• histone
  • In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone modifications, and dysregulation of DNA binding proteins. (wikipedia.org)
  • Many inhibitors of DNA methylation as well as of histone methylation, have been successfully tested in preclinical studies and some are currently undergoing evaluation in phase I, II or III clinical trials, either as cytostatic molecules-reducing the proliferation of cancerous cells-or as tumor angiogenesis inhibitors. (mdpi.com)
  • In this review, we will focus on the methylation status of the vascular epigenome, based on the genomic DNA methylation patterns with DNA methylation being mainly transcriptionally repressive, and lysine/arginine histone post-translational modifications which either promote or repress the chromatin transcriptional state. (mdpi.com)
  • Patients
  • Azacitidine causes anemia (low red blood cell counts), neutropenia (low white blood cell counts), and thrombocytopenia (low platelet counts), and patients should have frequent monitoring of their complete blood counts, at least prior to each dosing cycle. (wikipedia.org)
  • It can also be hepatotoxic in patients with severe liver impairment, and patients with extensive liver tumors due to metastatic disease have developed progressive hepatic coma and death during azacitidine treatment, especially when their albumin levels are less than 30 g/L. It is contraindicated in patients with advanced malignant hepatic tumors. (wikipedia.org)
  • Renal toxicity, ranging from elevated serum creatinine to kidney failure and death, have been reported in patients treated with intravenous azacitidine in combination with other chemotherapeutic agents for conditions other than myelodysplastic syndrome. (wikipedia.org)
  • Renal tubular acidosis developed in five patients with chronic myelogenous leukemia (an unapproved use) treated with azacitidine and etoposide, and patients with renal impairment may be at increased risk for renal toxicity. (wikipedia.org)
  • Brock looked at genetic markers that affect DNA methylation and found that patients with specific markers responded better to the therapy. (latimes.com)
  • PURPOSE: This phase I trial is studying the side effects and best dose of bortezomib when given together with azacitidine in treating patients with relapsed or refractory T-cell lymphoma. (clinicaltrials.gov)
  • Patients receive bortezomib IV on days 4, 8, 11, and 15 and azacitidine subcutaneously (SC) on days 1-5. (clinicaltrials.gov)
  • The Phase 1 clinical trial combining SL-401 and azacitidine in patients with AML or MDS opened over the summer at Dana-Farber, MD Anderson Cancer Center, and City of Hope. (cancerconnect.com)
  • tumor cells
  • At the 59th American Society of Hematology (ASH) Annual Meeting and Exposition in Atlanta, the researchers presented laboratory findings that the drug azacitidine (5-azacytidine) can reverse tumor cells' resistance to the targeted agent SL-401. (cancerconnect.com)
  • dose
  • An oral dosage formulation of Azacitidine, in addition to the more desirable and convenient route of administration, would enable the evaluation of a low-dose regimen that could maximize demethylation and gene re-expression, as well as the evaluation of long-term or maintenance therapy. (bio-medicine.org)
  • Phase I - Recommended Phase Two Dose (RPTD) of Azacitidine and Docetaxel in Combination With Prednisone. (clinicaltrials.gov)
  • Determination of a safe and potentially efficacious phase II dose of azacitidine in combination with docetaxel and prednisone that can be used for the treatment of hormone refractory metastatic prostate cancer. (clinicaltrials.gov)
  • therapy
  • Because DNA methylation affects cellular function through successive generations of cells without changing the underlying DNA sequence, hypomethylating agents are considered a type of epigenetic therapy. (wikipedia.org)
  • The opportunity to explore the biological and clinical consequences of continuous oral dosing of Azacitidine is particularly exciting, since we know that DNA remethylation occurs between cycles of intermittent parenteral therapy. (bio-medicine.org)
  • cancer
  • In fact, cancer cell genomes have 20-50% less methylation at individual CpG dinucleotides across the genome. (wikipedia.org)
  • The amount of azacitidine that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition being treated. (chemocare.com)
  • pharmacodynamic
  • V. To explore the biologic role of microRNAs in determining clinical response to the VELCADE (BORTEZOMIB) plus Azacitidine combination and achievement of the other pharmacodynamic endpoints. (clinicaltrials.gov)
  • enzymes
  • These enzymes are responsible for the methylation of specific DNA sequences in order to prevent the host from digesting its own genome via its restriction enzymes. (wikipedia.org)
  • study
  • Furthermore, our study also provides mechanistic insight on how DNA methylation of distal regulatory sites is critical for the maintenance of tumor cell identity and malignancy with gene network perspective. (biomedcentral.com)
  • Treatment
  • The difference between the methylation indices post-and pre-treatment will be compared using paired Student's t-test. (clinicaltrials.gov)
  • Before starting azacitidine treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc. (chemocare.com)