Metastases tumor markers biological. Medical search. Frequent questions

circITGA7 serves as a tumor suppressor in CRC by inhibiting growth and metastasis by suppressing the Ras signaling pathway [ 8 ]. (hindawi.com)
This study was to examine the function involvement of AFAP1-AS1 in tumor growth and metastasis of CRC. (biomedcentral.com)

There are two main factors underlying the mortality associated with CRC: the high rates of recurrence and distant metastasis. (hindawi.com)
In a study of 56 patients with Hürthle cell cancer treated at Memorial Sloan-Kettering Cancer center, recurrence was a significant predictor of tumor-related mortality, and extent of invasion was the most significant predictor of outcome. (medscape.com)
IHC indicates low expression of cystatin-B in neoplastic islands from the ITF as an independent marker for local recurrence. (nature.com)
In summary, we identify a robust signature, which may enhance prognostic decisions in OSCC and better guide treatment to reduce tumor recurrence or lymph node metastasis. (nature.com)
Radical nephrectomy and nephron-sparing surgery are still the only effective treatments for localized RCC, but the characteristics of RCC recurrence and metastasis lead to a 5-year survival rate of approximately 12%, posing a great challenge to clinical therapies [ 4 ]. (biomedcentral.com)
Whereas some are cured after initial surgical resection, others develop local recurrence and distant metastases. (nyu.edu)
Although great progress has been made in the clinical management of MB, tumor metastasis and recurrence are still the main cause of death. (explorationpub.com)
To date, 5 years after surgery, the patient remains without evidence of tumor recurrence. (mdpi.com)
sis in primary breast cancer patients, toms of metastasis or recurrence and Tumour markers assays with elevated levels reflecting adverse with no other malignant disorders. (who.int)

Patients with clear cell RCC have the worst prognosis compared to other RCC subtypes based on the high frequency of distant metastases. (uroweb.org)
Finally, bulk RNA-seq was integrated to validate the prognosis effect of the marker gene and the maker gene of M2 macrophage, CCL20, showed the most related to LUAD prognosis. (aging-us.com)
Although several studies revealed the important role of immune cells and related marker genes impact on LUAD prognosis and process, a comprehensive understanding of TIME malignant and metastatic change in LUAD is still limited. (aging-us.com)
Immunohistochemistry (IHC) markers, together with clinicopathological variables such as tumor size, tumor grade, nodal involvement, histologic type, and surgical margins, have been widely used for prognosis, prediction and treatment selection [ 9 , 10 ]. (jcancer.org)
Therefore, identifying the crucial proteins and clarifying mechanisms that contribute to metastasis will be significant to provide biomarkers for prognosis and targets for treatment. (spandidos-publications.com)
Different regions of oral squamous cell carcinoma (OSCC) have particular histopathological and molecular characteristics limiting the standard tumor−node−metastasis prognosis classification. (nature.com)
Standard multimodal management of OSCC is based on the tumor−node−metastasis (TNM) classification 2 , in which the tumor size and location and the presence of metastasis are used to define OSCC prognosis and treatment in the clinical setting 3 . (nature.com)
Tumor spread through air spaces (STAS) has been shown to adversely affect the prognosis of lung cancer. (biomedcentral.com)
Each subtype of MB has a unique profile in copy number variation, DNA alteration, gene transcription, or post-transcriptional/translational modification, all of which are associated with different biological manifestations, clinical features, and prognosis. (explorationpub.com)
It is a high-grade and poorly differentiated neuroendocrine tumor, usually diagnosed in advanced stages, with a poor prognosis and few therapeutic options in that setting. (mdpi.com)
Therefore, identification of genomic instability related molecules in PAAD can provide new drug targets and markers, and provide information on diagnosis and prognosis of PAAD [ 10 ]. (biomedcentral.com)
Tumour development, histology and grade of breast cancers: prognosis and progression. (who.int)
ABSTRACT The value of serum tumour markers in the prognosis of patients with breast cancer is controversial. (who.int)

We explored molecular markers shared between TDEs and circulating tumor cells (CTCs) in the blood of cancer patients to identify candidate genes involved in CRC metastasis. (researchsquare.com)
Circulating tumor cells (CTCs) are isolated tumor cells disseminated from the site of disease in metastatic and/or primary cancers, including breast cancer, that can be identified and measured in the peripheral blood of patients. (biomedcentral.com)
As early as the 1800's when Recaimer first coined the term "metastasis", circulating tumor cells (CTCs) have been postulated to be critical to the process [ 5 , 6 ]. (biomedcentral.com)
Bone metastasis occurs through a complex cascade of events that ultimately results in circulating tumor cells (CTCs) from the blood extravasating and invading the bone marrow - these cells within the bone marrow are referred to as disseminated tumor cells (DTCs) [ 4 ]. (oncotarget.com)
60% of circulating tumor cells. (nature.com)
Protein markers commonly used for circulating tumor cells investigations. (medscape.com)

they can also serve as potential biomarkers and therapeutic targets for tumors, as demonstrated in multiple studies [ 7 ]. (hindawi.com)
She noted that specialists should understand and consider the inter-tumour heterogeneity as an essential step to individualize therapy based on biomarkers and to identify new targets. (uroweb.org)
Therefore, identifying early diagnostic markers and prognostic molecular biomarkers will enhance early KIRC diagnosis, thereby informing early and active treatment. (hindawi.com)
Aim: To explore metabolic characteristics assessed by PET as biomarkers for colorectal cancer liver metastases. (edu.au)

In addition, we learned that not only tumour cells but also the tumour microenvironment (or tumour stroma) including fibroblasts, endothelial cells and immune cells are important players in tumorigenesis and should be used for biomarker discovery and therapy targets," said Junker. (uroweb.org)
Wang H , Han G , Chen J , . Heterogeneity of tumor immune microenvironment in malignant and metastatic change in LUAD is revealed by single-cell RNA sequencing. (aging-us.com)
Then, marker genes were calculated and 709 genes were identified to play a vital role in the microenvironment of LUAD. (aging-us.com)
Plenty of research had reported that the tumor immune microenvironment (TIME) impacts cancer progression and metastases, as well as affects patient prognoses and outcomes [ 6 , 7 ], which emphasizes the important role of immune cells, vital components of the tumor microenvironment, impacting on patient survival and tumor progression [ 8 , 9 ]. (aging-us.com)
These results demonstrate that CREB3L1 maintains the CAF - like property of ATC cells by activating the ECM signaling, which remodels the tumor stromal microenvironment and drives the malignancy of ATC. (biomedcentral.com)
The extracellular matrix (ECM) is a fundamental part of the tumor microenvironment. (biomedcentral.com)
A known characteristic of ATC is its ability to easily shape the tumor matrix microenvironment. (biomedcentral.com)
Therefore, we speculated that the overexpression of CYP2J2 prolonged the survival outcome of KIRC patients, which may be related to the change of tumor immune microenvironment. (hindawi.com)
b) Chromatographic separation and characterization of the repertoire of EVs shed by tumors into the tumor microenvironment interstitial space using western blotting, mass spectrometry, and electron microscopy. (selectbiosciences.com)
Tumor cells need to detach from their primary tumor structure, invade the nearby parenchyma, intravasate into lymphatics or vasculature, endure circulatory stress, extravasate, and survive in a foreign microenvironment to ultimately establish a metastatic lesion. (nyu.edu)
Rates of brain metastasis in metastatic melanoma patients are among the highest among cancers, highlighting melanoma's unique ability to colonize and grow in the brain microenvironment. (nyu.edu)
CSCs are enriched near macrophages, particularly near macrophage-containing intravasation sites called Tumor Microenvironment of Metastasis (TMEM) doorways. (nature.com)

Lymph node metastasis is responsible for the high morbidity of head and neck squamous cell carcinoma (HNSCC). (spandidos-publications.com)
Targeted proteomics analysis of the prioritized proteins in saliva, combined with machine-learning methods, highlights a peptide-based signature as the most powerful predictor to distinguish patients with and without lymph node metastasis. (nature.com)
Several studies have suggested tumor lymph node metastasis (TNM) staging system is the main prognostic factor for KIRC [ 5 - 7 ]. (hindawi.com)

As with many targeted agents used to treat solid tumors, it is likely that c-Met/RON inhibitors will have greater benefit when used in combination with chemotherapy or other targeted agents. (oncotarget.com)
Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. (ujds.in)

therefore, definitive differentiation of Hürthle cell carcinoma from Hürthle-cell adenoma is based on vascular invasion and/or capsular invasion, as well as on permanent histologic sections or extrathyroidal tumor spread and lymph node and systemic metastases. (medscape.com)
Activating invasion and metastasis' and 'evading immune destruction' drive the differentiation of triple negative breast cancers. (jcancer.org)
P21-activated kinase 3 (PAK3) is a serine/threonine protein kinase, and PAK3 affects the EMT, proliferation, metastasis and invasion of HCC. (jcancer.org)
In a primary tumor mass, the ECM is strictly modulated in a tumor - permissive way, which in turn facilitates tumor progression and influences cancer cell invasion. (biomedcentral.com)
The presence of neoplastic islands, classified as large or small according to the number of cells in the ITF, has been described as the most aggressive pattern compared to tumors with a more uniform growth pattern, as tumor invasion occurs in a more widespread manner as cellular islands or single cells 4 . (nature.com)
Hypoxia is considered a critical contributor to renal cell carcinoma progression, including invasion and metastasis. (biomedcentral.com)
However, the potential mechanisms by which it promotes invasion and metastasis have not yet been clarified. (biomedcentral.com)
The potential function of AFAP1-AS1 in cancers is its regulatory role in tumor growth, invasion and metastasis. (biomedcentral.com)
SiRNA targeting PKM2 abolished leptin-induced migration invasion and EMT-associated marker appearance partially. (healthandwellnesssource.org)
Leptin/ObRs are portrayed at low amounts in the epithelial cells of regular individual mammary glands but overexpressed in breasts cancer tumor cells [9 11 12 Latest studies show that EMT is normally an essential initiator of and a contributor to tumor invasion and migration [13]. (healthandwellnesssource.org)
Twist is normally an extremely conserved transcription aspect and consists of in organ advancement cell proliferation differentiation and tumorigenesis [15 16 which is also a significant regulator in EMT and promotes tumor invasion and metastasis [17-19]. (healthandwellnesssource.org)
The metalloproteinase-9 (MMP-9) or gelatinase B belongs to the family of matrix metalloproteinases, enzymes which degrade extracellular matrix (ECM) and basement membrane components and are implicated in the carcinogenesis process, contributing to tumor progression, invasion and metastasis. (bvsalud.org)

Evidence points to a role for c-Met and RON signaling in tumor progression by increasing proliferation, inhibiting apoptosis, contributing to angiogenesis, promoting metastasis and in maintenance of cancer stem cells [ 11 - 14 ]. (oncotarget.com)
Evading growth suppressors', 'enabling replicative immortality', 'inducing angiogenesis' and 'tumor-promoting inflammation' have not been involved in breast cancer classification which need more focus in the future biomarker-related research. (jcancer.org)
Introduction of the large CD81 negative VEGF positive EV population (amphisome characteristics) to the SLN augmented tumor growth, angiogenesis, and metastasis, even when cytokine induction was used to remodel the SLN. (selectbiosciences.com)
Only recently several specific lymphatic markers have been discovered and „lymphangiogenesis" is now emerging as an exciting sector of angiogenesis research, largely due to potential clinical applications. (listarfish.it)

They express markers of less differentiated cone together with neuronal/ganglion cell markers with marked inter- and intra-tumor heterogeneity. (nih.gov)
Furthermore, the clear heterogeneity of CRC tumors indicates a clear need for new biological markers and therapeutic targets for CRC. (hindawi.com)

The special issue will focus on the application of new methods, viewpoints and technologies for the diagnosis and treatment of brain tumors including brain metastases. (explorationpub.com)

Colorectal cancer (CRC) is the third most common form of malignant tumor and is characterized by high rates of proliferation and metastases. (hindawi.com)
Colorectal cancer (CRC) is characterized by high rates of proliferation and metastasis and represents the third most common form of malignant tumor and the fourth leading cause of mortality in the world, thus creating a serious threat to health [ 1 ]. (hindawi.com)
β -Catenin is a transcription factor that plays an important role in cell proliferation, cellular differentiation, apoptosis, and metastasis [ 10 ]. (hindawi.com)
Previous research has demonstrated that β -catenin can contribute to malignant progression and distant metastasis in CRC by promoting proliferation, limiting apoptosis, and accelerating epithelial-mesenchymal transition [ 11 , 12 ]. (hindawi.com)
The present study revealed that E2F1 gene expression correlates with TS and Survivin gene expressions and tumor proliferation. (aacrjournals.org)
During the progression of NSCLC, E2F1 overexpression could produce more aggressive tumors with a high proliferation rate and chemoresistance. (aacrjournals.org)
However, recently Houghton et al ( 7 ) showed increased cell proliferation after silencing of IRS1 gene expression in A549 cells suggesting tumor suppression potential. (spandidos-publications.com)
Functional involvement of AFAP1-AS1 in tumor proliferation and metastasis was evaluated in AFAP1-AS1-specific siRNA-treated CRC cells and in CRC cell xenograft. (biomedcentral.com)
lncRNA-AFAP1-AS1 knock-down exhibits antitumor effect on colorectal carcinoma in respects of suppression of cell proliferation and metastasis of cancer cells. (biomedcentral.com)
Increasing evidences suggest that lncRNAs are involved in a larger range of cellular biological processes, including growth, proliferation and differentiation. (biomedcentral.com)

Permissive histologic interpretation may result in the designation of some non-neoplastic Hürthle cell lesions as malignant tumors. (medscape.com)
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. (jcancer.org)

Little is known on the molecular basis underlying the biological and clinical behavior of this cancer. (nih.gov)
Tumor size is an important feature for biological behavior. (medscape.com)
Early dissemination of tumor cells undergoing a protected period of dormancy in the target organs potentially explains this prevalent clinical behavior. (bmj.com)
Breast cancer is a complex disease encompassing multiple tumor entities, each characterized by distinct morphology, behavior and clinical implications. (jcancer.org)
The malignant biological behavior of HCC is closely related to epithelial-mesenchymal transition (EMT), and EMT plays an important role in the progression, migration and metastasis of HCC. (jcancer.org)
These markers and labels have allowed investigators to observe the behavior and properties of cell and molecular entities of interest in the context of complicated biological systems such as a mammalian cell or a whole mouse. (duke.edu)
New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors (NETs), which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma. (wjgnet.com)
Cancer stem cells (CSCs) play an important role during metastasis, but the dynamic behavior and induction mechanisms of CSCs are not well understood. (nature.com)
Moreover, mutational phenomena, such as chromothripsis and polyploidization, are associated with unstable tumors and aggressive tumor behavior. (biomedcentral.com)
The results indicate that expression of MMP-9 may be suggested as a predictor of aggressive biological behavior in OSCC. (bvsalud.org)

The understanding of cellular and molecular processes involved in tumour development and especially in tumour progression and metastasis in general, but also in each tumour and tumour subtype will increase the therapeutic options. (uroweb.org)
Several university hospitals established interdisciplinary molecular tumour boards, which is one of the steps in this direction," she said. (uroweb.org)
Many transcriptional factors such as snail, slug, twist and bmi1 have been confirmed to suppress E-cadherin transcription and thus identified as both molecular markers and inducers of EMT ( 13 , 14 ). (spandidos-publications.com)
CTD 2 is focused on efforts that advance cancer research by bridging the knowledge gap between the large volumes of comprehensive molecular characterizations of many cancer types and studies of the underlying etiology of cancer development, progression, and/or metastasis. (nih.gov)
identify molecular markers that can meaningfully predict responses or resistance to anticancer therapies and develop algorithms that can be applied to predict responses to treatments and/or define more precise treatment modalities. (nih.gov)
However, prognostic stratification by molecular markers (such as expression of specific genes) can improve the accuracy of prognostic prediction [ 8 ]. (hindawi.com)
Second primary tumors and field cancerization in oral and oropharyngeal cancer: molecular techniques provide new insights and definitions. (ujds.in)
Our lab is searching for molecular alterations in tumors that can be robustly measured at diagnosis and could be useful prognostic markers. (nyu.edu)
This article reviewed the research progress of different molecular pathology markers in MB and summarized some targeted drugs against these molecular markers, hoping to stimulate the clinical application of these molecular markers in the classification, diagnosis, and treatment of MB. (explorationpub.com)
This indicates that molecular markers have the potential to be a quantitative measure of genome instability. (biomedcentral.com)

In this present study, we found that circIFT80 was abnormally overexpression in colorectal cancer tissues and tumor cells. (hindawi.com)
demonstrated that copper played a significant part in the biological activity that was seen to be amplified after being associated with a lipid-based nanosystem for the treatment of colorectal cancer [ 6 ]. (biomedcentral.com)
Introduction: Over 50% of patients with colorectal cancer (CRC) will progress and/or develop metastases. (jcancer.org)
The majority of patients with colorectal cancer develop liver metastases but only those amenable for surgical resection have a possibility of long term survival. (edu.au)
Recent advances in achieving macroscopic resectability of colorectal liver metastases needs to be balanced urgently, by an ability to assess systemic micrometastatic disease. (edu.au)
Conclusion: This thesis showed tumour metabolism to be a powerful prognostic indicator for patients with colorectal cancer liver metastases. (edu.au)
Sprouty1 (SPRY1) appears to act as a tumour suppressor in cancer, whereas we demonstrated that SPRY2 functions as a putative oncogene in colorectal cancer. (omicsonline.org)
The clinic pathological correlation of G9a and S SPRY 1 Immuno-histochemical expression was assessed in tumour specimens of paraffin blocks retrieved from 50 colorectal carcinoma patients. (omicsonline.org)

c-Met and RON show increased expression or activity in a variety of tumors leading to tumor progression and may play a role in acquired resistance to therapy. (oncotarget.com)

Previous studies mainly focused on its roles in metabolism, but recently it was reported to be correlated with cancer progression and metastasis ( 5 ). (spandidos-publications.com)

Oral carcinogenesis is known as multifactorial process which engaged plentiful genetic events that transform normal activity of tumor suppressor genes and oncogenes. (ujds.in)
and a direct correlation between metabolic response and the expression of p16, a tumour suppressor. (edu.au)

For recurrent, invasive tumors, more aggressive attempts at excision or electroporation may be required. (merckvetmanual.com)
Overall, only about 33% of Hürthle cell tumors demonstrate signs of that invasive growth that indicates malignancy and the possibility of metastasis. (medscape.com)
Using histopathology-guided discovery proteomics, we analyze neoplastic islands and stroma from the invasive tumor front (ITF) and inner tumor to identify differentially expressed proteins. (nature.com)
Tumor STAS was associated with several invasive clinicopathological features. (biomedcentral.com)
Tumour staging by 18F-fluorodeoxyglucose positron emission tomography (PET) is a non-invasive tool already in routine use. (edu.au)
The medulloblastoma has been defined by the World Health Organization (WHO) as a "malignant, invasive embryonal tumor of the cerebellum with preferential manifestation in children , predominantly neuronal differentiation, and inherent tendency to metastasize via CSF [cerebrospinal fluid] pathways. (medscape.com)
Staining tended to be strongest at the periphery of pseudoglandular groups and at the invasive front of tumors. (medscape.com)
K17 is highly expressed in most cases of both invasive adenocarcinoma and in AIS and is a powerful, negative prognostic marker for patient survival. (medscape.com)

Assessment of Sprouty-1 and G9a expression markers can be considered as useful promising prognostic markers for CRC patients. (omicsonline.org)
We compared the power of gene expression measurements with that of conventional prognostic markers, i.e., clinical, histo- pathological, and cell biological parameters, for predicting distant metastases in breast cancer patients using both established prognostic indices (e.g., the Nottingham Prognostic Index (NPI)) and novel combinations of conventional markers. (lu.se)
Our analysis suggests that it might be possible to improve the combination of different conventional prognostic markers into one prognostic index. (lu.se)

7] In another study by Pisanu et al,[8] in a series of 23 patients, the mean tumor size was significantly greater for carcinomas than adenomas (3.1 cm vs 1.9 cm). (medscape.com)
The overall survival rate was significantly lower in patients with high- E2F1 tumors than in those with low- E2F1 tumors ( P = 0.0027), especially among patients with stage II to III NSCLCs ( P = 0.0188). (aacrjournals.org)
Background Metastatic relapse is the major causes of mortality in patients with cancer and occur due to metastatic reactivation of dormant tumor cells. (bmj.com)
25% for patients with bilateral metastasis. (spandidos-publications.com)
Through database analysis, we found that PAK3 was highly expressed in HCC patients and was positively correlated with tumor stage and grade, suggesting that PAK3 expression was closely related to HCC occurrence and development. (jcancer.org)
Therefore, defining biological signatures that allow assessing the prognostic outcomes for OSCC patients would be of great clinical significance. (nature.com)
Thus, the identification of complementary biological signatures that assist in the prognostic prediction of patients with OSCC is needed. (nature.com)
Due to the difficulty in sampling and detection, few techniques exist to efficiently and consistently detect and quantify disseminated tumor cells (DTCs) in the bone marrow of cancer patients. (oncotarget.com)
Globally, KIRC is associated with 175,000 annual mortalities, with about 30-35% of patients undergoing surgery presenting with distant metastases [ 4 ]. (hindawi.com)
Patients with relapsed or distant metastases of KIRC exhibit poor prognostic outcomes, with shorter median survival times of 21 months and 13 months [ 5 ], respectively. (hindawi.com)
The exclusion criteria were as follows: (1) Patients who underwent a needle biopsy of the tumor site before surgery. (biomedcentral.com)
Thus, the aim of the present study was to analyze the interleukin-18 single nucleotide polymorphisms (SNPs) as a diagnostic tumor marker for hepatocellular carcinoma in patients with hepatitis C-related cirrhosis. (springeropen.com)
It was reported that the serum level of IL-18 is a useful biological marker of tumor invasiveness and an independent prognostic factor for survival among patients with HCC [ 8 ]. (springeropen.com)
Nursing based on oxygen administration decreased the value of renal function indexes, serum inflammatory factors, and tumor markers in renal cell carcinoma patients. (biomedcentral.com)
Therefore, we hypothesized that CRC cancer stem cell markers (CRCSC) will identify a group of patients at high risk for progression. (jcancer.org)
For most cancer types, metastatic spread of tumor cells from a primary location to distal organs throughout the body is the pivotal determinant of poor outcomes for patients. (nyu.edu)
Such highly variable outcomes suggest underlying biological differences in tumors (cell-intrinsic) and/or the patients themselves (host, cell-extrinsic, e.g. immune response). (nyu.edu)
In breast cancers from patients, the density of TMEM doorways correlates with the proportion of cancer cells expressing stem cell markers, indicating that in human breast cancer TMEM doorways are not only cancer cell intravasation portals but also CSC programming sites. (nature.com)
[ 115 ] Moreover, CK19 releasing cells were found to be detectable in up to 65 and 70% of CRC and breast cancer patients, respectively, and correlated with presence of metastasis and poor survival in breast cancer. (medscape.com)
PET assessment of tumour metabolic response to chemotherapy should be routinely performed, particularly in patients undergoing complex liver surgery. (edu.au)
0.001 for all), and tumour site (p=0.002), No significant correlation was found between G9a expression and age or sex of our patients. (omicsonline.org)
This prospective study in Yazd, Islamic Republic of Iran, assessed the value of the tumour markers carcinoembryonic antigen (CEA) and cancer antigen (CA) 15-3 in 159 patients with primary breast cancer. (who.int)
During follow-up, 33 patients (20.8%) presented symptomatic metastasis. (who.int)
We used publicly available data on 97 patients, and the performance of metastasis prediction was represented by receiver operating char- acteristic (ROC) areas and Kaplan-Meier plots. (lu.se)
Breast cancer patients can be cured either by local markers are therefore called for. (lu.se)
Dissemination of medulloblastoma within CSF pathways is a defining pathobiologic characteristic of this tumor, and about 30% of patients will have CSF metastasis at presentation. (medscape.com)
HPV DNA was extracted from tumor tissue samples from patients in whom cancer was diagnosed during 1995-2005. (cdc.gov)

Roughly 90% of cancer deaths are attributable to metastasis, yet our understanding of the mechanisms responsible for metastatic spread is limited. (nyu.edu)
In animal models, overexpression of lymphangiogenic factors VEGF-C and VEGF-D in tumor cells enhances metastatic spread of tumors. (listarfish.it)

For tumors resistant to radiation and for those animals unable to receive radiation therapy, systemic treatment with administration of chemotherapeutic agents, including melphalan, chlorambucil, cyclophosphamide, and glucocorticoids, have been recommended and have yielded long-term survival. (merckvetmanual.com)
Previous studies have found that high CBX4 expression is associated with tumor size, pathologic differentiation and decreased patient survival in hepatocellular carcinoma (HCC). (scienceopen.com)
Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. (cancercentrum.se)

As CTCs play a crucial role in tumor dissemination, translational research is implicating CTCs in several biological processes, including epithelial to mesenchymal transition. (biomedcentral.com)
Loss of E-cadherin, not only results in loss of adherens junctions between neighbor cells resulting in dissemination of cells from the original tumor, but also results in releasing its cytoplasmic binding with β-catenin. (spandidos-publications.com)
Beyond single DTCs, death from bone metastasis may also be due to dissemination of disease via metastatic re-seeding from other secondary sites [ 7 , 8 ]. (oncotarget.com)
Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. (jcancer.org)

Similarly, RNA-seq and ChIRP-seq data suggest that KO of Malat1 hampers immune evasion and downregulates metastasis associated genes including Serpins and Wnts. (bmj.com)
While macrophages were reported to act as one of the cells in LUAD, enrichment analysis of macrophage marker genes revealed the important role of macrophages in the activation of neutrophils. (aging-us.com)
Simultaneously, CYP2J2 network-related functions were evaluated using the GeneMANIA interactive tool while the biological processes involved in CYP2J2 and its interactive genes were investigated through Metascape and FunRich. (hindawi.com)
Also AFAP1-AS1 knock-down inhibited tumor metastasis-associated genes expression in terms of EMT. (biomedcentral.com)

CSCs have an enhanced ability to self-renew, which makes them uniquely capable of initiating and sustaining primary and metastatic tumor growth 3 . (nature.com)

Medulloblastoma is the most common malignant CNS tumor of childhood with an annual incidence of about 0.5-0.8/100,000 in children younger than 19 years. (medscape.com)

The lymphatic system is the primary pathway of metastasis for most human cancers. (ox.ac.uk)
Unlike other cancers, melanoma metastasis frequently occurs from tiny primary tumors that are measured in millimeters, reflective of melanoma's highly aggressive nature. (nyu.edu)
During EMT cancers cells go through morphological changes such as for example cell-cell junction dissolution lack of apical-basolateral cell polarity and BMN673 acquisition of mesenchymal marker appearance [14]. (healthandwellnesssource.org)
European Journal of Cancer 40 (2004) 1837-1841 since approximately half of all new breast cancers are the St. Gallen criterion [1], which are based upon dif- diagnosed in the third world, where the analyses of ferent subsets of these conventional markers. (lu.se)
L'ACE et le CA19-9 ont une bonne sensibilité et une spécificité relative qui leur permettent de suivre l'évolution des cancers digestifs en particulier les cancers colorectaux. (bvsalud.org)

Differentiation of mammary tumors and reduction in metastasis upon Malat1 lncRNA loss. (bmj.com)
Here, we employ high-resolution intravital microscopy using a CSC biosensor to directly observe CSCs in live mice with mammary tumors. (nature.com)

The recognition of these two subtypes, one maintaining a cone-differentiated state, and the other, more aggressive, associated with cone dedifferentiation and expression of neuronal markers, opens up important biological and clinical perspectives for retinoblastomas. (nih.gov)
But we have to validate these highly potential markers in clinical trials as we are doing it for new therapeutics. (uroweb.org)
Currently, CTCs are being integrated into clinical trial design as a surrogate for phenotypic and genotypic markers in correlation with development of molecularly targeted therapies. (biomedcentral.com)
Different breast tumor subtypes have different risk factors, clinical presentation, histopathological features, outcome, and response to systemic therapies [ 3 - 8 ]. (jcancer.org)
As tumors are not conceivable as a single disease, breast cancer with different diagnostic features should differ in the hallmarks controlling their clinical differences. (jcancer.org)
The treatment for renal parenchymal tumors has changed over time, and this trend continues today as a result of technological progress made with clinical research and improved diagnostic and therapeutic tools. (biomedcentral.com)
Different Expression and Clinical Implications of Cancer-Associated Fibroblast (CAF) Markers in Brain Metastases. (cdc.gov)
In recent years, with the development of genomics, proteomics and metabolomics, the understanding of neuro-oncology has been deepened, and new diagnostic markers, diagnostic techniques and treatment strategies have been developed in both clinical diagnosis and therapeutics. (explorationpub.com)
Early tumour metabolic response after one cycle of chemotherapy did not predict eventual metabolic response or clinical outcome. (edu.au)
Imaging studies in- was one of the first serum-based tu- The study sample was women with cluding chest X-rays, liver ultrasonog- mour markers to be characterized, primary breast cancer attending a pri- raphy and bone scans were performed and its utility has been assessed in vate clinic in Yazd, Islamic Republic if there was clinical or laboratory a variety of malignancies including of Iran. (who.int)

Oral squamous cell carcinoma (OSCC) is the most common type of head and neck malignant tumor and is ranked the eighth leading cause of cancer worldwide. (nature.com)
In this work, MMP-9 was used as an immunohistochemical marker in order to correlate its expression with histological grading of 28 cases of oral squamous cell carcinoma (OSCC) obtained from the Laboratory of Oral Pathology, School of Dentistry of Pernambuco (FOP / UPE). (bvsalud.org)

Although Hürthle cell carcinoma was previously considered a variant of follicular cell neoplasms, which are generally less aggressive, the 2017 World Health Organization (WHO) classification of endocrine tumors reclassified it as a distinct entity. (medscape.com)

Through the Oncomine, GEIPA, DriverDBv3, and TIMER databases, we found that CYP2J2 was differentially expressed in multiple tumors, with its expression in KIRC being most significantly elevated. (hindawi.com)

Bone metastasis is a lethal and incurable disease. (oncotarget.com)
We are able to detect and quantify bone marrow DTCs in mice that do not have overt bone metastasis. (oncotarget.com)
Bone metastasis leads to approximately 280,000-350,000 cancer-related deaths in the United States each year [ 1 , 2 ]. (oncotarget.com)

Primary Cutaneous Neuroendocrine Tumors Ceruminous gland tumors are discussed in Tumors of the Ear Canal. (merckvetmanual.com)
Thus, the term "carcinoid" was replaced by the term "gastroenteropancreatic neuroendocrine tumors, GEP-NETs"[ 2 ]. (wjgnet.com)

1. National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Talent Highland of Bio-targeting Theranostics, Guangxi Medical University, China. (jcancer.org)
However, this widely used marker does not yield satisfactory results in the early diagnosis of HCC limiting the universality of its application due to its low positive rate, false-positive results, and finally false-negative results [ 5 ]. (springeropen.com)

Junker said genetic analyses have confirmed that these subtypes are characterized by different chromosomal alterations which suggest that each subtype represents a distinct tumour entity with different tumour biology. (uroweb.org)
It is important to design an optimal therapeutic strategy according to tumor biology to improve the treatment of NSCLC ( 2 ). (aacrjournals.org)
We will also introduce their utility in pharmacodynamic monitoring for rational selection of molecularly targeted therapies and briefly address how they can help elucidate the biology of cancer metastasis. (biomedcentral.com)
In fact, the initiation of metastasis may be a relatively early event in tumor biology, underscoring the need to understand the significance of CTCs. (biomedcentral.com)
Modern medicine and biology research has benefited greatly from an ever-expanding assortment of fluorescent markers and labels. (duke.edu)

Methods Using an in vivo screening platform for the isolation of genetic entities involved in either dormancy or reactivation of breast cancer tumor cells, we have identified Malat1 as a positive mediator of metastatic reactivation. (bmj.com)

A 1988 study found that a Hürthle tumor that is 4 cm or larger has an 80% chance of histologic evidence of malignancy. (medscape.com)
β-catenin, when translocating to and accumulating in the nucleus, induces transcription of other oncogenes involved in tumor progression, malignancy and metastasis ( 15 ). (spandidos-publications.com)

Tumor-derived EV modulates cellular activities in recipient cells by transferring genetic information from cancer cells. (researchsquare.com)
The factors and cellular processes required for the induction of dormancy and subsequent tumor cell reactivation remain largely undefined [ 6 ]. (oncotarget.com)
Macrophages are emerging as major cellular factors in the tumor ecosystem that can influence the stem phenotype and cancer progression. (nature.com)
Cancer metastasis, hypoxia and cellular metabolism. (lu.se)

For example, the epithelial−mesenchymal transition phenotype presents more cells with a lower degree of differentiation and greater cell dissociation in the ITF than in other tumor areas 14 , 15 . (nature.com)

Common markers were analyzed in gene expression profiles of two studies (GSE31023 and GSE72577). (researchsquare.com)
Gene ontology (GO) analysis suggested platelet-derived growth factor A (PDGFA) and proto-oncogene, Serine/Threonine kinase Raf-1 (RAF1) as new CRC candidate markers in CTCs and TDEs. (researchsquare.com)
Gefitinib and erlotinib would be effective for tumors with epidermal growth factor receptor (EGFR) mutations or increased EGFR gene copy numbers ( 6 ). (aacrjournals.org)
In this study, expression levels of CYP2J2 in various cancer types were determined using the Oncomine, the Gene Expression Profiling Interactive Analysis (GEIPA), DriverDBv3, UALCAN, and Tumor Immune Estimation Resource (TIMER) databases. (hindawi.com)
Scholars@Duke publication: Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals. (duke.edu)
Tumor metastasis is a process of multiple gene regulation cascades. (biomedcentral.com)
In recent exploratory regional therapy alone or by the addition of systemical studies, markers from microarray gene expression medical therapy with increased side effects and costs. (lu.se)
Although these comparisons favoured the gene expression markers, this was usually in comparison against single factors and the new tech- q Sources of support: Swedish Research Council, Swedish Founda- nology has not been tested against a combined index, tion for Strategic Research, Lund University Medical Faculty and the such as the Nottingham Prognostic Index (NPI). (lu.se)

Benign tumors are also challenging diseases for surgical procedures because of deep location with brain. (explorationpub.com)

5] The 2022 WHO classification of endocrine tumors has replaced the term Hürthle cell carcinoma with oncocytic carcinoma. (medscape.com)

For the amount of lymphatic vessels in a tumour to be a clinically useful parameter, a reliable quantification technique needs to be developed. (ox.ac.uk)

Treatment for these tumors targets local control using localized techniques described above. (merckvetmanual.com)

the highest expression levels were associated with moderately or poorly differentiated tumors (p=0.011). (jcancer.org)

5 However, the correlation of tumor intrinsic lncRNAs in regulation of tumor dormancy and immune evasion is largely unknown. (bmj.com)
In this study, we found a negative correlation of IRS-1 expression with tumor metastasis both in human tissue samples and in cell lines. (spandidos-publications.com)

The epithelial-mesenchymal transition (EMT) plays important roles in tumor metastasis. (spandidos-publications.com)
Background Accumulating studies show that epithelial-mesenchymal changeover (EMT) plays a part in tumor metastasis. (healthandwellnesssource.org)

The same authors have identified two emerging hallmarks, i.e., 'reprogramming of energy metabolism' and 'evading immune destruction', in 2011, and pointed out that all these hallmarks are enabled by two characteristics, i.e., 'genome instability and mutation' and 'tumor-promoting inflammation' [ 12 ]. (jcancer.org)
Renal cell carcinoma (RCC), a tumor whose origin is the renal epithelium [ 1 ], can be grouped into various subtypes based on its histological characteristics, with KIRC accounting for the vast majority of renal cell carcinoma subtypes. (hindawi.com)
The human renal cell carcinoma cell line A498 under hypoxia/normoxia was used as an experimental model in vitro and the biological characteristics and mitochondrial function of the cells were assessed. (biomedcentral.com)

It is a highly heterogeneous disease, encompassing a number of biologically distinct entities with specific pathologic features and biological behaviors [ 1 , 2 ]. (jcancer.org)

Anatomy8

Organisms6

Diseases91

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Phenomena and Processes36

Disciplines and Occupations1

Information Science6

Health Care17

Growth and metastasis2

Recurrence9

Prognosis13

Circulating tumor cells6

Biomarkers4

Microenvironment12

Lymph node metastasis3

Solid Tumors2

Invasion12

Angiogenesis4

Heterogeneity2

Treatment of brain tumors1

Proliferation10

Malignant tumors2

Behavior10

Molecular10

Colorectal8

Leading to tumor progression1

Progression and metastasis1

Suppressor2

Invasive8

Prognostic markers3

Patients27

Metastatic spread2

Survival3

Dissemination4

Genes4

Primary and metastatic tumor1

Common malignant1

Cancers5

Mammary tumors2

Clinical10

Squamous cell carc2

Aggressive1

Multiple tumors1

Bone metastasis3

Neuroendocrine Tumors2

Diagnosis2

Biology5

Breast cancer tumor1

Malignancy2

Cellular4

Differentiation1

Gene8

Benign1

20221

Clinically1

Targets1

Poorly differentiated1

Correlation2

Epithelial2

Characteristics3

Pathologic1