• Sodium
  • The product is supplied in 4 singledose, preservative-free liquid presentations, containing 25 mg/mL of methotrexate sodium?50 mg in 2 mL, 100 mg in 4 mL, 200 mg in 8 mL, 250 mg in 10 mL?and in a 1- g single-dose, preservative-free lyophilized powder. (pharmacytimes.com)
  • cancer
  • Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. (medhelp.org)
  • Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. (medhelp.org)
  • In cancer, methotrexate works by interfering with the synthesis of DNA and RNA. (hubpages.com)
  • Not all methotrexate products are used to treat cancer. (drugs.com)
  • Patients with cancer who take methotrexate injection (subcutaneous) may be at a greater risk of getting a bad health problem called tumor lysis syndrome (TLS). (drugs.com)
  • Methotrexate was made in 1947 and initially came into medical use to treat cancer, as it was less toxic than the then-current treatments. (wikipedia.org)
  • citation needed] In 1951, Jane C. Wright demonstrated the use of methotrexate in solid tumors, showing remission in breast cancer. (wikipedia.org)
  • Several years later at the National Cancer Institute, Roy Hertz and Min Chiu Li then demonstrated complete remission in women with choriocarcinoma and chorioadenoma in 1956, discovering that methotrexate alone could cure choriocarcinoma (1958), a germ-cell malignancy that originates in trophoblastic cells of the placenta. (wikipedia.org)
  • bone
  • Very bad side effects like bone marrow problems, liver problems, lung problems, infections, and skin reactions (Stevens-Johnson syndrome/toxic epidermal necrolysis) can happen with methotrexate injection (subcutaneous). (drugs.com)
  • commonly
  • Methotrexate is an abortifacient and is commonly used to terminate pregnancies during the early stages, generally in combination with misoprostol. (wikipedia.org)
  • works
  • How exactly methotrexate works in treating these rheumatoid conditions is not entirely clear, although it may be related to its effect on the immune system. (hubpages.com)
  • health
  • No test preparation is needed, but timing of the sample for testing is important and a health practitioner may specify collection at a certain number of hours after a methotrexate dose. (labtestsonline.org)