• N-Myc downstream-regulated gene 1 (NDRG1) plays vital roles in tumor metastasis suppression and is frequently silenced in metastatic colon cancers. (nih.gov)
  • Conclusion Clinicopathologic factors such as LNR, use of chemotherapy, age, co-morbidities, site of primary colon tumor, and number of sites of metastasis are all independent predictors of overall survival in patients who undergo primary colon tumor resection in the metastatic setting. (nebraska.edu)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
  • Cutaneous metastases of colonic neuroendocrine carcinomas (NECs) are very infrequent, while cases of scalp metastasis are even fewer. (biomedcentral.com)
  • This is the second case report of a colonic NEC with scalp metastasis. (biomedcentral.com)
  • In this report an unusual case of a colonic NEC with initial distant metastasis confined to the scalp is presented. (biomedcentral.com)
  • The term carcinosarcoma implies a mixed malignant tumor that is composed of an epithelial element, typically the common form of carcinoma seen in the tissue harboring the neoplasm, close to or intermixed with a sarcomatous component. (klinikitsekoura.gr)
  • Cases of primary colorectal signet-ring cell carcinoma metastatic to the tonsil are extremely rare. (omeka.net)
  • Carcinoid tumors of the colon are rare, comprising less than 11% of all carcinoid tumors and only 1% of colonic neoplasms. (jomi.com)
  • Treatment of these tumors depends on the size, location, and presence of metastatic disease. (jomi.com)
  • Colonic neuroendocrine neoplasms (NENs) are relatively rare tumors with an incidence rate of 0.11-0.21/100,000. (biomedcentral.com)
  • Neuroendocrine neoplasms (NENs) are rare tumors originating from neuroendocrine cells and include a series of heterogeneous tumors. (biomedcentral.com)
  • Chest wall tumors, whether malignant (cancerous) or benign (non-cancerous), are classified as primary or secondary (metastatic). (caballosperalta.es)
  • Ten cases of primary colonic malignant extrarenal rhabdoid tumors (MERT) have been reported. (practicalgastro.com)
  • To our knowledge, only 10 cases of primary rhabdoid colonic tumors (RCT) have been reported, and our patient, at 31 years of age, is the youngest (Table 1). (practicalgastro.com)
  • Papillary tumors are unusual entities, making up less than 5% of all new digestive tract neoplasms in the United States. (medscape.com)
  • Although malignant tumors of the main papilla are more common, a number of benign neoplasms also may arise in the periampullary area, including benign adenomas (tubular and villous), lipomas, hamartomas, fibromas, and neurogenic tumors. (medscape.com)
  • Malignant vascular tumors (MVTs), mainly composed of angiosarcoma (AS) and hemangioendothelioma (HE), are considered one of the rarest soft tissue neoplasms in contrast to their benign counterparts. (turkjpath.org)
  • Atypical lipomatous tumors are generally considered to be low-grade sarcomas, with a strong propensity to recurrence but little metastatic potential. (medscape.com)
  • Using tissue microarrays and full tissue sections of normal and 448 neoplastic tissues, HE4 immunoreactivity was found in normal glandular epithelium of the female genital tract and breast, the epididymis and vas deferens, respiratory epithelium, distal renal tubules, colonic mucosa, and salivary glands, consistent with HE4 gene expression. (nature.com)
  • Colonic polyps are projections from the surface of the colonic mucosa. (jomi.com)
  • Adenomatous polyps are benign neoplasms of colonic mucosa. (radiologykey.com)
  • Colonic mucosa with gastrointestinal stromal tumor (GIST) involving the adjacent submucosa (hematoxylin and eosin [H&E] stain, medium power). (medscape.com)
  • Scholars@Duke publication: Efficacy and safety of dilpacimab (ABT-165) versus bevacizumab plus FOLFIRI in metastatic colorectal cancer: a phase II study. (duke.edu)
  • Aim: This phase II study investigated safety and efficacy of dilpacimab or bevacizumab plus FOLFIRI in patients with previously treated metastatic colorectal cancer (mCRC). (duke.edu)
  • In general colonic carcinosarcomas constitute a rare category of malignant neoplasms whose nature is still incompletely understood. (klinikitsekoura.gr)
  • Of this uncommon group of highly malignant neoplasms, the leiomyosarcoma is the most common histiotype. (medscape.com)
  • Computed tomography (CT) imaging findings showed multiple lesions in the liver with ascites and descending colonic mass suspicious for malignancy. (gastrores.org)
  • As many as 55% of patients with recurrence have metastatic lesions to the liver at the time that their recurrence is discovered. (medscape.com)
  • Post-operative workup including positron emission tomography (PET) CT revealed multiple fluorodeoxyglucose (FDG) avid hepatic lesions, consistent with metastatic disease. (practicalgastro.com)
  • Conclusions: From our review of the clinical information available on these 9 patients, these splenic lesions were thought to be an entrapment of mucinous tumor within splenic surface trabeculae, which expand into the splenic parenchyma resembling metastatic disease. (johnshopkins.edu)
  • Deep learning and colon capsule endoscopy: automatic detection of blood and colonic mucosal lesions using a convolutional neural network. (cdc.gov)
  • The pathology diagnosis was liver with metastatic hepatoid adenocarcinoma consistent with colonic primary. (gastrores.org)
  • Surgical pathology after right hemi-colectomy revealed a malignant neoplasm with rhabdoid features. (practicalgastro.com)
  • Surgical pathology revealed a poorly differentiated malignant neoplasm with rhabdoid features, and 9 out of 15 pericolonic lymph nodes were positive for metastatic malignancy. (practicalgastro.com)
  • To evaluate the efficacy of intra-arterial chemotherapy combined with hyperthermia for metastatic liver cancer, our cooperative study group carried out a randomized clinical trial comparing intra-arterial chemotherapy alone and intra-arterial chemotherapy combined with hyperthermia. (nih.gov)
  • Our results suggest that intra-arterial chemotherapy combined with hyperthermia is a useful modality for the treatment of metastatic liver cancer. (nih.gov)
  • METHODS: Colonosphere cultures were established from human colorectal tumor specimens obtained from patients who underwent colon or liver resection for primary or metastatic adenocarcinoma. (knaw.nl)
  • No metastatic foci to the liver or the abdominal cavity could be detected. (klinikitsekoura.gr)
  • Over time, some colonic polyps develop into cancers. (jomi.com)
  • If the polyps are too large or cannot be removed safely, they may be removed by colonic resection. (jomi.com)
  • Metastatic clostridial myonecrosis is an uncommon complication of malignancy, particularly of the gastrointestinal tract, and of leukemia. (oaepublish.com)
  • These focal parenchymal defects from a non-metastasizing malignancy within an organ that rarely develops metastatic foci, even with high-grade cancer, were studied. (johnshopkins.edu)
  • abstract = "Background Resection of the primary tumor in metastatic colon cancer may occur for palliation of bleeding or obstruction despite distant metastases. (nebraska.edu)
  • T his is a state-of-the-art review of the molecular genetics of pancreatic neoplasms. (coek.info)
  • Although understanding of the molecular features underlying pancreatic neoplasms is still in its infancy, a strong emphasis on the relevance of these findings for the practicing surgical pathologist is provided. (coek.info)
  • INTRODUCTION Pancreatic cancer is the fourth leading cause of cancer death in both men and women in the United States.1 There have been significant advances in our understanding of the genetics of pancreatic neoplasms in the past 2 decades, as well as an explosion of information over the past 3 years, largely because of the availability of whole genome and exome sequencing technologies. (coek.info)
  • This article provides a state-of-the-art review of the molecular genetics of pancreatic neoplasms with a strong emphasis on the relevance of these findings for the practicing surgical pathologist. (coek.info)
  • A 62-year-old Chinese man, who had undergone radical surgery for a "locoregional" colonic NEC one and half months before, came to our hospital for adjuvant chemotherapy. (biomedcentral.com)
  • Treatment of colonic MRTs is typically surgical resection without chemotherapy or radiotherapy. (practicalgastro.com)
  • The metastatic power of cancers is determined by a series of angiogenic and metastatic factors. (edu.hk)
  • Conclusion: This article highlights the importance of angiogenesis and oxidative stress on the development of advanced and metastatic colon cancers, and provides new insights on alternative and effective treatment options. (edu.hk)
  • 2 A general rule of thumb is that colonic cancers located in the right (ascending) colon tend to slowly bleed leading to signs and symptoms of anemia including but not limited to fatigue, low energy, pallor, shortness of breath, and/or elevated heart rate. (jomi.com)
  • The 5-year survival rate for patients with localized disease after surgical resection is 20% and for those with metastatic disease, the survival rate is only 2%.1 Only about 20% of pancreatic cancers are detected early enough to be surgically resectable. (coek.info)
  • Le Centre Fédéral d Expertise des Soins de Santé (KCE) et le Collège d Oncologie ont réalisé une mise à jour des recommandations de bonne pratique pour la prise en charge des cancers de l sophage et de l estomac, qui dataient de 2008. (docressources.info)
  • Results: A significant percentage of intra-abdominal cancers prove to be inoperable because of metastatic or locally advanced disease despite a preoperative workup suggesting a potentially resectable disease. (bvsalud.org)
  • PANCREATIC DUCTAL ADENOCARCINOMA CLINICAL FEATURES Ductal adenocarcinoma of the pancreas is the most common malignant neoplasm of the pancreas. (coek.info)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • The scalp nodules proved to be metastases from colonic NEC as determined using pathological and immunohistochemical examinations following lumpectomy. (biomedcentral.com)
  • We now report a second case of a colonic NEC with multiple scalp metastases. (biomedcentral.com)
  • Case report: We report a case of a long-standing colon cancer with an atypical metastatic pattern and the appearance of a thyroid metastases. (utmb.edu)
  • Evaluation of Artificial Intelligence-assisted Diagnosis of Skin Neoplasms - a single-center, paralleled, unmasked, randomized controlled trial. (cdc.gov)
  • In the United Kingdom, approximately 55% of patients with CRC present at initial diagnosis with advanced disease (Dukes stages C and D). Of those with earlier disease who receive a curative resection, some 30% to 40% still go on to develop a local recurrence or metastatic disease. (radiologykey.com)
  • Yilmaz & Deshpande occasionally, they are cystic and thus can mimic primary cystic neoplasms of the pancreas. (coek.info)
  • the diagnosis of metastatic myonecrosis was based on a high index of suspicion, development of bullae containing gram-positive rods, and subcutaneous crepitus (although this was a late sign). (oaepublish.com)
  • It has a non-debatable contribution to the diagnosis of hematolymphoid neoplasm as well as in minimal residual disease. (ijpmonline.org)
  • Has distant metastatic disease. (who.int)
  • The application of positron emission tomography (PET) using fluorodeoxyglucose (FDG) has been frequently reported in the management of advanced and metastatic disease, and emerging data are continually redefining its clinical indications. (radiologykey.com)
  • 18 With the exception of the ovarian neoplasms, the same carcinomas analyzed for gene expression were also examined for HE4 by immunohistochemistry on tissue microarrays (see below). (nature.com)
  • Therefore, we aim to determine the incidence of appendiceal neoplasms in patients with acute appendicitis, tumor types and the importance of the anatomopathological study of the surgical piece. (bvsalud.org)
  • STUDY DESIGN: Retrospective study in which we described patients who underwent emergent appendectomy with histopathological findings of appendiceal neoplasms from January 2012 to September 2018. (bvsalud.org)
  • Advances made in treating patients with metastatic colon cancer are now being translated to the early colon cancer setting. (rug.nl)
  • Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
  • To our knowledge, only 10 cases of primary colonic MERT have been reported. (practicalgastro.com)
  • Thyroid neoplasm is a neoplasm or tumor of the thyroid. (wikipedia.org)
  • It can be a benign tumor such as thyroid adenoma, or it can be a malignant neoplasm (thyroid cancer), such as papillary, follicular, medullary or anaplastic thyroid cancer. (wikipedia.org)
  • The first step in diagnosing a thyroid neoplasm is a physical exam of the neck area. (wikipedia.org)
  • Thyroid nodules are a major presentation of thyroid neoplasms, and are diagnosed by ultrasound guided fine needle aspiration (USG/FNA) or frequently by thyroidectomy (surgical removal and subsequent histological examination). (wikipedia.org)
  • citation needed] Thyroid neoplasm might be classified as benign or malignant. (wikipedia.org)
  • citation needed] Thyroid adenoma is a benign neoplasm of the thyroid. (wikipedia.org)
  • As in the colon, these neoplasms range from well differentiated to moderately differentiated to poorly differentiated. (medscape.com)
  • The surgeons were able to resect both of the patient's abnormal growths because the patient's colonic polyp was located in his ascending (right) colon, just distal to the ileocecal valve, and had a blood supply that originated from the same major blood vessel. (jomi.com)
  • Cases of colonic NECs are very unusual and data from the Norwegian Registry of Cancer from 1993-2004 showed that the incidence rate of colonic NENs was 0.25/100,000 and 31.5% of colonic NENs were classified as NECs [ 2 ]. (biomedcentral.com)
  • Vitamin E succinate inhibits NF-kappaB and prevents the development of a metastatic phenotype in prostate cancer cells: implications for chemoprevention. (positivehealth.com)
  • Collectively, our results suggest that berberine-induced AMPK activation inhibits the metastatic potential of colon cancer cells by decreasing integrin β1 protein levels and downstream signaling. (korea.ac.kr)
  • These neoplasms usually arise in the female reproductive tract, urinary tract, the head and neck areas, breast and respiratory tract. (klinikitsekoura.gr)
  • Neoplasms containing cyst-like formations or producing mucin or serum. (lookformedical.com)