• specification
  • The exact developmental pathways that guide the specification of different cell types within the mesoderm are not well understood. (biologists.org)
  • We show that partial restoration of Tbx6 expression in null mutants rescues somite development, but that rostrocaudal patterning within them is defective, ultimately resulting in rib and vertebral fusions, demonstrating that Tbx6 activity in the paraxial mesoderm is required not simply for somite specification but also for their normal patterning. (biologists.org)
  • Functional studies have demonstrated that several T-box genes are involved in mesoderm specification in the developing embryo of mouse or Xenopus. (wikipedia.org)