• Trichomonas
  • For instance, researchers have shown that metronidazole acts against Trichomonas vaginalis by binding to a protein called Trichomonas vaginalis ferredoxin (hereafter referred to as TvFd), a protein that is found in the hydrogenosome of the protozoan and is a component of the creature's electron transport pathway. (everything2.com)
  • dose
  • Because metronidazole isn't approved for veterinary use, its manufacturers haven't established a dose for cats. (ehow.co.uk)
  • Plasma concentrations of metronidazole are proportional to the administered dose. (nih.gov)
  • The major route of elimination of metronidazole and its metabolites is via the urine (60% to 80% of the dose), with fecal excretion accounting for 6% to 15% of the dose. (nih.gov)
  • Decreased renal function does not alter the single-dose pharmacokinetics of metronidazole. (nih.gov)
  • A hemodialysis session lasting for 4 to 8 hours removed 40% to 65% of the administered metronidazole dose, depending on the type of dialyzer membrane used and the duration of the dialysis session. (nih.gov)
  • A peritoneal dialysis session lasting for 7.5 hours removed approximately 10% of the administered metronidazole dose. (nih.gov)
  • No adjustment in metronidazole dose is needed in ESRD patients undergoing CAPD. (nih.gov)
  • However, elderly patients are more likely to have unwanted effects and age-related liver problems, which may require caution and an adjustment in the dose for patients receiving metronidazole injection. (mayoclinic.org)
  • systemic
  • Common adverse drug reactions (≥1% of those treated with the drug) associated with systemic metronidazole therapy include: nausea, diarrhea, weight loss, abdominal pain, vomiting, headache, dizziness, and metallic taste in the mouth. (wikipedia.org)
  • High doses and long-term systemic treatment with metronidazole are associated with the development of leucopenia, neutropenia, increased risk of peripheral neuropathy, and central nervous system toxicity. (wikipedia.org)
  • allergic
  • It is a bad idea to take metronidazole if you are allergic to it, are in the first trimester of your pregnancy , are breast-feeding , or if you have a blood disorder, epilepsy , heart disease , or liver disease. (everything2.com)
  • anaerobic
  • Metronidazole -sensitive organisms all live under anaerobic conditions, and the more complex parasites all lack mitochondria , centrioles , and introns . (everything2.com)
  • This implies that metronidazole is activated by enzymes specific to anaerobic organisms, and this notion has been upheld by various findings. (everything2.com)
  • pregnant
  • Metronidazole was ineffective in preventing preterm delivery in high-risk pregnant women (selected by history and a positive fFN test) and, conversely, the incidence of preterm delivery was found to be higher in women treated with metronidazole. (wikipedia.org)
  • treatment
  • It usually takes two to three months of applying metronidazole to the skin to clear up the spots, so it is important to persevere with the treatment as prescribed by your doctor, even if it doesn't seem to make much difference to start with. (netdoctor.co.uk)
  • I had sex the day after I finished my 5 day treatment of metronidazole and I noticed some of it had? (drugs.com)
  • I just finished my 7 day treatment on metronidazole and now I see a few brown spots when I wipe? (drugs.com)
  • major
  • Metronidazole is the major component appearing in the plasma, with lesser quantities of metabolites also being present. (nih.gov)
  • patients
  • Following a single intravenous infusion of 500 mg metronidazole, the mean AUC 24 of metronidazole was higher by 114% in patients with severe (Child-Pugh C) hepatic impairment, and by 54% and 53% in patients with mild (Child-Pugh A) and moderate (Child-Pugh B) hepatic impairment, respectively, compared to healthy control subjects. (nih.gov)
  • There were no significant changes in the AUC 24 of hydroxyl-metronidazole in these hepatically impaired patients. (nih.gov)
  • clear
  • I am not clear as to what sort of scan revealed the anomaly of blood flow on one side of the brain but again cannot think of a plausible link between the finding and topical metronidazole use. (medhelp.org)
  • It is not clear from the information avavilable what exactly is going on here, but I suspect that the metronidazole will not turn out to be the culprit. (medhelp.org)