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FluoresceinLissamine Green DyesDry Eye SyndromesTearsFluorophotometryConjunctivaCorneaOphthalmic SolutionsFluoresceinsFluorescein AngiographyFluorescein-5-isothiocyanatePort-Wine StainAzure StainsStaining and LabelingFluorescent DyesFundus OculiThiocyanatesBlood StainsRetinal VesselsChoroidal NeovascularizationChoroidDextransColoring AgentsRetinal DiseasesPhenazines
CorneaEpitheliumLissamineTBUTKeratitisSlit-lamp examinationFundusInflammationVascularMeibomianVisual acuityStromalInjectionOcular surfaceClinicalEpithelial cellsTopicalDiseasesKeratoconjunctivitisExaminationEyelid2022NeovascularizationImmunofluorescentEfficacyBreeding strate1989ThicknessSensitivity2020InvolvementProliferationPatientsInferiorUlcerationAcuteSuspensionDiseaseDetectTreatmentDiagnosisDrugsSecondaryInadvertentlyContact lenses
Cornea8
  • Herpes simplex keratitis usually affects the corneal surface but sometimes involves the corneal stroma (the deeper layers of the cornea) or the inner corneal surface (endothelium), anterior chamber, and iris. (msdmanuals.com)
  • Bilateral punctuate epithelial involvement of the cornea with white intraepithelial infiltrates that stain irregularly with fluorescein is the typical pattern of ocular microsporidiosis described in immunocompromised individuals [ 6 ]. (springeropen.com)
  • Although he does have some residual neovascularization in the lower cornea, the lens provides an adequate vault over the surface and has succeeded in maintaining the corneal integrity. (sclerallens.com)
  • 3) A slit-lamp examination done with a thorough exam of clarity and regularity of the cornea and to rule out any conjunctival abnormality such injection of conjunctival vessels should be documented. (amretina.com)
  • In addition, these cells act as a barrier to prevent overgrowth of conjunctival tissue toward the cornea [ 2 ]. (ekjo.org)
  • However, effects on blinking, ptosis, the function of Meibomian glands, fluorescein and lissamine green staining of the conjunctiva and cornea, production of lid-parallel conjunctival folds and lid wiper epitheliopathy have received less research attention. (uwaterloo.ca)
  • METHODS: We collected the paraffin-embedded cornea tissues from 10 FK and 6 ocular trauma patients to explore the MIF expression by immunohistochemistry. (ijo.cn)
  • Ectatic corneal disease (ECD) comprises a group of disorders characterized by progressive thinning and protrusion of the cornea, leading to visual impairment. (contactlensupdate.com)
Epithelium8
  • 11] Mechanisms involving promotion of mast cell migration and activation in this disease are unclear, but recent research found an overexpression of stem cell factor (SCF) and thymic stromal lymphopoietin (TSLP) in the conjunctival epithelium of patients with SLK. (medscape.com)
  • Fluorescence lifetime imaging microscopy reveals quenching of fluorescein within corneal epithelium. (ucla.edu)
  • We standardized quality-controlled cord blood serum (CBS)-based eye drops and evaluated the efficacy of 1-month CBS treatment in the healing of diseased corneal epithelium in severe dry eye (DE) patients. (drcremers.com)
  • Heterologous CBS-based eye drops represent a promising therapeutic approach in the healing of severely injured corneal epithelium and in subjective symptom relief. (drcremers.com)
  • in cases of superficial keratitis the epithelium is likely to faintly stain, although true ulceration is absent. (vin.com)
  • Turner KPflugfelder SCJi ZFeuer WJStern M Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion. (jamanetwork.com)
  • Limbal epithelial stem cells (LSCs) maintain the corneal surface by providing precursors that differentiate and replace the corneal epithelium [ 1 ]. (ekjo.org)
  • Limbal stem cell deficiency (LSCD) is caused by destruction and/or dysfunction of precursors of the corneal epithelium in the basal limbal area, resulting in conjunctival epithelial growth onto the corneal surface [ 3 ]. (ekjo.org)
Lissamine2
  • Clinical data, including Ocular Surface Disease Index (OSDI) questionnaire, corneal fluorescein staining (CFS), conjunctival lissamine green staining, tear break-up time (TBUT), and Schirmer test, were evaluated before and after treatment. (uthscsa.edu)
  • Staining with fluorescein and lissamine green dyes can highlight specific patterns of allergy-associated changes (eg, pannus with superior stain in the setting of giant papillary conjunctivitis). (crstodayeurope.com)
TBUT4
  • This Phase I, prospective, open-label, 12-week study enrolled subjects ≥18 years old with symptoms of DED for at least 6 months and at least one of the following: Total ocular staining score ≥2 or tear film breakup time (TBUT) ≤7 s. (ajoclinicaltrials.com)
  • SICCA total ocular staining score, corneal and conjunctival staining score, TBUT, and subject-reported symptoms using the visual analog scale (VAS) symptom index were assessed at baseline and at every visit. (ajoclinicaltrials.com)
  • In the autologous serum (ALS) group, all the clinical parameters except Schirmer's I showed significant improvement in the first post-treatment analysis .This was sustained at a significant level in the second analysis except for tear film break-up time (TBUT) and conjunctival impression cytology grading. (drcremers.com)
  • secondary outcomes included evaluation of changes in Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, tear film break-up time (TBUT), corneal and conjunctival staining, tear osmolarity, matrix metalloproteinase-9 (MMP-9), artificial tear use and safety assessments. (springer.com)
Keratitis5
  • Herpes simplex keratitis is corneal infection with herpes simplex virus. (msdmanuals.com)
  • Most patients with disciform keratitis, which involves the corneal endothelium primarily, have a history of epithelial keratitis. (msdmanuals.com)
  • Disciform keratitis is a deeper, disc-shaped, localized area of secondary corneal stromal edema and haze accompanied by anterior uveitis. (msdmanuals.com)
  • METHODS: C57BL/6 mice were randomized into a control group and A. fumigatus keratitis group. (ijo.cn)
  • METHODS: C57BL/6 and BALB/c mice were used to establish fungal keratitis models. (ijo.cn)
Slit-lamp examination2
  • In any patient with ocular complaints, perform a complete physical examination of the eye, including visual acuity, fluorescein staining, slit-lamp examination, and tonometry. (medscape.com)
  • If an aqueous leak is present, it may be detected on slit-lamp examination following the instillation of fluorescein dye by a clear band in the stain extending downward from the suspected site of injury. (medscape.com)
Fundus2
  • The incidence and leakage area of CNV were measured with fundus fluorescein angiography, choroidal flat mounting, and hematoxylin and eosin (HE) staining. (molvis.org)
  • Color fundus photography, fluorescein angiography (FA), and optical coherence tomography (OCT) procedures were performed every 2 or 4wk until stable retinal vascular leakage was observed. (sciencegate.app)
Inflammation3
  • 10] These damages increase frictional forces between conjunctival surfaces and consequently create repetitive microtrauma, leading to SLK-like inflammation. (medscape.com)
  • The Schirmer's tear test should be done to any eye in which there is discharge, signs of inflammation, or corneal disease (there is no contraindication for this procedure). (vin.com)
  • This further results in decreased inflammation as measured by reduced MMP-9 levels in the tear fluid and decreased ocular surface damage as measured by corneal and conjunctival staining during the supplementation. (springer.com)
Vascular1
  • Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
Meibomian2
  • 5 The tear film, lacrimal glands, corneal and conjunctival epithelia and Meibomian glands work together as an integrated lacrimal functional unit (LFU). (touchophthalmology.com)
  • The approach discussed below is evidence-based, employing some of the stronger clinical markers-i.e., symptoms, meibomian gland dysfunction, lid wiper epitheliopathy (LWE), lid-parallel conjunctival folds (LIPCOFs)-and associated symptoms of contact lens discomfort. (reviewofoptometry.com)
Visual acuity2
  • This lens modality may be considered for any other case involving irregular corneal curvature following surgery and reduced visual acuity. (sclerallens.com)
  • If a patient with a history of CL wear for an extended period of time presents with decreased visual acuity, practitioners should perform detailed examinations with suspicion of CL-LSCD, including fluorescein staining. (ekjo.org)
Stromal2
  • Novel DCN Mutation in Armenian Family With Congenital Stromal Corneal Dystrophy. (ucla.edu)
  • fluorescein will pool in epithelialized stromal defects. (vin.com)
Injection1
  • Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
Ocular surface2
  • Therapeutic contact lenses for the treatment of corneal and ocular surface diseases: advances in extended and targeted drug delivery. (stanford.edu)
  • The extent of epithelial defect was evaluated in square millimeters area, and subjective symptom score (Ocular Surface Disease Index score), Schirmer test I, break-up time, tear osmolarity, corneal esthesiometry (Cochet-Bonnet esthesiometer), conjunctival scraping, and imprint cytology with goblet cell count were performed at baseline (V0) and after 15 (V1) and 30 (V2, endpoint) days of treatment. (drcremers.com)
Clinical4
  • Seventeen graft-versus-host disease (GVHD) and 13 Sjogren syndrome patients with severe persistent corneal defects were enrolled in the framework of a registered clinical trial (ClinicalTrials.gov NCT01234623 ). (drcremers.com)
  • Results In the cord blood serum (CBS) group, except for McMonnies score and staining score, all other clinical parameters showed continued improvement in the first and second post-treatment analyses. (drcremers.com)
  • Post DL-AAA delivery, clinical ophthalmic examinations were performed weekly following modified McDonald-Shadduck Scoring System. (sciencegate.app)
  • Corneal severity of rats' FK models was documented by clinical scores, and real-time PCR. (ijo.cn)
Epithelial cells2
  • Then we cultured telomease-immortalized human corneal epithelial cells (THCEs), stimulated by the hyphae suspension of Aspergillus fumigatus (A. fumigatus) to detect the change of MIF with or without the pretreatment of MIF inhibitor [4-Iodo-6-phenylpyrimidine (4-IPP)] by real-time polymerase chain reaction (PCR). (ijo.cn)
  • AIM: To evaluate the feasibility of mesenchymal stem cells (MSCs) to differentiate into corneal epithelial cells after being seeded on the decellularized small incision lenticule extraction (SMILE)-derived lenticules. (ijo.cn)
Topical3
  • The objective of the study was to evaluate the safety and efficacy of ALG-1007 topical ophthalmic solution in patients with dry eye disease (DED). (ajoclinicaltrials.com)
  • Belin MWBouchard CSFrantz SChmielinska J Topical cyclosporine in high-risk corneal transplants. (jamanetwork.com)
  • Kunert KSTisdale ASStern MESmith JAGipson IK Analysis of topical cyclosporine treatment of patients with dry eye syndrome: effect on conjunctival lymphocytes. (jamanetwork.com)
Diseases1
  • Many corneal diseases can lead to vision loss affecting the lives of people around the world. (stanford.edu)
Keratoconjunctivitis3
  • Other potential risk factors for development of superior limbic keratoconjunctivitis include prolonged eyelid closure with associated hypoxia or reduced tear volume, as well as morphologic or functional changes in superior conjunctival apposition to the globe following upper eyelid procedures. (medscape.com)
  • In keratoconjunctivitis, an associated corneal involvement is present. (medscape.com)
  • Diagnosis of microsporidial keratoconjunctivitis was confirmed by subspecialist examination and conjunctival swabs examined by light microscopy. (springeropen.com)
Examination2
  • The first part, and probably the most overlooked portion of the ophthalmic examination, is to scrutinize the patient from distance. (vin.com)
  • The initial prescription and renewal of the ophthalmic suspension should be made by a physician only after examination of the patient with the aid of magnification, such as slit lamp biomicroscopy and fluorescein staining (where appropriate). (pdr.net)
Eyelid1
  • Procedures such as repair of eyelid or conjunctival laceration are deferred until globe rupture is ruled out. (medscape.com)
20221
  • METHODS: We performed a search on EMBASE and PubMed for studies up to 15th July 2022. (bvsalud.org)
Neovascularization1
  • Scleral lenses offer a unique way of addressing many issues raised in this case report such as corneal neovascularization and ectasia. (sclerallens.com)
Immunofluorescent2
  • Immunofluorescent double staining was used to detect YAP cellular localization with CD31 (an endothelial cell marker) antibody. (molvis.org)
  • Immunofluorescent staining was used to test the expression of LC3 in corneas after A. fumigatus infection. (ijo.cn)
Efficacy3
  • Efficacy of standardized and quality-controlled cord blood serum eye drop therapy in the healing of severe corneal epithelial damage in dry eye. (drcremers.com)
  • Sall KStevenson ODMundorf TKReis BL Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. (jamanetwork.com)
  • Stevenson DTauber JReis BL Efficacy and safety of cyclosporine A ophthalmic emulsion in the treatment of moderate to severe dry eye disease: a dose-ranging, randomized trial, The Cyclosporine A Group. (jamanetwork.com)
Breeding strate1
  • Describes the method and breeding strategies for the breeds for which DNA testing for prcd-PRA is currently available. (malamute-health.org)
19891
  • 3 In 1989, it was first reported that tacrolimus suppressed corneal graft rejection in rabbits. (org.pk)
Thickness3
  • Note when high IOP spotted a corrected IOP documented after central corneal thickness measurement. (amretina.com)
  • Corneal thickness along a 10 mm cord was measured using the Visante OCT and tested for NI using a 30 μm margin. (uwaterloo.ca)
  • Results: The least-square mean differences (LSMD) and 95% confidence interval (95% CI) between etMF DD and habitual SiHy in central and peripheral corneal thickness (μm) were 3.64 (−2.0, 9.29) and 3.0 (−7.72, 13.72) in hyperopic, and 3.56 (−0.66, 7.78) and 6.40 (−1.62, 14.42) in myopic subjects. (uwaterloo.ca)
Sensitivity1
  • 1 Associated factors cited were loss of corneal sensitivity, increased tear osmolarity, trigeminal denervation, pre-lens tear film thinning (particularly of the lipid layer), higher water content contact lenses and shortened blink intervals. (reviewofoptometry.com)
20201
Involvement1
  • The initial (primary) infection is usually nonspecific self-limiting conjunctivitis, often in early childhood and usually without corneal involvement. (msdmanuals.com)
Proliferation1
  • AIM: To explore the effect of miR-184 and miR-205 on the proliferation and metastasis of conjunctival mucosa associated lymphoid tissue (MALT) lymphoma. (ijo.cn)
Patients8
  • Methods: This single-center study included 42 patients with moderate-to-severe DED associated with (n = 21) or without (n = 21) chronic GVHD. (uthscsa.edu)
  • In each group, patients received either loteprednol etabonate 0.5% ophthalmic suspension or artificial tears twice daily for 4 weeks. (uthscsa.edu)
  • Patients were given small amount of tacrolimus 0.1% ointment applied to the inferior conjunctival fornix before going to bed. (org.pk)
  • The panel agreed that following confirmed DED diagnosis, just two criteria, symptom-based assessment and corneal fluorescein staining were sufficient to diagnose the presence of severe DED in the majority of patients. (bmj.com)
  • Methods 144 consecutive patients were randomly divided into three groups. (drcremers.com)
  • Diagram and scale used to measure intensity of corneal staining in patients with dry eye disease. (jamanetwork.com)
  • A study by Williamson et al have reported that the overall incidence of fungi was 2.9% in patients with healthy conjunctival flora. (eophtha.com)
  • METHODS: Tissue of tumor and adjacent normal control from 5 patients with conjunctival MALT was included. (ijo.cn)
Inferior1
  • On the left eye, however, an adequate fit could not be obtained because there was progressive fibrovascular growth over the inferior temporal ICRS with lens touch and resulting fluorescein staining at every visit despite consequent steepening of the lens. (sclerallens.com)
Ulceration1
  • The tear test is especially important in cases of corneal ulceration. (vin.com)
Acute2
  • Key study:- Jessup (2003) 'Acute dermal irritation/corrosion study in the rabbit' conducted in line with OECD Guideline 404 and EU Method B.4. (europa.eu)
  • Key study: Shepard (2003) 'Acute eye irritating/corrosion study in the rabbit' conducted in line with OECD Guideline 405 and EU Method B.5. (europa.eu)
Suspension1
  • Apply ophthalmic solution or suspension topically to the eye. (pdr.net)
Disease1
  • This is the only way to detect lagophthalmos, which accounts for much of the corneal disease in brachycephalic breeds. (vin.com)
Detect1
  • Hematoxylin-eosin (H&E) staining was used to detect pathological changes of corneas. (ijo.cn)
Treatment2
  • Fluorescein angiograms were scored before and after treatment following a novel grading system, developed for the DL-AAA rabbit model. (sciencegate.app)
  • 3-7 To ensure successful management of ECDs, a thorough understanding of their underlying causes and up-to date knowledge of advancements in treatment methods is crucial. (contactlensupdate.com)
Diagnosis2
  • Diagnosis is based on the characteristic dendritic corneal ulcer and sometimes viral culture. (msdmanuals.com)
  • Light microscopic evaluation of conjunctival swabs may be a useful minimally invasive first step toward diagnosis of microsporidial keratoconjunctivis in settings where electron microscopy is not available. (springeropen.com)
Drugs1
  • Since traditional methods are less efficient ( 5%) at delivering drugs to ocular tissues, contact lenses have generated growing interest in ocular drug delivery due to their potential to enhance drug bioavailability in ocular tissues. (stanford.edu)
Secondary1
  • Secondary ectasias, on the other hand, refer to corneal shape changes caused by external factors, such as corneal surgery or trauma, with no underlying ectatic propensity existing, and would be considered "thinning disorders" as opposed to a primary ECD. (contactlensupdate.com)
Inadvertently1
  • Through careful scrutiny of the patient from a distance, you will have inadvertently evaluated nearly all cranial nerves of ophthalmic importance (cranial nerves II, III, IV, V, VI, and VII). (vin.com)
Contact lenses1
  • PURPOSE: To model between subject variability of corneal swelling (CS) and deswelling after overnight wear of silicone hydrogel (SiHy) contact lenses. (uwaterloo.ca)