Metastatic antigens tumor associated carbohydrate. Medical search. Frequent questions

This study showed that SBRT can significantly reduce pain, effectively control local tumor progression, and have acceptable toxicity for patients with locoregional recurrence after radical resection of primary pancreatic cancer. (frontiersin.org)
One retrospective observational study reported that the recurrence rates of local, metastatic and synchronous local/metastatic pancreatic cancer were 17%, 60% and 23%, respectively ( 6 ). (frontiersin.org)
SBRT combined with chemotherapy for the treatment of locally advanced pancreatic cancer can effectively control local tumors and alleviate local symptoms, prolong the overall survival of patients, and has tolerable toxicity ( 16 - 19 ). (frontiersin.org)
Targeting CA 19-9 with a humanized monoclonal antibody at the time of surgery may decrease recurrence rates for patients undergoing resections for pancreatic cancer, cholangiocarcinoma and metastatic colorectal cancer J Gastrointest Oncol. (moleculardepot.com)
Erlotinib has been approved by the FDA for use, in combination with gemcitabine, as a first-line treatment for locally advanced, unresectable, or metastatic pancreatic cancer. (medscape.com)
That test, a serology evaluation performed by Mayo Clinic Laboratories (Mayo ID: CA19) assesses levels of carbohydrate antigen 19-9 (CA-19-9), a biomarker associated with pancreatic cancer . (mayoclinic.org)
Jim was thrust into a world of unknowns in the fall of 2017 when he was diagnosed with what was thought to be metastatic pancreatic cancer. (mayoclinic.org)
Although recent advances in solid tumor treatment have dramatically improved patients' survival, the prognosis of pancreatic cancer remains dismal, with a 5-year survival rate of 9% in all stages [ 1 ]. (e-jyms.org)

Metastasis of infradiaphragmatic tumors to the left supraclavicular lymph node is reported to be rare. (biomedcentral.com)
We report three cases of malignant infradiaphragmatic tumor diagnosed following an initial finding of left supraclavicular node metastasis after surgery for tongue squamous cell carcinoma (follow-up period, range 18-62 months). (biomedcentral.com)
Supraclavicular lymph node metastasis has been reported to be more common in patients with lung and breast tumors (18.7% and 18.6%, respectively) [ 1 , 2 ]. (biomedcentral.com)
Nathan is a Biomedical Engineer and tumor immunologist working at the interfaces of cancer metastasis, tumor evolution, adaptive immunity, and immuno-oncology. (stanford.edu)
His work employs mouse models and systems biology and genetic engineering to investigate interactions between tumors and the immune system during cancer metastasis. (stanford.edu)
He performed his PhD work in Biomedical Engineering with Dr. Sangeeta Bhatia at MIT where he studied glycobiology and ECM interactions during cancer metastasis and his postdoctoral studies with Dr. Edgar Engleman at Stanford where he studied systemic immune responses during metastatic progression and in the context of immunotherapy. (stanford.edu)
Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. (stanford.edu)
Here, we develop a syngeneic melanoma mouse model of LN metastasis to investigate how tumors spread to LNs and whether LN colonization influences metastasis to distant tissues. (stanford.edu)
The presence of multiple types of metastases or peritoneal metastases in colorectal cancer is defined as stage IVb or IVc, respectively, in the eighth edition of the American Joint Committee on Cancer tumor-node-metastasis staging system because of its poorer prognosis than stage IVa [ 1 ]. (coloproctol.org)
Intraoperatively, we did not find tumor invasion to adjacent organs, peritoneal dissemination, or liver metastasis. (biomedcentral.com)
Metastasis is a dangerous phenomenon in which cancer cells separate from the original tumor, move into the bloodstream or lymphatic system and anchor in a distant tissue or organ. (algemenegezondheid.org)
No evidence of tumor was identified in adnexa, uterus or omentum in microscopy, but only GCT metastasis was detected in Douglas space peritoneal nodules. (researchsquare.com)
Although most patients with localized tumors can be cured with surgical therapies, 20-30 % of the patients without any evidence of metastasis will develop relapse and/or metastatic RCC in the future [ 3 ]. (biomedcentral.com)
However, the impact of M6P/IGF2R on tumour invasion and metastasis is so far only poorly understood. (boku.ac.at)
Future studies will aim at the identification of these anti-invasive M6P-modified protein(s) followed by a comprehensive assessment of their involvement in tumour invasion and metastasis. (boku.ac.at)
Pancreatic metastasis from PTC indicates an advanced tumor stage and poor prognosis. (kjco.org)

Even after radical resection, most patients will still have local and/or metastatic recurrence within 2 years ( 3 , 4 ), and the 5-year survival rate is only 20-25% ( 5 ). (frontiersin.org)
The various tumor markers differ in their usefulness for screening, diagnosis, prognosis, assessing therapeutic response, and detecting recurrence. (medscape.com)
Cancer antigen 19-9 (CA 19-9) is used to help differentiate between cancer of the pancreas and other conditions, as well as to monitor treatment response and recurrence. (medscape.com)
Its level is frequently measured for screening purposes in daily practice by physicians, while its main use is in the study of tumor recurrence and follow-up of recurrences. (endocrine-abstracts.org)
For example, better outcomes might be possible if, after standard therapy, an aggressive short-term course of antibiotics is used to clear F. nucleatum from sites of minimal residual disease and metastatic lesions, and then an effective vaccine is deployed to consolidate remissions by preventing re-infection and recurrence of treatment-refractory tumors," he says. (microbiomepost.com)

This includes the early recognition of these immunogenic membrane proteins that can serve as diagnostic markers, and the targeting of such markers for the destruction of the tumor, primarily thru ADCC. (jcancer.org)
What does CA mean in tumor markers? (pfeiffertheface.com)
Do high tumor markers always mean cancer? (pfeiffertheface.com)
Just because a person has tumor markers, it doesn't always mean cancer is present or has come back. (pfeiffertheface.com)
What are 3 tumor markers? (pfeiffertheface.com)
How accurate are tumor markers? (pfeiffertheface.com)
There has been no evidence to prove that tumor markers are 100 percent reliable for determining the presence or absence of cancer. (pfeiffertheface.com)
Can stress cause tumor markers to rise? (pfeiffertheface.com)
The presence of tumor markers alone is not enough to diagnose cancer. (pfeiffertheface.com)
What happens if tumor markers are high? (pfeiffertheface.com)
For example, noncancerous conditions can sometimes cause the levels of certain tumor markers to increase. (pfeiffertheface.com)
What causes tumor markers to increase? (pfeiffertheface.com)
At follow-up, 2 years after surgery, concentrations of the tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) had increased. (springeropen.com)
In spite of this treatment, the concentrations of tumor markers (CEA and CA19-9) increased further, and the swellings in multiple skeletal muscles progressively enlarged. (springeropen.com)
Serum sex hormone and other tumor markers including AFP, CA199, CEA, β-HCG and inhibin were within normal range. (researchsquare.com)
Serum tumor markers showed significant differences between primary hepatic SCC/ASC and HCC patients, especially for serum alpha fetal protein (AFP) level and carbohydrate antigen 19-9 (CA 19-9). (biomedcentral.com)
Tumor markers are soluble glycoproteins that are found in the blood, urine, or tissues of patients with certain types of cancer. (medscape.com)
Tumor markers are not elevated in all cancer patients, particularly patients with early-stage cancer. (medscape.com)
Many new tumor markers have been discovered since the development of monoclonal antibodies, and most tumor markers are now detected with them. (medscape.com)
Ovarian cancer, uterine cervical cancer, endometrial cancer, and trophoblastic neoplasms are gynecologic malignancies for which tumor markers are in clinical use. (medscape.com)
Because pathologic diagnosis of ovarian cancer is difficult without laparotomy, tumor markers such as CA-125, in addition to diagnostic imaging, are useful in preoperative evaluation for ovarian cancer. (medscape.com)
No tumor markers with high sensitivity and high specificity for endometrial cancer are known at present, although CA-125 is often used in clinical practice. (medscape.com)
Beta-hCG and alpha-fetoprotein have proved to be useful markers for ovarian germ cell tumors. (medscape.com)
Several histopathological variables such as tumour size lymph node status lymphatic or vascular invasion and the tumour grade of differentiation form have been widely used parameters in prognostic evaluations [2 3 In human breast cancer and other malignancies serum tumour markers play an important role in patient management [4 5 Tumour cells display protein molecules on their surfaces. (scienceexhibitions.org)
Currently CA 15-3 the circulating form of CACNG4 DF3 antigen is one of the most widely used WIKI4 serum biochemical markers in breast cancer. (scienceexhibitions.org)
Currently there is a lack of scientific documentation regarding the application of serum tumour markers in the canine mammary oncology WIKI4 field and only one preliminary report describing the possible use of serum CA 15-3 in dogs has been published [15]. (scienceexhibitions.org)
In this example, the T and Tn antigens are the stumps found in cancer, while the well-groomed yard has bushes, shrubs, and flowers, that correspond to the ABO markers and other antigens found on healthy cells. (dadamo.com)
So the hypothesis goes that because of the lower level of antibody against T and Tn antigens or stumps, and because of this tendency for the immune system of A's to be a bit confused or disinclined to attack Tn antigens, blood type A is at an immunologic disadvantage in attacking any cell bearing these T and Tn antigenic markers. (dadamo.com)
After five cycles of chemotherapy, the general condition of the patient improved and tumor markers (CEA, CA125, CA199) decreased. (biomedcentral.com)
Tumor markers were elevated (CEA 6.21 ng/mL, CA125 115.80 u/mL, and CA199 659.93 u/mL). (biomedcentral.com)
The levels of tumor markers were high, with a carbohydrate antigen 19-9 level of 110.8 U/mL (normal range, 0-39 U/mL) and a carcinoembryonic antigen level of 10.54 ng/mL (normal range, 0-5 ng/mL). (kjco.org)

This includes the amount of shed antigen in the serum at the time of treatment that could initiate immune complex formation as well as the shedding of inhibitory material into the serum possibly effecting an immune response. (jcancer.org)
In this respect, in contrast to predictors based for each serum protein was determined by comparing the samples upon tumor characteristics at the time of surgery, serum is a par- collected at the primary operation and then 3-6 mo later. (lu.se)
The results from this prevali- the field of cancer biomarkers (11-13), and that approach was dation study showed that patients could be classified into high- adopted here to define predictive serum biomarkers associated versus low-risk groups for developing metastatic breast cancer with tumor relapse in breast cancer patients. (lu.se)
While the serum carcinoembryonic antigen level (1.75 ng/mL) was within the normal range, the serum carbohydrate antigen 19-9 (151.3 U/mL) was elevated. (coloproctol.org)
Serum CEA levels rapidly decreased, and CT scan showed disappearance of the tumor with complete clinical response 8 months after HAIC. (biomedcentral.com)
Serum carcinoembryonic antigen (CEA) level was elevated to 185 ng/ml, but carbohydrate antigen (CA) 19-9 was 33 U/ml, which was within the normal range. (biomedcentral.com)
69 patients with nonmetastatic colorectal cancer (non-mCRC) and 57 with metastatic CRC (mCRC) were enrolled to evaluate the prognostic value of serum albumin (ALB), serum lactate (SLA), and lactate dehydrogenase (LDH) in patients with metastatic CRC. (hindawi.com)
We also investigated serum CA 15-3 activity to establish whether its expression could be assigned WIKI4 to several tumour characteristics to evaluate its potential use as a serum tumour marker in the canine mammary oncology field. (scienceexhibitions.org)
0.0019) between serum CA 15-3 levels and the degree of tumour proliferation and differentiation was shown which indicates that the values of this serum marker increase as the tumour stage progresses. (scienceexhibitions.org)
Conclusions The results of this study reveal that CA 15-3 is expressed in both canine mammary tumour cell lines and tissues and that serum levels significantly correlate with the histological grade of the malignancy. (scienceexhibitions.org)
These proteins called tumour-associated antigens may be present in higher than usual concentrations in other tissues serum urine or body fluids of patients with cancer. (scienceexhibitions.org)
Could it better to use Serum Taurine Level as a Biomarker for Colorectal Carcinoma Early Detection instead of the Specific Tumor Marker? (scitcentral.com)
Serum CA 19-9 (carbohydrate antigen 19-9) is a tumor marker of monosialoganglioside structure. (endocrine-abstracts.org)

The patient received 9 cycles of FOLFOX (5-fluorouracil/leucovorin/oxaliplatin) plus bevacizumab, following which the CT scan showed that the primary tumor and metastatic lesions had partially regressed. (coloproctol.org)

Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
No staging system exists for cancers of unknown primary origin-more precisely, histologically proven metastatic malignant tumors for which the primary site cannot be identified during pretreatment evaluation. (medscape.com)
Chapter 32 Gastrointestinal Cancers DIAGNOSIS TREATMENT DIAGNOSITC IMAGING MEDICATIONS CT scan, MRI, labeled somatostatin receptor-based diagnostic imaging ▪ Localization, TNM staging ▪ Presence of hepatic lesions SURGERY Endoscopy with biopsy ▪ Tumor visualization ▪ Histopathological analysis, grading ▪ Somatostatin analogues suppress tumor proliferation, decrease symptoms ▪ Surgical removal of tumor LAB RESULTS ▪ 5-hydroxyindoleacetic acid, chromogranin Figure 32.2 Gross pathology of carcinoid tumor of the terminal ileum. (osmosis.org)
Aberrant sialylated carbohydrate synthesis is frequently noted in various cancers. (biomedcentral.com)
It has been estimated that in about 90% of all cancers and some leukemias, T and Tn antigens are expressed and uncovered. (dadamo.com)
As a general rule, well-differentiated cancers usually have a preponderance of T antigens and less of the Tn antigens. (dadamo.com)
Furthermore, MCP also demonstrated anti-metastatic results on cancers cells in vitro or in vivo [8,10,11,24,26-28]. (bio2009.org)
Individual scientific studies with MCP demonstrated an boost in prostate particular antigen doubling period, a gun of delaying the development of prostate cancers [9], and significant improvement of quality of stabilization and lifestyle of disease for sufferers with advanced solid tumors [29]. (bio2009.org)
Most pancreatic cancers are exocrine tumors that develop from ductal and acinar cells. (msdmanuals.com)

Tumor marker tests can provide a lot of helpful information, but they aren't fail-safe. (pfeiffertheface.com)
Conditions besides cancer can raise tumor marker levels. (pfeiffertheface.com)
What is a high Tumour marker? (pfeiffertheface.com)
High tumor marker levels can be a sign of cancer. (pfeiffertheface.com)
Along with other tests, tumor marker tests can help doctors diagnose specific types of cancer and plan treatment. (pfeiffertheface.com)
Tumor marker tests are most commonly used to do the following: Learn if a person has cancer. (pfeiffertheface.com)
What is high tumor marker count? (pfeiffertheface.com)
Many circumstances, such as other health issues or disease, can contribute to raised tumor marker levels. (pfeiffertheface.com)
Tumor marker tests are not perfect. (pfeiffertheface.com)
Although an elevated level of a circulating tumor marker may suggest the presence of cancer and can sometimes help to diagnose cancer, this alone is not enough to diagnose cancer. (pfeiffertheface.com)
In addition, not everyone with a particular type of cancer will have a higher level of a tumor marker associated with that cancer. (pfeiffertheface.com)
Is TM CA72-4 a tumor marker? (pfeiffertheface.com)
Normalization of tumor marker values may indicate cure despite radiographic evidence of persistent disease. (medscape.com)
Sometimes, tumor marker values may rise after effective treatment (due to cell lysis), but the increase may not portend treatment failure. (medscape.com)
A consistent increase in a tumor marker value, combined with lack of clinical improvement, may indicate treatment failure. (medscape.com)
The usefulness of a tumor marker is in its sensitivity and specificity, as well as its influence on patient management decisions. (medscape.com)
In addition, beta-hCG serves as an ideal tumor marker for monitoring gestational trophoblastic disease and has set the standard with which other assays must be compared. (medscape.com)
Carbohydrate antigen 19-9 - tumor marker: Past, present, and future World J Gastrointest Surg. (moleculardepot.com)
An elevated tumor marker level needs to be interpreted within the context of the patient's history, physical examination, diagnostic imaging, and laboratory work-up findings. (medscape.com)
it is more valuable and more accurate early biomarker for early detection of any malignant change which may led to CRC by other means it is the most sensitive and more specific tumor marker for CRC. (scitcentral.com)
Many malignant cells (such as those found in breast and stomach cancer) develop a tumor marker called the Thomsen-Friedenreich (T) antigen. (dadamo.com)

With the ability of the mAbs to demonstrate therapeutic antitumor activity in those patients with relatively advanced malignancies, the term tumor specific was introduced. (jcancer.org)
Mabs capable of targeting the malignancies noted above were produced following immunization of BALBc mice with the Tumor Specific Antigens. (jcancer.org)
It is required by FDA that the potential effects of tumor control and toxicity be defined using the naked antibodies produced under GMP conditions, In those situations where patients with recurrent malignancies are to be studied we have come to realize that a number of factors can influence the response to monoclonal therapy. (jcancer.org)
For many solid malignancies, lymph node (LN) involvement represents a harbinger of distant metastatic disease and, therefore, an important prognostic factor. (stanford.edu)
In recent years, however, theranostics has been successfully applied to a whole range of other malignancies, including neuroendocrine tumors (NETs) and prostate cancer in particular. (snmjournals.org)
Modification with chimeric antigen receptors (CARs) endows T cells with tumor specific cytotoxicity and thus induce anti-tumor immunity against malignancies. (ijbs.com)
However, targeting solid tumors is more challenging than targeting B-cell malignancies with CAR-T cells because of the histopathological structure features, specific antigens shortage and strong immunosuppressive environment of solid tumors. (ijbs.com)
Nevertheless, targeting solid tumors is more challenging than targeting hematological malignancies because of tumor histopathological characteristics, shortage of specific antigens and local strong immunosuppressive microenvironment [ 4 ]. (ijbs.com)

Monoclonals that we were able to develop from tumor specific proteins derived from colon and pancreas cancer were found capable of targeting those tumors to induce apoptosis. (jcancer.org)
LN metastases have the potential to seed additional tissues and can induce metastatic tolerance, a process by which tumor-specific immune tolerance in LNs promotes further disease progression. (stanford.edu)
LN metastases resist T cell-mediated cytotoxicity, induce antigen-specific regulatory T cells, and generate tumor-specific immune tolerance that subsequently facilitates distant tumor colonization. (stanford.edu)
Several studies have shown that gut microbes can produce toxins that damage DNA, induce tumor-promoting inflammation and reduce a person's response to cancer treatment. (microbiomepost.com)

In the bladder carcinoma case, pathological analysis of fine-needle aspiration biopsy specimen of the metastatic cervical lymph node showed atypical cells with slight squamous differentiation. (biomedcentral.com)
Primary hepatic ASC was defined as a liver tumor containing definite components of both adenocarcinoma and squamous cell carcinoma, and sometimes it was considered as a variant of cholangiocarcinoma [ 9 ]. (biomedcentral.com)

Alternative vaccine conjugates have been developed which avoid issues associated with the protein carrier KLH by substituting it with a lipid or carbohydrate-based carrier. (wikipedia.org)
A CA 125 test measures the amount of the protein CA 125 (cancer antigen 125) in the blood. (pfeiffertheface.com)
Targeting of the fibroblast activation protein is currently being explored for different tumor entities using PET imaging with the fibroblast activation protein inhibitor (FAPI) 68 Ga-FAPI-04, and the first therapeutic applications of 90 Y-FAPI-04 have been applied. (snmjournals.org)
However, inclusion of protein antigens fromStreptococcus pneumoniaecombined with potent adjuvants and a suitable delivery system are expected to both extend protection to serotype strains not represented in the formulation and stimulate a broader immune response, thus more effective in young children, elderly, and immunocompromised populations. (univ-nantes.fr)
Cancer antigen 19-9 (CA 19-9) is a tumor-associated mucin glycoprotein antigen that is related to the Lewis blood group protein. (medscape.com)
In our search for potentially tumour-suppressive M6P/IGF2R interaction partners, we identified an essentially uncharacterized M6P-modified protein previously named Cellular Repressor of E1A-stimulated Genes (CREG). (boku.ac.at)
Another F. nucleatum surface protein, FadA, has been shown to bind to tumor cells and activate a specific signaling pathway that stimulates cell proliferation. (microbiomepost.com)

The pelvic peritoneal nodule was pathologically confirmed as a metastatic lesion. (coloproctol.org)
On inspection, occult blood was detected in stool, while preoperatively electronic gastroscopy and colonoscopy revealed no tumor lesion. (researchsquare.com)
Therefore, we divided in 3 groups, 1) metastatic lesion resection group with primary lesion resection (n = 52 in the Met/Prim lesion group), 2) primary lesion resection without metastatic lesion resection (n = 38 in the Primary lesion group) and 3) palliative operation (n = 24 in the Palliative group). (scirp.org)
Abdominal enhanced Magnetic Resonance Imaging (MRI) and Magnetic Resonance Cholangiopancreatography (MRCP) revealed an irregular mass (approximately 48 mm × 44 mm in its dimensions) mainly located at segment VIII (S8) of the liver involving the hepatic hilum with mild delayed enhancement, a small metastatic lesion at segment VII (S7), and several small sporadic cysts in the liver ( Figure 1A-1C ). (oncologyradiotherapy.com)
Positron Emission Tomography/Computed Tomography (PET/CT) clearly demonstrated hotspots (SUV max: 7.7 for the primary mass and 4.2 for the metastatic lesion) at the same locations as the tumors detected by MRI, but no hot spots for lymph nodes and distant metastases were observed ( Figure 1D ). (oncologyradiotherapy.com)
A) Axial T2-weighted Magnetic Resonance Image (MRI) and (B) coronal T2-weighted MRI show a hyperintense mass (black arrow) located at the perihilar area, with marked intrahepatic biliary dilatation in the adjacent liver (the metastatic lesion at segmental VII of the liver was not shown here). (oncologyradiotherapy.com)
We diagnosed the pancreatic lesion as either metastatic cancer or primary pancreas cancer. (kjco.org)
According to the surgical findings, a tumor lesion was found to invade the trachea, and tracheal shaving was additionally performed. (kjco.org)

Abdominal ultrasonography and abdominal computed tomography (CT) revealed no suspicious metastatic lesions in the liver, peritoneum, or lymph nodes. (biomedcentral.com)

As such we plan to eventually employ the therapeutic mAbs in combination with chemotherapy as a means of enhancing the immunogenicity of the tumor system being treated and to possibly weaken the malignant growth for easier destruction by the mAb. (jcancer.org)
In most cases, histopathologic analysis will permit classification of these tumors into those with a favorable prognosis, which are mostly approached with locoregional treatment or systemic platinum-based chemotherapy, or an unfavorable prognosis, which are treated with empirical combination regimens involiving platinum or taxane. (medscape.com)
Based on pathological report demonstrating that the primary tumor was HER2-positive, the patient was commenced on chemotherapy with trastuzumab. (springeropen.com)
Only one month of disease-free after four cycles of postoperative chemotherapy was remained when metastatic tumor developed in liver. (researchsquare.com)
Using a cohort of 386 colon cancer patients we demonstrate that high MGL binding to stage III tumors is associated with poor disease-free survival, independent of microsatellite instability or adjuvant chemotherapy. (oncotarget.com)
Finally, CA 19-9 levels can be used to monitor tumor response to active treatment with surgery, with or without chemotherapy, radiation therapy, and/or other targeted or biological therapies. (medscape.com)
A tumor at this stage is inoperable, and so the patient was started on chemotherapy with docetaxel, cisplatin, and fluorouracil (DCF). (biomedcentral.com)
Olaparib has US Food and Drug Administration (FDA) approval for adults with germline BRCA -mutated metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. (medscape.com)
It is indicated for maintenance treatment of adults with deleterious or suspected deleterious gBRCAm metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. (medscape.com)

However, a meticulous surgical dissection through a "no-touch" technique might allow a radical oncological resection with minimal risk of tumor dissemination and seeding. (bvsalud.org)
We investigated whether primary and metastatic resection of PDAC with oligometastases can improve the survival and then explored prognostic factors to identify indications for conversion surgery. (bvsalud.org)
before resection of the primary tumor and then postoperatively every 6-12 mo, resulting in three to five samples per patient. (lu.se)
Objective:To study the impact of number and location of metastatic lymph nodes on prognosis of patients after radical resection for intrahepatic cholangiocarcinoma (ICC).Methods:A retrospective study was conducted on 105 patients who underwent radical resection and lymphadenectomy for ICC at the First Affiliated Hospital of Xi'an Jiaotong University from January 2010 to December 2020. (bvsalud.org)
This patient series included those who underwent primary tumor resection, a bypass or a proctostomy and those who underwent the simultaneous resection of metastases with curative intent. (scirp.org)
A total of 75 liver tumor patients, who had received liver resection (LR) during the period from January 1998 to December 2011 in Eastern Hepatobiliary Surgery Hospital, were picked out and included in this study. (biomedcentral.com)

Playing a part in the formation of three different cancer-specific antigens, β3GalT5 is of particular interest in its relevance to cancer treatment, and it has been shown to be critical for cancer cell survival. (wikipedia.org)

It is one of the most malignant tumors with high morbidity and poor prognosis [ 2 ]. (hindawi.com)
Hypoxic microenvironment is another feature of malignant tumors [ 11 ]. (hindawi.com)

There are multiple therapies being developed to address this challenge, including chimeric antigen receptor (CAR)-T-cell therapy, anticancer vaccines, and therapeutic antibodies. (wesparkhealth.com)
Advances in our understanding on the interaction between the immune system and tumor cells have contributed to the rapid development of novel therapeutic strategies based on chimeric antigen receptor (CAR) or T cell receptor (TCR) modified T cells. (ijbs.com)

Often these changes make the cancer cells resistant to normal programmed cell death, and the cells will divide over and over, forming a solid tumor. (algemenegezondheid.org)

Endpoints included overall survival (OS), progression-free survival (PFS) and cumulative incidences of local failure (LF) and metastatic failure (MF). (frontiersin.org)
Therefore, the elevated levels of SLA and LDH indicate the aggravated tumor burden, tumor angiogenesis, tumor progression, and poor prognosis of patients [ 14 ]. (hindawi.com)
Elevated cell-surface expression of truncated carbohydrate structures such as Tn antigen (GalNAcα-Ser/Thr) is frequently observed during tumor progression. (oncotarget.com)
Irinotecan liposomal is used in combination with fluorouracil and leucovorin for metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy. (medscape.com)

OBI-888's human Phase I/II study for the treatment of metastatic and locally advanced solid tumors is estimated to finish in December 2022. (wikipedia.org)
By the time of diagnosis, 90% of patients have locally advanced tumors that have involved retroperitoneal structures, spread to regional lymph nodes, or metastasized to the liver or lung. (msdmanuals.com)
However, PS, disease extent (locally advanced or metastatic), and CEA level may help determine patients who could benefit from second-line treatment. (e-jyms.org)

also known as: Cancer Antigen - GI. (pfeiffertheface.com)

Prostate-specific antigen levels and magnetic resonance imaging findings aided the diagnostic process. (biomedcentral.com)
In Sweden, there has been a steady prostate-specific antigen (PSA) velocity for the diagnosis of pros- decrease in age-standardized breast cancer mortality in women up tate cancer (15). (lu.se)

In these cases, adenocarcinoma was diagnosed based on left supraclavicular node biopsies, and a second primary tumor was found, in a 78-year-old Japanese woman with a diagnosis of cholangiocarcinoma, a 64-year-old Japanese man with a diagnosis of bladder carcinoma, and a 61-year-old Japanese man with a diagnosis of prostate carcinoma. (biomedcentral.com)
The tumor was a moderately differentiated, microsatellite-stable, KRAS -mutated, and NRAS -wild type adenocarcinoma. (coloproctol.org)
Metastatic adenocarcinoma presenting as isolated axillary lymphadenopathy in women is usually a manifestation of an occult breast primary cancer . (medscape.com)
The tumor was completely resected, the pathological diagnosis being adenocarcinoma, and small clump of cancer cells having been found in the muscularis propria (pathological stage T2N0M0 (AJCC classification), pathological effect grade 2) (Fig. 2 ). (springeropen.com)
It is indicated for metastatic adenocarcinoma of the pancreas as first-line treatment in combination with gemcitabine. (medscape.com)

In the cholangiocarcinoma case, carbohydrate antigen 19-9 and alpha-fetoprotein levels helped to diagnose cholangiocarcinoma. (biomedcentral.com)

Persistent DDR induces a permanent proliferation arrest known as replicative senescence, which is thought to function as a tumor suppressor [ 6 - 8 ]. (oncotarget.com)
The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) is a multifunctional tumour suppressor which binds a variety of factors that impinge on the proliferation, migration and invasiveness of cancer cells. (boku.ac.at)

Since the pioneering use of 131 I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using 177 Lu-labeled somatostatin analogs or in the treatment of advanced prostate cancer using prostate-specific membrane antigen-directed radionuclide therapy. (snmjournals.org)

Globo H (globohexaosylceramide) is a globo-series glycosphingolipid antigen that is present on the outer membrane of some cancer cells. (wikipedia.org)
Globo H's biosynthetic pathway is involved in the synthesis pathways of other globo-series glycosphingolipid antigens that are also specific to cancer cells, including stage-specific embryonic antigen-3 (SSEA3) and stage-specific embryonic antigen-4 (SSEA4). (wikipedia.org)
We show that an epigenetically instilled tumor-intrinsic interferon response program confers enhanced LN metastatic potential by enabling the evasion of NK cells and promoting LN colonization. (stanford.edu)
A 2019 study, for example, showed that stress hormones can increase the number of pro-tumor immune cells in tumors. (pfeiffertheface.com)
That could mean that stress not only wakes up dormant tumor cells but also provides the right environment for them to grow, Dr. Hildesheim explained. (pfeiffertheface.com)
Along this line, nanoparticle (NP) delivery systems can enhance the immunogenicity of antigens by protecting them from degradation and increasing their uptake by antigen-presenting cells, as well as offering co-delivery with adjuvants. (univ-nantes.fr)
The metabolism of tumor cells has its own characteristics. (hindawi.com)
To cooperate with the rapid development of tumor, the tumor cells produce energy through glycolysis, which is called the Warburg effect [ 10 ]. (hindawi.com)
In hypoxic conditions, LDH can convert pyruvate to lactic acid to support tumor cells [ 12 ]. (hindawi.com)
Hypoxia inducible factor 1 α (HIF-1 α ) can transcriptionally upregulate LDH-A in tumor cells to ensure anaerobic glycolysis and produce enough lactate. (hindawi.com)
When tested in mouse models, both of these anti-tumor antibodies blocked the ability of human breast cancer cells to metastasize and they helped to extinguish breast cancer that had already spread. (algemenegezondheid.org)
Because tumor-derived, cell-free DNA (cfDNA) is often released from cancer cells and circulates in the bloodstream, we hypothesized that breast cancer development is associated with changes in the amount of telomeric cfDNA that can be detected in the plasma. (oncotarget.com)
However, as it turned out afterwards, cancer cells in the recurrent tumor were negative for HER2. (springeropen.com)
low mitotic rate TYPES ▪ Embryonic origin of GI tract (e.g. foregut, midgut, hindgut) Foregut tumors (e.g. stomach) ▪ Type I ▫ Most common ▫ Originates from enterochromafﬁn-like (ECL) cells ▫ In association with high gastrin levels secondary to chronic atrophic gastritis ▫ Small, usually benign ▪ Type II ▫ Originates from ECL cells ▫ In association with high gastrin levels induced by gastrinomas (e.g. (osmosis.org)
Switchable targeting of solid tumors by BsCAR T cells. (yale.edu)
Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells. (yale.edu)
They are typically produced by tumor cells, but in some cases they may be produced by the body in response to malignancy or to certain benign conditions. (medscape.com)
We have previously demonstrated that the C-type lectin macrophage galactose-type lectin (MGL), expressed by human antigen presenting cells, can distinguish healthy tissue from CRC through its specific recognition of Tn antigen. (oncotarget.com)
Immunotherapy requires both overcoming the mechanisms by which cancer cells circumvent immune surveillance as well as re-sensitizing the tumour to inflammation, for example, training the immune system to recognize cancer-related antigens and making 'invisible' cells visible to the immune system. (wesparkhealth.com)
These therapies have only achieved limited success, with a major issue being the low (acidic) pH of the tumour microenvironment (TME), which is highly detrimental to immune cells, including T-cells, rendering them less effective. (wesparkhealth.com)
This antigen is suppressed in normal healthy cells, much like a rock is covered over by water at high tide. (dadamo.com)
Healthy cells do not normally express the T or Tn antigen, which are 'encrypted' or covered up by polysaccharides much the same way that a rock is covered by water at high tide. (dadamo.com)
In malignant or pre-malignant cells, the ability to synthesize the polysaccharides which normally cover the T antigen is often lost, which causes T to be 'expressed' or uncovered, much like a falling tide will often uncover previously hidden rocks at a low tide. (dadamo.com)
One of the functions of these T and Tn antigens is to promote cancer cell adhesion----the ability for the cancer cell to stick to other cells including healthy cells. (dadamo.com)
MCP-activated NK-cells showed efficiency in causing cancer tumor cell loss of life. (bio2009.org)
These results indicate that the M6P/IGF2R status influences the metastatic propensity of cancer cells in a decisive manner. (boku.ac.at)
A vaccine could be targeted towards tumor-promoting antigens such as Fap2 and RadD, two F. nucleatum outer-membrane proteins that bind carbohydrates on the surface of tumor cells. (microbiomepost.com)
It made sense, says Jim, since Mayo Clinic Laboratories had already evaluated biopsy samples of his tumor cells that had been submitted by his medical team in Omaha. (mayoclinic.org)
The epitope that EBC-129 binds to is a specific glycosylation 1 site that is conserved on both carcinoembryonic antigen-related cell adhesion molecules (CEACAM) 5 and 6, which are proteins over-expressed in cancer cells. (a-star.edu.sg)
In this review, we discuss the current status and major obstacles for the treatment of solid tumors with CAR-T cells, thus provide some potential measures to refine this novel therapeutic modality. (ijbs.com)

While absent in normal tissues, the glycosphingolipid is overexpressed in a variety of epithelial cancer cell types including human pancreatic, gastric, lung, colorectal, esophageal, and breast tumors. (wikipedia.org)

Just as a paleontologist's fossil record suggests interactions of plants and animals that inhabited earth millions of years ago, the fossil record of a cancer patient's immune system may provide a glimpse of how people's immune system interacts with pathogens and cancerous tumors today. (algemenegezondheid.org)
cancerous tumors of the glands, such as in the ducts or lobules of the breast. (thewomenofhope.org)

As a Tumor Associated Carbohydrate Antigen (TACA), Globo-H is a promising clinical target for immunotherapy. (wikipedia.org)
Consequently, LN biopsy and lymphadenectomy are common clinical practices, not only because of their diagnostic utility but also as a means of deterring further metastatic spread. (stanford.edu)
Tumor immunology is undergoing a renaissance due to the recent profound clinical successes of tumor immunotherapy. (stanford.edu)
SCC antigen is useful in the clinical management of advanced cervical cancer. (medscape.com)
even tumors with the comparable stage or the same pathological type could show a wide variation in biological behavior and clinical outcomes. (biomedcentral.com)

These 2 theranostic approaches, as well as the therapy of osseous metastases of prostate cancer with 223 Ra ( 4 , 9 , 10 ), have unequivocally demonstrated that radionuclide therapy can be applied not only to thyroid cancer but also to other solid tumors. (snmjournals.org)
It may be achieved, at least partially, by more extensive basic studies investigating the spatiotemporal dynamics of T cell activation by CARs and unraveling the connection between T cell migration in solid tumors and the effectiveness in eradication of solid tumors and metastases [ 5 ]. (ijbs.com)

Additionally, in vivo studies of OBI-888 in various Globo H-positive (GH+) xenografts models showed promising tumor growth inhibition results. (wikipedia.org)

The operation to remove the tumor, a Whipple procedure , or pancreaticoduodenectomy, involves removing the head of the pancreas, the duodenum, the gall bladder and bile duct, and then reconfiguring the upper digestive system. (mayoclinic.org)

most of these tumors are adenocarcinomas containing pools of mucin. (biomedcentral.com)

CC is the second commonest primary liver tumour worldwide, after hepatocellular carcinoma (HCC). (bmj.com)
Meanwhile, 40 hepatocellular carcinoma (HCC) patients and 26 metastatic hepatic SCC or ASC patients who were hospitalized in the same period were also reviewed to make a comparison. (biomedcentral.com)
Though the majority of the primary tumors are hepatocellular carcinoma (HCC), some rare diseases also could not be ignored by the reason of their characteristics. (biomedcentral.com)

63cm small intestine with mesentery and the mass was resected merely in toto , and primary ileal mesenchymal tumor with whole intestinal layer invasion was suggested by the intraoperative frozen section. (researchsquare.com)

However, due to the special anatomical position of the tumor, the high position away from the broken esophagus and the narrow space in the mediastinum, laparoscopic anastomosis has the characteristics of difficult anastomosis and high anastomosis position. (bvsalud.org)
However, several reviews have highlighted similar characteristics between metastatic and primary pancreatic tumors. (kjco.org)
Some reports have revealed similar characteristics between pancreatic metastatic tumors and primary pancreatic tumors. (kjco.org)
PMID:19699081 assays, segregation, and tumor characteristics. (who.int)

The monoclonals (mAbs) that we have developed against specific immunogenic tumor membrane proteins have been studied in detail. (jcancer.org)
These tumor proteins, when first defined, were referred to as tumor associated antigens. (jcancer.org)

The relevant laboratory results were as follows: WBC 13.11 × 109/L, Alanine Aminotransferase (ALT) 299 IU/L, Total Bilirubin (TBIL) 586.0 μmol/L, albumin 26 g/L, carbohydrate antigen (CA) 19-9 453.5 U/mL, CA 125 21.60 U/mL, Carcinoembryonic Antigen (CEA) 1.73 ng/mL, Alpha-Fetoprotein (AFP) 4.69 ng/mL, Hepatitis B and hepatitis C were both negative. (oncologyradiotherapy.com)

Prognostic biomarkers can estimate the natural course of the disease and divide the tumor into two groups: good prognosis and poor prognosis [ 3 , 4 ]. (hindawi.com)

Receptor de la superficie celular con actividad tirosina cinasa que se sobreexpresa en un número significativo de ADENOCARCINOMAS. (bvsalud.org)

Preliminary results in colorectal cancer (CRC) patients enrolled in the GATTO study, a phase I study of Tomuzotuximab in combination with Gatipotuzumab in patients with EGFR positive solid tumors. (postersessiononline.eu)
So, researchers are racing to develop targeted approaches against onco-microbes, as vaccines against tumor-promoting microorganisms may help prevent diseases such as colorectal cancer . (microbiomepost.com)

High CA 19-9 levels (ie, greater than 1000 U/mL) correlate with unresectable or more advanced tumors, although this preoperative evaluation of CA 19-9 has not been widely used to establish inoperability. (medscape.com)

Choroid plexus neoplasms are rare, intraventricular, primary central nervous system (CNS) tumors derived from choroid plexus epithelium that are seen predominantly in children. (medscape.com)
[ 2 , 3 ] In adults, they account for less than 1% of primary intracranial neoplasms, whereas choroid plexus tumors represent up to 5% of pediatric brain tumors, and up to 20% of those arising in children aged 1 year and younger. (medscape.com)
Our differential diagnosis included myositis, tubercular muscle abscess, primary soft-tissue sarcoma, and metastatic carcinoma. (springeropen.com)
On the pathologic performance, primary SCC/ASC tumor was rarely accompanied with tumor capsule. (biomedcentral.com)
Due to the prevalence of hepatitis and some other reasons, the morbidity of primary liver tumor is high in Asia, especially in China [ 1 ]. (biomedcentral.com)
Before their final diagnoses were made, each of these nine primary tumor patients had undergone imageological examination and hematological and blood biochemical determinations to preclude other primary tumor diseases. (biomedcentral.com)

Tumors provided for pathologic review should come from tissue that has, whenever possible, been excised, if such tissue is available and accessible. (medscape.com)
While surgeons can remove cancerous tissue, such procedures are greatly complicated if a tumor has metastasized and established many new tumors in several other organs. (algemenegezondheid.org)
Microfollicular containing eosinophilic material, gland-like arrangement with pyknotic nuclei and resembling Call-Exner bodies were noted in tumor tissue in Figure 2b,c. (researchsquare.com)
It is so rare to find the T antigen in healthy tissue, that we actually have antibodies against it. (dadamo.com)

Meanwhile, the on-target/off-tumor toxicity caused by relative expression of target on normal tissues is another issue that should be reckoned. (ijbs.com)
Furthermore, the on-target/off-tumor toxicity can pose significant risks. (ijbs.com)

These tumor components presented more malignant biological behavior, and that may be the common reason for the poor prognosis of the both [ 11 ]. (biomedcentral.com)

Only a few cases were reported about ophthalmopathy in the years following a thyroidectomy and RAI therapy or metastatic papillary thyroid cancer.Case: A forty-six-year-old female patient was operated on for the fine needle aspiration biopsy (FNAB) result of a suspicious follicular neoplasia. (endocrine-abstracts.org)

Metastatic lung cancer was considered as a preliminary diagnosis and PET/CT was performed. (endocrine-abstracts.org)

one-hundred and six patients-after their approval-were classified into three groups: The first group consisted of ninety-one patients who were diagnosed with colorectal carcinoma with various stages, the second group involved eight patients who were diagnosed as benign tumors, and the third group including only seven patients that were diagnosed with specific chronic Inflammation diseases. (scitcentral.com)
While CEA and CA 19.9 showed highly significant differences in all groups compared with the control group but still clinically-for the inflammatory group and benign tumor group-they were within normal ranges. (scitcentral.com)

Armed with these technologies and their associated computational and modeling toolsets, systems biologists have turned their attention to tumor immunology in an effort to understand the precise nature and consequences of interactions between tumors and the immune system. (stanford.edu)
In fact, the T and Tn antigens, and blood type A antigens are actually immunologically considered to be quite similar because of their shared terminal sugar (N-acetylgalactosamine), and so might be readily confused by the immune system of blood type A individuals. (dadamo.com)

Laparoscopic surgery has gradually become the main means of surgical treatment of this kind of tumor. (bvsalud.org)

The mass was diagnosed for ovarian tumor initially, followed by laparotomy. (researchsquare.com)

Since Fap2 and FadA directly mediate microbe-tumor interaction, an antibody response against them may be effective in blocking tumor colonization and mitigating immune inhibition ," Holt says. (microbiomepost.com)

Arlen M, Arlen P, Tsang A, Wang X, Gupta R. The Therapeutic Value of Monoclonal Antibodies Directed Against Immunogenic Tumor Glycoproteins. (jcancer.org)

The Phase III GLORIA study is underway evaluating the carbohydrate-based immunogen's effects in high risk triple-negative breast cancer (TNBC) patients with an estimated completion date in 2027. (wikipedia.org)
The ADC is currently undergoing phase II trial in patients with advanced solid tumors, with an estimated completion date in Dec 2023. (wikipedia.org)
The work of the Scripps Research team gives hope that antibodies that were originally produced by cancer patients may help to block cancer spreading and interfere with already existing metastatic disease. (algemenegezondheid.org)
Nonetheless, approximately 20% - 25% of CRC patients have metastatic disease at the time of first presentation. (scirp.org)

Examples include the use of lipid A derivatives or entirely carbohydrate vaccine conjugates such as Globo H-PS A1 Globo H-targeting antibodies are another strategy currently being evaluated in the cancer therapeutic space. (wikipedia.org)
What the fossil record shows is that the human body is capable of making numerous antibodies that have the ability to recognize metastatic breast cancer tumors. (algemenegezondheid.org)
All humans normally possess antibodies that react with the Thomsen-Friedenreich (T) and the Tn antigens. (dadamo.com)
Here, a vaccine that elicits antibodies that block specific mechanisms of F. nucleatum tumor homing and tumor promotion could be beneficial ," Holt says. (microbiomepost.com)

OBI Pharma's OBI-888 is a humanized IgG1 antibody that selectively binds to the Globo H antigen among other Globo series glycosphingolipids such as SSEA-3 and SSEA-4. (wikipedia.org)
Not surprisingly, blood type A individuals have the least aggressive antibody immune response against the T and probably Tn antigens. (dadamo.com)

Figure 32.1 Histological appearance of a carcinoid tumor of the lung. (osmosis.org)

The pathological stage of the tumor was determined to be T3N2bM1c. (coloproctol.org)
After surgery, the pathological report revealed that the mass was metastatic PTC. (kjco.org)

Anatomy17

Organisms11

Diseases36

Chemicals and Drugs116

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes44

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science4

Health Care5

Pancreatic cancer8

Metastasis16

Recurrence5

Markers31

Serum13

Showed that the primary tumor1

Cancers9

Marker21

Malignancies8

Induce4

Squamous2

Protein7

Lesion8

Lesions1

Chemotherapy9

Resection6

Specific Antigens1

Malignant tumors2

Chimeric antigen receptor2

Solid tumor1

Progression4

Locally advanced3

Cancer Antigen1

Prostate-specifi2

Adenocarcinoma5

Cholangiocarcinoma1

Proliferation2

Neuroendocrine1

Cells30

Breast tumors1

Cancerous tumors2

Clinical5

Metastases2

Promising tumor growth1

Pancreas1

Mucin1

Hepatocellular carcinoma3

Invasion1

Characteristics4

Proteins2

Alpha-fetoprotein1

Prognostic1

Receptor1

Colorectal cancer2

Preoperative evaluation1

Primary6

Tissue4

Toxicity2

Poor prognosis1

Biopsy1

Diagnosis1

Benign2

Immune system2

Surgical1

Laparotomy1

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Patients4

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Antibody2

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Pathological2