NeckMetastasisMelanomaTumorDiagnosisPenile squamous cell carcUnresectable or metastaticTumorsCSCCCancersMerkel Cell CarcLymphAdenocarcinomaAdenoid Cystic CaBasal cellRecurrent or metastaticDifferentiationLesionsPembrolizumabPatients with cutaneousSituActinic KeratosisCancerPrognosisAnal canalHistologyOropharyngealOral cavityNasopharynxInvasiveRadiationPlatinum-based chemotherapyPrimaryPathologyOccursKeratinocytesCancerousDiseaseTreatmentBiopsyMutationsExcisionEpidermisArisesPrognosticDysplasiaInhibitor
Neck30
- Computed tomographic density of metastatic lymph nodes as a treatment-related prognostic factor in advanced head and neck cancer. (nih.gov)
- The majority (70%) of cutaneous squamous cell carcinoma (SCC) occurs on the head and neck, with an additional 15% found on the upper extremities. (medscape.com)
- The objective of this study is to evaluate in a 3 +3 design, the safety of escalating doses of Monalizumab given IV in combination with cetuximab in patients who have received prior systemic regimen(s) for recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN). (stanford.edu)
- Objectives To assess health-related quality of life (HRQoL) with first-line pembrolizumab, pembrolizumab-chemotherapy, or cetuximab-chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) in the phase 3 KEYNOTE-048 trial (NCT02358031). (gencat.cat)
- Background: Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer that affects the head and neck region with highest mortality rate among all malignancies and it is the sixth common malignancy reported worldwide. (journalcra.com)
- The efficacy of cetuximab is poor in metastatic head and neck squamous cell carcinoma (HNSCC). (figshare.com)
- 80-90% of cSCCs with metastatic potential are located on the head and neck. (wikipedia.org)
- Retrospective study of palliative radiotherapy in newly diagnosed head and neck carcinoma. (nih.gov)
- Long-term results of the combined modality therapy for advanced cervical metastatic head and neck squamous cell carcinoma. (nih.gov)
- To construct a prognostic signature composed of DNA repair genes to effectively predict the prognosis of patients with head and neck squamous cell carcinoma (HNSCC). (frontiersin.org)
- Head and neck squamous cell carcinoma (HNSCC) is a type of tumor that originates from the squamous epithelium of the head and neck areas, including the mucous membranes of the lips, tongue, pharynx, larynx, and others ( 1 ). (frontiersin.org)
- Cases without a numeric score, non-squamous cell carcinoma primary tumors, and primary squamous cell carcinoma outside the head and neck were excluded. (ajnr.org)
- Advanced head and neck squamous cell carcinoma (HNSCC) is treated with radiotherapy, chemotherapy, targeted therapy or a combination of these treatments. (researchsquare.com)
- Cancers that are known collectively as head and neck cancers usually begin in the squamous cells that line the mucosal surfaces of the head and neck (for example, those inside the mouth, throat, and voice box). (cancer.gov)
- These cancers are referred to as squamous cell carcinomas of the head and neck. (cancer.gov)
- Head and neck cancers can also begin in the salivary glands , sinuses , or muscles or nerves in the head and neck, but these types of cancer are much less common than squamous cell carcinomas ( 1 , 2 ). (cancer.gov)
- If a squamous cell carcinoma of the head and neck is going to spread, it almost always does so locally and/or to the lymph nodes in the neck. (cancer.gov)
- Sometimes, cancerous squamous cells can be found in the lymph nodes of the upper neck when there is no evidence of cancer in other parts of the head and neck, possibly because the original primary tumor is too small. (cancer.gov)
- More information about this cancer type can be found in the Metastatic Squamous Neck Cancer with Occult Primary (PDQ®) cancer treatment summary. (cancer.gov)
- Most head and neck squamous cell carcinomas of the mouth and voice box are caused by tobacco and alcohol use ( 8 ). (cancer.gov)
- A conservative approach to treatment of patients with squamous cell carcinoma from unknown head and neck primary cancers compares favorably with results of other reported more aggressive protocols utilizing comprehensive irradiation or concurrent chemoradiation, according to study results reported by Rajan S. Patel, MBChB, MD, April 29 at the American Head and Neck Society's program during the Combined Otolaryngology Spring Meeting. (enttoday.org)
- My brother Dale is battling Stage 4 Metastatic Squamous Cell Carcinoma in his neck/throat. (gofundme.com)
- Inhibiting the inhibitors: Development of the IAP inhibitor xevinapant for the treatment of locally advanced squamous cell carcinoma of the head and neck. (dana-farber.org)
- Unresectable recurrent and/or metastatic head and neck squamous cell carcinoma (R/M HNSCC) has a very poor prognosis. (mdpi.com)
- He studies how to improve the efficacy of immune checkpoint inhibitors (drugs that turn off the ability of some cancer cells to evade detection by immune system cells) with combination approaches to treating head and neck squamous cell carcinomas. (ucsfhealth.org)
- 90% of head and neck cancers are squamous cell (epidermoid) carcinomas. (msdmanuals.com)
- As with most head and neck sites, squamous cell carcinoma is the most common oral cancer. (msdmanuals.com)
- Expression of p63 is almost exclusively restricted to epithelial cells, mutations in this gene are infrequent, and its expression is increased in a variety of solid tumors, particularly those of the head and neck area 12,13 . (bvsalud.org)
- Both melanoma, basal cell carcinoma and squamous cell carcinoma are commonly found in sun-exposed areas, such as the head, neck, and face. (lu.se)
- Most head and neck cancers are squamous cell cancers . (medlineplus.gov)
Metastasis8
- However, its role in the development and metastasis of tongue squamous cell carcinoma (TSCC) remains unclear. (oncotarget.com)
- PKM2 knockdown inhibited cell migration and invasion, reduced SOD2 (manganese superoxide dismutase) activity and the intracellular H 2 O 2 level, and inhibited tumour growth and lung metastasis in vivo . (oncotarget.com)
- Aims: To evaluate the level of cervical lymph node metastasis in patients with oral squamous cell carcinoma. (journalcra.com)
- Squamous-cell cancers of the lip and ears have high rates of local recurrence and distant metastasis. (wikipedia.org)
- Our purpose was to compare squamous cell carcinoma metastasis and mortality between patients with chronic lymphocytic leukemia and control subjects. (nih.gov)
- The rate of metastasis and mortality from cutaneous squamous cell carcinoma were determined on a per-patient basis. (nih.gov)
- Three of 28 patients with chronic lymphocytic leukemia had metastasis and died of metastatic disease. (nih.gov)
- Compared with control subjects, chronic lymphocytic leukemia patients with cutaneous squamous cell carcinoma were more likely to have metastasis (P = .0031) and die of metastasis (P = .0033). (nih.gov)
Melanoma11
- KEYTRUDA is indicated for the treatment of patients with unresectable or metastatic melanoma. (merck.com)
- Cutaneous squamous-cell carcinoma (cSCC), or squamous-cell carcinoma of the skin, also known as squamous-cell skin cancer, is, with basal-cell carcinoma and melanoma, one of the three principal types of skin cancer. (wikipedia.org)
- Cutaneous squamous-cell carcinoma is the second-most common cancer of the skin (after basal-cell carcinoma, but more common than melanoma). (wikipedia.org)
- Basal cell carcinoma and squamous cell carcinoma are the two most common types of non-melanoma skin cancer. (medicalnewstoday.com)
- Melanocytes are a type of skin cells, and cancers that grow from these cells are called melanoma skin cancers. (medicalnewstoday.com)
- Recent immunotherapy approvals for patients with metastatic melanoma has widened the treatment landscape, but new research shows that patients associated with positive sociodemographic factors are more likely to receive immunotherapy. (curetoday.com)
- MCC is about 30 times less common than melanoma and far less common than basal or squamous cell carcinoma, and the clinical features of MCC are not extremely specific. (medscape.com)
- We are currently working on 3 different skin tumor types, melanoma, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). (lu.se)
- Early diagnosis is crucial for patient survival as, in contrast to metastatic melanoma, early-stage melanoma is highly curable. (lu.se)
- MOHAPATRA P, PRASAD CP and ANDERSSON T. Combination therapy targeting the elevated interleukin-6 level reduces invasive migration of BRAF inhibitor-resistant melanoma cells. (lu.se)
- Demonstration of a WNT5A-IL-6 positive feedback loop in melanoma cells: Dual interference of this loop more effectively impairs melanoma cell invasion. (lu.se)
Tumor15
- Microsatellite instability (or MSI) is defined by the National Cancer Institute as a change that occurs in the DNA of certain cells, such as tumor cells, in which the number of repeats of microsatellites (short, repeated sequences of DNA) is different from the number of repeats that was in the DNA when it was inherited. (merck.com)
- KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (merck.com)
- KEYTRUDA is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. (merck.com)
- Subcutaneous injection of NIH 3T3 cells cotransfected with DNAs from AS tumor and pSV2‐neo plasmid not only induced tumors at the site of injection, but also metastasized spontaneously to the lungs in 100% of nude mice injected. (houstonmethodist.org)
- These results suggest that the amplified Ha‐ras oncogene may be responsible for induction of both tumorigenic and metastatic phenotypes in NIH 3T3 cells transfected with DNA from AS tumor. (houstonmethodist.org)
- The abscopal effect is a rare phenomenon in the setting of radiation therapy (RT) for metastatic cancer where tumor regression occurs distant from the site of treatment. (amegroups.org)
- In a recent study, it has also been shown that the deletion or severe down-regulation of a gene titled Tpl2 (tumor progression locus 2) may be involved in the progression of normal keratinocytes into becoming squamous-cell carcinoma. (wikipedia.org)
- The aim of the present study was to investigate the association between tumor protein 53 (TP53) gene deletion and protein expression and clinical features in esophageal squamous cell carcinoma (ESCC), and to evaluate the predictive value of these two characteristics in the prognosis of ESCC. (spandidos-publications.com)
- Mutations in TP53 can lead to the loss of these functions, inducing uncontrolled cell growth and the promotion of tumor development ( 11 , 12 ). (spandidos-publications.com)
- We also analyzed the tumor-infiltrating immune cells, immune-related gene expression, tumor mutation burden, and drug sensitivity of patients with HNSCC in the high- and low-risk groups. (frontiersin.org)
- Cosibelimab's primary mechanism of action is based on the inhibition of the interaction between PD-L1 and its receptors PD-1 and B7.1, which removes the suppressive effects of PD-L1 on anti-tumor CD8+ T-cells to restore the cytotoxic T cell response. (globenewswire.com)
- 99% target tumor occupancy to reactivate an antitumor immune response and the additional benefit of a functional Fc domain capable of inducing antibody-dependent cell-mediated cytotoxicity ("ADCC") for potential enhanced efficacy in certain tumor types. (globenewswire.com)
- It has been suggested that radiation sensitivity and chemosensitivity of cancer cells may play an important role in the local control of the tumor following these therapies. (researchsquare.com)
- We are investigating the PA spectral signature of different tumor cells to enable automatic measure-ment of the tumor borders, and test the developed method in the clinical setting, ultimately developing PA imaging into a diagnostic tool for skin cancer. (lu.se)
- MEHDAWI LM, PRASAD CP, EHRNSTRÖM R, ANDERSSON T and SJÖLANDER A. Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH via JNK1 and induces differentiation of colon cancer cells. (lu.se)
Diagnosis4
- [ 2 ] Marjolin ulcer (SCC in a chronic ulcer) and anogenital SCC of the usual type demonstrate increased metastatic tendency, likely resulting from delayed recognition and diagnosis. (medscape.com)
- Margaritaville' singer-songwriter Jimmy Buffett died four years after receiving a diagnosis of Merkel cell carcinoma that 'can be really nasty,' one expert tells CURE. (curetoday.com)
- Metastatic Squamous Cell Carcinoma in Cerebrospinal Fluid: Why a Rare Diagnosis on Cytology? (karger.com)
- Molecular and cytogenetic studies in the diagnosis of patients with poorly differentiated carcinomas of unknown primary site. (medscape.com)
Penile squamous cell carc1
- The cause of penile squamous cell carcinoma (SCC) is unclear, although human papillomavirus (HPV) appears to play a major role. (medscape.com)
Unresectable or metastatic3
- ients with recurrent unresectable or metastatic cervix carcinoma with squamous cell, adenocarcinoma or adenosquamous histology immediately after at the very least on prior platinum-based chemotherapy for metastatic/recurrent illness.Coquan et al. (trpv1inhibitor.com)
- BMC Cancer(2021) 21:Page 5 ofTable 1 Study eligibility criteriaInclusion criteria - Female 18 years of age or older, with histologically confirmed recurrent unresectable or metastatic cervix carcinoma with squamous cell, adenocarcinoma or adenosquamous histology. (trpv1inhibitor.com)
- Evidence-based recommendations on trastuzumab deruxtecan (Enhertu) for treating HER2-positive unresectable or metastatic breast cancer after 1 or more anti-HER2 treatments in adults. (bvsalud.org)
Tumors7
- In January 2022, Checkpoint announced that the metastatic cSCC cohort met its primary endpoint, with cosibelimab demonstrating a confirmed objective response rate ("ORR") of 47.4% (95% CI: 36.0, 59.1) based on independent central review of 78 patients enrolled in the cohort using Response Evaluation Criteria in Solid Tumors version 1.1 ("RECIST 1.1") criteria. (globenewswire.com)
- Histological cell typing of lung tumors was initially evaluated according to WHO classification of lung tumors in 306 cases by a panel of 4 pathologists, without prior knowledge of autopsy findings or smoking and mining histories. (cdc.gov)
- In addition, patients with cancer of unknown primary origin are defined as patients with histologically proven metastatic malignant tumors in which the primary site cannot be identified during pretreatment evaluation. (medscape.com)
- A subpopulation of these can be potentially curable, including patients with lymphomas, germ cell tumors, or neuroendocrine tumors. (medscape.com)
- Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
- The purpose of the project is to develop PA imaging into a diagnostic tool for skin tumors by identifying the spectral signature of the cancerous cells. (lu.se)
- Some localized melanomas may result from azathioprine, which acts synergistically with ultraviolet radiation, while T-cell depleting induction therapies may promote late stage tumors. (cdc.gov)
CSCC12
- ASCO 2018: Phase II trial of pembrolizumab (MK-3475) in metastatic cutaneous squamous cell carcinoma (cSCC). (larvol.com)
- cSCC begins from squamous cells found in the upper layers of the skin. (wikipedia.org)
- In vivo and in vitro studies have shown that the upregulation of FGFR2, a subset of the fibroblast growth factor receptor (FGFR) immunoglobin family, has a critical role to play in the progression of cSCC cells. (wikipedia.org)
- Mutations in the TPL2 gene cause over-expression of FGFR2, which activates the mTORC1 and AKT pathways in both primary and metastatic cSCC cell lines. (wikipedia.org)
- By using a chemical substance, called a "pan FGFR inhibitor", cell migration and cell proliferation in cSCC have been attenuated in vitro. (wikipedia.org)
- Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the first and second most common types of skin cancer, respectively. (medscape.com)
- Actinic keratosis and basal cell carcinoma are easily excised and have a very good prognosis, while cSCC has a poor prognosis, especially if it invades the lymph nodes and adjacent vital structures. (medscape.com)
- Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and one of the most common cancers overall in the United States. (medscape.com)
- of those, approximately 80% were basal cell carcinoma (BCC) and 20% were cSCC. (medscape.com)
- The BLA submission is based on positive efficacy and safety results from Checkpoint's ongoing registration-enabling, multi-regional, multicohort clinical trial evaluating cosibelimab administered as fixed doses of either 800 mg every two weeks or 1200 mg every three weeks in patients with selected recurrent or metastatic cancers, including pivotal cohorts in metastatic and locally advanced cSCC. (globenewswire.com)
- Based upon interactions with the FDA, the BLA submission includes both the metastatic and locally advanced cSCC indications. (globenewswire.com)
- Cutaneous squamous cell carcinoma (cSCC) is the second most common form of human skin cancer with at least 200,000 to 400,000 new cases of cSCC expected each year in the US. (aad.org)
Cancers4
- Distribution of lung cancers by histological cell type in 306 cases showed no major differences in 3 major cell types of squamous, small cell, and adenocarcinomas. (cdc.gov)
- Conversely adenocarcinoma was the most frequent cancer (84%) in the cases excluded as probably metastatic cancers. (cdc.gov)
- Distribution of lung cancer by site of origin and cell type showed that the majority of the squamous cancers originated in the main stem bronchus whereas adenocarcinomas tended to originate predominantly in the peripheral lung. (cdc.gov)
- In the US, 3% of cancers in men and 2% in women are oral squamous cell carcinomas, most of which occur after age 50. (msdmanuals.com)
Merkel Cell Carc5
- As reported in The Lancet by Becker et al, an interim analysis of a European phase II study (ADMEC-O) showed that adjuvant nivolumab was associated with a numeric benefit in disease-free survival vs observation in patients with completely resected Merkel cell carcinoma. (ascopost.com)
- Mohs micrographic surgery offered better survival outcomes for patients with early-stage Merkel cell carcinoma, compared with wide local excision. (curetoday.com)
- Characterization of clinical outcomes after shorter course hypofractionated and standard-course radiotherapy for stage I-III curatively-treated Merkel cell carcinoma. (dana-farber.org)
- Merkel cell carcinoma (MCC) is a rare, aggressive, and often fatal neuroendocrine skin cancer. (medscape.com)
- Merkel cell carcinoma on a patient's sun-exposed forearm. (medscape.com)
Lymph4
- Lymph Node Status and Outcomes for Nasopharyngeal Carcinoma According to Histological Subtypes: A SEER Population-Based Retrospective Analysis. (nih.gov)
- Machine learning to predict occult metastatic lymph nodes along the recurrent laryngeal nerves in thoracic esophageal squamous cell carcinoma. (bvsalud.org)
- Esophageal squamous cell carcinoma (ESCC) metastasizes in an unpredictable fashion to adjacent lymph nodes , including those along the recurrent laryngeal nerves (RLNs). (bvsalud.org)
- We report the first case, to our knowledge, of the abscopal effect in squamous carcinoma of the anal canal with metastases to pelvic lymph nodes, liver and bone. (amegroups.org)
Adenocarcinoma1
- Second-line and subsequent therapy may involve single agents (eg, taxanes) or molecular therapy, such as ramucirumab to target vascular endothelial growth factor (VEGF) receptor or trastuzumab for metastatic adenocarcinoma that overexpresses HER2. (medscape.com)
Adenoid Cystic Ca1
- A Phase 2 Trial of Rivoceranib, an Oral Vascular Endothelial Growth Factor Receptor 2 Inhibitor, for Recurrent or Metastatic Adenoid Cystic Carcinoma. (ucsfhealth.org)
Basal cell13
- Cutaneous squamous-cell carcinoma is more likely to spread to distant areas than basal cell cancer. (wikipedia.org)
- A biopsy should be performed for any lesion suspected of being a cutaneous neoplasm to rule out basal cell carcinoma and other dermal lesions. (medscape.com)
- What is the difference between squamous cell carcinoma and basal cell carcinoma? (medicalnewstoday.com)
- Basal cell carcinoma starts in the lower area of the epidermis, the basal cell layer. (medicalnewstoday.com)
- Read on to learn more about basal cell carcinoma and squamous cell carcinoma. (medicalnewstoday.com)
- basal cell carcinoma and squamous cell carcinoma . (medicalnewstoday.com)
- Basal cell carcinoma is the most common type . (medicalnewstoday.com)
- Basal cell carcinomas often appear round, raised, and shiny. (medicalnewstoday.com)
- Most basal cell carcinomas are pink or red, but they may be other colors, such as brown, black, or the same color as the skin. (medicalnewstoday.com)
- Some research suggests that use of indoor tanning beds can increase a person's chance of developing basal cell carcinoma by 24% . (medicalnewstoday.com)
- People with a history of skin cancer, including basal cell carcinoma, are also more likely to develop squamous cell carcinoma. (medicalnewstoday.com)
- Treatment for basal cell carcinoma generally begins with surgery to remove a cancerous growth. (medicalnewstoday.com)
- However, this form of cancer has a higher chance of spreading than basal cell carcinoma. (medicalnewstoday.com)
Recurrent or metastatic1
- Evidence-based recommendations on nivolumab (Opdivo) with fluoropyrimidine- and platinum-based chemotherapy for untreated unresectable advanced, recurrent, or metastatic oesophageal squamous cell carcinoma in adults. (nice.org.uk)
Differentiation7
- SSTR2a is constantly expressed in lymphoepithelioma-like carcinoma with squamous differentiation other than that with glandular differentiation. (nih.gov)
- Cutaneous squamous cell carcinoma (SCC) is an invasive malignant neoplasm of epidermal keratinocytes showing squamous phenotypic differentiation (see the following image). (medscape.com)
- Relative to Bowen disease, actinic keratosis (AK) only occurs on sun-damaged skin, is usually smaller, and retains a squamous differentiation toward the surface, often even when dermal invasion is developing. (medscape.com)
- SCC of the prostate is a rare malignant epithelial neoplasm arising in the prostate, with squamous differentiation of the neoplastic cells. (medscape.com)
- [ 12 , 13 ] The time course for the appearance of squamous differentiation in the carcinoma varies from 3 months to many years (up to 9 y) after therapy. (medscape.com)
- Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)
- Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)
Lesions5
- almost invariably, these are markedly invasive metastatic lesions with a poor prognosis. (family-health-information.com)
- Predisposing factors associated with squamous cell carcinoma include overexposure to the sun's ultraviolet rays, radiation therapy, ingestion of herbicides containing arsenic, chronic skin irritation and inflammation, exposure to local carcinogens (such as tar and oil), hereditary diseases (such as xeroderma pigmentosum and albinism), and the presence of premalignant lesions (such as actinic keratosis or Bowen's disease). (family-health-information.com)
- In situ carcinomas may progress to invasive lesions. (medscape.com)
- Immunohistochemical identification of molecular genetic events in the progression of preneoplastic lesions to spindle cell squamous-cell carcinoma enables early detection of lesions with the potential for malignant progression, thus permitting timely intervention 1,2 . (bvsalud.org)
- The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)
Pembrolizumab2
- In the phase II KEYNOTE-B61 trial reported in The Lancet Oncology, Laurence Albiges, MD, PhD, and colleagues found that first-line pembrolizumab plus lenvatinib produced durable responses in patients with advanced non-clear cell renal cell carcinoma. (ascopost.com)
- Immunotherapy with an anti-programmed cell death protein 1 (PD-1) inhibitor-pembrolizumab (Keytruda)-showed encouraging responses in patients with advanced cutaneous T-cell lymphoma (either mycosis fungoides or Sézary syndrome). (ascopost.com)
Patients with cutaneous1
- Commenting on this talk during the discussion afterward, Youn Kim, MD , of Stanford University School of Medicine, Stanford, California, said: "At our center, we use high-throughput sequencing of T-cell receptors daily in patients with cutaneous T-cell lymphomas, and it is a billable. (ascopost.com)
Situ3
- Bowen disease (BD) is a squamous cell carcinoma in situ (SSCIS) with full-epidermal thickness dysplasia that has the potential for significant lateral spread before invasion. (medscape.com)
- When SCC is confined to the epidermis, it is called squamous cell carcinoma in-situ, sometimes referred to as Bowen's disease. (family-health-information.com)
- In situ carcinomas include Bowen disease, erythroplasia of Queyrat, and bowenoid papulosis. (medscape.com)
Actinic Keratosis1
- See Squamous Cell Carcinoma , Bowen Disease , and Actinic Keratosis for more information. (medscape.com)
Cancer23
- The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
- PKM2 is encoded by the PKM gene and is expressed in embryonic cells, adult stem cells, and cancer cells [ 3 ]. (oncotarget.com)
- Nivolumab for previously treated unresectable metastatic anal cancer (NCI9673): a multicentre, single-arm, phase 2 study. (buzzsprout.com)
- Cutaneous squamous cell carcinoma is the second most common type of skin cancer in the United States, with an estimated annual incidence of approximately 1 million cases according to the Skin Cancer Foundation. (globenewswire.com)
- As reported in The New England Journal of Medicine by Masahiro Tsuboi, MD, and colleagues, the planned final overall survival analysis of the phase III ADAURA trial has shown a significant benefit with osimertinib vs placebo in patients with resected EGFR-mutant non-small cell lung cancer (NSCLC). (ascopost.com)
- In a phase III trial (LASER301) reported in the Journal of Clinical Oncology, Byoung Chul Cho, MD, PhD, and colleagues found that lazertinib improved progression-free survival vs gefitinib in the first-line treatment of EGFR-mutated advanced non-small cell lung cancer (NSCLC). (ascopost.com)
- When this happens, the cancer is called metastatic squamous cell carcinoma with unknown (occult) primary. (cancer.gov)
- Neoadjuvant immunotherapy with the programmed cell death protein 1 (PD-1) inhibitor nivolumab (Opdivo) is safe and feasible in early-stage non-small cell lung cancer (NSCLC). (ascopost.com)
- For patients with advanced non-small cell lung cancer (NSCLC) harboring the ALK gene rearrangement, ceritinib (Zykadia) provided longer progression-free survival than chemotherapy in patients previously treated with chemotherapy and crizotinib (Xalkori), but gastrointestinal toxicity was. (ascopost.com)
- Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy. (dana-farber.org)
- Ten to forty years can pass between the time of sun exposure and the development of a squamous cell skin cancer. (family-health-information.com)
- His expertise encompasses conventional chemotherapy, targeted therapy (which selectively goes after cancer cells) and immunotherapy (which stimulates the patient's own immune system to fight the cancer). (ucsfhealth.org)
- Histological cell type frequencies of lung cancer in groups occupationally exposed to asbestos, chloromethyl ether and uranium workers have shown promising results on the separation of risk factors. (cdc.gov)
- On the other hand, in the 171 primary lung cancer cases the squamous cell cancer was the predominant type followed by equal proportions of adenocarcinomas and small cell carcinomas. (cdc.gov)
- Evidence-based recommendations on regorafenib (Stivarga) for previously treated metastatic colorectal cancer in adults. (bvsalud.org)
- Oropharyngeal Squamous Cell Carcinoma Oropharyngeal cancer refers to cancer of the tonsil, base and posterior one third of the tongue, soft palate, and posterior and lateral pharyngeal walls. (msdmanuals.com)
- One third of patients with cancer of unknown primary origin have poorly or undifferentiated carcinoma. (medscape.com)
- The cancer cells may spread into deeper tissue as the cancer grows. (medlineplus.gov)
- A biopsy or other procedure to collect cells from the area that might have cancer. (medlineplus.gov)
- OSMAN J, BELLAMONDO K, LIU Q, ANDERSSON T* & SJÖLANDER A*. The WNT5A agonist Foxy5 reduces the number of colonic cancer stem cells in a xenograph mouse model of human colonic cancer. (lu.se)
- CANESIN G, EVANS-AXELSSON S, HELLSTEN R, KRZYZANOWSKA A, PRASAD CP, BJARTELL A and ANDERSSON T. Treatment with the Wnt5a-mimicking peptide Foxy5 effectively reduces the metastatic spread of Wnt5a-low prostate cancer cells in an orthotopic mouse model. (lu.se)
- PRASAD CP, SÖDERGREN K and ANDERSSON T. Reduced production and uptake of lactate are essential for the ability of WNT5A signaling to inhibit breast cancer cell migration and invasion. (lu.se)
- PRASAD CP, CHAURASIYA SK, GUILMAIN W, and ANDERSSON T. WNT5A signaling impairs breast cancer cell migration and invasion via mechanisms independent of the epithelial-mesenchymal transition. (lu.se)
Prognosis1
Anal canal1
- Role of mitomycin in combination with fluorouracil and radiotherapy, and of salvage chemoradiation in the definitive nonsurgical treatment of epidermoid carcinoma of the anal canal: results of a phase III randomized intergroup study. (buzzsprout.com)
Histology1
- 2 cm in diameter, growth into the fat layer and along nerves, presence of lymphovascular invasion, poorly differentiated cell architecture on histology, or thickness greater than 6 mm. (wikipedia.org)
Oropharyngeal2
- Screening for extranodal extension in HPV-associated oropharyngeal carcinoma: evaluation of a CT-based deep learning algorithm in patient data from a multicentre, randomised de-escalation trial. (dana-farber.org)
- Diagnostic performance of computed tomography features in detecting oropharyngeal squamous cell carcinoma extranodal extension. (dana-farber.org)
Oral cavity2
- 2. Histologically or cytologically-confirmed, HPV (+) or HPV (-) squamous cell carcinoma of the nasopharynx (WHO Type 1), oropharynx, hypopharynx, larynx (supraglottis, glottis, subglottis) or oral cavity. (stanford.edu)
- Other markers, such as retinoblastoma and p53, may be related with early steps of carcinogenesis in oral cavity squamous cell carcinoma. (bvsalud.org)
Nasopharynx1
Invasive1
- If untreated, these conditions may evolve to invasive carcinomas. (medscape.com)
Radiation3
- Radiation generates an abscopal response and complete resolution of metastatic squamous cell carcinoma of the anal. (amegroups.org)
- Avoiding exposure to ultraviolet radiation and the use of sunscreen appear to be effective methods of preventing cutaneous squamous-cell carcinoma. (wikipedia.org)
- Adjuvant radiation following clear margin resection of high T-stage cutaneous squamous cell carcinoma halves the risk of local and locoregional recurrence: A dual-center retrospective study. (dana-farber.org)
Platinum-based chemotherapy1
- Patient may possibly have received at least 1 prior chemotherapy regimen of platinum-based chemotherapy for recurrence or metastatic disease. (trpv1inhibitor.com)
Primary1
- Unusual presentation of HPV-positive squamous cell carcinoma of the nasolacrimal duct as carcinoma of unknown primary. (dana-farber.org)
Pathology1
- Methods: fifteen histological specimens of spindle cell squamous cell carcinoma of the lower lip were obtained from the Department of Oral Pathology, Bahia Federal University. (bvsalud.org)
Occurs1
- Squamous cell carcinoma occurs most commonly in fair-skinned white men over age 60. (family-health-information.com)
Keratinocytes1
- Once keratinocytes begin to grow uncontrollably, they have the potential to become cancerous and produce cutaneous squamous-cell carcinoma. (wikipedia.org)
Cancerous1
- When diagnosing basal or squamous cell carcinoma, a doctor will generally begin with a physical exam, during which they will examine potentially cancerous skin growths. (medicalnewstoday.com)
Disease5
- Prior remedy for advanced/metastatic disease with bevacizumab and/or immune checkpoint inhibitors are permitted. (trpv1inhibitor.com)
- 1. For phase II cohort #1 and cohort #2: Patients who received more than 2 prior systemic regimens for recurrent and/or metastatic disease (no restriction in the phase Ib part of the trial). (stanford.edu)
- In the phase III CONTACT-03 trial reported in The Lancet, Sumanta Pal, MD, FASCO, and colleagues found that the addition of atezolizumab to cabozantinib did not improve outcomes in patients with renal cell carcinoma whose disease progressed on or after prior immune checkpoint inhibitor treatment. (ascopost.com)
- As there are limited treatment options for metastatic disease, early and complete treatment is important. (aad.org)
- This is a tricky one because 92% of MCC patients are not immune compromised, but those with long-term T-cell dysfunction (organ transplant recipients, autoimmune disease patients receiving immune suppression, HIV patients, chronic lymphocytic leukemia patients) are at much higher risk of developing MCC, but they represent less than 10% of all cases. (medscape.com)
Treatment4
- [ 3 ] occupational exposure, medical treatment (psoralen + ultraviolet A [PUVA]), or tanning beds is principally responsible for the development of squamous cell carcinoma (SCC). (medscape.com)
- Mitomycin or cisplatin chemoradiation with or without maintenance chemotherapy for treatment of squamous-cell carcinoma of the anus (ACT II): A randomised, phase 3, open-label, 2×2 factorial trial. (buzzsprout.com)
- Surgery is the most frequent treatment for squamous cell carcinoma as well. (medicalnewstoday.com)
- Allogeneic hematopoietic stem cell transplantation is the only potentially curative treatment for myelofibrosis. (ascopost.com)
Biopsy1
- If a doctor suspects basal or squamous cell carcinoma, they may order a skin biopsy . (medicalnewstoday.com)
Mutations1
- [ 12 ] An underrecognized role for UV-A was also previously described that localizes the corresponding fingerprint mutations in the basal epidermis harboring the vital stem cells, as opposed to the suprabasal UV-B-induced mutations. (medscape.com)
Excision1
Epidermis1
- Squamous cell carcinoma starts in the upper region of the epidermis, the top layer of skin. (medicalnewstoday.com)
Arises1
- When squamous cell carcinoma arises from normal skin, the nodule grows slowly on a firm, indurated base. (family-health-information.com)
Prognostic1
Dysplasia1
Inhibitor1
- In a single-institution, phase I, first-in-human trial reported in The Lancet Oncology, Cowan et al found that the combination of the γ-secretase inhibitor (GSI) crenigacestat and B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell therapy was tolerable and produced a high. (ascopost.com)