Metastases radiotherapy adjuvant. Medical search. Frequent questions

The primary endpoint was MFS, while secondary endpoints included biochemical recurrence, OS, and distant metastases. (medpagetoday.com)
We also wanted to quantify the benefits of these interventions, so we calculated the numbers needed to treat to avoid distant metastases at 10 years," Kishan said. (medpagetoday.com)
In terms of numbers needed to treat, to avoid one distant metastasis event at 10 years, we would have to treat 18 patients with intermediate-risk disease and 8.4 patients with high-risk disease. (medpagetoday.com)
The new findings showed no difference in the rate of 10-year freedom from distant metastases or overall survival in patients who received adjuvant radiotherapy vs those who underwent observation with salvage radiotherapy if their disease progressed and provided further confirmation of earlier results reported in The Lancet in 2020 . (medscape.com)
Women with early-stage breast cancer face three late breast cancer consequences: disease recurrence within the conserved breast, development of a contralateral breast cancer, and manifestation of distant metastases. (news-medical.net)
Often, patients show recurrency within 2 years from the initial diagnosis, and almost the total of these ones, in a percentage quantifiable in about 90%, develops distant metastases both alone or in association with pelvic recurrence [ 1 ]. (hindawi.com)
No other distant metastases or local recurrence was found. (hindawi.com)
Restaging PET-CT brain, thorax, abdomen, and pelvis were negative for local recurrence or distant metastases. (hindawi.com)
Early T stage GBC patients with distant metastasis are proven to have a worse prognosis. (medsci.org)
In this study, our aim was to construct and validate a novel nomogram for predicting distant metastasis in T1 and T2 GBC. (medsci.org)
Univariate and multivariate analyses were used to assess significant predictive factors associated with distant metastasis. (medsci.org)
Younger age, high pathological grade, nonadenocarcinoma, T1, N1 and larger tumor size correlated positively with the risk of distant metastasis. (medsci.org)
A novel nomogram was established to predict distant metastasis in early T stage GBC patients. (medsci.org)
Although some limitations exist in this predictive model, the nomogram revealed the relationship between the clinicopathological characteristics of T1 and T2 GBC patients and the risk of distant metastasis. (medsci.org)
thus, early distant metastasis usually occurs. (medsci.org)
For patients with resected T2 lesions, 16% have been found to have distant metastasis [ 3 ]. (medsci.org)
According to the American Joint Committee on Cancer (AJCC) staging system, distant metastasis (M1) with any T or any N stage is defined as Stage IV [ 5 ]. (medsci.org)
This trend suggests that distant metastasis often has a worse prognosis. (medsci.org)
Particularly for early T stage patients, such as T1 and T2, oncologists or hepatobiliary surgeons may overlook the possibility of distant metastasis, resulting in insufficient preoperative diagnostic examinations, follow-up, and postoperative comprehensive treatment. (medsci.org)
However, few studies to date have evaluated the risk factors or a predictive model of distant metastasis in GBC. (medsci.org)
A recent 10-institution study from America showed that advanced T-stage, grade, and presence of lymphovascular and perineural invasion were all associated with increased rates of distant metastasis [ 7 ]. (medsci.org)
Merkel cell carcinoma (MCC) is a rare malignant cutaneous tumor of the elderly that is characterized by an aggressive course with regional nodal involvement, distant metastases and a high rate of recurrence. (ispub.com)
Patients without distant metastases who merit adjuvant radiotherapy will be eligible for inclusion in the study. (authorea.com)
Once distant metastasis occurs, there is almost no opportunity for surgery and the prognosis is poor. (spandidos-publications.com)
Of note, distant metastases occur most commonly in the brain, liver, adrenal glands and bones. (spandidos-publications.com)
Ready-to-use antibodies, which were not diluted, were purchased from Beijing Zhongshan Golden Bridge Biological Technology Co., Ltd. Whole-body CT examination revealed no distant metastases anywhere, including the brain. (spandidos-publications.com)
The poor prognosis is generally related to loco-regional recurrence, regional lymphnode invasion, and distant metastases[ 8 , 9 ]. (ijpsonline.com)
or nasopharyngeal carcinoma subjects who have a local-regional recurrence and/or distant metastasis more than 6 months after the end of previous radical treatment (radiotherapy with induction, concurrent, adjuvant chemotherapy)；No systemic treatment has been received for recurrent or metastatic nasopharyngeal carcinoma, and local regional recurrence is not suitable for local treatment or has received local treatment. (cancercenter.com)
Although the predominant failures were distant metastasis in PORT group and loco-regional recurrence in non-PORT group, there was no statistically significant difference in loco-regional recurrence-free survival (LRRFS) (p = 0.362) or distant metastasis-free survival (DMFS) (p = 0.548). (e-roj.org)
Considering that adjuvant radiotherapy after surgical resection was effective to decrease loco-regional recurrence and most treatment failures were distant metastasis, multimodal therapy including surgery, radiotherapy, and chemotherapy might be an optimal treatment for uterine carcinosarcoma patients. (e-roj.org)
However, unlike the uterine leiomyosarcomas, the uterine carcinosarcomas exhibit more isolated local recurrences or lymph node metastasis rather than distant failure, which is similar to the failure pattern in uterine carcinomas [ 4 ]. (e-roj.org)
Background/Aim: Distant metastasis has a strong influence on prognosis in patients with soft tissue sarcoma (STS). (iiarjournals.org)
While various risk factors have been reported for distant metastases, risk factors for distant metastases early after treatment of primary tumor have not been investigated. (iiarjournals.org)
This study aimed to evaluate the factors of early distant metastasis after primary tumor resection in patients with STS. (iiarjournals.org)
We evaluated clinical information as a risk factor for distant or lung metastases. (iiarjournals.org)
Additionally, we evaluated risk factors for metastases in patients with distant metastases as early as 6 months after the initial resection of the primary tumor. (iiarjournals.org)
Multivariate analysis revealed that the size of the primary tumor (p=0.0011 and p=0.0167), consultation in a short period after onset (p=0.0325 and p=0.0402), histological high grade (p=0.0006 and p=0.0002), and inadequate surgical margin (p=0.0151 and p=0.0055) were significant predictors for poor prognosis for all distant and lung metastases, respectively. (iiarjournals.org)
Conclusion: The only risk factor for early distant metastasis after primary tumor resection in patients with STS was young age, even though large tumor diameter and histological high grade were risk factors for distant metastasis. (iiarjournals.org)
Particularly, distant metastasis, primarily involving the lungs, has a strong effect on the prognosis of patients with STS. (iiarjournals.org)
However, distant metastases still appear frequently after excision of the primary tumor. (iiarjournals.org)
In such cases, it is predicted that the prognosis will be worse if distant metastasis appears earlier. (iiarjournals.org)
While various risk factors have been reported for distant metastases that significantly affect the prognosis of soft tissue sarcoma ( 12 - 17 ), risk factors for the appearance of distant metastases early after treatment of the primary tumor have not been investigated. (iiarjournals.org)
Two patients with distant metastases also received chemotherapy. (springeropen.com)
Most transcriptomic signatures were highly prognostic for distant metastasis, but considerable discordance was observed on the individual patient level. (lu.se)

These important studies have illuminated the extent to which postoperative radiotherapy (RT) may provide benefit to patients with adverse pathologic features (extraprostatic extension, seminal vesicle invasion, or positive surgical margins) or biochemical recurrence after radical prostatectomy. (jnccn.org)
2 The argument for postoperative radiotherapy (RT) is predicated on the assumption that some patients may have residual local disease of a potentially lethal phenotype after surgery and that the delivery of secondary local therapy may interrupt the natural history of disease and prevent progression to systemic disease. (jnccn.org)
To evaluate the impact of postoperative radiotherapy (PORT) on patterns of failure and survivals in uterine carcinosarcoma patients treated with radical surgery. (e-roj.org)
The patient received postoperative radiotherapy as an adjuvant treatment, but it was discontinued halfway through when multiple bone metastases were identified. (springeropen.com)
Treatment is primarily surgical, but in patients with lymph node metastasis, postoperative radiotherapy is recommended as well. (medscape.com)

MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group study 26951. (thieme-connect.de)
Surgery and locoregional radiotherapy may offer optimal clinical and radiological outcomes but have a limited role in improving local tumor control and overall survival. (iiarjournals.org)
Tumor diameter, pelvic lymph node metastasis, vascular invasion, deep stromal invasion and close resection margins are most often used to target adjuvant treatment to those patients with highest risk of relapse [ 4 - 7 ]. (medsci.org)
The diagnosis of pulmonary metastases was obtained by reviewing the histology of the previous uterine tumor: the tumor cells were immunoreactive for CD10, PR, and smooth muscle actin (SMA), but negative for desmin, S100, CD34, CD 117, cytokeratins AE1AE3, CD68R, and ER. (hindawi.com)
These results were compared with the histological data of the previous tumor, and a final diagnosis of pulmonary metastasis was obtained: the immune histochemistry supported the diagnosis of metastases of leiomyosarcoma. (hindawi.com)
However, the present limited ability to predict tumor stage and grade accurately before surgery makes it difficult to select proper candidates for neoadjuvant therapy, while the loss of renal unit would limit the use of cisplatin-based chemotherapy in adjuvant therapy [ 10 , 11 ]. (hindawi.com)
Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
Conventional radiation therapy has not been effective in controlling this type of tumor in the curative or adjuvant settings. (cancernetwork.com)
On the other hand, the failure of radiation to control RCC in the curative or adjuvant setting may have more to do with the tolerance of neighboring structures to the kidney than intrinsic tumor resistance. (cancernetwork.com)

The initial treatment of choice of uterine leiomyosarcoma is the surgical resection and, in addition to this, adjuvant therapy (including chemotherapy and radiotherapy) can be used to reduce the risk of recurrence, despite the fact that the clinical efficacy is still uncertain [ 2 ]. (hindawi.com)
Both chemotherapy and radiotherapy reduce the risk of breast cancer recurring and the risk of dying from breast cancer. (cochrane.org)
However, it has also been suggested that using chemotherapy and radiotherapy at the same time may be more toxic than keeping them separate. (cochrane.org)
This review examined the current evidence on the best way to administer chemotherapy and radiotherapy following breast-conserving surgery. (cochrane.org)
The limited evidence available does suggest that the frequency and severity of side effects of chemotherapy and radiotherapy are similar regardless of which sequence is used. (cochrane.org)

This review details the role of radiotherapy in various subgroups of patients with RCC brain metastases as well as the associated toxicities and outcomes. (cancernetwork.com)
The objective of this review article is to outline the role of radiotherapy in a curative multimodal treatment concept. (uni-luebeck.de)
The role of radiotherapy and chemoradiation in the management of primary liver tumours. (cancercentrum.se)

specific techniques for treating pain from bone metastases (bisphosphonates and radiotherapy). (ehospice.com)

CHICAGO -- The use of androgen deprivation therapy (ADT) in conjunction with radiotherapy, as well as its prolonged use in the adjuvant setting, improved metastasis-free survival (MFS) and overall survival (OS) in patients with localized prostate cancer, a meta-analysis found. (medpagetoday.com)
Adjuvant procarbazine, lomustine, and vincristine improves progression-free survival but not overall survival in newly diagnosed anaplastic oligodendrogliomas and oligoastrocytomas: a randomized European Organisation for Research and Treatment of Cancer phase III trial. (thieme-connect.de)
After surgery for localised breast cancer, radiotherapy (RT) improves both local control and breast cancer-specific survival. (cochrane.org)
In patients at risk of harbouring micro-metastatic disease, adjuvant chemotherapy (CT) improves 15-year survival. (cochrane.org)
There were no significant differences between the various methods of sequencing adjuvant therapy for local recurrence-free survival, overall survival, relapse-free survival and metastasis-free survival based on 1166 randomised women in three trials. (cochrane.org)
Although surgical treatment with adjuvant chemo-radiotherapy, targeted therapy and immunotherapy have been used in patients with this disease, the long-term survival is still disappointing[ 6 , 7 ]. (ijpsonline.com)
5] Untreated, patients with brain metastasis from RCC have a poor prognosis and a mean survival of 3.2 months. (cancernetwork.com)
In general, the median survival time for patients with brain metastases treated with steroids alone is about 2 months. (cancernetwork.com)
When these variables are taken into account, adjuvant radiotherapy does not seem to result in a better survival for patients with a single occult intranodal metastasis. (dermatoljournal.com)
Whether the addition of chemotherapy to the radiotherapy for patients with more than one positive node or extracapsular spread results in a better survival remains uncertain. (dermatoljournal.com)
The conclusion is that adjuvant radiotherapy improves survival of patients with positive groin nodes, with the exception of patients with a single intranodal metastasis. (dermatoljournal.com)
We have analyzed the data from major multi-institutional prospective trials in Ewing tumors for to evaluate the impact of radiotherapy on local control and survival. (uni-luebeck.de)
Surgery yields in general better local control and survival figures as compared to radiotherapy. (uni-luebeck.de)
In addition, the three-year recurrence-free survival (RFS) of 124 patients with stage II or stage III CRC was analyzed in order to assess the effectiveness of fluoropyrimidine-based adjuvant chemotherapy with respect to CIMP status. (biomedcentral.com)
A previous study reported that CIMP positivity appears to result in improved survival among patients receiving 5-fluorouracil-based adjuvant chemotherapy for stage III CRC [ 22 ]. (biomedcentral.com)
Conclusion: Re-resection for breast cancer liver metastases can be safely performed and may bring survival benefit. (iiarjournals.org)
Patients suffering glioblastoma have a short median overall survival time despite extensive surgical resection and adjuvant chemo- and radiotherapy. (lu.se)

Phase III trial of chemotherapy plus radiotherapy compared with radiotherapy alone for pure and mixed anaplastic oligodendroglioma: Intergroup Radiation Therapy Oncology Group Trial 9402. (thieme-connect.de)
Ductal carcinoma in situ with microinvasion (DCIS-MI) is a subtype of breast cancer with good prognosis, for which both breast conserving surgery plus radiotherapy (BCS+RT) and mastectomy are feasible surgical methods, but their effects on the prognosis of patients are still unclear. (researchsquare.com)
Patients with high-risk lesions probably benefit from combined local treatment (surgery plus radiotherapy). (uni-luebeck.de)

Traditionally, whole-brain radiotherapy has been used for palliation. (cancernetwork.com)

We present the case of a 67-year-old woman with lung metastasis after eighteen years since uterine leiomyosarcoma diagnosis and its following surgical resection. (hindawi.com)
Early en bloc surgical resection of the primary tumour with clear margins remains the best curative treatment. (nih.gov)
In 2006, the patient underwent resection of an ipsilateral squamous cell carcinoma in the parotid bed that was presumably a nodal metastasis. (doctorsmedicalopinion.com)
He then experienced local relapse treated with resection and adjuvant radiotherapy. (doctorsmedicalopinion.com)
The aim of the present study was to evaluate the effectiveness and safety of hepatic re-resection for breast cancer liver metastases. (iiarjournals.org)
Patients and Methods: Between January 2004 and December 2014 seven patients were submitted to liver re-resection for breast cancer liver metastases at our Center. (iiarjournals.org)
In order to be considered eligible for the study, the patients had to meet the following criteria: histopathological confirmation of breast cancer liver metastases diagnosis at the moment of primary liver resection and re-submission to surgery for preoperative diagnosis of hepatic recurrence. (iiarjournals.org)
age at initial diagnosis of breast cancer, histopathological result, age at diagnosis of the first and second liver resection, type of resection, number and diameter of the lesions, type of resection at both primary and secondary liver surgery, association of neo-adjuvant and adjuvant oncologic treatment at each moment including breast surgery, first and second liver resection. (iiarjournals.org)

Although local therapy with surgery and radiotherapy is used to minimize the first possibility, adjuvant systemic therapy may theoretically reduce the likelihood of all three events. (news-medical.net)
analyzing the velocity (i.e., the change over time) of the markers, malignancy we could stipulate for each patient the risk of developing metas- tasis after the end of adjuvant systemic therapy. (lu.se)

The beneficial effect of chemo radiotherapy for subgroups of patients with positive nodes seems likely, although more data are needed before a definite conclusion can be made. (dermatoljournal.com)

Guidelines recommend adjuvant treatment when positive lymph nodes are found after surgical treatment for squamous cell cancer of the vulva except for cases with a single occult intranodal metastasis. (dermatoljournal.com)
The patient underwent a right quadrantectomy and axillary lymph nodes removal, adjuvant chemotherapy and radiation therapy. (doctorsmedicalopinion.com)
Thus, sentinel lymph node biopsy with selective lymph node dissection has been embraced as an alternative to elective lymphadenectomy or observation for patients with clinically negative regional lymph nodes who are at risk for nodal metastases. (medscape.com)

Several reports have evaluated changes in renal function following RNU and demonstrated that the decline in renal function may render a substantial number of patients ineligible to receive adjuvant chemotherapy (AC) [ 10 - 15 ]. (hindawi.com)
Patients in the control arm will receive adjuvant radiotherapy to the breast or chest wall (with/without regional nodes) to a dose of 40 Gy / 15 fractions / 3 weeks, while those in the experimental arm will receive a dose of 26 Gy / 5 fractions / 1 week (to the same volume). (authorea.com)

Improving resectability of hepatic colorectal metastases: expert consensus statement. (cancercentrum.se)

Although there are clear criteria (pT3-pT4 disease and/or positive margins) for the use of adjuvant radiotherapy, no specific clinical or tumour-related criteria have yet been defined for SRT. (wjgnet.com)
Reflecting this, the most recent update of the NCCN Clinical Practice Guidelines in Oncology: Prostate Cancer states "new evidence supports offering adjuvant/salvage RT in all men with adverse pathologic features or detectable PSA" 3 (to view the most recent version of these guidelines, visit the NCCN Web site at www.NCCN.org ). (jnccn.org)
This suggests that the process of GI metastasis of lung cancer is subtle and lacks specific clinical symptoms. (spandidos-publications.com)
However, these studies did not take into account important nodal characteristics, such as clinical node status, extranodal spread or size of the metastasis. (dermatoljournal.com)
All patients with breast cancer liver metastases surgically treated in the "Dan Setlacec" Center of Gastrointestinal Disease and Liver Transplantation, the Fundeni Clinical Institute between January 2004 and December 2014 were retrospectively reviewed. (iiarjournals.org)
The objectives of combining sentinel lymph node biopsy with selective lymphadenectomy in clinical practice include both decreasing the extent of the operation for selected patients (decreasing the number of nontherapeutic lymphadenectomies) and increasing the identification rate of occult lymph node metastases (increasing the accuracy of staging) by providing the pathologist with the lymph node (or nodes) most likely to contain metastatic disease. (medscape.com)
Purpose: There is currently no molecular signature in clinical use for adjuvant endocrine therapy omission in breast cancer. (lu.se)
In the past two decades, a multi-therapy approach has increased the rates of clinical response through neoadjuvant chemotherapy, particularly usinga nthracyclines and taxanes-based combination, surgery, radiotherapy and hormone-based therapy 5 . (bvsalud.org)

These tumors have a high tendency to recur and there is high possibility of metastasis. (thieme-connect.com)
Background/Aim: Intradural cauda equina metastases (ICEM) are rare tumors that reduce functional status. (iiarjournals.org)
Neoplastic CES may arise from cauda equina primary tumors or secondary metastases, which may involve the vertebral bones, resulting in fracture and external nerve compression ( 5 ). (iiarjournals.org)

Patients with stage II or III seminoma are considered to have good risk, with the exception of patients who have stage III disease with nonpulmonary visceral metastases, who are classified as intermediate-risk patients. (medscape.com)

The occurrence of small intestinal metastases from primary lung cancer is rare. (spandidos-publications.com)
Postoperative pathological analysis confirmed the final diagnosis to be small intestinal metastasis from primary lung cancer. (spandidos-publications.com)
Although small intestinal metastasis from lung cancer is rare and difficult to diagnose accurately, it should be considered when encountering a patient with lung cancer exhibiting abdominal symptoms and associated imaging findings. (spandidos-publications.com)
Lung cancer is the leading cause of cancer-related death worldwide, with most patients presenting with metastases during diagnosis ( 1 ). (spandidos-publications.com)
Patients with early-stage lung cancer are asymptomatic, whereas those with advanced metastasis are frequently symptomatic due to metastatic sites. (spandidos-publications.com)
Furthermore, the gastrointestinal (GI) tract is not a common site of primary lung cancer metastasis ( 4 ). (spandidos-publications.com)
The present report describes an uncommon case of small intestinal metastasis from lung cancer. (spandidos-publications.com)
Furthermore, the literature relevant to the occurrence, diagnosis and treatment of GI metastasis of lung cancer was reviewed. (spandidos-publications.com)
Bilateral lung irradiation (as consolidation after chemotherapy) seems to improve prognosis in patients with metastases at diagnosis. (uni-luebeck.de)
Her initial work-up revealed lung metastasis. (doctorsmedicalopinion.com)

the liver, an adjacent organ, is the leading metastatic site, accounting for over 50% of GBC patients with metastasis [ 4 ]. (medsci.org)
The metastatic workup showed multiple retroperitoneal lymphadenopathies with liver metastases. (ispub.com)
The organs of the abdomen including the liver and small bowel have a relatively low tolerance for radiation, and thus the curative and adjuvant trials have generally been restricted to moderate radiation doses of 30 to 55 Gy. (cancernetwork.com)
A 72 years old female that 8 years ago was diagnosed with adenocarcinoma of the sigma with liver metastasis. (doctorsmedicalopinion.com)
The main inclusion criteria were presence of isolated liver metastases and absence of systemic recurrent disease Results: The median age at the time of breast surgery was 51 years (range=39-69 years). (iiarjournals.org)
However it seems that in the progression of breast cancer up to 60% of patients will develop liver metastases, 20% of them being estimated to be diagnosed within five years from breast surgery. (iiarjournals.org)
the largest reported group of patients submitted to hepatectomy for breast cancer liver metastases was conducted by Groeschl et al . (iiarjournals.org)

Nearly half of patients present with stage I disease and about one third of patients treated with surgery received adjuvant treatment [ 2 ]. (medsci.org)
The indication for salvage radiotherapy (RT) (SRT) in patients with biochemically-recurrent prostate cancer after surgery is based on prostate-specific antigen (PSA) levels at the time of biochemical recurrence. (wjgnet.com)
Recent developments in the urologic oncology literature suggest that residual local disease-as opposed to the presence of occult metastases at surgery-may characterize a more substantial component of the natural history of the recurrence and progression of initially clinically localized prostate cancer than previously appreciated. (jnccn.org)
A basic question in this context is the extent to which this sequence of events-versus the presence of occult metastases at surgery-characterizes the natural history of recurrent and progressive disease. (jnccn.org)
The evidence produced by these three well-conducted trials suggests that recurrence of a woman's cancer and her chances of dying from breast cancer are similar regardless of the order of the treatments, provided that both radiotherapy and chemotherapy are commenced within seven months of the surgery. (cochrane.org)
3) Patients who did not receive radiotherapy after breast-conserving surgery. (researchsquare.com)
The efficacy of radiotherapy as compared to surgery varies among the studies and seems to be dependent on patient selection and sequencing with chemotherapy. (uni-luebeck.de)
5 years ago, after diagnostic finding of reappearance of infiltrating ductal carcinoma of the right breast, the patient underwent right mastectomy and revisional surgery of axillary armpit, and another adjuvant chemotherapy. (doctorsmedicalopinion.com)
Breast-conserving surgery (BCS), i.e. a partial mastectomy, followed by radiotherapy, is today a common alternative to mastectomy, when treating early breast cancer. (springer.com)
For patients with stage II or III CIMP-low/negative CRCs, no significant difference was found in RFS between those undergoing surgery alone and those receiving surgery with fluoropyrimidine-based adjuvant chemotherapy. (biomedcentral.com)
5) One of 4 cases received total hysterectomy and radiotherapy after surgery, and the others accepted wide hysterectomy and pelvic lymph node dissection, but no radiotherapy after operation. (biomedres.info)
Radiotherapy can be considered in cases of local disease that is poorly differentiated or for those who are poor candidates for surgery. (medscape.com)
Experimental Design: We performed a whole-transcriptome analysis of SweBCG91-RT, a randomized phase III trial of ± radiotherapy after breast-conserving surgery for node-negative stage I-IIA breast cancer. (lu.se)

earlier cohort exclusively underwent radical mastectomy plus adjuvant radiotherapy, while later cohort had radical mastectomy alone. (scirp.org)

PURPOSEThere remains a lack of clarity regarding the influence of sequencing of androgen deprivation therapy (ADT) and radiotherapy (RT) on outcomes in prostate cancer (PCa). (wustl.edu)
Adjuvant radiotherapy after radical prostatectomy provided no meaningful benefit in patients with prostate cancer but increased the risk for urinary and bowel morbidity compared with men followed with observation alone, according to the latest results from the phase 3 RADICALS-RT trial. (medscape.com)
The aim of the RADICALS-RT study was to clarify the optimal timing for radiotherapy after radical prostatectomy in men with prostate cancer, which previously had been uncertain. (medscape.com)
Are all prostate cancer patients 'fit' for salvage radiotherapy? (wjgnet.com)
González-San Segundo C, Gómez-Iturriaga A, Couñago F. Are all prostate cancer patients "fit" for salvage radiotherapy? (wjgnet.com)

During the 50 years, radical mastectomy alone compared with radical mastectomy plus adjuvant radiotherapy is associated with a significantly higher cure rate, and higher survivals regardless of whether the death was from breast cancer, second cancer, benign causes or any causes. (scirp.org)
Overall, the trial results "support the use of early salvage radiotherapy for PSA failure after radical prostatectomy rather than early adjuvant intervention, " concluded Clarke, a professor and consultant urologist at The Christie Hospital and Salford Royal Hospital, Manchester, United Kingdom. (medscape.com)
To report the decline of renal function after radical nephroureterectomy (RNU) in upper tract urothelial carcinoma (UTUC) patients and to develop a nomogram to predict ineligibility for cisplatin-based adjuvant chemotherapy (AC). (hindawi.com)

The analysis included 10,853 patients from 12 radiotherapy trials, for whom the researchers analyzed outcomes related to three aspects of ADT: the addition of ADT to radiation therapy (median follow-up 12 years), and the prolongation of adjuvant ADT (median 10.9 years follow-up), and neoadjuvant ADT (median 10.3 years follow-up). (medpagetoday.com)
With advances in radiation oncology, stereotactic radiosurgery and hypofractionated stereotactic radiotherapy have been utilized for RCC brain metastases, producing excellent outcomes. (cancernetwork.com)
Recent developments in surgical treatment, radiotherapy, and chemotherapy have improved patient outcomes. (iiarjournals.org)

Ottawa 0101 randomly assigned patients to neoadjuvant or concurrent versus concurrent or adjuvant short-term ADT. (wustl.edu)
Radiation Therapy Oncology Group 9413, a 2 × 2 factorial trial, included a random assignment of neoadjuvant or concurrent versus adjuvant short-term ADT. (wustl.edu)
The neoadjuvant or concurrent ADT arms of both trials were combined into the neoadjuvant group, and the arms receiving adjuvant ADT were combined into the adjuvant group. (wustl.edu)
Overall, 1,065 patients were included (531 neoadjuvant and 534 adjuvant). (wustl.edu)
Our findings favor use of an adjuvant over a neoadjuvant approach, without any increase in long-term toxicity. (wustl.edu)
The use of cisplatin-based chemotherapy has gained greater acceptance as evidenced by its use in neoadjuvant and adjuvant therapy, especially in patients with pT3-4 or pTxN+ [ 5 - 8 ]. (hindawi.com)

New insights have been gained particularly in anaplastic glioma, primary CNS lymphoma as well as brain metastases by answering the basic question about the optimal place for radiotherapy in the treatment of these diseases. (thieme-connect.de)
This adjuvant treatment is accompanied by considerable morbidity [ 3 ]. (medsci.org)
If a five-fraction regimen of breast cancer is proven to be non-inferior, this will result in a significant improvement in the access to radiotherapy, as well as reduced costs of treatment. (authorea.com)
Post-orchiectomy primary treatment for pure seminoma includes surveillance, radiotherapy, 0r chemotherapy. (medscape.com)
If the prior neo (adjuvant) therapy included aromatase inhibitors, the disease free interval must be greater than 12 months from the completion of aromatase inhibitor treatment until randomization. (who.int)

The efficacy of classical adjuvant therapies, such as radiotherapy and chemotherapy, in management of persistent, recurrent, or metastatic disease has been disappointing. (nih.gov)
However, the roles of other therapies such as ovariectomy, lymphadenectomy, and postoperative adjuvant therapy, remain controversial [7-9]. (heraldopenaccess.us)

HYPOfractionated Radiation Therapy comparing a standard radiotherapy schedule (over three weeks) with a novel one week schedule in Adjuvant breast cancer: An open-label randomised controlled study (HYPORT- Adjuvant): study protocol for a multicenter, randomized phase III trial. (authorea.com)
If they are used sequentially, the radiotherapy or the chemotherapy could be used first and concerns have been expressed that the effectiveness of the therapy that is delayed might be reduced. (cochrane.org)
However, the best sequence of administering these two types of adjuvant therapy for early-stage breast cancer is unclear. (cochrane.org)
Radiotherapy, chemotherapy, targeted therapy, and immunotherapy are basically intended to provide another choice for patients with post- or non-operative conditions. (frontiersin.org)
Chemotherapy, as the most common and indispensable adjuvant therapy, is updated constantly with advances in research. (frontiersin.org)
Whole-brain radiation therapy (WBRT) has been the community standard for treating brain metastases from many types of cancers. (cancernetwork.com)
One hundred and nine (80.7%) patients received ovariectomy, 73 (54.1%) patients had lymphadenectomy and 83 (61.5%) patients received adjuvant therapy. (heraldopenaccess.us)
He was treated with antiandrogens and adjuvant radiation therapy. (doctorsmedicalopinion.com)
Given the unique trial design of SweBCG91-RT, where adjuvant endocrine and chemotherapy were largely unadministered, we sought to evaluate the potential of transcriptomic profiling for identifying patients who may be spared adjuvant endocrine therapy. (lu.se)
Ninety-two percent of patients were untreated by both adjuvant endocrine therapy and chemotherapy. (lu.se)
Within the MET141 low-risk subgroup (lowest 25th percentile of scores), 95% of patients were free of metastasis at 15 years, even in the absence of adjuvant endocrine therapy. (lu.se)
Conclusions: Transcriptomic profiling identifies patients with an excellent outcome without any systemic adjuvant therapy in clinically low-risk patients of the SweBCG91-RT and METABRIC cohorts. (lu.se)
Patients who received (neo) adjuvant therapy for breast cancer are eligible. (who.int)
2.Patient has received extended-field radiotherapy or limited field radiotherapy = 2 weeks prior to randomization, and has not recovered to grade 1 or better from related side effects of such therapy (with the exception of alopecia or other toxicities not considered a safety risk for the patient at investigator's discretion). (who.int)
It also may be used as an additional "adjuvant" therapy after cancer has been surgically removed from the brain to help reduce the risk of recurrence. (medlineplus.gov)

The primary characteristics of TNBC include younger age, higher grade and mitotic index, more advanced stage at diagnosis, and increased aggressiveness with a higher risk of brain metastasis [1]. (karger.com)
He later developed brain metastases within two months of completion of chemotherapy and eventually succumbed to the disease within 8 months of diagnosis. (ispub.com)
A third of the patients with RCC have evidence of metastases at the time of the diagnosis, and up to half of the patients treated for localized disease eventually develop a recurrence. (cancernetwork.com)

PFS was significantly improved in the adjuvant group (15-year PFS, 29% v 36%, hazard ratio [HR], 1.25 [95% CI, 1.07 to 1.47], P =.01). (wustl.edu)
Adding ADT to radiotherapy significantly improved 12-year rates of MFS, the primary endpoint (HR 0.83, 95% CI 0.77-0.89), increasing from 43% without ADT to 51% with it. (medpagetoday.com)
However, self-reported urinary and fecal incontinence rates at 1 year were significantly higher in the adjuvant radiotherapy group vs the observation group, 60% of whom had not received salvage radiotherapy at that time. (medscape.com)
In patients with chest wall primaries, adjuvant hemithorax irradiation has reduced the relapse rate significantly. (uni-luebeck.de)

Observation with early salvage radiotherapy in cases of biochemical failure should be the standard of care, concluded study co-author Noel Clarke, MBBS, who presented the results at the European Society for Medical Oncology (ESMO) Congress 2023 in Madrid on October 20. (medscape.com)
Invited discussant and session co-chair Shahneen Sandhu, MBBS, said that the findings definitively confirm the value of observation with salvage radiotherapy over adjuvant radiotherapy in this patient population. (medscape.com)
The approach of early salvage radiotherapy spared morbidity [from] radiation in the vast majority of patients, and further bowel and bladder toxicity is reduced in the setting of salvage radiotherapy," said Sandhu, an associate professor and consultant medical oncologist at Peter MacCallum Cancer Centre, Victoria, Australia. (medscape.com)
In the study, 697 patients were randomly assigned to adjuvant radiotherapy and 699 to observation with salvage radiotherapy. (medscape.com)
Patients in the observation arm received salvage radiotherapy if they experienced two consecutive PSA increases ≥ 0.1 ng/mL or three consecutive rises. (medscape.com)
Nevertheless, the question of whether all patients with the aforementioned adverse features should undergo immediate adjuvant RT versus initial observation with more selective-but early-salvage RT in the event of biochemical failure remains the subject of heated controversy. (jnccn.org)
In 2010, the dilemma is not in the question of whether postprostatectomy adjuvant or salvage RT are effective among high-risk patients as a group, but rather which individual patients ought to receive it and when. (jnccn.org)

The possible curative potential of radiotherapy in metastatic disease requires further investigation. (uni-luebeck.de)

Brain metastases from renal cell carcinoma (RCC) cause significant morbidity and mortality. (cancernetwork.com)

Adjuvant Cisplatin Plus Gemcitabine in Operable Cholangiocellular Carcinoma. (cancercentrum.se)

Lymph node metastasis was found to be a significant prognostic factor in predicting poor LRRFS (p = 0.013) and DMFS (p = 0.021), while the International Federation Gynecology and Obstetrics (FIGO) stage (p = 0.043) was associated with LRRFS. (e-roj.org)

Radiotherapy for glioblastoma in the elderly. (thieme-connect.de)
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. (nature.com)

CRC spreads by direct extension through the bowel wall, hematogenous metastasis, regional lymph node metastasis, and perineural spread. (msdmanuals.com)

Newer radiosensitizers (eg, motexafin gadolinium [Xcytrin]) and chemotherapeutic agents (eg, temozolomide [Temodar]) used in combination with radiotherapy will also be discussed. (cancernetwork.com)

In contrast to the curative or adjuvant setting, radiation has been effective in palliating RCC, especially in the metastatic setting. (cancernetwork.com)

Brain metastases. (nature.com)
4] Approximately 4% to 17% of all RCC patients eventually develop brain metastases, with 50% of these suffering from multiple lesions. (cancernetwork.com)
6] The distribution of RCC brain metastases, as with many other types of brain metastases, parallels brain weight and blood flow. (cancernetwork.com)

The use of ADT and the prolongation of adjuvant ADT with radiotherapy provides clinically meaningful benefit and should remain the standard of care, with level 1 evidence," he said during a presentation at the American Society for Radiation Oncology annual meeting. (medpagetoday.com)

Factors associated with less satisfied patients regarding skin sensitivity in the operated breast were an excision of ≥20% of preoperative breast volume, a BMI of 25-30 kg/m 2 , axillary clearance, and radiotherapy. (springer.com)

Radiotherapy to breast cancer may adversely affect not only mortality from breast cancer, but mortalities unrelated to breast cancer. (scirp.org)
To determine the effects of different sequencing of adjuvant CT and RT for women with early breast cancer. (cochrane.org)
This predict the likelihood of a later recurrence, i.e., an indicator that unique longitudinal sample material was collected from each pa- allows risk assessment for breast cancer metastasis, would be tient between 0 and 36 mo after the primary operation. (lu.se)

Anatomy7

Organisms4

Diseases87

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment96

Phenomena and Processes11

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Humanities1

Information Science6

Health Care33

Distant44

Postoperative radiotherapy5

Tumor9

Chemotherapy and radiotherapy5

Role of radiotherapy3

Bone metastases1

Survival17

Plus radiotherapy3

Whole brain radiotherapy1

Resection8

Systemic therapy2

Chemo-radiotherapy1

Lymph nodes3

Receive adjuvant2

Hepatic1

Clinical8

Tumors3

Visceral metastases1

Lung10

Liver7

Surgery13

Underwent1

Prostate cancer5

Radical3

Outcomes3

Neoadjuvant6

Treatment5

Therapies2

Therapy15

Diagnosis3

Significantly4

Salvage7

Metastatic disease1

Morbidity1

Cisplatin1

Prognostic1

Glioblastoma2

Regional lymph1

Temozolomide1

Curative1

Brain3

Clinically1

Axillary1

Breast cancer3