• Treatment of high-grade spinal cord astrocytoma of childhood with '8-in-1' chemotherapy and radiotherapy: a pilot study of CCG-945. (nih.gov)
  • five received craniospinal radiotherapy and five spinal radiotherapy. (nih.gov)
  • Radiotherapy (RT) is an effective treatment for palliative patients with painful bone metastases. (centerwatch.com)
  • Some suggest that direct decompressive surgery combined with postoperative radiotherapy, provide better outcomes than treatment with radiotherapy alone for patients with spinal cord compression due to metastatic cancer. (gloucestershirespinalsurgery.com)
  • The patient received postoperative radiotherapy as an adjuvant treatment, but it was discontinued halfway through when multiple bone metastases were identified. (springeropen.com)
  • Metastatic lesions are responsible for about 85% of neoplastic spinal cord compression cases, with the other 15% due to primary neoplastic lesions of the spine. (medscape.com)
  • Metastatic lesions that involve the spinal cord affect about 5-10% of patients with cancer. (medscape.com)
  • Metastatic lesions are featured in this discussion since they cause 85% of the cases of neoplastic spinal cord compression. (medscape.com)
  • [ 3 ] Approximately 15% of all primary CNS lesions arise from the spinal cord, with an estimated incidence rate of 0.5-2.5 cases per 100,000 population. (medscape.com)
  • Case Description: We present an illustrative case of a 47-year-old female with metastatic lesions to the lumbosacral vertebrae years after the initial diagnosis of an intradural, intramedullary spinal cord tumor (IMSCT). (bvsalud.org)
  • Extra-spinal myxopapillary ependymoma is very rare, but it must be considered in the differential diagnosis of pelvic mass lesions. (balkanmedicaljournal.org)
  • Extranodal Rosai-Dorfman disease with multiple spinal lesions: Arare presentation. (jbstjournal.com)
  • Spinal neoplastic lesions of metastatic origin severely affect patient quality of life. (123dok.net)
  • A total of 196 patients with 270 lesions of spinal metastases were treated with this procedure from May 2001 to October 2005. (elsevierpure.com)
  • 5. Spinal cord compression, brain metastases or leptomeningeal metastases unless these lesions are definitively treated (eg. (who.int)
  • Neoplastic disease that involves the spine and results in spinal cord or cauda equina compression may have devastating neurologic and functional consequences. (medscape.com)
  • The spine is the most frequent area of bone metastasis in patients with systemic neoplastic disease. (bvsalud.org)
  • Neoplastic disease that involves the spine with spinal cord compression may be devastating. (medscape.com)
  • Consequent signs and symptoms may be referable to the spine or spinal cord. (medscape.com)
  • Isolated extradural Rosai-Dorfman disease of the thoracic spine: A rare cause of spinal cord compression: Case report. (jbstjournal.com)
  • Image guided spinal radiosurgery can be successfully applied to treat patients with focal spine metastases. (elsevierpure.com)
  • The goals of surgical treatment for spinal tumors can include histologic diagnosis, tumor local control or oncological cure, pain relief, spinal cord decompression and restoration of neurological function, restoration of spine stability, and deformity rectification. (gloucestershirespinalsurgery.com)
  • As the director of Spine Surgery for the Department of Neurosurgery at the University of Maryland, I see a large volume of patients with spinal deformity, degenerative disease, spinal oncology and spine trauma. (umaryland.edu)
  • Sansur CA , Pouratian N, Dumont AS, Schiff D, Shaffrey CI, Shaffrey ME.Spinal Cord Neoplasms, Part II: Primary tumors of the bony spine and adjacent soft tissues. (umaryland.edu)
  • Leptomeningeal metastases spread by means of diffuse or multifocal seeding of the meninges from advanced systemic cancer (eg, lung or breast cancer, melanoma, lymphoma). (medscape.com)
  • Metastases to the substance of the cord (intramedullary) are relatively rare. (medscape.com)
  • Principles of treating intramedullary cancer are similar to those for epidural spinal cord compression. (medscape.com)
  • Anatomically, neoplasms of the spinal cord may be classified according to the compartment of origin, either intramedullary (inside the cord) or extramedullary (outside the cord). (medscape.com)
  • Most primary intramedullary spinal cord tumors are astrocytomas or ependymomas . (medscape.com)
  • We report an intramedullary spinal cord metastasis from a bronchial carcinoid, and discuss its mechanisms and management. (elsevierpure.com)
  • Intramedullary spinal cord metastases from any cancer are rare, and bronchial carcinoids account for only a small fraction of lung cancers. (elsevierpure.com)
  • To our knowledge, an intramedullary spinal cord metastasis from a bronchial carcinoid has been described only once previously. (elsevierpure.com)
  • Shin, John H. / Intramedullary spinal metastasis of a carcinoid tumor . (elsevierpure.com)
  • This neoplasm may present with renal signs and symptoms, such as hypertension, hematuria and abdominal pain. (aafp.org)
  • Surgical repair of spinal metastases from renal origin is often complicated by excessive bleeding. (ajnr.org)
  • Twenty spinal metastases from renal origin (17 patients) treated by preoperative embolization with polyvinyl alcohol particles were analyzed retrospectively. (ajnr.org)
  • A control group of 10 patients with 11 spinal metastases of renal origin underwent surgery without embolization. (ajnr.org)
  • Preoperative embolization of spinal metastases of renal origin with polyvinyl alcohol particles is safe and might reduce intraoperative blood loss significantly. (ajnr.org)
  • About 40% of patients with renal cell carcinoma develop bone metastases. (ajnr.org)
  • Vertebral metastases of renal origin are highly vascular and often cause life-threatening intraoperative bleeding (6, 7) . (ajnr.org)
  • There is, however, limited data about the effect of preoperative embolization on intraoperative blood loss in spinal metastases of renal origin (6, 7, 15) . (ajnr.org)
  • The purpose of this retrospective study was to evaluate the effects of state-of-the-art selective embolization with polyvinyl alcohol (PVA) particles on intraoperative blood loss in vertebral metastases of renal cell carcinoma. (ajnr.org)
  • All patients had histologically proved metastases of renal carcinoma origin. (ajnr.org)
  • The control group consisted of 10 consecutive patients with 11 spinal metastases of renal carcinoma, which were treated surgically without preoperative embolization between April 1994 and April 1997. (ajnr.org)
  • The most highly vascularized vertebrae are those with metastases originating from renal cell and thyroid carcinoma [7]. (123dok.net)
  • blood transfusion), spinal cord, lung cancer (oncology), respiratory cancer, radiology Background Multiple myeloma is a malignant proliferation of plasma cells mostly affecting the bone marrow and commonly presents with anaemia, hypercalcaemia, renal dysfunction, bone and skeletal involvement. (2011globalhealth.org)
  • Up to 75% of women with metastatic breast cancer develop bone metastases, a cause of significant morbidity, including pain, pathologic fracture, spinal cord compression, and hypercalcemia requiring surgery and/or radiation therapy. (medscape.com)
  • 0.0001), being female (p = 0.0056), or being referred for bone metastases (p = 0.0185) significantly correlated with higher levels of fatigue. (nih.gov)
  • Bone metastases are the most common site of distant metastases and can cause severe and disabling effects, including pain, spinal cord compression and pathologic fracture. (centerwatch.com)
  • Therefore, single fraction radiation therapy (SFRT) is encouraged, but 20 Gy in 5 fractions is also allowed in this study, though should be chosen only in patients with a complicated bone metastases by fracture, neurological deficit (e.g. spinal cord compression), or a large soft tissue component. (centerwatch.com)
  • Currently, the standard of care in British Columbia for palliative patients with bone metastases is SUPR. (centerwatch.com)
  • It may prompt a bone scan to confirm or exclude spinal metastasis. (gloucestershirespinalsurgery.com)
  • Dr Shapiro and colleagues used these data to construct a hypothetical cohort of 10,000 women with breast cancer and bone metastases to analyze the value of monthly zoledronic acid and zoledronic acid every 3 months and compare them to monthly denosumab. (medscape.com)
  • After conducting a targeted literature review, the joint ASCO-CCO update committee concluded there was insufficient evidence to support the use of one bone-modifying agent over another in the treatment of patients with breast cancer with bone metastases. (medscape.com)
  • Distant vertebral body and intracranial metastasis are even rarer yet possible. (bvsalud.org)
  • Six patients showed evidence of leptomeningeal metastases at diagnosis based on staging MR examinations. (nih.gov)
  • Seven patients suffered a relapse at the primary site, four of whom also had leptomeningeal metastases. (nih.gov)
  • The presentation depends on the local effects of the solid tumor and any metastases. (aafp.org)
  • We performed high-throughput Luminex assays to profile the transcriptional levels of 36 genes in 70 operable NSCLC patients, among whom 37 developed brain metastases as the first relapse within 3 years after surgery. (biomedcentral.com)
  • Is perioperative blood transfusion associated with postoperative thromboembolism or infection after metastatic spinal tumor surgery? (elsevierpure.com)
  • The combination of minimally invasive surgery and radiation or chemotherapy is a new technique for treating spinal tumors. (gloucestershirespinalsurgery.com)
  • Impact of Primary Tumor Location and Genomic Alterations on Survival Following Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion for Colorectal Peritoneal Metastases. (cdc.gov)
  • Most common primary tumors of vertebral metastases are localized in the breast, lung, prostate and kidney. (123dok.net)
  • UCLA Neoplasms Trial → Patients With Different Types of Cancer (Solid Tumours) Aims to Find a Safe Dose of Xentuzumab in Combination With Abemaciclib With or Without Hormonal Therapies. (researcherprofiles.org)
  • Eighteen children with newly diagnosed high-grade astrocytomas arising in the spinal cord were enrolled in the Children's Cancer Group (CCG) protocol 945. (nih.gov)
  • This trial aims to find out if adding bevacizumab to atezolizumab and chemotherapy can help patients with ES-SCLC and liver metastases live longer without cancer progression. (withpower.com)
  • Brain metastasis is an extremely serious sequela with a dismal prognosis in non-small cell lung cancer (NSCLC). (biomedcentral.com)
  • Patients with a genitourinary primary cancer (p = 0.0078) and/or referred for malignant spinal cord compression (p = 0.0004) reported less fatigue. (nih.gov)
  • Of particular interest is the treatment of malignant urological neoplasms, which include prostate cancer, testicular cancer, kidney and bladder cancer. (bookinghealth.com)
  • Utilizing cell-free DNA to predict risk of developing brain metastases in patients with metastatic breast cancer. (cdc.gov)
  • At a time when rising healthcare costs in the United States are coming under intense scrutiny, one of the first independent analyses to compare a proprietary drug with its generic counterpart shows that zoledronic acid given every 3 months is more cost-effective than monthly denosumab ( Prolia , Xgeva , Amgen) in women with breast cancer and skeletal metastases, say researchers. (medscape.com)
  • Dissemination of medulloblastoma within cerebrospinal fluid (CSF) pathways is a defining pathobiologic characteristic of this tumor, and about 30% of patients will have CSF metastasis at presentation. (medscape.com)
  • The previously mentioned tendency of medulloblastoma to spread via CSF pathways can lead to diffuse "sugar coating" of the subarachnoid space and to nodular growths along the spinal cord or even ventricular surfaces. (medscape.com)
  • Secondary extension may affect the spinal cord. (ivis.org)
  • The severity of spinal cord compromise secondary to a tumor spans a wide range. (medscape.com)
  • Myelopathy can be the result of primary intrinsic disorders of the spinal cord or from secondary conditions, which result in extrinsic compression of the spinal cord. (bvsalud.org)
  • Embolization has been used as a presurgical maneuver in the treatment of a variety of primary and secondary spinal tumors (6-22) . (ajnr.org)
  • Neoplastic CES may arise from cauda equina primary tumors or secondary metastases, which may involve the vertebral bones, resulting in fracture and external nerve compression ( 5 ). (iiarjournals.org)
  • This retrospective study included 18 consecutive patients with 21 symptomatic spinal metastases who underwent preoperative spinal angiography and embolization at our institution between October 1995 and August 1999. (ajnr.org)
  • Twenty-four patients underwent preoperative transarterial embolization of hyper-vascular spinal metastases. (123dok.net)
  • Osseous destruction is often associated with mechanical instability, intractable pain, radiculopathy, and symptoms of cord compression. (ajnr.org)
  • Neoplastic disease can cause neurologic symptoms by compression of the thecal sac, spinal cord, or cauda equina, as well as compression of the attendant vascular supply, which results in cord edema and ischemia. (medscape.com)
  • Metastatic spinal cord compression is due to invading lesion(s) in the epidural space, between the vertebral bones and the dura of the thecal sac, compressing the thecal sac, spinal cord, or cauda equina. (medscape.com)
  • The cauda equina is the conglomeration of lumbar and sacral nerve roots distally to the terminal portion of the spinal cord, starting at the L1-L2 vertebral level in most people. (iiarjournals.org)
  • Cauda equina syndrome (CES) frequently results from nerve root compression and damage from herniated lumbar discs, spinal stenosis, post-traumatic fractured vertebral fragments, or tumors, which result in devastating morbidity ( 1 ). (iiarjournals.org)
  • Myxopapillary ependymomas are well differentiated low-grade tumors which have been documented to local or distant metastasis. (balkanmedicaljournal.org)
  • Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
  • RMS is very aggressive with distant metastases developing early in the course of disease. (biomedcentral.com)
  • Two patients with distant metastases also received chemotherapy. (springeropen.com)
  • Under the diagnosis of uterine neoplasm, we carried out radical hysterectomy, omentectomy and pelvic lymphadenectomy as the surgical procedure. (balkanmedicaljournal.org)
  • Myelopathy is a clinical diagnosis with localization of the neurological findings to the spinal cord, rather than the brain or the peripheral nervous system, and then to a particular segment of the spinal cord. (bvsalud.org)
  • A nodule extending from the dorsal lamina of T8 (black arrow) causes ventral and leftward displacement and compression of the spinal cord (white arrow) and the subarachnoid space. (avma.org)
  • Over time the T2 lesion number and volume (the T2 burden of disease) increases on average in the brain or spinal cord in the absence of treatment, and most often less so when treatment is effective [Fig. (tradingsignalsforex.com)
  • Metastatic spinal cord compression usually follows arterial hematogenous dissemination of malignant cells to the vertebral bodies, with subsequent expansion into the epidural space. (medscape.com)
  • Anterior surgical decompression and stabilization are the treatments of choice for radiation-resistant metastatic spinal tumors, resulting in improved neurologic function and pain reduction in more than 80% of patients (4, 5) . (ajnr.org)
  • Here, the authors describe a 50-year-old male with an aggressive ENB, initially treated with resection and chemotherapy/radiation, who developed multiple thoracic and lumbar spinal metastases. (thejns.org)
  • We performed a blinded, retrospective study of 38 ALS patients, examining the association between pathologic measures in motor cortex, hypoglossal nucleus, and lumbar cord with clinical data, including progression rate and disease duration, site of symptom onset, and upper and lower motor neuron signs. (bvsalud.org)
  • Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. (lookformedical.com)
  • They are slow growing neoplasms and their clinical signs appear insidiously. (ivis.org)
  • Nonetheless, much is still unknown about the exact mechanisms of brain metastasis, and little has been translated to clinical research and application. (biomedcentral.com)
  • He is currently working on understanding the extreme responders and extreme clinical phenotypes of brain and spinal cord tumors to identify factors that may modulate responses to therapy. (hopkinsmedicine.org)
  • Although ENBs often recur and have an aggressive clinical course, spinal metastases are extremely rare and the underlying molecular mechanisms are poorly understood. (thejns.org)
  • The authors performed targeted exome sequencing on both the resected primary tumor and biopsied spinal metastases, which revealed 12 total variants of unknown clinical significance in genes associated with the PI3K/AKT/mTOR pathway, chromatin remodeling, DNA repair, and cell proliferation. (thejns.org)
  • This study is to demonstrate the technical and clinical experience of applying image guided spinal radiosurgery for treatment of localized spinal metastasis. (elsevierpure.com)
  • The preliminary clinical results have demonstrated that pain response was achieved in 85% of patients, with neurological improvement in patients with spinal cord compression. (elsevierpure.com)
  • We describe a patient with an ACTH-producing carcinoma of the pituitary with refractory Cushing's disease and hepatic metastases. (biomedcentral.com)
  • Abstract The aim of this study was to evaluate the impact of preopera-tive devascularization of spinal metastases in relation to the pre-embolization tumor vascularization degree and in relation to the intra-operative blood loss. (123dok.net)
  • She underwent tumor resection eight times due to the recurrence of spinal tumor in the same region in nine years. (balkanmedicaljournal.org)
  • For IMRT treatment planning, seven posterior/oblique fields were generally used for spinal radiosurgery as the optimal setup to balance conformality versus complexity. (elsevierpure.com)
  • Metastatic tumors that cause epidural cord compression and dysfunction are the most common causes of oncologic CNS injury. (medscape.com)
  • A region of the spinal cord immediately cranial to the area of compression has a slightly larger diameter, compared with the more cranial or caudal regions, consistent with mild dilation of the central canal of the spinal cord. (avma.org)
  • Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. (lookformedical.com)
  • Conclusion: Metastasis from primary IMSCTs is extremely rare. (bvsalud.org)