Drug DesignDrug Delivery SystemsModels, MolecularComputer-Aided DesignDelivery, ObstetricEnergy MetabolismLipid MetabolismCrystallography, X-RayMolecular Docking SimulationLigandsStructure-Activity RelationshipBinding SitesProtein ConformationQuantitative Structure-Activity RelationshipMolecular StructureDrug DiscoveryProtein BindingMolecular Sequence DataAmino Acid SequenceResearch DesignPharmaceutical PreparationsCystine Knot MotifsMolecular ConformationPregnancyTime FactorsDrug Evaluation, PreclinicalProteinsKineticsProtein Structure, TertiaryComputer SimulationMetabolismCatalytic DomainMolecular Dynamics SimulationGlucoseChemistry, PharmaceuticalEnzyme InhibitorsDrug CarriersModels, BiologicalHydrogen BondingLiverAlgorithmsStructural Homology, ProteinDose-Response Relationship, DrugMagnetic Resonance SpectroscopyCystine-Knot MiniproteinsModels, ChemicalAntineoplastic AgentsComputational BiologyProtein Structure, SecondarySmall Molecule LibrariesNeoplasmsTreatment OutcomeThermodynamicsCyclotidesEquipment DesignSubstrate SpecificityCesarean SectionNanoparticlesAdministration, OralMutationDelivery of Health CareMetabolic Networks and PathwaysSoftwareGene Transfer TechniquesRecombinant ProteinsOxidation-ReductionPeptidesSequence Homology, Amino AcidCell Line, TumorDatabases, PharmaceuticalBiotransformationSignal TransductionProspective StudiesInfant, NewbornEnzymesCell LineDatabases, ProteinCells, CulturedDouble-Blind MethodHydrophobic and Hydrophilic InteractionsGenetic TherapyBoranesInhibitory Concentration 50Chromatography, High Pressure LiquidGenetic VectorsSequence AlignmentLactic AcidCytochrome P-450 Enzyme SystemDelayed-Action PreparationsNuclear Magnetic Resonance, BiomolecularCrystallizationLipoxygenasesRats, Sprague-DawleyProdrugsMicrosomes, LiverInformaticsStereoisomerismDrug-Related Side Effects and Adverse ReactionsAntiviral AgentsHeterocyclic Compounds, 2-Ring