• patient controlle
  • In a double-blind, crossover study of post-Cesarian patients, plasma levels during EPIDURAL administration were about one-half that of the period during which patients received INTRAVENOUS patient controlled analgesia meperidine. (answers.com)
  • serum
  • Serum/CSF concentration ratios for both the parent and metabolite were 0.46 and 0.42, respectively, at 240 minutes (Boreus et al, 1983). (answers.com)
  • P450
  • In addition, discontinuation of a concomitantly used cytochrome P450 3A4 inducer may result in an increase in meperidine plasma concentration. (drugs.com)
  • The results of our experiments will help to predict clinically significant drug-drug interactions that may occur when drugs that alter P450 activity are coadministered with meperidine, affecting its pharmacological and toxicological properties. (aspetjournals.org)
  • drug
  • The FDA drug label carries a warning of the risk of serotonin syndrome when rasagiline is used with antidepressants or with meperidine. (wikipedia.org)
  • liver
  • After normalization by its relative abundance in human liver microsomes, CYP2B6, CYP3A4, and CYP2C19 accounted for 57, 28, and 15% of the total intrinsic clearance of meperidine. (aspetjournals.org)
  • effects
  • Buprenorphine Metabolites do not cause undesirable effects. (lineburg.ru)
  • metabolites accumulate, but have no heparin unwanted effects. (lineburg.ru)
  • citation needed] Use of hydroxyzine for premedication as a sedative has no effects on tropane alkaloids, such as atropine, but may, following general anesthesia, potentiate meperidine and barbiturates, and use in pre-anesthetic adjunctive therapy should be modified depending upon the state of the individual. (wikipedia.org)
  • found
  • d) Lower mean plasma levels of meperidine were found in patients using patient-controlled epidural analgesia than in patients using PCA delivered intravenously (Paech et al, 1994a). (answers.com)
  • plasma
  • a) Mean maximal plasma levels of 200 to 230 ng/mL were reached within 25 minutes after 100 mg meperidine intramuscular, persisting for 120 minutes (Boreus et al, 1983). (answers.com)
  • parent
  • 1) Following 100 mg intramuscular meperidine (equivalent to 87 mg base), parent compound was detected in CSF within 18 minutes (25 ng/mL), reaching a plateau within 90 minutes. (answers.com)