by maintaining sufficient serum levels of glucose through gluconeogenesis using deaminated amino acids with dicarboxylate products of peroxisomal lipid beta-oxidation shuttled through the tricarboxylic acid cycle. (duke.edu)
Conversely, 11β-HSD1 null mice exhibit a protective glycemic, lipid, and lipoprotein profile and show increased expression of hepatic mRNAs encoding regulators of fatty acid beta-oxidation. (biomedcentral.com)
its potential mechanism could improve the metabolism of sugar and lipid in muscle and liver tissues, reduce the oxidative damage of cells, improve the adaptability and endurance of the body to strenuous exercise, and enhance the immunity and antioxidant ability of cells, to play an anti-fatigue role. (phcog.com)
In addition, FXR is critical in regulating lipid metabolism and reducing inflammation, processes critical in the development of cholestasis and fatty liver diseases. (aspetjournals.org)
Geberhiwot T, Alger S, McKiernan P, Packard C, Caslake M, Elias E. Serum lipid and lipoprotein profile of patients with glycogen storage disease types I, III and IX. (medscape.com)

Magnetic Luminex Assay Kit for Glycogen Phosphorylase, Liver (PYGL) ,etc. (uscnk.com)

BACKGROUND: Glycogen storage disease type 1a (GSD Ia) is an inborn error of metabolism caused by a defect in glucose-6-phosphatase (G6PC1) activity, which induces severe hepatomegaly and increases the risk for liver cancer. (rug.nl)
Here we investigated the extent to which a gnotobiotic microbiota can mimic the influence of a complete microbiota on mouse metabolism using an isolator-housed TSE-PhenoMaster® system. (biorxiv.org)
But further studies are needed to uncover how CST suppresses liver inflammation to improve metabolism. (sciencedaily.com)
Since the mice preferred lard to cocoa butter, lard induced excess energy intake and poorer metabolism. (biomedcentral.com)
When we realized that our experiments to investigate protein folding abnormalities were producing fatty liver disease as a consequence, it tied in with previous circumstantial evidence suggesting that ER stress might be involved in the liver's role in fat metabolism," he added. (sciencedaily.com)
Further analysis of the mice models identified some of the genes that connect prolonged ER stress with faulty fat metabolism in the liver. (sciencedaily.com)
Our goals were twofold: 1) to characterize the gene expression, protein expression, and activity of key synthesizing and regulating enzymes of energy metabolism in the whole mouse retina, retinal compartments, and/or cells and 2) to provide an integrative analysis of the results related to function. (molvis.org)
Coordinated recovery of hepatic glucose metabolism is prerequisite for normal liver regeneration. (elsevierpure.com)
This approach has revealed several new mechanisms and biomarkers associated with AD, including alteration of glycogen metabolism, the toxicity of various amyloid peptides aggregation forms, and secretion of a variety of pathology-specific molecules. (lu.se)

Liver transplantation may be indicated for patients with hepatic malignancy. (medscape.com)
Orthotopic liver transplantation is a beneficial therapeutic option, which shows that restoration of only a fraction of whole-body BCKD enzyme activity is therapeutic. (stanford.edu)
The only curative treatment for acute liver failure is liver transplantation, but there are many restrictions on the application of liver transplantation. (springer.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
The only curative treatment for ALF is liver transplantation, but there are many restrictions on the application of liver transplantation because of financial considerations, a shortage of donor livers, and immunosuppression-related complications [ 3 ]. (springer.com)
Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
In some cases, liver transplantation may abolish biochemical abnormalities. (medscape.com)

Interestingly, insulin injection of wild-type mice, which activates PKB (protein kinase B) and inhibits GSK3 to a greater degree than feeding (50% versus 25%), does not repress these genes. (portlandpress.com)

BAs are critical molecules for life, and disruption of BA homeostasis has been closely linked to hepatic, intestinal, and systemic diseases, including cholestasis, fatty liver diseases, and hepatic and colon tumors. (aspetjournals.org)

METHODS: Hepatocyte-specific G6pc knockout (L-G6pc-/-) mice were treated with AAV-shChREBP to normalize hepatic ChREBP activity. (rug.nl)
RESULTS: Hepatic ChREBP normalization in GSD Ia mice induced dysplastic liver growth, massively increased hepatocyte size, and was associated with increased hepatic inflammation. (rug.nl)
Hepatic ChREBP normalization furthermore induced DNA damage and mitotic activity in GSD Ia mice, while gene signatures of chromosomal instability, the cytosolic DNA-sensing cGAS-STING pathway, senescence, and hepatocyte dedifferentiation emerged. (rug.nl)
As ChREBP has been proposed as a pro-oncogenic molecular switch that supports tumour progression, we hypothesized that ChREBP normalization protects against liver disease progression in hepatic GSD Ia.METHODS: Hepatocyte-specific G6pc knockout (L-G6pc-/-) mice were treated with AAV-shChREBP to normalize hepatic ChREBP activity.RESULTS: Hepatic ChREBP normalization in GSD Ia mice induced dysplastic liver growth, massively increased hepatocyte size, and was associated with increased hepatic inflammation. (rug.nl)
The Forkhead box (Fox) transcription factor Foxa2 (HNF-3beta) and related family members Foxa1 (HNF-3alpha) and Foxa3 (HNF-3gamma) act in concert with other hepatocyte nuclear factors (HNF) to coordinately regulate liver-specific gene expression. (duke.edu)
To circumvent the hepatic functional redundancy of the Foxa proteins, we used the T-77 transgenic (TG) mouse line in which the -3-kb transthyretin (TTR) promoter functioned to increase hepatocyte expression of the Foxa2 cDNA. (duke.edu)
The postnatal TG mice displayed significant reduction in serum glucose levels and in hepatocyte glycogen storage without increased serum levels of ketone bodies and free fatty acid suggesting that they are not undergoing a starvation response. (duke.edu)
Following partial hepatectomy (PH), recovery of residual liver weight was initially retarded in the mutant mice by down-regulation of hepatocyte proliferation, but occurred comparably between the mutant and control mice at 72 h after PH. (elsevierpure.com)

Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report researchers. (sciencedaily.com)
Treating obese mice with CST inhibited the recruitment of monocyte-derived macrophages to the liver and decreased inflammation, suggesting CST is an anti-inflammatory peptide. (sciencedaily.com)
This difference may be explained by the reduced levels of normal CST in obese mice compared to the lean control animals. (sciencedaily.com)
Objective Indole‐3‐carbinol (I3C), a naturally occurring compound found in cruciferous vegetables, and its metabolite 3,3′‐diindolylmethane (DIM) reduce body mass and serum glucose levels in high‐fat‐diet‐induced obese mice. (researchgate.net)
Previous studies have found that DIM can improve type 2 diabetes by enhancing glucose uptake through the activation of insulin signaling in 3T3-L1 cells, and by lowering the plasma glucose levels in high-fat-diet-fed obese mice [13, 14]. (researchgate.net)

The liver glycogen and lactate content was measured. (scirp.org)
Se-Na significantly increases liver glycogen and lactate content at 3 minutes post mortem. (scirp.org)

Using mice with an engineered ERCC1-XPF defect in tissue-infiltrating macrophages, we provide evidence for a fundamental mechanism by which irreparable DNA damage triggers an exosome-based, metabolic reprogramming that leads to chronic inflammation and tissue pathology in NER progeroid syndromes and likely also during aging. (nature.com)
Microbiota composition correlates with host metabolic health in both humans and mice. (biorxiv.org)
However, each group of mice have a distinctive circadian metabolic profile. (biorxiv.org)
Although fatty liver itself does not necessarily cause illness, it is associated with serious conditions like diabetes, metabolic syndrome, cirrhosis of the liver and liver failure. (sciencedaily.com)
Liver carcinogenesis is a multistep, long process associated with multiple risk factors, e.g. viral hepatitis, alcohol abuse, metabolic disorders, and obesity [ 2 ]. (aging-us.com)
With an enzyme defect, carbohydrate metabolic pathways are blocked and excess glycogen accumulates in affected tissues. (medscape.com)
Schwahn B, Rauch F, Wendel U, Schönau E. Low bone mass in glycogen storage disease type 1 is associated with reduced muscle force and poor metabolic control. (medscape.com)

Previously, we showed that ChREBP activation limits non-alcoholic fatty liver disease (NAFLD) in hepatic GSD Ia. (rug.nl)
As ChREBP has been proposed as a pro-oncogenic molecular switch that supports tumour progression, we hypothesized that ChREBP normalization protects against liver disease progression in hepatic GSD Ia. (rug.nl)
CONCLUSIONS: In conclusion, our findings indicate that ChREBP activity limits hepatomegaly while decelerating liver disease progression and protecting against chromosomal instability in hepatic GSD Ia. (rug.nl)
These results disqualify ChREBP as a therapeutic target for treatment of liver disease in GSD Ia. (rug.nl)
In addition, they underline the importance of establishing the context-specific roles of hepatic ChREBP to define its therapeutic potential to prevent or treat advanced liver disease. (rug.nl)
12 Similar to patients, the dystrophin mutant mdx mice do not express dystrophin 13 and have been widely used as a model system to study DMD and to make important advances in understanding therapeutic strategies as well as the molecular processes and underlying causes of the disease. (nature.com)
Type III glycogen storage disease (GSD III) is an autosomal recessive disease caused by mutations in the AGL gene, which codes for glycogen debranching enzyme. (medscape.com)
A glycogen storage disease (GSD) results from the absence of enzymes that ultimately convert glycogen compounds to glucose. (medscape.com)
Now my Mom is not an entrepreneur in the classical sense but she recently discovered a cure for a rare disease called Glycogen Storage Disease. (mywifequitherjob.com)
Today, I have my mom Janice Chou on the show and my mom is not an entrepreneur in the classical sense, but she recently discovered a cure for a rare disease called glycogen storage disease. (mywifequitherjob.com)
Von Gierke disease (GSD type Ia and Ib) was first reported in 1929 based on the autopsy findings in 2 children who had excessive hepatic and renal glycogen accumulation. (medscape.com)
As Postdoc she developed innovative in vivo AAV gene therapy approaches based on liver gene transfer or multi-tissue gene expression to target the multi-organ manifestations of Pompe disease, a LSD that presents with neuromuscular impairment. (stanford.edu)
They concluded that despite dietary changes, liver and muscle disease progression is evident in adults with 3a, muscle weakness being the major cause of illness. (agsd.org.uk)
Researchers have discovered a direct link between disruption of a critical cellular housekeeping process and fatty liver disease, a condition that causes fat to accumulate in the liver. (sciencedaily.com)
The findings might open new avenues for understanding and perhaps treating fatty liver disease, which is the most common form of liver disease in the Western world. (sciencedaily.com)
The findings, published in the Dec. 9 issue of the journal Developmental Cell, might open new avenues for understanding and perhaps treating fatty liver disease, which is the most common form of liver disease in the Western world and may affect as many as one in three American adults. (sciencedaily.com)
We did not set out to understand fatty liver disease," said Rutkowski, who was a postdoctoral researcher in Kaufman's University of Michigan lab when the study was done. (sciencedaily.com)
If this finding holds true for fatty liver disease in humans, therapies aimed at improving protein folding in the ER, or inhibiting CHOP, could help treat the condition. (sciencedaily.com)
The next step is to investigate whether real physiological stresses like chronic alcohol consumption, obesity and viral infection also lead to fatty liver disease through protein folding problems in the ER. (sciencedaily.com)
Silybin combined with Phosphatidylcholine and Vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. (livermedic.com)
Is Silymarin Hepatoprotective in Alcoholic Liver Disease? (livermedic.com)
Non-Alcoholic Fatty Liver Disease (NAFLD) Nutritional and Supplemental Support. (livermedic.com)
The effect of a Silybin , Vitamin E , Phospholipid complex on non alcoholic fatty liver disease. (livermedic.com)
N-Acetylcysteine (NAC) Improves Liver Function in Patients with Non-Alcoholic Fatty Liver Disease. (livermedic.com)
Effects of probiotics on nonalcoholic fatty liver disease. (livermedic.com)
Numerous treatment strategies for acute liver failure simply prevent complications and decelerate disease progression. (springer.com)
Environmental chemical exposure could affect liver disease development. (aspetjournals.org)
Understanding these effects will help to determine liver disease pathogenesis and provide better prevention and treatment in the future. (aspetjournals.org)
A glycogen storage disease (GSD) is the result of an enzyme defect. (medscape.com)
As noted above, G-6-P, which is found in the liver and kidney, is the specific enzyme that is deficient in von Gierke disease. (medscape.com)
Because many causes of hepatic injury exist, suspicion of glycogen storage disease (GSD) must be high. (medscape.com)
Early diagnosis and treatment may prevent the development of complications in an adult patient with glycogen storage disease type Ia. (medscape.com)
Increased de novo lipogenesis and delayed conversion of large VLDL into intermediate density lipoprotein particles contribute to hyperlipidemia in glycogen storage disease type 1a. (medscape.com)
Natural history of hepatocellular adenoma formation in glycogen storage disease type I. J Pediatr . (medscape.com)
A monocentric pilot study of an antioxidative defense and hsCRP in pediatric patients with glycogen storage disease type IA and III. (medscape.com)
Nutritional deficiencies in a patient with glycogen storage disease type Ib. (medscape.com)
Contrast-enhanced ultrasonography in patients with glycogen storage disease type Ia and adenomas. (medscape.com)
Seydewitz HH, Matern D. Molecular genetic analysis of 40 patients with glycogen storage disease type Ia: 100% mutation detection rate and 5 novel mutations. (medscape.com)
Correction of glycogen storage disease type 1a in a mouse model by gene therapy. (medscape.com)
Bijvoet AG, Van Hirtum H, Vermey M. Pathological features of glycogen storage disease type II highlighted in the knockout mouse model. (medscape.com)
Caution should be used if [NT005 trade name] is given to patients with liver disease, since albendazole is metabolised by the liver and has been associated with idiosyncratic hepatotoxicity. (who.int)

FGF15 and FGF19 proteins share about 50% amino acid identity, are found in the same tissues, and have similar functions in mouse and humans. (wikipedia.org)
Enzyme deficiency results in glycogen accumulation in tissues. (medscape.com)
LJP increased swimming time to exhaustion, the liver and muscle glycogen content, and levels of superoxide dismutase, glutathione peroxidase, and catalase in the serum, liver, and muscle, which were accompanied by corresponding decreases in the malondialdehyde (MDA) content of the same tissues. (biomedcentral.com)
0.05), and the lesions of the liver and kidney tissues were enhanced to some extent. (phcog.com)

Furthermore, nuclear levels of the oncoprotein Yes Associated Protein (YAP) were increased and its transcriptional targets were induced in ChREBP-normalized GSD Ia mice. (rug.nl)
Fibroblast growth factor 15 is a protein in mouse encoded by the Fgf15 gene. (wikipedia.org)
The liver of animals pretreated with the toxin showed marked declines of glycogen and microsomal protein and an increase of cyclic AMP content. (go.jp)
The study, led by Tom Rutkowski, Ph.D., assistant professor of anatomy and cell biology at the UI Roy J. and Lucille A. Carver College of Medicine, and Randal Kaufman, Ph.D., professor of biological chemistry and internal medicine at the University of Michigan Medical School, shows that disrupted protein folding causes fatty liver in mice. (sciencedaily.com)
However, the mutated mice were much less able to cope with cellular stress caused by disrupted protein folding than wild-type mice. (sciencedaily.com)
In addition, the team found that protein misfolding caused fatty liver in mice with the mutation. (sciencedaily.com)
The results suggest that it is not disruption of a specific protein that caused fatty liver, but rather anything that perturbs the ER's ability to fold proteins correctly that is important. (sciencedaily.com)
Our study does prove that perturbing protein folding can lead to fatty liver," Rutkowski said. (sciencedaily.com)
GSK3 inhibition in liver reduces expression of the gluconeogenic genes PEPCK (phosphoenolpyruvate carboxykinase), G6Pase (glucose-6-phosphatase), as well as IGFBP1 (insulin-like growth factor binding protein-1). (portlandpress.com)

We generated mice that possess a heterozygous deletion of the PTG gene. (jci.org)
The mouse Fgf15 gene is syntenic with the human FGF19 gene. (wikipedia.org)
Successful treatment of severe MSUD in Bckdhb-/- mice with neonatal AAV gene therapy. (stanford.edu)
We and others have tested AAV gene therapy in mice for two of the three genes involved in MSUD, BCKDHA and DBT. (stanford.edu)
Based on our previous experience in Bckdha-/- mice, we designed a transgene carrying the human BCKDHB gene under the control of a ubiquitous EF1α promoter, encapsidated in an AAV8 capsid. (stanford.edu)
The Affymetrix data revealed varied gene expression patterns of the ATP synthesizing and regulating enzymes found in the muscle, liver, and brain. (molvis.org)
Over the last two decades, studies based on genome-wide gene expression and functional profiling have revealed the great diversity of transcriptional alterations occurring in liver carcinogenesis. (aging-us.com)

These enzymes normally catalyze reactions that ultimately convert glycogen compounds to glucose. (medscape.com)

[ 1 ] leading to a defect in the last step of glycogenolysis, resulting in fat accumulation and dysfunction of the liver and kidneys, infantile hypoglycemia, hepatomegaly, and life-threatening seizures if not treated early. (medscape.com)

Although 4 other cases were reported of excess glycogen storage in the livers of autopsy patients, it was not until 1978 when Narisawa et al were able to differentiate GSD type Ia and type Ib, recognizing type Ia was due to a deficiency in the G6Pase enzyme, and type Ib was due to deficiency in the G6P transporter. (medscape.com)

Simple carbohydrate intake should be limited, as excess sugar is stored as glycogen, which cannot be broken down. (medscape.com)

Promotes transdifferentiation of hepatocytes from mouse pancreatic cells (Shen et al. (stemcell.com)
Promotes differentiation of mature hepatocytes from mouse and human embryonic stem (ES) cells (Cai et al. (stemcell.com)
Promotes maturation of fetal mouse hepatocytes (Kamiya et al. (stemcell.com)
The idea of using hepatocytes to treat liver failure depends on a simple hypothesis that liver function can be improved by supplementing exogenous hepatocytes. (springer.com)

In the current study, we investigate the effects of Dehydroepiandrosterone (DHEA), one of the most abundant circulating steroids in humans and a precursor hormone, supplementation combined with a weight-loading whole-body vibration (WWBV) on exercise performance, physical fatigue-related biochemical responses and testosterone content in middle-aged 9 months old C57BL/6 mice. (medsci.org)
Here, the study aimed to explore the effects of LCD/high-fat diet (HFD) in both humans and mice. (biomedcentral.com)
Different food preferences may be the underlying mechanism behind the opposite effects of the LCD/HFD in humans and mice. (biomedcentral.com)

Glycogen storage diseases (GSDs) are inherited disorders due to enzymatic defects that prevent breakdown of stored glycogen into glucose. (medscape.com)
Glycogen storage diseases ( GSD ) are a group of inherited autosomal recessive disorders caused by genetic mutations that lead to the inability to breakdown and metabolize glycogen into glucose. (medscape.com)
Dr. Colella is committed to researching innovative ways to combat genetic diseases and making a positive impact on the lives of patients. (stanford.edu)
Chen Y. Glycogen Storage Diseases. (medscape.com)
Fernandes J, Smit G. The Glycogen Storage Diseases. (medscape.com)

Goji berries extract reduces the aging process of the skin, i.e. inhibits glycation, shows a study done on mice. (myfolkmedicine.com)

FGF15 has been implicated in liver regeneration and repair. (wikipedia.org)
Fgf15-deficient mice have impaired regeneration. (wikipedia.org)
The hepatic nervous system has been implicated in physiological functions and regeneration of the liver. (biologists.com)
In conclusion, these findings provide evidence for roles of HIF-1α in the regulation of gluconeogenesis under liver regeneration. (elsevierpure.com)

When the liver stops responding to insulin, blood glucose levels rise, causing insulin production to go into overtime. (sciencedaily.com)
DIM decreased STZ-increased high blood glucose levels and food and water intake in diabetic mice. (researchgate.net)

Although young PTG heterozygous mice initially demonstrate normal glucose tolerance, progressive glucose intolerance, hyperinsulinemia, and insulin resistance develop with aging. (jci.org)
Insulin resistance in older PTG heterozygous mice correlates with a significant increase in muscle triglyceride content, with a corresponding attenuation of insulin receptor signaling. (jci.org)
In a study published in Diabetes on February 6, researchers identified CST's role in the recruitment and function of macrophages in the liver as well as regulation of obesity-induced liver inflammation and insulin resistance. (sciencedaily.com)

Additionally, WWBV+DHEA supplementation improved exercise performance, testosterone levels and glycogen contents of both liver and muscle. (medsci.org)

We conclude that selenium supplementation decreases food intake and improves meat quality by improving colour and decreasing drip loss, likely by a modulation of reserve of glycogen in liver. (scirp.org)

The sc LD & lt50> values of Cl-peptide for mice, rats and guinea-pigs were all in the range of 0.5 mg/kg, while the po LD & lt50> values for mice and rats were around 5mg/kg. (go.jp)
The acutely intoxicated mice and rats showed a marked elevation of serum transaminases and a transient increment followed by a marked decline of blood glucose level. (go.jp)
Dietary dose response studies in rats are described in which induction times were determined for tumor development, especially liver and kidney tumors. (cdc.gov)
Other studies are summarized on the incidence of eye, mammary, ear duct, and liver tumors in rats fed 2-AAF, and on the effects of other dietary components on 2-AAF carcinogenicity including casein (9000719), tryptophane (73223), indole (120729), vitamin-B6 (8059243), and liver powder. (cdc.gov)
The author concludes that 2-AAF has been proven to be carcinogenic in rats, mice, rabbits, dogs, hamsters, and fowl, and should probably be considered as a human carcinogen. (cdc.gov)

The mutant mice exhibited impairment of hepatic gluconeogenesis as assessed by alanine tolerance test. (elsevierpure.com)

DIM also improved diabetic nephropathy by inhibiting the expression of PKC-α, the marker of albuminuria, and TGF-β1, an indicator of renal hypertrophy, in diabetic mice. (researchgate.net)

MLK3-deficient mice were significantly protected from APAP-induced liver injury, compared with wild-type mice. (aspetjournals.org)
In female mice only, absolute and relative liver weights were significantly increased at the highest dose. (canada.ca)

Therefore, inhibition of the initial phase of JNK activation may be key to protection against APAP-induced liver injury. (aspetjournals.org)

But in obesity, accumulation of lipids can cause fatty liver, resulting in cellular damage to the organ. (sciencedaily.com)

Meanwhile, C57BL/6J mice were assigned to five groups: chow diet (CD, 10% fat), HFD with 60%, 70%, and 75% fat from cocoa butter (HFD-C), and HFD with 60% fat from lard (HFD-L) and fed for 24 weeks. (biomedcentral.com)
Fixed-frozen retinas from adult C57BL/6N mice were used for immunohistochemistry, laser scanning confocal microscopy, and enzymatic histochemistry. (molvis.org)

and decreases in liver catalase, alkaline RNase, and serum alkaline RNase. (cdc.gov)

Acute liver failure is a life-threatening clinical syndrome characterized by rapid development of hepatocellular necrosis leading to high mortality and resource costs. (springer.com)
Acute liver failure (ALF) is a life-threatening clinical syndrome characterized by rapid hepatocellular necrosis due to various acute injuries induced by hepatotoxic drugs, immune-mediated attack, or viral infections. (springer.com)

When sugar levels increase in the blood, the pancreas secretes insulin to decrease glucose production from the liver to maintain balance. (sciencedaily.com)
We have identified a novel pathway for suppression of liver glucose production that could be used to compensate for the loss of naturally occurring CST or to bolster its impact. (sciencedaily.com)

these foci are absent from subtype H1N1-infected mouse livers. (cdc.gov)

Glucose-6-phosphate is an intermediate in the glycogen pathway. (medscape.com)

This has been shown to prevent glycogen accumulation in the liver of a GSD3 mouse and reduces the fatty liver of a GSD1 mouse. (agsd.org.uk)

In the present study we demonstrate that regulation of these three genes by feeding is normal in mice that express insulin-insensitive GSK3. (portlandpress.com)

Promotes osteogenic, adipogenic, and chondrogenic differentiation of mouse mesenchymal cells (Tropel et al. (stemcell.com)

Il s'agissait d'une étude descriptive avec une collecte rétrospective des données des patients hospitalisés et/ou reçus en consultation dans le service de Néphrologie du CHU de Yopougon à Abidjan entre Janvier 1991 et Décembre 2015. (bvsalud.org)
L'ectopie rénale croisée a été notée chez deux patients et l'ectopie bilatérale chez quatre dont un cas de fusion en fer à cheval. (bvsalud.org)
Le contrôle radiologique effectué chez les patients ayant présenté un traumatisme au stade IV a montré une reconstruction du rein et une absence d'extravasion de produit de contraste.Conclusion :Les traumatismes du rein sont de plus en plus fréquents. (bvsalud.org)

The Er1 F/− EV cargo is taken up by recipient cells leading to an increase in insulin-independent glucose transporter levels, enhanced cellular glucose uptake, higher cellular oxygen consumption rate and greater tolerance to glucose challenge in mice. (nature.com)
CST treatment also lowered blood sugar and insulin levels to normal, and reduced fatty liver. (sciencedaily.com)
It was also found that these samples increased the liver glycogen levels. (nih.gov)
Cholinesterase levels were decreased at the two highest dose groups in female mice. (canada.ca)
The elevated levels of insulin detected in response to glucose challenge together with increased fasting insulin levels in older mice suggest that they progressively develop IR. (biomedcentral.com)

In response to this damage, immune cells residing in the liver are activated, especially macrophages, and additional immune cells are recruited from the circulating blood. (sciencedaily.com)

Tracer experiments revealed a preferencial accumulation of the toxin in the liver of mice and an excretion through feces. (go.jp)

Partial least squares discriminant analysis was applied to the spectral dataset acquired from blood serum of a mouse model of Duchenne muscular dystrophy ( mdx ) and control mice. (nature.com)
This proof-of-concept study presents Raman hyperspectroscopic analysis of blood serum as an easy, fast, non-expensive, and minimally invasive detection method for distinguishing control and mdx model mice, with a strong potential for clinical diagnosis of DMD. (nature.com)
We performed the first characterization of a Bckdhb-/- mouse model, which recapitulates the severe human phenotype of MSUD with early-neonatal symptoms leading to death during the first week of life with massive accumulation of MSUD biomarkers. (stanford.edu)
With this method, they have demonstrated the possibility, in a mouse model, of correction of GSD3. (agsd.org.uk)
Using a mouse model, they demonstrated that Pullalanase is a possible treatment for GSD3. (agsd.org.uk)
Therefore, this study was conducted to investigate the effects of LJP on exercise endurance and oxidative stress in a forced swimming mouse model. (biomedcentral.com)
Mouse model with selective liver 11β-HSD1 overexpression show IR, dyslipidemia, and hypertension, but unaltered adiposity. (biomedcentral.com)
Our HCC signature covered well-established liver cancer hallmarks, and network analyses revealed coordinated interaction between several MRs. One novel MR, SEC14L2 , exerted an anti-proliferative effect in HCC cells and strongly suppressed tumor growth in a mouse model. (aging-us.com)

Anatomy13

Organisms13

Diseases30

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Psychiatry and Psychology1

Phenomena and Processes36

Technology, Industry, Agriculture1

Information Science3

Synthesis13

Adipose tissue3

Accumulation of glycogen2

Hepatic glycogen1

Synthase kinase4

Lipid8

Phosphorylase1

Metabolism9

Transplantation7

Kinase1

Homeostasis1

Hepatocyte8

Obese mice5

Lactate2

Metabolic7

Disease41

Tissues4

Protein9

Gene7

Enzymes1

Hepatomegaly1

Deficiency1

Excess1

Hepatocytes4

Humans3

Diseases5

Inhibits1

Regeneration4

Blood glucose levels2

Insulin resistance3

Muscle1

Food intake1

Rats5

Gluconeogenesis1

Renal1

Significantly2

Inhibition1

Obesity1

C57BL2

Decreases1

Hepatocellular2

Glucose production2

Foci1

Pathway1

Reduces1

GSK31

Mesenchymal cells1

Patients3

Levels5

Macrophages1

Excretion1

Model8