• The ALS Therapy Development Institute, which studies the motor-neuron disease amyotrophic lateral sclerosis, has concluded - through its own animal studies - that several compounds that failed clinical trials entered human testing on the basis of poorly conducted or poorly designed preclinical experiments. (bioedonline.org)
  • GsONC201 in vitro and in vivo efficacy and drug bioavailability studies showed no difference compared to Oncoceutics ONC201. (thecurestartsnow.org)
  • The drug discovery process requires that upwards of 10,000 molecules be screened for each new lead compound developed and relies upon an expensive and time consuming combination of in vitro cell culture-based and in vivo whole animal-based models to identify, validate, and ensure the safety of any resulting potential therapeutic agents. (inknowvation.com)
  • Main methods in vitro and in vivo. (uniroma1.it)
  • Now a days, for scientific validation and global acceptance of homoeopathic drugs, in vitro as well as in vivo pharmacological evaluation of these drugs has been greatly increased[ 1 ]. (ijpsonline.com)
  • Animascope experts have several years of experience in discovery and preclinical imaging in vivo. (pharmaceutical-business-review.com)
  • In biomedical research, non-invasive in vivo imaging is applicable to exploratory research and bridges the gap between preclinical and clinical research. (pharmaceutical-business-review.com)
  • Here, we introduce a novel approach to assess in vivo drug synergy with high sensitivity and low false discovery rate. (bvsalud.org)
  • We show that our method can effectively validate in vitro drug synergy discovered from cell line assays in in vivo xenograft experiments, and can help to elucidate the mechanism of action for immune checkpoint inhibitors in syngeneic mouse models by combining an anti-PD-1 antibody and several tumor-infiltrating leukocytes depletion treatments. (bvsalud.org)
  • Finally, we provide an open-source software package named invivoSyn that enables automated analysis of in vivo synergy using our method and several other existing methods. (bvsalud.org)
  • SIGNIFICANCE: This work presents a general solution to reliably determine in vivo drug synergy in single-dose 4-group animal combination studies. (bvsalud.org)
  • ISO 25539-1 also provides information relevant to the preclinical in vivo and clinical evaluations of such stents. (iso.org)
  • Toxicology is one of the sciences that have slowly but surely embraced technology and new methods, focusing on high throughput and high content screenings, omics technologies, and mathematical modeling. (brill.com)
  • Thus, a transition in toxicology-from a traditional reductionist paradigm towards 21st century methods based on human biology and holistic multi- omics studies-is now becoming a reality. (brill.com)
  • In vitro methods, based on human primary cells, cell lines, and genetically modified reporter cell lines, have greatly expanded the scope of in vitro toxicology. (brill.com)
  • The use of Integrated Testing Strategies (ITS) in toxicological hazard identification and characterisation is becoming increasingly common as a method for enabling the integration of diverse types of toxicology data. (unimi.it)
  • Ordering of drug screens should be decided in coordination with a regional toxicology center because most of these tests are costly and add little to a complete history with a known ingestion. (medscape.com)
  • toxicology, and risk evaluation. (cdc.gov)
  • The course will cover a range of aspects of drug development including pharmacology, target identification, safety requirements. (uniroma1.it)
  • The services encompass method development, validation and sample analyses covering drug characterization, mode-of-action, pharmacology and preclinical safety evaluation with a broad panel of bioanalytical and immunological methods, including cell based assays. (atlab.com)
  • Pharmacology -- methods. (hacettepe.edu.tr)
  • Pharmacology is the science of investigating the effects of drugs on certain structures. (toxicologyconferences.com)
  • Development, Characterization and In Vitro Evaluation of Single o. (ingentaconnect.com)
  • Develops and applies analytical methods to support product characterization, formulation development, and stability testing of mAbs, bispecifics and other modalities. (biospace.com)
  • You have strong technical knowledge base and proven experience with biophysical/biochemical characterization, bioanalytical method development or biomolecule product development. (biospace.com)
  • Imatinib has shown preclinical activity against HRPC although minimal clinical therapeutic efficacy. (ingentaconnect.com)
  • These models are more predictive of clinical outcomes and are superior to cell lines for preclinical drug evaluation and therapeutic strategies. (biorxiv.org)
  • These results signify the potential importance of CD38-CAR T cells as therapeutic tools for CD38 + malignancies, including MM, and warrant further safety and efficacy evaluation in appropriate models. (biomedcentral.com)
  • Preclinical imaging technologies support the development of innovative diagnostic, prognostic and therapeutic applications. (pharmaceutical-business-review.com)
  • Preclinical imaging studies are therefore of great interest for the development of new pharmaceuticals through the use of a broad range of existing methodologies and the development of new diagnostic and therapeutic options for the management of pathologies. (pharmaceutical-business-review.com)
  • The validation of the method has been achieved through the high number of recognized drugs within the library, which exhibit in the same time a wide variety of therapeutic activities and interact with a broad spectrum of molecular targets. (canada.ca)
  • The drug -enriched chimera libraries are expected to provide a highly efficient access to novel drug candidates whose unspecified therapeutic effects should be further revealed through high-throughput screening. (canada.ca)
  • As a result, the classical paradigm of preclinical testing of drug candidates in animals may not be appropriate. (eurekaselect.com)
  • Evaluation of clinical candidates: pharmacodynamic activity of a new molecular entity. (uniroma1.it)
  • We contend that a lack of emphasis on evidence for the efficacy of drug candidates is all too common in decisions about whether an experimental medicine can be tested in humans. (bioedonline.org)
  • The drug evolution method represents a novel approach towards efficient rational drug design by implementing the drug evolution concept to the creation and development of general chemical libraries with the purpose of allowing the identification of drug candidates with improved odds and lesser costs than the traditional drug design strategies. (canada.ca)
  • The method allows the creation of a library containing both drugs and prospective drug candidates without any priorly required knowledge on the pursued disease or molecular target. (canada.ca)
  • Since 1991, Catalent's small molecule analytical team has developed and applied thousands of analytical methods to help customers progress their drug candidates. (catalent.com)
  • MIC testing is performed in both diagnostic and drug discovery laboratories. (wikipedia.org)
  • The first step in drug discovery is often measurement of the MICs of biological extracts, isolated compounds or large chemical libraries against bacteria and fungi of interest. (wikipedia.org)
  • The purpose of the National Cooperative Drug Discovery Group (NCDDG) Program is to create multidisciplinary research groups or partnerships for the discovery of pharmacological agents to treat and to study mental illness, drug or alcohol addiction. (nih.gov)
  • The objectives of this program are to accelerate innovative drug discovery, the development of pharmacologic tools for basic and clinical research on mental disorders, or drug or alcohol addiction, and the development and validation of models for evaluating novel therapeutics for mental disorders. (nih.gov)
  • The National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) invite applications to advance the discovery, preclinical development, and testing of new, rationally based candidate medications to treat mental disorders, drug or alcohol addiction, and the development of novel ligands as tools to further characterize existing or to validate new drug targets. (nih.gov)
  • Basic concepts of drug discovery and testing. (uniroma1.it)
  • The application of natural drugs is increasing day by day in every field and recent scientific community have been focused for drugs from natural sources in drug discovery due to their meagre side effects. (ijpsonline.com)
  • The Molecular Therapeutics Program focuses on developing new approaches for treating cancer, ranging from drug discovery to mechanism-based efforts emphasizing mechanisms-of-action of novel tumor-targeted and standard agents and critical signaling pathways. (cancer.gov)
  • Accordingly, the early assessment of hERG-related cardiotoxicity has become a common practice in drug discovery. (springer.com)
  • To provide a comprehensive understanding of the drug discovery process including past, current and future trends in discovery and to develop skills in designing discovery, lead optimisation and preclinical development programs. (edu.au)
  • case studies in drug discovery - success stories and failures. (edu.au)
  • The goals of the Molecular Imaging Program include the development and testing of new imaging methods ranging from preclinical work on the synthesis of new probes and development of new devices to the clinical evaluation of imaging approaches to assess cancer risk, detect cancer, guide treatment and monitor therapy. (cancer.gov)
  • Journal of Pharmacological and Toxicological Methods 107, 106947. (awionline.org)
  • The report notes that the 63-page Investigator Brochure describing the trial included fewer than two pages of evidence that the drug had the desired pharmacological activity. (bioedonline.org)
  • For instance, neuroimaging is now central to research and drug development in the neurosciences since it can be used to detect the pharmacological and physiological consequences of drug action within the living brain. (pharmaceutical-business-review.com)
  • Species difference in drug metabolism and drug toxicity is a well-established phenomenon. (eurekaselect.com)
  • One preclinical approach to evaluate human drug properties, especially ADMET (absorption, disposition, metabolism, elimination, and toxicity) properties, is to apply in vitro experimental systems with relevant human properties. (eurekaselect.com)
  • The use of hepatocyte to evaluate the role of metabolism in drug toxicity represents a major advance in drug toxicity evaluation. (eurekaselect.com)
  • The use of the novel integrated discrete multiple organ coculture (IdMOC) system allows the evaluation of the role of hepatic metabolism on nonhepatic toxicity. (eurekaselect.com)
  • Understanding the absorption, distribution, metabolism and excretion (ADME) of candidate drugs in preclinical species is an integral part of the safety and efficacy evaluation in drug development. (awionline.org)
  • In co-operation with our clinical collaborators, Professor Martin Englund, Professor Leif Dahlberg and Associate Professor Carl-Johan Tiderius at Lund University, our methods are implemented in longitudinal studies of patient cohorts with OA or at risk of developing OA. (lu.se)
  • Lund University is one of the 21 sites within the consortium named TRISTAN (Translational Imaging in Drug Safety Assessment), that perform preclinical models and apply imaging techniques such as MRI, CT and PET to assess lesions in the lung tissue caused by drug administration. (lu.se)
  • Preclinical experiments were carried out on rats, allowed to drink Uliveto or oligomineral water for 30 days. (nih.gov)
  • Englund focuses on osteoarthritis research, including preclinical experiments as well as clinical studies and epidemiological research using population-based register data. (lu.se)
  • With an average of 10,000 novel molecules that must be screened for each new lead compound developed, and an average of 10 to 15 years of research and development at a cost of up to $1B to manufacture one new drug, pharmaceutical companies must develop new testing regimens that provide more data at a lower cost in order to achieve the economics necessary to remain profitable. (inknowvation.com)
  • The phases of clinical development: determination of the safety and effectiveness of a new drug in humans. (uniroma1.it)
  • PROGRAM: Stages of development of a drug-medicament. (uniroma1.it)
  • Pharmacogenomics in drug development. (uniroma1.it)
  • The goal of this study was to develop the first successful iron labeling method of breast cancer cells derived from patient brain metastases and validate this method with imaging during tumour development. (biorxiv.org)
  • CiToxLAB has acquired AccelLAB, a preclinical medical device contract research organization (CRO) as the industry works to align the development of new drugs and medical devices. (outsourcing-pharma.com)
  • Within CiToxLAB Group, AccelLAB allows the convergence process between the development of new drugs and medical devices which represents a new offer to the customers ​," he said. (outsourcing-pharma.com)
  • Several CROs are preparing for this convergence of drug development and medical devices, as they look to expand offerings into the area - most recently demonstrated with CSSI LifeSciences announcement ​ yesterday. (outsourcing-pharma.com)
  • Global regulatory standards govern bioanalytical method development, validation and the subsequent assays. (outsourcing-pharma.com)
  • The Principal Scientist in FDG leads formulation and drug product development that may include candidate screening and selection for preclinical and Phase 1 clinical studies, developing formulations for Phase 2/3 clinical studies and commercialization. (biospace.com)
  • Lead formulation and drug product development activities for multiple programs, in collaboration with analytical and drug product process development and other cross functional teams. (biospace.com)
  • The goal of this study was therefore the development and preclinical evaluation of a 68 Ga-labeled adnectin protein ( 68 Ga-BMS-986192) to facilitate clinical trials. (snmjournals.org)
  • We have also demonstrated how pre-clinical imaging can accelerate the development of promising new treatments, or force early closure of a project which ultimately may not deliver a useful/safe drug. (icr.ac.uk)
  • DRUG DESIGN AND DEVELOPMENT, PRECLINICAL ASPECT is intended to give propelled training to enrolled individuals by preclinical parts of translational medicine and related research. (skillzip.com)
  • This program is intended to create specialists for the high-demand field of drug development. (skillzip.com)
  • It makes individual specialists in drug development and its usage. (skillzip.com)
  • Module 2 - Detailed learning of drug design and development. (skillzip.com)
  • More-thorough assessments of clinical potential before trials begin could lower failure rates and drug-development costs. (bioedonline.org)
  • Drug development. (hacettepe.edu.tr)
  • In countries that adhere to the principles of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) the Development Safety Update Report (DSUR) is considered the standard report for informing regulators of the evolving safety profile of drugs under development. (canada.ca)
  • By discovering and characterizing the diversity of solid-state forms, it becomes possible to select an optimal form that displays an appropriate balance of properties that are critical for successful preclinical evaluation and product development, as well as robust manufacturing processes. (catalent.com)
  • Accelerated Approach high throughput API screening platform that will help accelerate your development and optimization of drug molecules. (catalent.com)
  • Guidance for the development of in vitro test methods is included in Annex D. This document is supplemental to ISO 14630, which specifies general requirements for the performance of non-active surgical implants. (iso.org)
  • We believe that MRI can provide the solution and we work on the development and improvement of methods for measuring the amount and chemical composition of fat in various parts of the human body. (lu.se)
  • It is therefore a call for academic and industry partners to accelerate preclinical and clinical testing of vaccines against filoviruses that pose a public health threat (e. g. (who.int)
  • Efforts to use computational methods for the prediction of hERG blocking effects have ranged from the use of simple rules based on structural and functional features, through to more complex quantitative structure-activity relationship (QSAR) models [ 12 - 16 ]. (springer.com)
  • Preclinical medical imaging is applicable to dynamic distribution and biomarker validation studies, and assessment of the delivery, liberation, efficacy and safety of drugs, biologics, biopharmaceuticals, nanoparticles, biomaterials and stem/progenitor cells. (pharmaceutical-business-review.com)
  • ASTER (Assessment Tools for the Evaluation of Risk) ecotoxicity profile: Ethanol, 2-butoxy. (cdc.gov)
  • immunotoxicology--protein part of the safety assessment of drugs, chemicals, and other allergy. (cdc.gov)
  • It is also rec- important target organ in the safety assessment of drugs and ognized that different types of immune-mediated responses can be triggered by different classes of compounds and that some immune chemicals, as well as protein- or peptide-based products. (cdc.gov)
  • Similarly, destruction of neonatally abundant pluripotent stem cells would likely have a more pervasive outcome than destruction of The value of incorporating immunologic appeared more severe and/or persistent when single lineages or differentiated cells that pre- data for the toxicologic assessment of drugs, the exposure occurred perinatally when com- dominate in adults. (cdc.gov)
  • Ethical review boards must focus on clinical promise as well as safety to hold the first tests of drugs in humans to a higher standard, say Jonathan Kimmelman and Carole Federico. (bioedonline.org)
  • Moreover, Bial's drug had been tested at a range of doses in micethat made it impossible to estimate the most likely effective dose in humans. (bioedonline.org)
  • We call for infrastructure, resources and better methods to rigorously evaluate the clinical promise of new interventions before testing them on humans for the first time. (bioedonline.org)
  • Favoured picks for the next commissioner of the US Food and Drug Administration (FDA) are likely to lower the current requirements that a drug must demonstrate efficacy in humans before entering the market. (bioedonline.org)
  • Exploiting our combined expertise, we have been responsible for the pre-clinical evaluation of numerous functional MRI methods/biomarkers that have been successfully translated and proved informative when translated into aligned clinical imaging investigations of cancer patients. (icr.ac.uk)
  • New imaging technologies will ultimately contribute to identify important biomarkers and surrogate endpoints both for preclinical and clinical research. (pharmaceutical-business-review.com)
  • Human leukocyte antigen-associated severe cutaneous adverse drug reactions: from bedside to bench and beyond. (nace.org.au)
  • It is against this background that cellular immune responses to an otherwise innocuous antigen, a review of the methods used to assess the potential for immune- which can lead to tissue damage (Janeway et al. (cdc.gov)
  • Some preclinical data have shown some anticancer calculated using the statistical formula n = Z2 P(1-P)/ properties of camel urine but it has not been investigated d2, where Z was the statistic corresponding to level of clinically ( 5 - 7 ). (who.int)
  • The main aim of the work was to develop novel liposomal formulations comprising imatinib co-encapsulated with mitoxantrone, by different loading methods and experimental conditions, in order to achieve the highest drug loading and maximum physical stability. (ingentaconnect.com)
  • Postmarketing surveillance, its role in the detection of adverse drug reactions. (uniroma1.it)
  • Definition and classification of adverse drug reactions. (uniroma1.it)
  • The study aimed to analyse the adverse drug reactions report form data received by the State Expert Center of the Ministry of Health of Ukraine from healthcare professionals in the Lviv region in 2022. (bvsalud.org)
  • The highest proportion among all adverse drug reactions caused by penicillins and cephalosporins was attributed to allergic reactions. (bvsalud.org)
  • With current in vitro screening assays now representing a $1.4B market with a predicted 12% annual growth rate, we believe we possess a product capable of significantly impacting the chemical/drug screening market and, here in particular, advancing our understanding of cytotoxic chemical biotransformations as they pertain to public health and consumer safety. (inknowvation.com)
  • Pre-clinical studies to assess the safety of a drug. (uniroma1.it)
  • Since origin of most of the homoeopathic drugs are plant based and raw materials for many homeopathic drugs are known to be toxic, the safety evaluation should not be ignored specifically when using low concentrations of a toxic starting material. (ijpsonline.com)
  • In the wake of the tragedies, the French medicines safety agency (ANSM) ordered an examination of the information that the drug developer, Bial, based in Trofa, Portugal, had supplied to ethics committees and potential researchers before the trial. (bioedonline.org)
  • With the intention of protecting clinical trial participants and patients, the International Conference of Harmonization published a guideline (S7B) recommending that "all new drugs" should be tested pre-clinically for hERG sensitivity and cardiac safety before submitting an application to regulatory reviews [ 7 ]. (springer.com)
  • Periodic analysis of safety information is essential to identify and mitigate the risks associated with the administration of an investigational drug. (canada.ca)
  • By preparing DSURs on an annual basis sponsors can reassure the regulators that they have adequate oversight of the safety profile of the investigational drug. (canada.ca)
  • This document will provide guidance on how sponsors can disclose in the DSUR the way they have recorded safety information during the reporting period and reviewed it in the context of the cumulative safety profile of the investigational drug. (canada.ca)
  • Sponsors should use the DSUR to present a comprehensive annual review of pertinent safety information collected during the reporting period and to evaluate whether it is consistent with the previous knowledge of the safety profile of the investigational drug (ICH E2F, 1.2). (canada.ca)
  • Sponsors are reminded that the ICH E2F guidance recommends that the overall safety of an investigational drug is assessed taking into consideration the reporting period data in the context of the cumulative experience with the drug itself (ICH E2F, 3.18). (canada.ca)
  • The region-specific information section of the DSUR should be used to include a summary description of the process used by the sponsor to review the worldwide safety data of the investigational drug (for example: regular analyses of accumulating data, in-house safety review meetings, proposal of specific pharmacovigilance activities, substantial modifications of protocol, etc. (canada.ca)
  • Cincinnati, OH: Hazard Evaluations and Technical Assistance Branch, National Institute for Occupational Safety and Health, U. S. Department of Health and Human Services. (cdc.gov)
  • The preclinical study suggests that the clinical actions of Uliveto water depend mainly on its ability to enhance gastric motor and secretory functions. (nih.gov)
  • Our study presented for the first time an active loading method for imatinib and suggests that the optimized liposomal formulation co-encapsulates both drugs with high encapsulation efficiency (>95%), shows enhanced drug retention under tested conditions and delivers a drug:drug ratio capable of improving tumor cell growth inhibition with a mitoxantrone dose reduction of 2.6-fold as compared to single liposomal formulation. (ingentaconnect.com)
  • This review summarizes the latest findings on human hepatocytes isolation, cryopreservation, culturing, as well as application in the evaluation of metabolic stability, metabolite profiling, hepatic uptake and efflux, metabolic drug-drug interactions, and drug toxicity. (eurekaselect.com)
  • Mechanisms are not fully elucidated and several hundreds of various types of drugs are able to cause the type of toxicity and injury, called Drug-induced interstitial lung disease (DIILD). (lu.se)
  • Many in vitro assays exist for the pre-clinical evaluation of hERG-related cardiotoxicity [ 8 ], examples include rubidium-flux assays, radioligand binding assays, in vitro electrophysiology measurements, and fluorescence-based assays [ 9 ]. (springer.com)
  • Field evaluations were conducted during September 2017, in Kinshasa province, DRC. (cdc.gov)
  • Both preclinical studies showed only "moderate" positive effects. (bioedonline.org)
  • With a core competence in inflammation research IBR provides bioanalytical services for preclinical and clinical studies to biotechnology and pharmaceutical companies. (atlab.com)
  • In R&D, imaging is particularly useful for pathophysiology, drug efficacy evaluation and model validation studies. (pharmaceutical-business-review.com)
  • however, its efficacy and synergy require rigorous evaluation in preclinical studies before going to clinical trials. (bvsalud.org)
  • Existing methods have limited power to detect synergy in animal studies. (bvsalud.org)
  • In one, Bial had data for a different marketed drug showing it was more effective than Bial's drug at relieving pain in animals, but did not include that information in a summary figure. (bioedonline.org)
  • In the field of MRI physics we develop new methods for image acquisition and data processing. (lu.se)
  • The main cause attributed to the observations described above is a publication and incentive system that rewards the impact and novelty of scientific findings, but does not systematically assess their reproducibility, which is rarely considered in the evaluation of researchers (14,15). (bvsalud.org)
  • As another example of successful translation of the biological evolution into chemical evolution, the chimera method comprises the grafting of selected building blocks, identified through a basic search within a drug library, onto the same substitution sites on a rationally chosen scaffold. (canada.ca)
  • Since the calcium folinate rescue dosage regimen depends heavily on the posology and method of the intermediate- or high-dose methotrexate administration, the methotrexate protocol will dictate the dosage regimen of calcium folinate rescue. (janusinfo.se)
  • At a workshop of the US National Academy of Sciences in September, Robert Temple, a veteran at the FDA's Center for Drug Evaluation and Research, said that the agency largely left it to drug sponsors to evaluate their rationale that an experimental drug was likely to work. (bioedonline.org)
  • Drugs -- Research. (hacettepe.edu.tr)
  • Jonas' research spans such diverse fields as methods for estimating renal function, risk modeling in clinical epidemiology, the importance of the local environment for health and well-being and more theoretical issues in epidemiological methodology. (lu.se)
  • They also lysed primary malignant cells from acute myeloid leukemia, and multi-drug resistant MM patients. (biomedcentral.com)
  • Clinical potential of nanotechnlogy as smart therapeutics: A step toward targeted drug delivery.In Advances in Nanotechnology-Based Drug Delivery Systems. (benthamscience.com)
  • Animascope services bring ethical and cost advantages to your study and help you save a significant amount of time in the R&D process, accelerating the transfer of a potential new drug from the preclinical stage to the market. (pharmaceutical-business-review.com)
  • All major clinical and preclinical departments were made aware of the study objectives and referred HCWs who self-identified as having TB to the study team. (cdc.gov)
  • The BJGMC-SGH Institutional Ethics Committee approved all study methods. (cdc.gov)
  • refer to the applied intermediate or high dose methotrexate protocol for posology and method of administration of calcium folinate. (janusinfo.se)
  • Auseinandersetzung der statistischen Methode [Deliberation about the statistical method]. (jameslindlibrary.org)
  • Medications and Pregnancy: teratogenic drug. (uniroma1.it)
  • Second-tier imaging with molecular methods, preferably with fluorodeoxyglucose positron emission tomography (FDG-PET) (or single-photon emission CT [SPECT] if PET is unavailable), can provide greater diagnostic specificity. (medscape.com)
  • Although the throughput of this assay is lower than that of radiometric methods, the assay is easier to set up and cheaper, and avoids the problems related to radioactive waste disposal. (unimi.it)
  • Complete Suite of Analytical Services from early preclinical through clinical and commercial stages, Catalent delivers a single-provider solution for all your analytical needs. (catalent.com)
  • Drug evolution concept in drug design: 2. (canada.ca)
  • This document specifies requirements for the evaluation of stent systems (vascular stents and delivery systems) and requirements with respect to nomenclature, design attributes and information supplied by the manufacturer, based upon current medical knowledge. (iso.org)
  • 2) the effects of Uliveto on preclinical models of gastric functions. (nih.gov)
  • We documented the demographics of each patient, the method of administering the urine, reasons for refusing conventional treatment, period of follow-up, and the outcome and side effects. (who.int)
  • Careful evaluations comparing percutaneous approaches with conventional surgical approaches are likely to serve as an impetus for extending the use of the new, less invasive techniques from high-risk patients to other, lower-risk patient groups. (medscape.com)
  • A microtitre-based method for measuring the haem polymerization inhibitory activity (HPIA) of antimalarial drugs / N. Basilico, E. Pagani, D. Monti, P. Olliaro, D. Taramelli. (unimi.it)