• Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. (wikipedia.org)
  • Overexpression of MMP-1 degrades extracellular matrix causing damage to the colon mucosa in patients with ulcerative colitis. (guidetopharmacology.org)
  • It normally helps modify and break down various components of the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells. (encyclopedia.pub)
  • Matrix metallopeptidase 14 also turns on (activates) a protein called matrix metallopeptidase 2 in the extracellular matrix. (encyclopedia.pub)
  • Although most research has focused on the role of matrix metallopeptidase 14 in the extracellular matrix, studies suggest that it may also be involved in signaling pathways within cells. (encyclopedia.pub)
  • As a result, not enough of the enzyme is available to break down components of the extracellular matrix and activate matrix metallopeptidase 2. (encyclopedia.pub)
  • FUNCTION: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. (utsouthwestern.edu)
  • Cellular components and processes associated with DD pathogenesis include altered gene and protein expression of cytokines, growth factors, adhesion molecules, and extracellular matrix components. (biomedcentral.com)
  • Orthologous to human MMP9 (matrix metallopeptidase 9). (nih.gov)
  • Amongst these, we validate calpain 2, matrix metalloproteinase 9 (MMP9) and a RhoGTPase Rac1 as well as Tumor necrosis factor alpha (TNFα) as transcriptional targets of G-/GMCSF and demonstrate the importance of MMP9 and Rac1 in GMCSF-induced nociceptor sensitization. (biomedcentral.com)
  • Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. (embl.de)
  • High expression of lncRNA H19 promotes cell migration and enhances angiogenesis ( 11 , 12 ). (spandidos-publications.com)
  • RESULTS: In bronchoalveolar lavage fluid, WPS increased neutrophil and lymphocyte numbers, lactate dehydrogenase, myeloperoxidase and matrix metallopeptidase 9 activities, as well as several proinflammatory cytokines. (who.int)
  • Matrix metalloproteinases cleave tissue factor pathway inhibitor. (wikipedia.org)
  • The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). (embl.de)
  • It is suggested that the hemopexin domain facilitates binding to a variety of molecules and proteins, for example the HX repeats of some matrixins bind tissue inhibitor of metallopeptidases (TIMPs). (embl.de)
  • Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2. (embl.de)
  • The binding properties of the newly described tissue inhibitor of metalloproteinases-4 (TIMP-4) to progelatinase A and to the COOH-terminal hemopexin-like domain (C domain) of the enzyme were examined. (embl.de)
  • Furthermore, novel mechanistic investigations revealed that CXCL1 expression stimulated interleukin 6 (IL6) expression and repressed tissue inhibitor of metalloproteinase 4 (TIMP4). (thno.org)
  • It is possible that a loss of matrix metallopeptidase 2 activation somehow disrupts the balance of new bone creation and the breakdown of existing bone during bone remodeling, causing a progressive loss of bone tissue. (encyclopedia.pub)
  • Expression of tissue inhibitor of metalloproteinases (TIMPs) during early cardiac development. (arizona.edu)
  • Enzyme-linked immunosorbent assay (ELISA) was employed to measure levels of five serum proteins previously demonstrated to be up-regulated in papillary thyroid cancer (PTC): angiopoietin-1 (Ang-1), cytokeratin 19 (CK-19), tissue inhibitor of metalloproteinase-1 (TIMP-1), chitinase 3 like-1 (YKL-40), and galectin-3 (GAL-3). (biomedcentral.com)
  • Data suggest that matrix metalloproteinase-1 and neutrophil elastase may be important but heretofore unrecognized players in stimulating uterine contractions at the time of labor, and they may explain why indomethacin delays, but does not prevent, preterm labor because indomethacin inhibits the prostaglandin component but not the protease component of labor. (cusabio.com)
  • Matrix metalloproteinase 8(MMP8) also called neutrophil collagenase. (rockland.com)
  • Neutrophil collagenase, a member of the family of matrix metalloproteinases, is distinct from the collagenase of skin fibroblasts and synovial cells in substrate specificity and immunologic cross reactivity. (rockland.com)
  • The mutation changes a single protein building block (amino acid) in matrix metallopeptidase 14. (encyclopedia.pub)
  • Additionally, SDC-1 overexpression restrained cell migration via inhibiting the protein expression of matrix metallopeptidase 9 (MMP-9), and elicited cell adhesion through increasing intercellular cell adhesion molecule-1 (ICAM-1). (biomedcentral.com)
  • In order to gain insight into the red coral biomineralization process and cnidarian biomineralization evolution, we studied the protein repertoire forming the organic matrix (OM) of its two biominerals. (biomedcentral.com)
  • Contrary to reef building corals, the red coral organic matrix possesses a large number of collagen-like proteins. (biomedcentral.com)
  • The inferred regulatory function of these OM proteins suggests that the difference between the two biominerals is due to the modeling of the matrix network, rather than the presence of specific structural components. (biomedcentral.com)
  • Devel L, Czarny B, Beau F, Georgiadis D, Stura E, Dive V. (2010) Third generation of matrix metalloprotease inhibitors: Gain in selectivity by targeting the depth of the S1' cavity. (guidetoimmunopharmacology.org)
  • Mutation of membrane type-1 metalloproteinase,MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchestersyndrome. (encyclopedia.pub)
  • Khan F, Liu H, Reyes A, Witkowska HE, Martinez-Avila O, Zhu L, Li W, Habelitz S. The proteolytic processing of amelogenin by enamel matrix metalloproteinase (MMP-20) is controlled by mineral ions. (medlineplus.gov)
  • Toxins with hemorrhagic and myonecrotic activity are generally found in the venoms of the Viperidae family due to synergic action of proteolytic enzymes, such as metalloproteinases and serine proteinases 4 . (nature.com)
  • In an experimental mouse OA model using a microsurgical technique, MMP-13 levels correlate with the presence of pathological chondrocytes that undergo hypertrophic differentiation in the early stage of OA development [ 11 ] and its over-expression can induce the onset of OA through excessive ECM degradation [ 12 ]. (biomedcentral.com)
  • Expression of Matrix Metalloproteinases in Intraductal Papillary Mucinous Neoplasm of the Pancreas. (cancerindex.org)
  • Biomarkers that are related to the onset of articular cartilage degeneration during the early phase of OA include a number of matrix-degrading enzymes, such as the matrix metalloproteinase (MMP) family, the a disintegrin and metalloproteinase with thrombospondin type-1 motifs (ADAMTS) family, aggrecanases, etc. [ 8 ]. (biomedcentral.com)
  • In general, TME mainly consists of genetically heterogeneous cancer cells, endothelial cells, cancer-associated fibroblasts(CAFs), and different populations of immune cells [2] , establishing a complex cross-talk with tumor via producing growth factors, chemokines and matrix-degrading enzymes. (ommegaonline.org)
  • Matrix metalloproteinase-12 (MMP-12) also known as macrophage metalloelastase (MME) or macrophage elastase (ME) is an enzyme that in humans is encoded by the MMP12 gene. (wikipedia.org)
  • The MMP14 gene (also known as MT1-MMP ) provides instructions for making an enzyme called matrix metallopeptidase 14. (encyclopedia.pub)
  • The identified mutation alters matrix metallopeptidase 14 so that less of the enzyme is able to reach the cell surface. (encyclopedia.pub)
  • 8. Rasmussen HS, McCann PP. (1997) Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. (guidetopharmacology.org)
  • In fact, matrix metalloproteinase 2 (MMP-2) and integrin alphavbeta3 are functionally associated on the surface of angiogenic blood vessels. (embl.de)
  • Biochemical assays indicated that SVEVs are functionally active, showing high metalloproteinase and fibrinogenolytic activity besides being cytotoxic against HUVEC cells. (nature.com)
  • 2012 Nov-Dec;91(11-12):889-95.doi: 10.1016/j.ejcb.2012.07.003. (encyclopedia.pub)
  • Enables fibronectin binding activity and metallopeptidase activity. (nih.gov)
  • The activity of matrix metallopeptidase 2 appears to be important for a variety of body functions, including bone remodeling, which is a normal process in which old bone is broken down and new bone is created to replace it. (encyclopedia.pub)
  • Matrix metalloproteinases (MMPs) have been considered to be associated with tumor progression or poor prognosis. (cancerindex.org)
  • Macrophage metalloelastase, MMP-12, cleaves human apolipoprotein(a) in the linker region between kringles IV-4 and IV-5. (wikipedia.org)
  • Aiken A, Khokha R. (2010) Unraveling metalloproteinase function in skeletal biology and disease using genetically altered mice. (guidetoimmunopharmacology.org)
  • 2003) A potent, selective inhibitor of matrix metalloproteinase-3 for the topical treatment of chronic dermal ulcers. (guidetopharmacology.org)