• metabolite of ethanol
  • Xiaolei Shi, Dan Yao, Chi Chen (2012-02-24), "Identification of N-Acetyltaurine as a Novel Metabolite of Ethanol through Metabolomics-guided Biochemical Analysis" (in English), Journal of Biological Chemistry 287 (9): pp. 6336-6349, doi:10.1074/jbc.m111.312199, ISSN 0021-9258, PMID 22228769, http://www.jbc.org/content/287/9/6336. (wikipedia.org)
  • rats
  • One high affinity site [ K m = 19 ± 5 (SD) µ m ] and one low affinity site [K m = 0.3 ± 0.1 m m ] for benzene metabolism were present in microsomes of acetone-treated rats, and similar sites were seen in microsomes from control or ethanol-treated rats. (aacrjournals.org)
  • This spin adduct was proven to be the 1-hydroxyethyl radical adduct of POBN through injection of [1-13C]ethanol to rats, which resulted in the presence of an adduct with a 12-line EPR spectrum. (aspetjournals.org)
  • Intake of ethanol by rats, at a dose of 10 to 12 g/kg daily for two weeks, led to a slower onset and shorter duration of pentobarbital-induced sleep (30 mg/kg i.p.) than in pair-fed controls with isocaloric substitution of sucrose for ethanol. (aspetjournals.org)
  • R)-Salsolinol which has been shown to be a product of ethanol metabolism, stereospecifically induces behavioral sensitization and leads to excessive alcohol intake in rats 6-Hydroxydopamine MPTP Rotenone Maruyama W, Takahashi T, Minami M, Takahashi A, Dostert P, Nagatsu T, Naoi M (1993). (wikipedia.org)
  • fatty
  • Such a functionality is needed because all organisms actually produce alcohol in small amounts by several pathways, primarily along the fatty acid synthesis, glycerolipid metabolism, and bile acid biosynthesis pathways. (wikipedia.org)
  • decreases
  • Ethanol decreases the clearance of cocaine by inhibiting the hydrolysis of cocaine to benzoylecgonine and ecgonine methyl ester by carboxylesterases, and there is a large body of literature describing this interaction as it relates to the abuse of cocaine. (aspetjournals.org)
  • Ethanol decreases excretion of uric acid by promoting dehydration and (rarely) clinical ketoacidosis. (wikipedia.org)
  • molecule
  • It is also important to note that step 1 on this reaction is endothermic, requiring 47.2 kJ/mol of alcohol, or about 3 molecules of ATP (adenosine triphosphate) per molecule of ethanol. (wikipedia.org)
  • A hydrogen ion protonates the electronegative oxygen atom of the ethanol, giving the ethanol molecule a positive charge: CH3CH2OH + H3O+ → CH3CH2OH2+ + H2O A nucleophilic oxygen atom of unprotonated ethanol displaces a water molecule from the protonated (electrophilic) ethanol molecule, producing water, a hydrogen ion and diethyl ether. (wikipedia.org)
  • inhibition
  • Thus, in addition to reducing ethanol action on the GlyRs, these mutations reduced glycinergic inhibition, which may also alter sensitivity to GABAergic drugs. (aspetjournals.org)
  • MEOS
  • As the concentration of ethanol increases above 100 mg/dL, there is increased contribution from the MEOS system, which does not rely upon NAD + as a cofactor. (diff.org)
  • The increase in rest energy expenditure has, according to some studies, been explained by indicating that the MEOS "expends" nine calories per gram of ethanol to metabolize versus 7 calories per gram of ethanol ingested. (wikipedia.org)
  • allele
  • When individuals with this allele consume ethanol chronically, a significant increased risk for upper alimentary tract and colorectal cancer is noted. (biomedcentral.com)
  • thus
  • Catabolic degradation of ethanol is thus essential to life, not only of humans, but of almost all living organisms. (wikipedia.org)
  • significance
  • The clinical significance of the interaction of ethanol with specific drugs subject to carboxylesterase hydrolysis is not well recognized and has not been adequately studied. (aspetjournals.org)
  • produces
  • The average human digestive system produces approximately 3g of ethanol per day merely through fermentation of its contents. (wikipedia.org)
  • substrate
  • Cocaine, which is a high-extraction drug, should demonstrate route-dependent disposition and would therefore be an excellent model substrate for the effect of ethanol on carboxylesterase-mediated hydrolysis of orally administered drugs. (aspetjournals.org)
  • carbohydrates
  • Softened metabolism of carbohydrates in human body ppt Ansell moseyed Agatha surlily fortes. (8338.tk)
  • Endogenous aldehydes are generated during the metabolism of amino acids, carbohydrates, lipids, and vitamins as well as the biotransformation of many drugs and environmental chemicals [ 10 , 13 - 15 ]. (hindawi.com)
  • yields
  • the production of methylglyoxal and its further metabolism yields L-(+)-lactate and D-(-)-lactate, while deletion of the MGS gene leads to observation of optically pure D-(-)-lactate. (wikipedia.org)
  • concentration
  • Major applications of drug testing include detection of the presence of performance enhancing steroids in sport, employers and parole/probation officers screening for drugs prohibited by law (such as cannabis, cocaine, methamphetamine, and heroin) and police officers testing for the presence and concentration of alcohol (ethanol) in the blood commonly referred to as BAC (blood alcohol content). (wikipedia.org)