Cell surface rNeurotransmitterOxytocinExtracellularPolypeptideProteinMechanismHormoneProteinsVascularActivationFunctionHumanExpressionPeopleRoleGlutamateProtein-coupled receptorsCannabinoid receptorLigandsOrphan receptorMolecularAffinitySubtypeAgonistsPeptidesHumansActivateDiseasesFunctionalHumanMiceTypeYearPlay
Cell surface r2
- G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. (wikipedia.org)
- The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. (harvard.edu)
Neurotransmitter1
- The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter. (nih.gov)
Oxytocin2
- Voinsky I, Bennuri SC, Svigals J, Frye RE, Rose S, Gurwitz D. Peripheral Blood Mononuclear Cell Oxytocin and Vasopressin Receptor Expression Positively Correlates with Social and Behavioral Function in Children with Autism. (uams.edu)
- Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. (nih.gov)
Extracellular3
- They pass through the cell membrane seven times in the form of six loops (three extracellular loops interacting with ligand molecules, three intracellular loops interacting with G proteins, an N-terminal extracellular region and a C-terminal intracellular region) of amino acid residues, which is why they are sometimes referred to as seven-transmembrane receptors. (wikipedia.org)
- Ligands can bind either to the extracellular N-terminus and loops (e.g. glutamate receptors) or to the binding site within transmembrane helices (rhodopsin-like family). (wikipedia.org)
- Seven years later, the crystallization of β2-adrenergic receptor (β2AR) with a diffusible ligand brought surprising results because it revealed quite a different shape of the receptor extracellular side than that of rhodopsin. (wikipedia.org)
Polypeptide5
- Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies. (harvard.edu)
- Receptors, Islet Amyloid Polypeptide" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- Their affinity for ISLET AMYLOID POLYPEPTIDE is dependent upon which of several receptor activity-modifying protein subtypes they are bound to. (uchicago.edu)
- Below are the most recent publications written about "Receptors, Islet Amyloid Polypeptide" by people in Profiles. (uchicago.edu)
- Below are the most recent publications written about "Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide" by people in Profiles. (ouhsc.edu)
Protein12
- G protein-coupled receptors are found only in eukaryotes, including yeast, and choanoflagellates. (wikipedia.org)
- G protein-coupled receptors are involved in many diseases. (wikipedia.org)
- There are two principal signal transduction pathways involving the G protein-coupled receptors: the cAMP signal pathway and the phosphatidylinositol signal pathway. (wikipedia.org)
- With the determination of the first structure of the complex between a G-protein coupled receptor (GPCR) and a G-protein trimer (Gαβγ) in 2011 a new chapter of GPCR research was opened for structural investigations of global switches with more than one protein being investigated. (wikipedia.org)
- Receptors, G-Protein-Coupled" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
- This graph shows the total number of publications written about "Receptors, G-Protein-Coupled" by people in Harvard Catalyst Profiles by year, and whether "Receptors, G-Protein-Coupled" was a major or minor topic of these publication. (harvard.edu)
- Below are the most recent publications written about "Receptors, G-Protein-Coupled" by people in Profiles. (harvard.edu)
- G-protein coupled receptors that are formed through the dimerization of the CALCITONIN RECEPTOR with a RECEPTOR ACTIVITY-MODIFYING PROTEIN. (uchicago.edu)
- A family of G-protein-coupled receptors that share significant homology with GLUCAGON RECEPTORS. (ouhsc.edu)
- Melanocortin receptor 3 is a protein that in humans is encoded by the MC3R gene . (wikidoc.org)
- This gene encodes MC 3 , a G-protein coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. (wikidoc.org)
- The receptor is a G-protein coupled receptor , which activates the G protein G s . [2] . (wikidoc.org)
Mechanism1
- The relaxin receptor RXFP1 signals through a mechanism of autoinhibition. (harvard.edu)
Hormone1
- Among the many responses mediated by these receptors are smooth muscle contraction, increased vascular permeability, hormone release, and cerebral glyconeogenesis. (uchicago.edu)
Proteins1
- The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. (wikipedia.org)
Vascular1
- Two types of vasopressin receptor exist, the V1 receptor in the vascular smooth muscle and the V2 receptor in the kidneys. (uams.edu)
Activation2
- They are all activated by agonists, although a spontaneous auto-activation of an empty receptor has also been observed. (wikipedia.org)
- New structures complemented with biochemical investigations uncovered mechanisms of action of molecular switches which modulate the structure of the receptor leading to activation states for agonists or to complete or partial inactivation states for inverse agonists. (wikipedia.org)
Function2
- The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. (harvard.edu)
- Methamphetamine decreases K+ channel function in human fetal astrocytes by activating the trace amine-associated receptor type-1. (rush.edu)
Human2
- Studies performed by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) , found that two specific polymorphisms in the MC3R gene may be associated with pediatric obesity and greater body mass because of greater energy intake. (wikidoc.org)
- It also denotes the human gene encoding the receptor. (wikidoc.org)
Expression1
- Srivastava R, Cornett LE, Chaturvedi CM. Impact of estrogen and photoperiod on arginine vasotocin and VT3 receptor expression in the shell gland of quail. (uams.edu)
People1
- Below are the most recent publications written about "Receptors, Vasopressin" by people in Profiles over the past ten years. (uams.edu)
Role1
- Mice deficient for this gene have increased fat mass despite decreased food intake suggesting a role for this gene product in the regulation of energy homeostasis. (wikidoc.org)
Glutamate2
- Ligands can bind either to the extracellular N-terminus and loops (e.g. glutamate receptors) or to the binding site within transmembrane helices (rhodopsin-like family). (wikipedia.org)
- Several types of metabotropic glutamate receptors have been cloned. (nih.gov)
Protein-coupled receptors7
- G protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. (wikipedia.org)
- G protein-coupled receptors are found only in eukaryotes, including yeast, and choanoflagellates. (wikipedia.org)
- G protein-coupled receptors are involved in many diseases. (wikipedia.org)
- There are two principal signal transduction pathways involving the G protein-coupled receptors: the cAMP signal pathway and the phosphatidylinositol signal pathway. (wikipedia.org)
- A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. (harvard.edu)
- A class of G-protein-coupled receptors that react to varying extracellular CALCIUM levels. (childrensmercy.org)
- GPR109B is a low affinity receptor for nicotinic acid (niacin) [3] and is a member of the nicotinic acid receptor family of G protein-coupled receptors (the other identified member being GPR109A ). (f15ijp.com)
Cannabinoid receptor1
- [8] Later it was identified by an in silico screen as a putative cannabinoid receptor because of a similar amino acid sequence in the binding region. (wikipedia.org)
Ligands4
- The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters, and vary in size from small molecules to peptides to large proteins. (wikipedia.org)
- However, non-formylated peptide ligands have also been found for this receptor class. (harvard.edu)
- This profile as a distinct non-CB 1 /CB 2 receptor which responds to a variety of both endogenous and exogenous cannabinoid ligands has led some groups to suggest GPR55 should be categorised as the CB 3 receptor, and this re-classification may follow in time. (wikipedia.org)
- Few highly selective ligands are commercially available for the 5-HT 5A receptor. (wikipedia.org)
Orphan receptor2
- Evidence accumulated during the last few years suggests that GPR55 plays a relevant role in cancer and opens the possibility of considering this orphan receptor as a new therapeutic target and potential biomarker in oncology. (wikipedia.org)
- The gene product of GPR12 is an orphan receptor , meaning that its endogenous ligand is currently unknown. (wikidoc.org)
Molecular1
- New structures complemented with biochemical investigations uncovered mechanisms of action of molecular switches which modulate the structure of the receptor leading to activation states for agonists or to complete or partial inactivation states for inverse agonists. (wikipedia.org)
Affinity1
- GPR109B is a G i / G o protein-coupled receptor with low affinity for nicotinic acid. (f15ijp.com)
Subtype1
- Rodents have been shown to possess two functional 5-HT 5 receptor subtypes, 5-HT 5A and 5-HT 5B , [9] however while humans possess a gene coding for the 5-HT 5B subtype, its coding sequence is interrupted by stop codons, making the gene non-functional, and so only the 5-HT 5A subtype is expressed in human brain. (wikipedia.org)
Agonists1
- [5] [6] Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. (wikipedia.org)
Peptides1
- Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. (harvard.edu)
Humans4
- G protein-coupled receptor 55 also known as GPR55 is a G protein-coupled receptor that in humans is encoded by the GPR55 gene . (wikipedia.org)
- 5-Hydroxytryptamine (serotonin) receptor 5A , also known as HTR5A , is a protein that in humans is encoded by the HTR5A gene . (wikipedia.org)
- Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene . (wikidoc.org)
- Niacin receptor 2 , also known as NIACR2 or GPR109B , is a protein which in humans is encoded by the NIACR2 gene . (f15ijp.com)
Activate1
- Exocannabinoids such as the synthetic cannabinoid CP-55940 are also able to activate the receptor [12] while the structurally unrelated cannabinoid mimic WIN 55,212-2 fails to activate the receptor. (wikipedia.org)
Diseases1
- A knowledge graph of biological entities such as genes, gene functions, diseases, phenotypes and chemicals. (edu.sa)
Functional1
- [5] The 5-HT 5A receptor has been shown to be functional in a native expression system. (wikipedia.org)
Human1
- Research in a human being intestinal xenograft style of disease indicated that trophozoites which were transfected with an antisense plasmid towards the gene didn't induce intestinal epithelial cell creation from the inflammatory cytokines IL-1 and IL-8 and triggered considerably less intestinal swelling and injury (33). (cancer-ecosystem.com)
Mice2
- Mice with a target deletion of the GPR55 gene show no specific phenotype . (wikipedia.org)
- Gene disruption of GPR12 in mice results in dyslipidemia and obesity [4] . (wikidoc.org)
Type1
- Linkage study of the glucagon receptor gene with type 2 diabetes mellitus in Italians. (jefferson.edu)
Year1
- This graph shows the total number of publications written about "Receptors, Formyl Peptide" by people in Harvard Catalyst Profiles by year, and whether "Receptors, Formyl Peptide" was a major or minor topic of these publication. (harvard.edu)
Play1
- Calcium-sensing receptors in the PARATHYROID GLANDS play an important role in the maintenance of calcium HOMEOSTASIS by regulating the release of PARATHYROID HORMONE. (childrensmercy.org)