• Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)
  • Short-chain fatty acids (SCFAs) were also higher in the MD group, whereas lipid-metabolism-associated and amino acid compounds were higher in the WD group. (news-medical.net)
  • Rutin prevents experimental selenite-induced cataractogenesis in rat pups, possibly by preventing depletion of antioxidant enzymes and of GSH, and by inhibiting lipid peroxidation. (molvis.org)
  • Sub-chronic concomitant ingestion of L-arginine and monosodium glutamate improves feed efficiency, lipid metabolism and antioxidant capacity in male Wistar rats. (scialert.net)
  • Cardiovascular risks and impaired lipid metabolism in asymptomatic petroleum depot workers in Calabar Metropolis, Nigeria. (scialert.net)
  • Strong associations exist between branched chain amino acids (BCAA) and dysregulated glucose and lipid metabolism, but underlying mechanisms are not well understood. (diabetesjournals.org)
  • We studied the impact of modulating the activity of the BCKDH kinase (BDK) and phosphatase (PPM1K) on amino acid, glucose and lipid metabolism in Zucker fatty rats (ZFR). (diabetesjournals.org)
  • Together these studies reveal a novel regulatory function for BDK and PPM1K in integration of BCAA and lipid metabolism. (diabetesjournals.org)
  • We investigated a phospholipid-protein complex (PPC) from krill that is hypothesized to influence lipid metabolism, inflammation, and redox status. (uib.no)
  • The present data show that PPC has lipid-lowering effects in rats, and may modulate risk factors related to cardiovascular disease progression. (uib.no)
  • Sun B, Kudo M, Hayashi M, Qin LL, Wu LL, Liu TH, Gao M. YNCRG Alleviated Hepatic Steatosis in Metabolic Syndrome Model Rats by Improving Lipid Metabolism and Chronic Inflammatory Reaction. (lidsen.com)
  • We found that YNCRG can reduce the accumulation of lipids in the liver of rats with metabolic syndrome, probably by affecting lipid metabolism and the signaling pathway associated with inflammatory reactions. (lidsen.com)
  • Adequate design of juvenile toxicity studies in rats, for instance with respect to dose levels per age group, requires an understanding of age-dependent pharmacokinetics. (aspetjournals.org)
  • This age-dependent HPGL profile will be instrumental for hepatic drug clearance prediction when designing juvenile toxicity studies in Wistar rats. (aspetjournals.org)
  • These changes indicate that ethanol toxicity induces profound changes in explorative behavior, mediated, at least partly, by changes in the free radical metabolism. (nih.gov)
  • Thirteen-week inhalation toxicity of p -dichlorobenzene in mice and rats. (cdc.gov)
  • Carcinogenicity and chronic toxicity in mice and rats exposed by inhalation to para -dichlorobenzene for two years. (cdc.gov)
  • Coumarin was previously found to cause tissue-selective toxicity in the olfactory mucosa (OM) of rats and mice, with rats being the more sensitive species. (aspetjournals.org)
  • Thus, target tissue activation seems to play an important role in the tissue-selective toxicity, whereas differences in the rates of hepatic metabolism may be responsible for the species difference in olfactory toxicity. (aspetjournals.org)
  • To assess sub-acute oral toxicity of Acephate and its amelioration with Picrorhiza kurroa in female Wistar rats through haemato-biochemical studies. (ijlr.org)
  • The acute toxicity, carcinogenicity, and metabolism of sterigmatocystin has been compared with those for aflatoxin and several other hepatotoxic mycotoxins. (wikipedia.org)
  • Influence of L-arginine on the heart histology and function markers of metabolic syndrome in female Wistar albino rats. (scialert.net)
  • Alterations in the liver histology and markers of metabolic syndrome associated with inflammation and liver damage in L-arginine exposed female Wistar albino rats. (scialert.net)
  • 24 ] have also shown that 0.2% of G-rutin (a rutin-glucose derivative), given in a 20% casein diet for a period of one month to streptozotocin-induced diabetic rats, decreased thiobarbituric acid reactive substance (TBARS) in kidneys. (molvis.org)
  • Here we show that PNN abundance within the Arc is markedly reduced in the Zucker diabetic fatty (ZDF) rat model of T2D, compared with normoglycaemic rats, correlating with altered PNN-associated sulfation patterns of chondroitin sulfate glycosaminoglycans in the MBH. (nature.com)
  • This study investigates the effect of stevia on serum omentin and visfatin levels as novel adipocytokines in diabetic induced rats to find potential mechanisms for the anti hyperglycemic effect of stevia. (researchgate.net)
  • Rats in group 1 (non-diabetic control) and group 2 (diabetic control) were treated with distilled water, and the rats in the treated groups, group 3 (T250), group 4 (T500), and group 5 (T750) were treated with stevia, gavaged every day at 9 a.m. in doses of 250, 500, and 750 mg/kg, respectively. (researchgate.net)
  • The conclusion is that prescription of stevia in the doses of 250 and 500 mg/kg/d decreases the omentin level indirectly via activating insulin sensitivity and lowering blood glucose in STZ-induced diabetic rats. (researchgate.net)
  • Diabetic GK rats and control animals were randomly assigned to receive E4 or vehicle by intravitreal injection. (molvis.org)
  • The purpose of this study was to examine the effects of aerobic training on serum RBP4 levels and insulin resistance index in type 2 diabetic male rats. (ac.ir)
  • Five days after inducing diabetes, fasting blood was measured using blood glucose strips and rats that the level of fasting blood glucose was between 400-126 mg was selected as diabetic. (ac.ir)
  • The rates of metabolic activation of coumarin, as indicated by the formation of o -HPA, were comparable in OM microsomes of the two species but about 25- and 3-fold higher in OM than in liver microsomes of rats and mice, respectively. (aspetjournals.org)
  • The purpose of the present study was to clarify the species differences between mice and rats in UGT activities using duodenal and liver microsomes. (aspetjournals.org)
  • In male liver, the CL int values for 4-NP O -, propofol O -, MPA O -, and morphine 3- O -glucuronidation and the CL max value for 4-methylumbelliferone O -glucuronidation in mice were higher than those in rats. (aspetjournals.org)
  • Liver and intestine are the important tissues for drug metabolism including glucuronidation. (aspetjournals.org)
  • Furthermore, adenovirus-mediated overexpression of BDK increased ACL phosphorylation and activated de novo lipogenesis in liver of lean Wistar rats. (diabetesjournals.org)
  • We studied its effects and mechanism of action on a rat model of non-alcoholic fatty liver with metabolic syndrome. (lidsen.com)
  • citation needed] Chronic symptoms include induction of hepatomas in rats, pulmonary tumours in mice, renal lesions and alterations in the liver and kidneys of African Green monkeys. (wikipedia.org)
  • Rats fed 5-10 mg/kg of sterigmatocystin for two years showed a 90% incidence of liver tumours. (wikipedia.org)
  • Comparative metabolism study of ß-lapachone in mouse, rat, dog, monkey, and human liver microsomes using liquid chromatography-tandem mass spectrometry. (medlineplus.gov)
  • This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
  • The experimental rats were divided into 5 groups each comprising of 6 rats. (ijlr.org)
  • In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy. (scielo.br)
  • Methods Hearts from male Wistar rats (320-360 g) were isolated and perfused with buffer to alter the glycogen content, before perfusion with either 11 mM glucose or 11 mM glucose plus 4 mM βHB. (bmj.com)
  • We examined the effects of taurine supplementation on outcomes related to growth and metabolism in offspring in a rat model of maternal obesity. (mcmaster.ca)
  • Hepatic uptake of a modified low molecular weight heparin in rats. (jci.org)
  • Skin and hepatic tumours are induced in rats by dermal application. (wikipedia.org)
  • Randomização de 32 ratos Wistar machos em quatro grupos: Controle (CG), Exposição à Fumaça (ESG), Antioxidante (AG) e Exposição à Fumaça+Antioxidante (ESAG). (bvsalud.org)
  • Plasma kinetics were investigated in order to determine the pharmacokinetic parameters of the test substances in rats. (europa.eu)
  • There were significant differences in the rates and metabolite profiles of coumarin metabolism in the livers of Wistar rats and C57BL/6 mice. (aspetjournals.org)
  • The results of the Western blotting assay showed that YNCRG did not affect the AMPK/ACC signaling pathway, but it strongly promoted the phosphorylation of PKA, ERK, and C/EBPβ in rat livers. (lidsen.com)
  • Male Wistar rats were randomized into four groups: Control Group (CG), Exposure to Smoke Group (ESG), Antioxidant Group (AG) and Exposure to Smoke plus Antioxidant Group (ESAG). (bvsalud.org)
  • There is little information on species differences between mice and rats in UGT activities, especially in intestine. (aspetjournals.org)
  • For 4-nitrophenol (4-NP) O -glucuronidation, the K m values were different between mice and rats. (aspetjournals.org)
  • Which UGT enzyme in mice and rats corresponds to human UGT enzyme is controversial. (aspetjournals.org)
  • Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model. (scielo.br)
  • Safety of SGLT2i with regard to bone and mineral metabolism. (lww.com)
  • Emerging evidence suggests that SGLT2i may also affect bone and mineral metabolism. (lww.com)
  • This review analyzes recent evidence on the safety of SGLT2i with respect to bone and mineral metabolism in people with CKD, and discusses potential underlying mechanisms and clinical implications. (lww.com)
  • Although SGLT2i are associated with abnormalities of bone and mineral metabolism, they have not been linked to a higher risk of fracture among patients with CKD. (lww.com)
  • The deleterious effects of long-term cyclosporine A, cyclosporine G, and FK506 on bone mineral metabolism in vivo. (bvsalud.org)
  • Application of PBM to the recipient site before and after fat transfer improved outcomes in rats at 56 day after fat grafting by means of volume retention, increased neovascularization and adipocyte viability and reduced necrosis, fibrosis and inflammation. (google.com)
  • Sub-chronic oral esculetin (6, 7-dihydroxy-coumarin) exposure in male Wistar rats: Effect on some serum functions and organ histology. (scialert.net)
  • Effect of L-arginine on some biochemical markers of metabolic syndrome associated with brain function in female Wistar rats. (scialert.net)
  • Effect of L-arginine on some anthropometric parameters of metabolic syndrome in normal female Wistar rats. (scialert.net)
  • Rats consuming a liquid diet containing 7% ethanol for 4, 7, 14, or 21 days exhibited a significantly decreased ambulation activity, accompanied by a reduced frequency and duration of explorative rearing in an open-field task 4, 7, and 14 days after chronic ethanol ingestion, whereas presumed adaptation to the neurologic effects of ethanol was observed on day 21. (nih.gov)
  • The present study aimed at investigating the effects of curcumin on the motor coordination and the estimate of the total number of cerebellar Purkinje cells of adolescent Wistar rats exposed to ethanol. (jcimjournal.com)
  • The total of 21 male Wistar rats aged 37 d old were divided into three groups, namely ethanol, ethanol-curcumin, and control groups. (jcimjournal.com)
  • Curcumin may exert beneficial effects on the motor coordination of adolescent rats exposed to ethanol via undetermined hormetic mechanisms. (jcimjournal.com)
  • Therefore, interactions between the host and a reductionist microbiota are non-uniform over the circadian cycle, revealing a promising tool to identify key microbiota species/functions that modify host metabolism. (biorxiv.org)
  • Sub-chronic esculetin (6,7-Dihydroxy-Coumarin)-induced alteration in some haematological and serum parameters in normal male Wistar rats. (scialert.net)
  • After eight weeks of intervention, YNCRG effectively reduced the weight of rats and significantly reduced the serum levels of AST, ALT, CHO, and TG compared to the weight of the rats in the control group. (lidsen.com)
  • Embryonic knockdown of the function of homologs of these genes in rat neocortical projection cell progenitors by in utero electroporation of plasmids encoding small hairpin RNA (shRNA) revealed that all three genes disrupted neuronal migration to the neocortex. (nih.gov)
  • Recently the Styrene Information and Re- search Center (SIRC) conducted subchronic and chronic inhalation studies exposing both rats and mice to various concentrations of ST. No evidence of treatment-related increases in any type of tumor was observed in rats, com- pared to controls, at the end of the 2-yr inhalation study (Cruzan et al. (cdc.gov)
  • Fig. 2: T2D-ZDF rats exhibit abnormal hypothalamic CS/DS-GAG sulfation patterns. (nature.com)
  • Each of these PNN-associated changes is reversed following a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) at a dose that induces sustained diabetes remission in male ZDF rats. (nature.com)
  • Forty male wistar rats weighing 180-250 g were induced with diabetes by intraperitoneal injection of streptozotocin (STZ). (researchgate.net)
  • While the link between metabolism and aging is well known, the work of Guo and García offers insights into some of the molecular mechanisms that may form the basis of this relationship. (elifesciences.org)
  • An experimental trial on subacute toxico-pathological studies of Acephate and its amelioration by Picrorhiza kurroa was attempted in thirty female Wistar rats for 28 days through haemato-biochemical assessment. (ijlr.org)
  • Dose of Acephate was calculated as 1/20th of LD 50 (1127mg/kg) which was in powder form and mixed with propylene glycol as a vehicle and fed daily through oral gavage to the experimental rats. (ijlr.org)
  • On postpartum day ten, Group I rat pups received an intraperitoneal injection of saline. (molvis.org)
  • Twenty male Wistar rats were divided into 2 groups: Group 1 (rats treated with FK506) and Group 2(rats treated with saline solution vehicle). (bvsalud.org)
  • We examined the pharmacokinetics of the compound by intravenous injection of 131I-tyramine-heparin into Wistar rats. (jci.org)
  • To further investigate this hypothesis an adenine-induced model of CKD was used in male wistar rats. (uwo.ca)
  • RePub, Erasmus University Repository: Pulmonary surfactant protein A, B, and C mRNA and protein expression in the nitrofen-induced congenital diaphragmatic hernia rat model. (eur.nl)
  • We investigated this hypothesis in the nitrofen-induced CDH rat model and assessed the cellular concentrations of surfactant protein (SP)-A, -B, and -C mRNA with a quantitative radioactive in situ hybridization technique. (eur.nl)
  • We conclude that there is no primary deficiency of surfactant proteins in the nitrofen-induced CDH rat model. (eur.nl)
  • To test the hypothesis that bone quality may affect the stability of anchorage devices implanted in a rat model. (bvsalud.org)
  • Orthodontic mini-implants did not present good primary stability in a rat model with osteopenia. (bvsalud.org)
  • Fig. 3: Effect of a single icv FGF1 injection on Arc PNN assembly and composition in ZDF rats. (nature.com)
  • Quality Assessment of Waterside River, Ogbor Hill Aba 3: Effect of Three-Point Samples on Kidney Histo-architecture and Some Seric Bio-functional Indicators of Wistar Rats Res. (scialert.net)
  • Our findings evidenced the cardioprotective effect of trans- resveratrol in rats exposed to cigarette smoke. (bvsalud.org)
  • To characterize the change(s) in mRNA and protein expression of SIRT1-7 and their associated proteins in the brain of "physiologically" aged Wistar rats. (frontiersin.org)
  • We tested mRNA and protein expression levels of rat SIRT1-7, and the levels of associated proteins in the brain using RT-PCR and western blotting. (frontiersin.org)
  • E4 significantly prevented the reduction of the b-wave and oscillatory potential amplitudes and retinal cell loss and maintained the Bcl-2/Bax and Bcl-xL/Bax ratio balances in GK rats. (molvis.org)
  • 0.001) for rat pups until 3 weeks of age compared with adults. (aspetjournals.org)
  • To investigate whether rutin retards selenite-induced cataractogenesis in Wistar rat pups. (molvis.org)
  • Group II and III rat pups received a subcutaneous injection of sodium selenite. (molvis.org)
  • In the first experiment, 62% (15/24) of 6-OHDA pre-treated rats and 45% (11/24) of those receiving ascorbic acid as control solution progressed to motor limbic seizures evolving to SE, after the administration of pilocarpine. (scielo.br)
  • Male Wistar rats were fed a control diet (2% soy oil, 8% lard, 20% casein), or diets where corresponding amounts of casein and lard were replaced with PPC at 3%, 6%, or 11% (wt %), for four weeks. (uib.no)
  • Eight-week-old male SHRcp rat(s) and Wister Kyoto (WKY) rats were adaptively fed for one week, after which they were randomly divided into three groups, including the control group (n = 9), the YNCRG group (n = 8), and the WKY group (n = 8). (lidsen.com)
  • Rats were randomly and According to homogenization of body weight assigned into two groups including control (n=9) and trained (n=9).Rats in the training groups carried out an 8-week exercise program on a motorized treadmill with 10-25 m/min for 15-40 min/day and a 5% slope for 5 days. (ac.ir)
  • The present work profiles the hepatocellularity number in male Wistar rats as a function of age. (aspetjournals.org)
  • When you prepare green tea the right way , the antioxidants help protect the cells, which function normally and keep your metabolism going. (stylecraze.com)
  • 1992. The differential hepatotoxicity and cytochrome P450 responses of Fischer-344 rats to the three isomers of dichlorobenzene. (cdc.gov)